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Volumn 85, Issue 3, 2007, Pages 253-267

Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets

Author keywords

Dilated cardiomyopathy; Genomic expression profiling; Heart failure; Human inflammatory cardiomyopathy; Molecular pathomechanisms; Molecular therapeutic targets

Indexed keywords

ADIPONECTIN; CYSTEINE RICH PROTEIN 61; INTERLEUKIN 27; TRANSCRIPTION FACTOR NFAT; CYR61 PROTEIN, HUMAN; CYTOKINE; IMMEDIATE EARLY PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

EID: 33847121668     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0122-9     Document Type: Article
Times cited : (62)

References (59)
  • 2
    • 14044279226 scopus 로고    scopus 로고
    • High prevalence of viral genomes and multiple viral infections in the myocardium of adults with " Idiopathic" left ventricular dysfunction
    • Kühl U, Pauschinger M, Noutsias M, Seeberg B, Bock T, Lassner D, Poller W, Kandolf R, Schultheiss H-P (2005) High prevalence of viral genomes and multiple viral infections in the myocardium of adults with " Idiopathic" left ventricular dysfunction. Circulation 111:887-893
    • (2005) Circulation , vol.111 , pp. 887-893
    • Kühl, U.1    Pauschinger, M.2    Noutsias, M.3    Seeberg, B.4    Bock, T.5    Lassner, D.6    Poller, W.7    Kandolf, R.8    Schultheiss, H.-P.9
  • 4
    • 0038120010 scopus 로고    scopus 로고
    • Interferon-β treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction
    • Kühl U, Pauschinger M, Schwimmbeck P, Seeberg B, Lober C, Noutsias M, Poller W, Schultheiss H-P (2003) Interferon-β treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation 107:2793-2798
    • (2003) Circulation , vol.107 , pp. 2793-2798
    • Kühl, U.1    Pauschinger, M.2    Schwimmbeck, P.3    Seeberg, B.4    Lober, C.5    Noutsias, M.6    Poller, W.7    Schultheiss, H.-P.8
  • 6
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25:402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 7
    • 0031725441 scopus 로고    scopus 로고
    • Influence of different culture conditions on sarcoplasmic reticular calcium transport in isolated neonatal rat cardiomyocytes
    • Vetter R, Kott M, Schulze W, Rupp H (1998) Influence of different culture conditions on sarcoplasmic reticular calcium transport in isolated neonatal rat cardiomyocytes. Mol Cell Biochem 188:177-185
    • (1998) Mol Cell Biochem , vol.188 , pp. 177-185
    • Vetter, R.1    Kott, M.2    Schulze, W.3    Rupp, H.4
  • 8
    • 33646761944 scopus 로고    scopus 로고
    • Microarray analysis of gene expression: Considerations in data mining and statistical treatment
    • Verducci JS, Melfi VF, Lin S, Wang Z, Roy S, Sen CK (2006) Microarray analysis of gene expression: considerations in data mining and statistical treatment. Physiol Genomics 25:355-363
    • (2006) Physiol Genomics , vol.25 , pp. 355-363
    • Verducci, J.S.1    Melfi, V.F.2    Lin, S.3    Wang, Z.4    Roy, S.5    Sen, C.K.6
  • 9
    • 24344446240 scopus 로고    scopus 로고
    • Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells
    • Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AM (2005) Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol 33:297-302
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 297-302
    • Jin, Y.1    Kim, H.P.2    Ifedigbo, E.3    Lau, L.F.4    Choi, A.M.5
  • 10
    • 33644683065 scopus 로고    scopus 로고
    • Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M (2005) Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97:1245-1252. See also related comment by Touyz RM, Circ Res 97:1216-1219
    • Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M (2005) Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97:1245-1252. See also related comment by Touyz RM, Circ Res 97:1216-1219
  • 16
    • 14744294890 scopus 로고    scopus 로고
    • A systematic review of large scale and heterogeneous gene array data in heart failure
    • Sharma UC, Pokharel S, Evelo CT, Maessen JG (2005) A systematic review of large scale and heterogeneous gene array data in heart failure. J Mol Cell Cardiol 38:425-432
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 425-432
    • Sharma, U.C.1    Pokharel, S.2    Evelo, C.T.3    Maessen, J.G.4
  • 21
    • 0346098139 scopus 로고    scopus 로고
    • Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: Altered expression of apoptotic and cytoskeletal genes
    • Yung CK, Halperin VL, Tomaselli GF, Winslow RL (2004) Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes. Genomics 83:281-297
    • (2004) Genomics , vol.83 , pp. 281-297
    • Yung, C.K.1    Halperin, V.L.2    Tomaselli, G.F.3    Winslow, R.L.4
  • 27
    • 0347915577 scopus 로고    scopus 로고
