Utility of immunofluorescence and electron microscopy in endomyocardial biopsies from patients with unexplained heart failure

Cardiovascular Pathology

Volumn 19, Issue 4, 2010, Pages

  She, Rosemary C ^a   Hammond, Elizabeth H ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b LDS HOSPITAL   (United States)

Author keywords

Complement; Electron microscopy; Immunoglobulin; Myocarditis

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3D; FIBRINOGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; ANTIGEN ANTIBODY COMPLEX;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CAPILLARY; CLINICAL ARTICLE; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FEMALE; FROZEN SECTION; HEART; HEART FAILURE; HEART MUSCLE BIOPSY; HUMAN; HUMAN TISSUE; IMMUNE COMPLEX DEPOSITION; IMMUNOFLUORESCENCE; MALE; MEDICAL RECORD REVIEW; MYOCARDITIS; MYOFILAMENT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ACTIN FILAMENT; ADOLESCENT; AGED; ANTIGEN ANTIBODY COMPLEX; BIOPSY; CHILD; COMPLICATION; ENDOCARDIUM; FLUORESCENCE MICROSCOPY; INFANT; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROCEDURES; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIGEN-ANTIBODY COMPLEX; BIOPSY; CAPILLARIES; CHILD; CHILD, PRESCHOOL; CORONARY ANGIOGRAPHY; ENDOCARDIUM; FEMALE; HEART FAILURE; HLA-DR ANTIGENS; HUMANS; INFANT; MICROFILAMENTS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MYOCARDITIS; RETROSPECTIVE STUDIES; YOUNG ADULT; ACTIN CYTOSKELETON;

EID: 77956894055     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carpath.2009.04.004     Document Type: Article

References (42)

