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Volumn 15, Issue 8, 2010, Pages 819-825

Bevacizumab

Author keywords

Angiogenesis; Anti VEGF monoclonal IgG1 antibody; Bevacizumab; Safety

Indexed keywords

ALPHA2A INTERFERON; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PEMETREXED; PLACEBO; RANIBIZUMAB; SUNITINIB; TRASTUZUMAB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 77956855572     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2009-0317     Document Type: Review
Times cited : (218)

References (47)
  • 1
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso MR, Davis R, Norberg SM et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 2006;116:2610-2621.
    • (2006) J Clin Invest , vol.116 , pp. 2610-2621
    • Mancuso, M.R.1    Davis, R.2    Norberg, S.M.3
  • 2
    • 77956856256 scopus 로고    scopus 로고
    • U. S. Food and Drug Administration. Center for Drug Evaluation and Research. Final Labeling Text, BL125085 Supplement, Available at, accessed February 15, 2010
    • U. S. Food and Drug Administration. Center for Drug Evaluation and Research. Final Labeling Text, BL125085 Supplement, 2008. Available at http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/125085s0168lbl.pdf, accessed February 15, 2010.
    • (2008)
  • 3
    • 77956791014 scopus 로고    scopus 로고
    • The European Medicines Agency. European Public Assessment Report. Avastin Product Information. Avastin-H-C-582-II-23, August, Available at, accessed January 24, 2009
    • The European Medicines Agency. European Public Assessment Report. Avastin Product Information. Avastin-H-C-582-II-23, August 2008. Available at http://www.emea.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-_Variation/human/000582/WC500029270.pdf, accessed January 24, 2009.
    • (2008)
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 5
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 6
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer:Arandomized phase III study
    • Saltz LB, Clarke S, Díaz-Rubio E et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer:Arandomized phase III study. J Clin Oncol 2008;26:2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3
  • 7
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative Oncology group study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group study E3200. J Clin Oncol 2007;25:1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 8
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009;27: 1227-1234.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 9
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel- carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC et al. Paclitaxel- carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355: 2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 10
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 11
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010;28:3239-3247.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 12
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007;370:2103-2111.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 13
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital Phase II Consortia
    • Garcia AA, Hirte H, Fleming G et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital Phase II Consortia. J Clin Oncol 2008;26:76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 14
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • July 6 [Epub ahead of print]
    • Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010 July 6 [Epub ahead of print].
    • (2010) J Clin Oncol
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3
  • 15
    • 58149242792 scopus 로고    scopus 로고
    • Long-term effect of intravitreal bevacizumab (Avastin) in patients with chronic diffuse diabetic macular edema
    • Kook D, Wolf A, Kreutzer T et al. Long-term effect of intravitreal bevacizumab (Avastin) in patients with chronic diffuse diabetic macular edema. Retina 2008;28:1053-1060.
    • (2008) Retina , vol.28 , pp. 1053-1060
    • Kook, D.1    Wolf, A.2    Kreutzer, T.3
  • 16
    • 34447298651 scopus 로고    scopus 로고
    • A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer
    • Micha JP, Goldstein BH, Rettenmaier MA et al. A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer. Int J Gynecol Cancer 2007;17:771-776.