    • CCN proteins: Multifunctional signalling regulators
    • Perbal B (2004) CCN proteins: multifunctional signalling regulators. Lancet 363:62-64
    • (2004) Lancet , vol.363 , pp. 62-64
    • Perbal, B.1
  • 28
    • 27744465454 scopus 로고    scopus 로고
    • The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
    • Todorovic V, Chen CC, Hay N, Lau LF (2005) The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol 171:559-568
    • (2005) J Cell Biol , vol.171 , pp. 559-568
    • Todorovic, V.1    Chen, C.C.2    Hay, N.3    Lau, L.F.4
  • 29
    • 0038190938 scopus 로고    scopus 로고
    • Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor
    • Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC (2003) Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. J Biol Chem 278:13847-13854
    • (2003) J Biol Chem , vol.278 , pp. 13847-13854
    • Kim, K.H.1    Min, Y.K.2    Baik, J.H.3    Lau, L.F.4    Chaqour, B.5    Chung, K.C.6
  • 31
    • 0035861590 scopus 로고    scopus 로고
    • The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts
    • Chen CC, Mo FE, Lau LF (2001) The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem 276:47329-47337
    • (2001) J Biol Chem , vol.276 , pp. 47329-47337
    • Chen, C.C.1    Mo, F.E.2    Lau, L.F.3
  • 32
    • 33645085566 scopus 로고    scopus 로고
    • Tumor-derived Cyr61 (CCN1) promotes stromal matrix metalloproteinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells
    • Nguyen N, Kuliopulos A, Graham RA, Covic L (2006) Tumor-derived Cyr61 (CCN1) promotes stromal matrix metalloproteinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells. Cancer Res 66:2658-2665
    • (2006) Cancer Res , vol.66 , pp. 2658-2665
    • Nguyen, N.1    Kuliopulos, A.2    Graham, R.A.3    Covic, L.4
  • 33
    • 0036214660 scopus 로고    scopus 로고
    • The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin α6β1 and cell surface heparan sulfate proteoglycans
    • Grzeszkiewicz TM, Lindner V, Chen N, Lam SC, Lau LF (2002) The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin α6β1 and cell surface heparan sulfate proteoglycans. Endocrinology 143:1441-1450
    • (2002) Endocrinology , vol.143 , pp. 1441-1450
    • Grzeszkiewicz, T.M.1    Lindner, V.2    Chen, N.3    Lam, S.C.4    Lau, L.F.5
  • 34
    • 0035877765 scopus 로고    scopus 로고
    • CYR61 stimulates human skin fibroblast migration through Integrin αvβ5 and enhances mitogenesis through integrin αvβ3, independent of its carboxyl-terminal domain
    • Grzeszkiewicz TM, Kirschling DJ, Chen N, Lau LF (2001) CYR61 stimulates human skin fibroblast migration through Integrin αvβ5 and enhances mitogenesis through integrin αvβ3, independent of its carboxyl-terminal domain. J Biol Chem 276:21943-21950
    • (2001) J Biol Chem , vol.276 , pp. 21943-21950
    • Grzeszkiewicz, T.M.1    Kirschling, D.J.2    Chen, N.3    Lau, L.F.4
  • 35
    • 0037097845 scopus 로고    scopus 로고
    • Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): Immediate-early gene products expressed in atherosclerotic lesions
    • Schober JM, Chen N, Grzeszkiewicz TM, Jovanovic I, Emeson EE, Ugarova TP, Ye RD, Lau LF, Lam SC (2002) Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 99:4457-4465
    • (2002) Blood , vol.99 , pp. 4457-4465
    • Schober, J.M.1    Chen, N.2    Grzeszkiewicz, T.M.3    Jovanovic, I.4    Emeson, E.E.5    Ugarova, T.P.6    Ye, R.D.7    Lau, L.F.8    Lam, S.C.9
  • 36
    • 12144286634 scopus 로고    scopus 로고
    • Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways
    • Xie D, Yin D, Tong X, O'Kelly J, Mori A, Miller C, Black K, Gui D, Said JW, Koeffler HP (2004) Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Cancer Res 64:1987-1996
    • (2004) Cancer Res , vol.64 , pp. 1987-1996
    • Xie, D.1    Yin, D.2    Tong, X.3    O'Kelly, J.4    Mori, A.5    Miller, C.6    Black, K.7    Gui, D.8    Said, J.W.9    Koeffler, H.P.10
  • 39
    • 27144457438 scopus 로고    scopus 로고
    • Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 11:1096-1103. See also related comment by Yuhki K et al, Nat Med 11:1048-1049
    • Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 11:1096-1103. See also related comment by Yuhki K et al, Nat Med 11:1048-1049
  • 41
    • 3042702881 scopus 로고    scopus 로고
    • Inflammatory cytokines and postmyocardial infarction remodeling
    • Nian M, Lee P, Khaper N, Liu P (2004) Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res 94:1543-1553
    • (2004) Circ Res , vol.94 , pp. 1543-1553
    • Nian, M.1    Lee, P.2    Khaper, N.3    Liu, P.4
  • 42
    • 10644266787 scopus 로고    scopus 로고
    • Cytokine-induced modulation of cardiac function
    • Prabhu SD (2004) Cytokine-induced modulation of cardiac function. Circ Res 95:1140-1153
