Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats

Pathology

Volumn 42, Issue 6, 2010, Pages 564-573

  Kaneyama, Tomoki ^a   Kobayashi, Satoshi ^b   Aoyagi, Daiju ^a   Ehara, Takashi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

EMT; Epithelial mesenchymal transition; Fibrosis; Heparan sulfate; Tranilast; Unilateral ureteral obstruction; UUO

Indexed keywords

EID: 77956917268     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.3109/00313025.2010.508784     Document Type: Article

References (31)

1. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210.
2. Gao X, Mae H, Ayabe N, et al. Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy. Kidney Int 2002; 62: 1238-1248
3. Wu MJ, Wen MC, Chiu YT, et al. Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis. Kidney Int 2006; 69: 2029-2036
4. Yang J, Liu Y. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 2002; 13: 96-107.
5. Iwano M, Plieth D, Danoff TM, et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341-350
6. Potenta S, Zeisberg E, Kalluri R. The role of endothelial-tomesenchymal transition in cancer progression. Br J Cancer 2008; 99: 1375-1379
7. Zeisberg EM, Potenta SE, Sugimoto H, et al. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008; 19: 2282-2287
8. Le Hir M, Hegyi I, Cueni-Loffing D, et al. Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem Cell Biol 2005; 123: 335-346
9. Picard N, Baum O, Vogetseder A, et al. Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem Cell Biol 2008; 130: 141-155
10. Lin SL, Kisseleva T, Brenner DA, et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627
11. Yoshino J, Monkawa T, Tsuji M, et al. Snail1 is involved in the renal epithelial-mesenchymal transition. Biochem Biophys Res Commun 2007; 362: 63-68
12. Klymkowsky MW, Savagner P. Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol 2009; 174: 1588-1593
13. Nishigaki T. Mast cell degranulation and its inhibition by an antiallergic agent tranilast. An electron microscopic study. Virchows Arch B Cell Pathol Incl Mol Pathol 1988; 55: 311-322
14. Taniguchi S, Yorifuji T, Hamada T. Treatment of linear localized scleroderma with the anti-allergic drug, tranilast. Clin Exp Dermatol 1994; 19: 391-393
15. Akahori H, Ota T, Torita M, et al. Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression. J Pharmacol Exp Ther 2005; 314: 514-521
16. Kelly DJ, Zhang Y, Gow R, et al. Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model. J Am Soc Nephrol 2004; 15: 2619-2629
17. Mifsud S, Kelly DJ, Qi W, et al. Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. Nephron Physiol 2003; 95: 83-91.
18. Miyajima A, Asano T, Asano T, et al. Tranilast ameliorates renal tubular damage in unilateral ureteral obstruction. J Urol 2001; 165: 1714-1718 (Pubitemid 32410295)
19. Soma J, Sato K, Saito H, et al. Effect of tranilast in early-stage diabetic nephropathy. Nephrol Dial Transplant 2006; 21: 2795-2799
20. Prud'homme GJ, Pathobiology of transforming growth factor b in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab Invest 2007; 87: 1077-1091
21. Qi W, Chen X, Twigg S, et al. Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney Int 2006; 69: 989-995
22. Chakrabarti R, Subramaniam V, Abdalla S, et al. Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 2009; 20: 334-345
23. Docherty NG, Calvo IF, Quinlan MR, et al. Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction. Kidney Int 2009; 75: 205-213
24. Duffield JS. The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci (Lond) 2003; 104: 27-38.
25. Broekema M, Harmsen MC, van Luyn MJ, et al. Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J Am Soc Nephrol 2007; 18: 165-175
26. Kure S, Yoshie O. A syngeneic monoclonal antibody to murine Meth- A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1. J Immunol 1986; 137: 3900-3908
27. Lamanna WC, Frese MA, Balleininger M, et al. Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. J Biol Chem 2008; 283: 27724-27735
28. Roussoulieres A, McGregor B, Chalabreysse L, et al. Expression of VE-cadherin in peritubular endothelial cells during acute rejection after human renal transplantation. J Biomed Biotechnol 2007; 2007: 41705.
29. Sutton TA, Fisher CJ, Molitoris BA. Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int 2002; 62: 1539-1549
30. Ohashi R, Shimizu A, Masuda Y, et al. Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol 2002; 13: 1795-1805
31. Isaji M, Miyata H, Ajisawa Y, et al. Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)- induced increase in vascular permeability in rats. Life Sci 1998; 63: PL71-4.