    • (2007) Int J Gynecol Cancer , vol.17 , pp. 771-776
    • Micha, J.P.1    Goldstein, B.H.2    Rettenmaier, M.A.3
  • 17
    • 34848854906 scopus 로고    scopus 로고
    • Platelets take up the monoclonal antibody bevacizumab
    • Verheul HM, Lolkema MP, Qian DZ et al. Platelets take up the monoclonal antibody bevacizumab. Clin Cancer Res 2007;13:5341-5347.
    • (2007) Clin Cancer Res , vol.13 , pp. 5341-5347
    • Verheul, H.M.1    Lolkema, M.P.2    Qian, D.Z.3
  • 18
    • 0242559086 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1_ polymorphisms associated with enhanced transactivation capacity, implying clinical significance
    • Tanimoto K, Yoshiga K, Eguchi H et al. Hypoxia-inducible factor-1_ polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis 2003;24:1779-1783.
    • (2003) Carcinogenesis , vol.24 , pp. 1779-1783
    • Tanimoto, K.1    Yoshiga, K.2    Eguchi, H.3
  • 19
    • 0032530717 scopus 로고    scopus 로고
    • VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface
    • Muller YA, Chen Y, Christinger HW et al. VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface. Structure 1998;6: 1153-1167.
    • (1998) Structure , vol.6 , pp. 1153-1167
    • Muller, Y.A.1    Chen, Y.2    Christinger, H.W.3
  • 20
    • 33845961014 scopus 로고    scopus 로고
    • Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies
    • Shih T, Lindley C. Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies. Clin Ther 2006;28:1779-1802.
    • (2006) Clin Ther , vol.28 , pp. 1779-1802
    • Shih, T.1    Lindley, C.2
  • 21
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • Herbst RS, O'Neill VJ, Fehrenbacher L et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007;25:4743-4750.
    • (2007) J Clin Oncol , vol.25 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3
  • 22
    • 33744812137 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients
    • Ramaswamy B, Elias AD, Kelbick NT et al. Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients. Clin Cancer Res 2006;12:3124-3129.
    • (2006) Clin Cancer Res , vol.12 , pp. 3124-3129
    • Ramaswamy, B.1    Elias, A.D.2    Kelbick, N.T.3
  • 23
    • 34247243265 scopus 로고    scopus 로고
    • Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer [abstract S28]
    • Pegram M, Chan D, Dichmann RA et al. Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer [abstract S28]. Breast Cancer Res Treat 2006;100(1 suppl):S28.
    • (2006) Breast Cancer Res Treat , vol.100 , Issue.1 SUPPL.
    • Pegram, M.1    Chan, D.2    Dichmann, R.A.3
  • 24
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • van Cutsem E, Vervenne WL, Bennouna J et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;27:2231-2237.
    • (2009) J Clin Oncol , vol.27 , pp. 2231-2237
    • van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 25
    • 49749124673 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of bevacizumab in patients with solid tumors
    • Lu JF, Bruno R, Eppler S et al. Clinical pharmacokinetics of bevacizumab in patients with solid tumors. Cancer Chemother Pharmacol 2008;62:779-786.
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 779-786
    • Lu, J.F.1    Bruno, R.2    Eppler, S.3
  • 26
    • 0032962265 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor
    • Lin YS, Nguyen C, Mendoza JL et al. Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J Pharmacol Exp Ther 1999;288:371-378.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 371-378
    • Lin, Y.S.1    Nguyen, C.2    Mendoza, J.L.3
  • 27
    • 42149169958 scopus 로고    scopus 로고
    • Specific imaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody
    • Stollman TH, Scheer MG, Leenders WP et al. Specific imaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody. Int J Cancer 2008;122:2310-2314.
    • (2008) Int J Cancer , vol.122 , pp. 2310-2314
    • Stollman, T.H.1    Scheer, M.G.2    Leenders, W.P.3
  • 28
    • 52649096967 scopus 로고    scopus 로고
    • Antibody-based therapy for solid tumors
    • Yan L, Hsu K, Beckman RA. Antibody-based therapy for solid tumors. Cancer J 2008;14:178-183.
    • (2008) Cancer J , vol.14 , pp. 178-183
    • Yan, L.1    Hsu, K.2    Beckman, R.A.3
  • 29
    • 0010775027 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of bevacizumab (BV) in colorectal cancer (CRC)
