Morphological characteristics of modified freeze-dried poly(N-isopropylacrylamide) microspheres studied by optical microscopy, SEM, and DLS

Chemical Papers

Volumn 64, Issue 5, 2010, Pages 602-612

  Musial, Witold ^a,b   Vincent, Brian ^c   Szumny, Antoni ^d   Voncina, Bojana ^a  

^a UNIVERSITY OF MARIBOR   (Slovenia)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

microsphere; morphology; N isopropylacrylamide; scanning electron microscopy; surface; thermosensitivity

Indexed keywords

EID: 77956897645     PISSN: 03666352     EISSN: 13369075     Source Type: Journal    
DOI: 10.2478/s11696-010-0041-7     Document Type: Article

References (56)

1. Brown, B. N., Barnes, C. A., Kasick, R. T., Michel, R., Gilbert, T. W., Beer-Stolz, D., Castner, D. G., Ratner, B. D., & Badylak, S. F. (2009). Surface characterization of extracellular matrix scaffolds. Biomaterials, 3, 428-437. DOI: 10. 1016/j. biomaterials. 2009. 09. 061.
2. Castanheira, E. M. S., Martinho, J. M. G., Duracher, D., Charreyre, M. T., Elaïssari, A., & Pichot, C. (1999). Study of cationic N-isopropylacrylamide-styrene copolymer latex particles using fluorescent probes. Langmuir, 15, 6712-6717. DOI: 10. 1021/la990130p.
3. Chen, G., McCarley, R. L., Soper, S. A., Situma, C., & Bolivar, J. G. (2007). Functional template-derived poly(methyl methacrylate) nanopillars for solid-phase biological reactions. Chemistry of Materials, 19, 3855-3857. DOI: 10. 1021/cm0702870.
4. Chen, J.-P., & Chiu, S.-H. (2000). A poly(N-isopropylacrylamide-co-N-acryloxysuccinimide-co-2-hydroxyethyl methacrylate) composite hydrogel membrane for urease immobilization to enhance urea hydrolysis rate by temperature swing. Enzyme and Microbial Technology, 265, 359-367. DOI: 10. 1016/S0141-0229(99)00181-7.
5. Chung, J. E., Yokoyama, M., Aoyagi, T., Sakurai, Y., & Okano, T. (1998). Effect of molecular architecture of hydrophobically modified poly(N-isopropylacrylamide) on the formation of thermoresponsive core-shell micellar drug carriers. Journal of Controlled Release, 53, 119-130. DOI: 10. 1016/S0168-3659(97)00244-7.
6. Coates, J. (2000). Interpretation of infrared spectra, a practical approach. In R. A. Meyers (Ed.), Encyclopedia of analytical chemistry (pp. 10815-10837). Chichester, UK: Wiley.
7. Coughlan, D. C., & Corrigan, O. I. (2006). Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems. International Journal of Pharmaceutics, 313, 163-174. DOI: 10. 1016/j. ijpharm. 2006. 02. 005.
8. Delair, T., Meunier, F., Elaïssari, A., Charles, M.-H., & Pichot, C. (1999). Amino-containing cationic latex-oligodeoxyribonucleotide conjugates: application to diagnostic test sensitivity enhancement. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 153, 341-353. DOI: 10. 1016/S0927-7757(98)00456-7.
9. Dudek, M. J., & Ponder, J. W. (1995). Accurate modeling of the intramolecular electrostatic energy of proteins. Journal of Computational Chemistry, 16, 791-816. DOI: 10. 1002/jcc. 540160702.
10. Eke, I., Elmas, B., Tuncel, M., & Tuncel, A. (2006). A new, highly stable cationic-thermosensitive microgel: Uniform isopropylacrylamide-dimethylaminopropylmethacrylamide copolymer particles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 279, 247-253. DOI: 10. 1016/j. colsurfa. 2006. 01. 011.
11. Elaïssari, A., & Bourrel, V. (2001). Thermosensitive magnetic latex particles for controlling protein adsorption and desorption. Journal of Magnetism and Magnetic Materials, 225, 151-155. DOI: 10. 1016/S0304-8853(00)01244-0.
