Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6116-6120

  Kobayashi, Yutaka ^a   Ichioka, Maki ^a   Hirose, Tomoyasu ^a   Nagai, Kenichiro ^a   Matsumoto, Atsuko ^a   Matsui, Hidehiro ^a   Hanaki, Hideaki ^a   Masuma, Rokuro ^a   Takahashi, Yoko ^a   Omura, Satoshi ^a   Sunazuka, Toshiaki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Anti MRSA and anti VRE agent; Bottromycin; Metabolite stability; Natural product

Indexed keywords

BOTTROMYCIN A2; ESTER; HYDRAZIDE DERIVATIVE; KETONE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; PROPANE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; DRUG RESISTANCE; IN VITRO STUDY; MASS SPECTROMETRY; METABOLITE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCACEAE; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; PEPTIDES, CYCLIC; PLASMA; VANCOMYCIN;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA;

EID: 77956922344     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.037     Document Type: Article

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