1. Aretz HT Myocarditis: the Dallas criteria Hum Pathol 18 1987 619 624
2. Fairweather D, Kaya Z, Shellam GR, Lawson CM, and Rose NR From infection to autoimmunity J Autoimmun 16 2001 175 186
3. Neu N, Klieber R, Fruhwirth M, and Berger P Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity Eur Heart J 12 Suppl D 1991 117 120
4. Opavsky MA, Penninger J, and Aitken K Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection Circ Res 85 1999 551 558
5. Anand IS, Ganguly NK, Khanna AK, Chakravarti RN, and Wahi PL Humoral immunity in experimental immune carditis Pathology 16 1984 291 299
6. Caforio AL, Grazzini M, and Mann JM Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy Circulation 85 1992 1734 1742
7. Caforio AL, Mahon NJ, and McKenna WJ Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy Autoimmunity 34 2001 199 204
8. Fairweather D, Lawson CM, and Chapman AJ Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross-react with virus and cardiac myosin Immunology 94 1998 263 270
9. Lowry PJ, Thompson RA, and Littler WA Humoral immunity in cardiomyopathy Br Heart J 50 1983 390 394
10. Maisch B, Ristic AD, Hufnagel G, and Pankuweit S Pathophysiology of viral myocarditis: the role of humoral immune response Cardiovasc Pathol 11 2002 112 122
11. O'Donoghue HL, Lawson CM, and Reed WD Autoantibodies to cardiac myosin in mouse cytomegalovirus myocarditis Immunology 71 1990 20 28
12. Liu PP, and Mason JW Advances in the understanding of myocarditis Circulation 104 2001 1076 1082
13. Schulze K, Becker BF, and Schultheiss HP Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo Circ Res 64 1989 179 192
14. Martin AB, Webber S, and Fricker FJ Acute myocarditis. Rapid diagnosis by PCR in children Circulation 90 1994 330 339
15. Why HJ, Meany BT, and Richardson PJ Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy Circulation 89 1994 2582 2589
16. Baughman KL Diagnosis of myocarditis: death of Dallas criteria Circulation 113 2006 593 595
17. Ardehali H, Qasim A, and Cappola T Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy Am Heart J 147 2004 919 923
18. Arbustini E, Gavazzi A, and Dal Bello B Ten-year experience with endomyocardial biopsy in myocarditis presenting with congestive heart failure: frequency, pathologic characteristics, treatment and follow-up G Ital Cardiol 27 1997 209 223
19. Hammond EH, Menlove RL, and Anderson JL Predictive value of immunofluorescence and electron microscopic evaluation of endomyocardial biopsies in the diagnosis and prognosis of myocarditis and idiopathic dilated cardiomyopathy Am Heart J 114 1987 1055 1065
20. Dawson L, Talwar KK, and Chopra P. Significance of pathological parameters of endomyocardial biopsy in clinical outcome of patients of dilated cardiomyopathy-II. Value of cardiac immune complexes and heart reactive antibodies Indian Heart J 43 1991 421 425
21. Richardson P, McKenna W, and Bristow M Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies Circulation 93 1996 841 842
22. Noutsias M, Seeberg B, Schultheiss HP, and Kuhl U Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy Circulation 99 1999 2124 2131
23. Leon ML, and Suckerman SH Gamma interferon: a central mediator in atherosclerosis Inflamm Res 54 2005 395 411
24. Herskowitz A, Ahmed-Ansari A, and Neumann DA Induction of major histocompatibility complex antigens within the myocardium of patients with active myocarditis: a nonhistologic marker of myocarditis J Am Coll Cardiol 15 1990 624 632
25. Wojnicz R, Nowalany-Kozielska E, and Wodniecki J Immunohistological diagnosis of myocarditis. Potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury Eur Heart J 19 1998 1564 1572
26. Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, and Maseri A Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders Circulation 107 2003 857 863
27. Wojnicz R, Nowalany-Kozielska E, and Wojciechowska C Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results Circulation 104 2001 39 45
28. Tincani A, Rebaioli CB, Taglietti M, and Shoenfeld Y Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus Rheumatology (Oxford) 45 Suppl 4 2006 iv8 iv13
29. Fairweather D, Frisancho-Kiss S, and Njoku DB Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart J. Immunol 176 2006 3516 3524
30. Radhakrishnan VV Experimental myocarditis in the guinea-pig Cardiovasc Res 31 1996 651 654
31. Neumann DA, Burek CL, Baughman KL, Rose NR, and Herskowitz A Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy J Am Coll Cardiol 16 1990 839 846
32. Maisch B Immunologic regulator and effector mechanisms in myocarditis and perimyocarditis Heart Vessels Suppl 1 1985 209 217 (Pubitemid 16137184)
33. Afanasyeva M, and Rose NR Cardiomyopathy is linked to complement activation Am J Pathol 161 2002 351 357
34. Zwaka TP, Manolov D, and Ozdemir C Complement and dilated cardiomyopathy: a role of sublytic terminal complement complex-induced tumor necrosis factor-alpha synthesis in cardiac myocytes Am J Pathol 161 2002 449 457
35. Banasik M, Boratynska M, and Nowakowska B C4D deposition and positive posttransplant crossmatch are not necessarily markers of antibody-mediated rejection in renal allograft recipients Transplant Proc 39 2007 2718 2720
36. Freese PM, Svalander CT, Molne J, and Nyberg G Renal allograft glomerulopathy and the value of immunohistochemistry Clin Nephrol 62 2004 279 286
37. Figulla HR, Rahlf G, Nieger M, Luig H, and Kreuzer H Spontaneous hemodynamic improvement or stabilization and associated biopsy findings in patients with congestive cardiomyopathy Circulation 71 1985 1095 1104
38. Pelliccia F, d'Amati G, and Cianfrocca C Histomorphometric features predict 1-year outcome of patients with idiopathic dilated cardiomyopathy considered to be at low priority for cardiac transplantation Am Heart J 128 1994 316 325
39. Prochorec-Sobieszek M, Bilinska ZT, and Grzybowski J Assessment of the inflammatory process by endomyocardial biopsy in patients with dilated cardiomyopathy based on pathological and immunohistochemical methods Kardiol Pol 64 2006 479 487 [discussion 88]
40. Maisch B, Buschel G, and Izumi T Four years of experience in endomyocardial biopsy-an immunohistologic approach Heart Vessels Suppl 1 1985 59 67
41. Kuhl U, Pauschinger M, and Schwimmbeck PL Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction Circulation 107 2003 2793 2798
42. Wittchen F, Suckau L, and Witt H Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets J Mol Med 85 2007 257 271