12. Elaïssari, A., Rodrigue, M, Meunier, F., & Herve, C. (2001). Hydrophilic magnetic latex for nucleic acid extraction, purification and concentration. Journal of Magnetism and Magnetic Materials, 225, 127-133. DOI: 10. 1016/S0304-8853(00)01240-3.
13. Elmas, B., Onur, M. A., Şenel, S., & Tuncel, A. (2004). Thermosensitive N-isopropylacrylamide-vinylphenyl boronic acid copolymer latex particles for nucleotide isolation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 232, 253-259. DOI: 10. 1016/j. colsurfa. 2003. 11. 007.
14. Fu, G., & Soboyejo, W. O. (2010). Swelling and diffusion characteristics of modified poly (N-isopropylacrylamide) hydrogels. Materials Science and Engineering: C, 30, 8-13. DOI: 10. 1016/j. msec. 2009. 07. 017.
15. Gilányi, T., Varga, I., Mészáros, R., Filipcsei, G., & Zrínyi, M. (2000). Characterisation of monodisperse poly(N-isopropylacrylamide) microgel particles. Physical Chemistry Chemical Physics, 2, 1973-1977. DOI: 10. 1039/b000571l.
16. Hellweg, T., Kratz, K., Pouget, S., & Eimer, W. (2002). Internal dynamics in colloidal PNIPAM microgel particles immobilised in mesoscopic crystals. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 202, 223-232. DOI: 10. 1016/S0927-7757(01)01077-9.
17. Hirashima, Y., Sato, H., & Suzuki, A. (2005). ATR-FTIR spectroscopic study on hydrogen bonding of poly(N-isopropylacrylamide-co-sodium acrylate) gel. Macromolecules, 38, 9280-9286. DOI: 10. 1021/ma051081s.
18. Huo, D., Li, Y., Qian, Q., & Kobayashi, T. (2006). Temperature -pH sensitivity of bovine serum albumin protein-microgels based on cross-linked poly(N-isopropylacrylamide-co-acrylic acid). Colloids and Surfaces B: Biointerfaces, 50, 36-42. DOI: 10. 1016/j. colsurfb. 2006. 03. 020.
19. Ichikawa, H., & Fukumori, Y. (2000). A novel positively thermosensitive controlled-release microcapsule with membrane of nano-sized poly(N-isopropylacrylamide) gel dispersed in ethylcellulose matrix. Journal of Controlled Release, 63, 107-119. DOI: 10. 1016/S0168-3659(99)00181-9.
20. Ignatyev, I. S., Lazarev, A. N., Smirnov, M. B., Alpert, M. L., & Trofimov, B. A. (1981). Vibrational spectra and molecular structure of methyl vinyl ether. Journal of Molecular Structure, 72, 25-39. DOI: 10. 1016/0022-2860(81)85005-3.
21. Imaz, A., & Forcada, J. (2009). Optimized buffered polymerizations to produce N-vinylcaprolactam-based microgels. European Polymer Journal, 45, 3164-3175. DOI: 10. 1016/j. eurpolymj. 2009. 08. 003.
22. Kato, N., Sakai, Y., & Shibata, S. (2003). Wide-range control of deswelling time for thermosensitive poly(N-isopropylacrylamide) gel treated by freeze-drying. Macromolecules, 36, 961-963. DOI: 10. 1021/ma0214198.
23. Katsumoto, Y., Tanaka, T., & Ozaki, Y. (2005). Molecular interpretation for the solvation of poly(acrylamide)s. I. Solventdependent changes in the C=O stretching band region of poly(N, N-dialkylacrylamide)s. Journal of Physical Chemistry B, 109, 20690-20696. DOI: 10. 1021/jp052263r.
24. Kondo, A., Imura, K., Nakama, K., & Higashitani, K. (1994). Preparation of immobilized papain using thermosensitive latex particles. Journal of Fermentation and Bioengineering, 78, 241-245. DOI: 10. 1016/0922-338X(94)90297-6.
25. Kratz, K., Hellweg, T., & Eimer, W. (2001). Structural changes in PNIPAM microgel particles as seen by SANS, DLS, and EM techniques. Polymer, 42, 6631-6639. DOI: 10. 1016/S0032-3861(01)00099-4.
26. 4 magnetic composite latex particle that is synthesized by a novel method. European Polymer Journal, 44, 2768-2776. DOI: 10. 1016/j. eurpolymj. 2008. 07. 001.