    • (2004) Circ Res , vol.95 , pp. 1140-1153
    • Prabhu, S.D.1
  • 44
    • 24944465681 scopus 로고    scopus 로고
    • Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation
    • Schaerli P, Willimann K, Ebert LM, Walz A, Moser B (2005) Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation. Immunity 23:331-342
    • (2005) Immunity , vol.23 , pp. 331-342
    • Schaerli, P.1    Willimann, K.2    Ebert, L.M.3    Walz, A.4    Moser, B.5
  • 45
    • 17844381906 scopus 로고    scopus 로고
    • Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo
    • Shurin GV, Ferris R, Tourkova IL, Perez L, Lokshin A, Balkir L, Collins B, Chatta GS, Shurin MR (2005) Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo. J Immunol 174:5490-5498
    • (2005) J Immunol , vol.174 , pp. 5490-5498
    • Shurin, G.V.1    Ferris, R.2    Tourkova, I.L.3    Perez, L.4    Lokshin, A.5    Balkir, L.6    Collins, B.7    Chatta, G.S.8    Shurin, M.R.9
  • 46
    • 23444441982 scopus 로고    scopus 로고
    • Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells
    • Vargas-Leal V, Bruno R, Derfuss T, Krumbholz M, Hohlfeld R, Meinl E (2005) Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. J Immunol 175:2301-2308
    • (2005) J Immunol , vol.175 , pp. 2301-2308
    • Vargas-Leal, V.1    Bruno, R.2    Derfuss, T.3    Krumbholz, M.4    Hohlfeld, R.5    Meinl, E.6
  • 47
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467-476
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 48
    • 0037100263 scopus 로고    scopus 로고
    • Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis
    • Starnes T, Broxmeyer HE, Robertson MJ, Hromas R (2002) Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J Immunol 169:642-646
    • (2002) J Immunol , vol.169 , pp. 642-646
    • Starnes, T.1    Broxmeyer, H.E.2    Robertson, M.J.3    Hromas, R.4
  • 49
    • 1642576088 scopus 로고    scopus 로고
    • Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members
    • Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, Kirkwood KL, Gaffen SL (2004) Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem 279:2559-2567
    • (2004) J Biol Chem , vol.279 , pp. 2559-2567
    • Ruddy, M.J.1    Wong, G.C.2    Liu, X.K.3    Yamamoto, H.4    Kasayama, S.5    Kirkwood, K.L.6    Gaffen, S.L.7
  • 50
    • 18044377011 scopus 로고    scopus 로고
    • Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
    • Takahashi H, Numasaki M, Lotze MT, Sasaki H (2005) Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunol Lett 98:189-193
    • (2005) Immunol Lett , vol.98 , pp. 189-193
    • Takahashi, H.1    Numasaki, M.2    Lotze, M.T.3    Sasaki, H.4
  • 51
    • 1942501856 scopus 로고    scopus 로고
    • Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways
    • Prause O, Bozinovski S, Anderson GP, Linden A (2004) Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways. Thorax 59:313-317
    • (2004) Thorax , vol.59 , pp. 313-317
    • Prause, O.1    Bozinovski, S.2    Anderson, G.P.3    Linden, A.4
  • 52
  • 53
    • 8444237368 scopus 로고    scopus 로고
    • Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-κB in human neutrophils
    • Jo E, Lee H-Y, Lee Y-N, Kim J, Kang H-K, Park D-W, Baek S-H, Kwak J-Y, Bae Y-S (2004) Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-κB in human neutrophils. J Immunol 173:6433-6439
    • (2004) J Immunol , vol.173 , pp. 6433-6439
    • Jo, E.1    Lee, H.-Y.2    Lee, Y.-N.3    Kim, J.4    Kang, H.-K.5    Park, D.-W.6    Baek, S.-H.7    Kwak, J.-Y.8    Bae, Y.-S.9
  • 54
    • 0033609029 scopus 로고    scopus 로고
    • Expression of cell adhesion molecules in dilated cardiomyopathy: Evidence for endothelial activation in inflammatory cardiomyopathy
    • Noutsias M, Seeberg B, Schultheiss H, Kuhl U (1999) Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 99:2124-2131
    • (1999) Circulation , vol.99 , pp. 2124-2131
    • Noutsias, M.1    Seeberg, B.2    Schultheiss, H.3    Kuhl, U.4
  • 56
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian F (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5:472-484
    • (2005) Nat Rev Immunol , vol.5 , pp. 472-484
    • Macian, F.1
  • 57
    • 33745143956 scopus 로고    scopus 로고
    • Robust systemic transduction with AAV9 vectors in mice: Efficient global cardiac gene transfer superior to that of AAV8
    • Inagaki K, Fuess S, Storm TA, Gibson GA, McTiernan CF, Kay MA, Nakai H (2006) Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Molec Ther 14:45-53
    • (2006) Molec Ther , vol.14 , pp. 45-53
    • Inagaki, K.1    Fuess, S.2    Storm, T.A.3    Gibson, G.A.4    McTiernan, C.F.5    Kay, M.A.6    Nakai, H.7


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