Novel 3D porous multi-phase composite scaffolds based on PCL, thermoplastic zein and ha prepared via supercritical CO2 foaming for bone regeneration

Composites Science and Technology

Volumn 70, Issue 13, 2010, Pages 1838-1846

  Salerno, Aurelio ^a,b   Zeppetelli, Stefania ^b   Maio, Ernesto Di ^c   Iannace, Salvatore ^b   Netti, Paolo A ^a,c  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

A. Functional composite; B. Mechanical properties; Bone scaffold; D. Scanning electron microscopy

Indexed keywords

B. MECHANICAL PROPERTIES; BIODEGRADABLE POROUS SCAFFOLDS; BONE REGENERATION; BONE SCAFFOLD; BONE TISSUE ENGINEERING; CAPROLACTONE; FOAMING PROCESS; FOAMING TECHNOLOGY; FOAMING TEMPERATURE; FUNCTIONAL COMPOSITES; HUMAN MESENCHYMAL STEM CELLS (HMSCS); HYDROXYAPATITE PARTICLES; IN-VITRO; MICRO-STRUCTURAL; MULTIPHASE COMPOSITES; POROSITY AND PORE SIZE; POROUS SCAFFOLD; POROUS STRUCTURES; SCANNING ELECTRONS; SUPERCRITICAL CO;

BIOCOMPATIBILITY; BIODEGRADATION; BIOMECHANICS; BONE; CELL CULTURE; HYDROXYAPATITE; MECHANICAL PROPERTIES; PORE SIZE; REINFORCED PLASTICS; SCANNING ELECTRON MICROSCOPY; STEM CELLS; TISSUE ENGINEERING;

SCAFFOLDS;

EID: 77956912824     PISSN: 02663538     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compscitech.2010.06.014     Document Type: Article

References (32)

1. Hutmacher D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21(24):2529-2543.
2. Salgado A.J., Coutinho O.P., Reis R.L. Bone tissue engineering: state of the art and future trends. Macromol Biosci 2004, 4(8):743-765.
3. Burg K.J.L., Porter S., Kellam J.F. Biomaterial developments for bone tissue engineering. Biomaterials 2000, 21(23):2347-2359.
4. Petrie Aronin C.E., Sadik K.W., Lay A.L., Rion D.B., Tholpady S.S., Ogle R.C., et al. Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds. J Biomed Mater Res Part A 2009, 89(3):632-641.
5. Leong K.F., Chua C.K., Sudarmadji N., Yeong W.Y. Engineering functionally graded tissue engineering scaffolds. J Mech Behav Biomed Mater 2008, S1:140-152.
6. Karageorgiou V., Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005, 26(27):5474-5491.
7. Hollister S.J. Porous scaffold design for tissue engineering. Nature Mater 2005, 4(7):518-524.
8. Kim H., Knowles J.C., Kim H. Hydroxyapatite and gelatin composite foams processed via novel freeze-drying and crosslinking for use as temporary hard tissue scaffolds. J Biomed Mater Res 2005, 72A(2):136-145.
9. Gong S., Wang H., Sun Q., Xue S., Wang J. Mechanical properties and in vitro biocompatibility of porous zein scaffolds. Biomaterials 2006, 27(20):3793-3799.
10. Qu Z., Wang H., Tang T., Zhang X., Wang J., Dai K. Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation. Acta Biomat 2008, 4(5):1360-1368.
11. Kim S., Ahn K., Park M.S., Lee J., Choi C.Y., Kim B. A poly(lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity. J Biomed Mater Res 2007, 80A(1):206-215.
12. Murugan R., Ramakrishna S. Development of nanocomposites for bone grafting. Compos Sci Technol 2005, 65(15-16):2385-2406.
13. She H., Xiao X., Liu R. Preparation and characterization of polycaprolactone-chitosan composites for tissue engineering applications. J Mater Sci 2007, 42(19):8113-8119.
14. Rosa D.S., Lopes D.R., Calil M.R. Thermal properties and enzymatic degradation of blends of poly(3-caprolactone) with starches. Polym Test 2005, 24(6):756-761.
15. Tu J., Wang H., Li H., Dai K., Wang J., Zhang X. The in vivo bone formation by mesenchymal stem cells in zein scaffolds. Biomaterials 2009, 30(26):4369-4376.
16. Mathieu L., Bourban P., Månson J. Processing of homogeneous ceramic/polymer blends for bioresorbable composites. Compos Sci Technol 2006, 66(11-12):1606-1614.
17. Tai H., Mather M.L., Howard D., Wang W., White L.J., Crowe J.A., et al. Control of pore size and structure of tissue engineering scaffolds produced by supercritical fluid processing. Eur Cells Mater 2007, 14:64-77.
18. 2 in the fabrication of polymer systems for drug delivery and tissue engineering. Adv Drug Deliv Rev 2008, 60(3):373-387.
19. 2 injection system for the production of polymer/mammalian cell composites. J Supercr Fluids 2008, 43(3):535-541.
20. Salerno A., Oliviero M., Di Maio E., Iannace S., Netti P.A. Design of porous polymeric scaffolds by gas foaming of heterogeneous blends. J Mater Sci: Mater Med 2009, 20(10):2043-2051.
21. Salerno A., Oliviero M., Di Maio E., Iannace S. Thermoplastic foams from gelatin and zein. Int Polym Proc 2007, 5:480-488.
22. Joubert C., Cassagnau P., Michel A. Influence of the processing conditions on a two-phase reactive blend system: EVA/PP thermoplastic vulcanizate. Polym Eng Sci 2002, 42(11):2222-2233.
23. Sessa D.J., Mohamed A., Byars J.A. Chemistry and physical properties of melt-processed and solution-cross-linked corn zein. J Agric Food Chem 2008, 56:7067-7075.
24. Mariani P.D.S.C., Allganer K., Oliveira F.B., Cardoso E.J.B.N., Innocentini-Mei L.H. Effect of soy protein isolate on the thermal, mechanical and morphological properties of poly(3-caprolactone) and corn starch blends. Polym Test 2009, 28:824-829.
25. Salerno A., Di Maio E., Iannace S., Netti P.A. Engineering of foamed structures for biomedical applications. J Cell Plast 2009, 45(2):103-117.
26. Doroudiani S., Kortschot M.T. Polystyrene foams. I. Processing-structure relationships. J Appl Polym Sci 2003, 90(5):1412-1420.
27. Salerno A., Iannace S., Netti P.A. Open-pore biodegradable foams prepared via gas foaming and microparticulate templating. Macromol Biosci 2008, 8(7):655-664.
28. 2. J Mater Sci: Mater Med 2008, 19(4):1497-1502.
29. Gibson L.J., Ashby M.F. The mechanics of foams: basic results. Cellular solids 1997, 175-217. Cambridge. D.R. Clarke, S. Suresh, I.M. Ward (Eds.).
30. Shor L., Güçeri S., Wen X., Gandhi M., Sun W. Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro. Biomaterials 2007, 28(35):5291-5297.
31. Yao C., Li X., Song T., Li Y., Pu Y. Biodegradable nanofibrous membrane of zein/silk fibroin by electrospinning. Polym Int 2009, 58(4):396-402.
32. Chastain S.R., Kundu A.K., Dhar S., Calvert J.W., Putnam A.J. Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation. J Biom Mater Res Part A 2006, 78A(1):73-85.