27. Liapis, A. I., & Bruttini, R. (2009). A mathematical model for the spray freeze drying process: The drying of frozen particles in trays and in vials on trays. International Journal of Heat and Mass Transfer, 52, 100-111. DOI: 10. 1016/j. ijheatmasstransfer. 2008. 06. 026.
28. Lima, K. M., & Rodrigues, J. M., Jr. (1999). Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system. Brazilian Journal of Medical and Biological Research, 32, 171-180. DOI: 10. 1590/S0100-879X1999000200005.
29. Lin, C.-L., Chiu, W.-Y., & Lee, C.-F. (2005). Thermal/pHsensitive core-shell copolymer latex and its potential for targeting drug carrier application. Polymer, 46, 10092-10101. DOI: 10. 1016/j. polymer. 2005. 07. 098.
30. Lindman, S., Lynch, I., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007). Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity. Nano Letters, 7, 914-920. DOI: 10. 1021/nl062743.
31. López-León, T., Ortega-Vinuesa, J. L., Bastos-González, D., & Elaïssari, A. (2006). Cationic and anionic poly(N-isopropylacrylamide) based submicron gel particles: Electrokinetic properties and colloidal stability. The Journal of Physical Chemistry B, 110, 4629-4636. DOI: 10. 1021/jp0540508.
32. Lynch, I., Miller, I., Gallagher, W. M., & Dawson, K. A. (2006). Novel method to prepare morphologically rich polymeric surfaces for biomedical applications via phase separation and arrest of microgel particles. The Journal of Physical Chemistry B, 110, 14581-14589. DOI: 10. 1021/jp061166a.
33. MacAdam, A. B., Shafi, Z. B., James, S. L., Marriott, C., & Martin, G. P. (1997). Preparation of hydrophobic and hydrophilic albumin microspheres and determination of surface carboxylic acid and amino residues. International Journal of Pharmaceutics, 151, 47-55. DOI: 10. 1016/S0378-5173(97)04886-2.
34. Meersman, F., Wang, J., Wu, Y., & Heremans, K. (2005). Pressure effect on the hydration properties of poly(N-isopropylacrylamide) in aqueous solution studied by FTIR spectroscopy. Macromolecules, 38, 8923-8928. DOI: 10. 1021/ma051582d.
35. Michailova, V., Berlinova, I., Iliev, P, Ivanov, L., Titeva, S., Momekov, G., & Dimitrov, I. (2010). Nanoparticles formed from PNIPAM-g-PEO copolymers in the presence of indomethacin. International Journal of Pharmaceutics, 384, 154-164. DOI: 10. 1016/j. ijpharm. 2009. 09. 034.
36. Murugan, R., Mohan, S., & Bigotto, A. (1998). FTIR and polarised Raman spectra of acrylamide and polyacrylamide. Journal of the Korean Physical Society, 32, 505-512.
37. Ono, Y., & Shikata, T. (2007). Contrary hydration behavior of N-isopropylacrylamide to its polymer, P(NIPAm), with a lower critical solution temperature. The Journal of Physical Chemistry B, 111, 1511-1513. DOI: 10. 1021/jp068954k.
38. Pelton, R. (2000). Temperature-sensitive aqueous microgels. Advances in Colloid and Interface Science, 85, 1-33. DOI: 10. 1016/S0001-8686(99)00023-8.
39. Pelton, R. H., & Chibante, P. (1986). Preparation of aqueous latices with N-isopropylacrylamide. Colloids and Surfaces, 20, 247-256. DOI: 10. 1016/0166-6622(86)80274-8.
40. Principi, T., Goh, C. C. E., Liu, R. C. W., & Winnik, F. M. (2000). Solution properties of hydrophobically modified copolymers of N-isopropylacrylamide and N-glycine acrylamide: A study by microcalorimetry and fluorescence spectroscopy. Macromolecules, 33, 2958-2966. DOI: 10. 1021/ma9919054.
41. Rasband, W. S. (1997-2008). Image J [computer software]. Retrieved March 2, 2008, from http://rsb. info. nih. gov/ij.
