Podoplanin, a novel marker for seminoma: A comparison study evaluating immunohistochemical expression of podoplanin and OCT3/4

Annals of Diagnostic Pathology

Volumn 14, Issue 5, 2010, Pages 331-336

  Idrees, Muhammad ^a   Saxena, Romil ^a   Cheng, Liang ^a   Ulbright, Thomas M ^a   Badve, Sunil ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Germ cell tumors; OCT3 4; Podoplanin; Seminoma

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; PODOPLANIN; POLYCLONAL ANTIBODY;

ARTICLE; CHORIOCARCINOMA; COMPARATIVE STUDY; DISEASE MARKER; EMBRYONAL CARCINOMA; GERM CELL TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; STAINING; TERATOMA; TESTIS TUMOR; YOLK SAC TUMOR;

DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; SEMINOMA; TESTICULAR NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77956863637     PISSN: 10929134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2010.05.008     Document Type: Article

References (15)

1. Ulbright T.M., and Young R.H. Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor Am J Surg Pathol 29 2005 500 505
2. Emerson R.E., and Ulbright T.M. The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis Semin Diagn Pathol 22 2005 33 50
3. Kato Y., Sasagawa I., and Kaneko M. Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors Oncogene 23 2004 8552 8556
4. Jones T.D., Ulbright T.M., and Eble J.N. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma Am J Surg Pathol 28 2004 935 940
5. Jones T.D., Ulbright T.M., and Eble J.N. OCT4: A sensitive and specific biomarker for intratubular germ cell neoplasia of the testis Clin Cancer Res 10 2004 8544 8547
6. Yu H., Pinkus G.S., and Hornick J.L. Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms Am J Clin Pathol 128 2007 767 775
7. Ulbright T.M. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues Mod Pathol 18 Suppl 2 2005 S61 S79
8. Marks A., Sutherland D.R., and Bailey D. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours Br J Cancer 80 1999 569 578
9. Schacht V., Dadras S.S., and Johnson L.A. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors Am J Pathol 166 2005 913 921
10. Agarwal B., Saxena R., and Morimiya A. Lymphangiogenesis does not occur in breast cancer Am J Surg Pathol 29 2005 1449 1455
11. Kimura N., and Kimura I. Podoplanin as a marker for mesothelioma Pathol Int 55 2005 83 86
12. Ordonez N.G. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma Hum Pathol 36 2005 372 380
13. Ordonez N.G. The diagnostic utility of immunohistochemistry and electron microscopy in distinguishing between peritoneal mesotheliomas and serous carcinomas: a comparative study Mod Pathol 19 2006 34 48
14. Ordonez N.G. Immunohistochemical diagnosis of epithelioid mesothelioma: an update Arch Pathol Lab Med 129 2005 1407 1414
15. Ordonez N.G. Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases Mod Pathol 19 2006 373 383