42. Scherer, J. R., & Potts, W. J. (1959). Normal coordinates for the out-of-plane deformations of vinyl bromide. Journal of Chemical Physics, 30, 1527-1529. DOI: 10. 1063/1. 1730231.
43. Shamim, N., Hong, L., Hidajat, K., & Uddin, M. S. (2006). Thermosensitive-polymer-coated magnetic nanoparticles: Adsorption and desorption of Bovine Serum Albumin. Journal of Colloid and Interface Science, 304, 1-8. DOI: 10. 1016/j. jcis. 2006. 08. 047.
44. Shibayama, M., Mizutani, S., & Nomura, S. (1996). Thermal properties of copolymer gels containing N-isopropylacrylamide. Macromolecules, 29, 2019-2024. DOI: 10. 1021/ma9513 90q.
45. Snowden, M. J., & Vincent, B. (1992). The temperaturecontrolled flocculation of crosslinked latex particles. Journal of the Chemical Society, Chemical Communications, 16, 1103-1105. DOI: 10. 1039/C39920001103.
46. Tan, B. H., & Tam, K. C. (2008). Review on the dynamics and micro-structure of pH-responsive nano-colloidal systems. Advances in Colloid and Interface Science, 136, 25-44. DOI: 10. 1016/j. cis. 2007. 07. 002.
47. Taniguchi, T., Duracher, D., Delair, T., Elaïssari, A., & Pichot, C. (2003). Adsorption/desorption behavior and covalent grafting of an antibody onto cationic amino-functionalized poly(styrene-N-isopropylacrylamide) core-shell latex particles. Colloids and Surfaces B: Biointerfaces, 29, 53-65. DOI: 10. 1016/S0927-7765(02)00176-5.
48. Taşddelen, B., Kayaman-Apohan, N., Güven, O., & Baysal, B. M. (2005). Anticancer drug release from poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels. Radiation Physics and Chemistry, 73, 340-345. DOI: 10. 1016/j. radphyschem. 2004. 09. 028.
49. Tokuyama, H., & Kato, Y. (2008). Preparation of poly(N-isopropylacrylamide) emulsion gels and their drug release behaviors. Colloids and Surfaces B: Biointerfaces, 67, 92-98. DOI: 10. 1016/j. colsurfb. 2008. 08. 003.
50. Varshosaz, J. (2007). The promise of chitosan microspheres in drug delivery systems. Expert Opinion on Drug Delivery, 4, 263-273. DOI: 10. 1517/17425247. 4. 3. 263.
51. Wang, F., Bronich, T. K., Kabanov, A. V., Rauh, R. D., & Roovers, J. (2008). Synthesis and characterization of star poly(ε-caprolactone)-b-poly(ethylene glycol) and poly(l-lactide)-b-poly(ethylene glycol) copolymers: Evaluation as drug delivery carriers. Bioconjugate Chemistry, 19, 1423-1429. DOI: 10. 1021/bc7004285.
52. Wang, G., Pelton, R., & Zhang, J. (1999). Sodium dodecyl sulfate binding to poly(N-isopropylacrylamide) microgel latex studied by isothermal titration calorimetry. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 153, 335-340. DOI: 10. 1016/S0927-7757(98)00455-5.
53. Wei, H., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2009). Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriers. Progress in Polymer Science, 34, 893-910. DOI: 10. 1016/j. progpolymsci. 2009. 05. 002.
54. Wei, H., Zhang, X.-Z., Cheng, H., Chen, W.-Q., Cheng, S.-X., & Zhuo, R.-X. (2006). Self-assembled thermo- and pH responsive micelles of poly(10-undecenoic acid-b-N-isopropylacrylamide) for drug delivery. Journal of Controlled Release, 116, 266-274. DOI: 10. 1016/j. jconrel. 2006. 08. 018.
55. Yashida, H., Furukawa, Y., & Tasumi, M. (1989). Structural studies and vibrational analyses of stable and less stable conformers of 1, 3, 5-hexatriene based on ab initio MO calculations. Journal of Molecular Structure, 194, 279-299. DOI: 10. 1016/0022-2860(89)80086-9.
56. Zhang, X.-Z., Yang, Y.-Y., Chung, T.-S., & Ma, K.-X. (2001). Preparation and characterization of fast response macroporous poly(N-isopropylacrylamide) hydrogels. Langmuir, 17, 6094-6099. DOI: 10. 1021/la010105v.