    • Gaudreault J, Lieberman G, Kabbinavar F et al. Pharmacokinetics (PK) of bevacizumab (BV) in colorectal cancer (CRC). Clin Pharmacol Ther 2001; 69:25.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 25
    • Gaudreault, J.1    Lieberman, G.2    Kabbinavar, F.3
  • 30
    • 38649105118 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children's Oncology Group Study
    • Glade Bender JL, Adamson PC, Reid JM et al. Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children's Oncology Group Study. J Clin Oncol 2008;26:399-405.
    • (2008) J Clin Oncol , vol.26 , pp. 399-405
    • Glade Bender, J.L.1    Adamson, P.C.2    Reid, J.M.3
  • 31
    • 58249088835 scopus 로고    scopus 로고
    • Addition of bevacizumab to fluorouracil- based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
    • Kabbinavar FF, Hurwitz HI, Yi J et al. Addition of bevacizumab to fluorouracil- based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol 2009;27:199-205.
    • (2009) J Clin Oncol , vol.27 , pp. 199-205
    • Kabbinavar, F.F.1    Hurwitz, H.I.2    Yi, J.3
  • 32
    • 9244222682 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease
    • Kariyazono H, Ohno T, Khajoee V et al. Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease. Pediatr Res 2004;56:953-959.
    • (2004) Pediatr Res , vol.56 , pp. 953-959
    • Kariyazono, H.1    Ohno, T.2    Khajoee, V.3
  • 33
    • 33746877877 scopus 로고    scopus 로고
    • A variable number of tandem repeats polymorphism influences the transcriptional activity of the neonatal Fc receptor alpha-chain promoter
    • Sachs UJ, Socher I, Braeunlich CG et al. A variable number of tandem repeats polymorphism influences the transcriptional activity of the neonatal Fc receptor alpha-chain promoter. Immunology 2006;119:83-89.
    • (2006) Immunology , vol.119 , pp. 83-89
    • Sachs, U.J.1    Socher, I.2    Braeunlich, C.G.3
  • 34
    • 0037442985 scopus 로고    scopus 로고
    • Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
    • Stevens A, Soden J, Brenchley PE et al. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res 2003;63:812-816.
    • (2003) Cancer Res , vol.63 , pp. 812-816
    • Stevens, A.1    Soden, J.2    Brenchley, P.E.3
  • 35
    • 56649123212 scopus 로고    scopus 로고
    • Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A metaanalysis
    • Nalluri SR, Chu D, Keresztes R et al. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A metaanalysis. JAMA 2008;300:2277-2285.
    • (2008) JAMA , vol.300 , pp. 2277-2285
    • Nalluri, S.R.1    Chu, D.2    Keresztes, R.3
  • 36
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • Verheul HM, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007;7:475-485.
    • (2007) Nat Rev Cancer , vol.7 , pp. 475-485
    • Verheul, H.M.1    Pinedo, H.M.2
  • 37
    • 77956828892 scopus 로고    scopus 로고
    • U. S. Food and Drug Administration. Center for Drug Evaluation and Research. 2008 Safety Alerts for Human Medical Products. Dear Healthcare Professional Letter - Genentech. Available at, accessed December 14
    • U. S. Food and Drug Administration. Center for Drug Evaluation and Research. 2008 Safety Alerts for Human Medical Products. Dear Healthcare Professional Letter - Genentech. Available at http://www.fda.gov/downloads/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm126434.pdf, accessed December 14, 2008.
    • (2008)
  • 38
    • 0037007037 scopus 로고    scopus 로고
    • A role for survivin in chemoresistance of endothelial cells mediated by VEGF
    • Tran J, Master Z, Yu JL et al. A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci U S A 2002;99: 4349-4354.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4349-4354
    • Tran, J.1    Master, Z.2    Yu, J.L.3
  • 39
    • 0035684431 scopus 로고    scopus 로고
    • Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer. Implications for the treatment with VEGF inhibitors
    • Cascinu S, Graziano F, Catalano V et al. Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer. Implications for the treatment with VEGF inhibitors. Clin Exp Metastasis 2000;18:651-655.
    • (2000) Clin Exp Metastasis , vol.18 , pp. 651-655
    • Cascinu, S.1    Graziano, F.2    Catalano, V.3
  • 40
    • 34248386965 scopus 로고    scopus 로고
    • Challenges for patients selection with VEGF inhibitors
    • Longo R, Gasparini G. Challenges for patients selection with VEGF inhibitors. Cancer Chemother Pharmacol 2007;60:151-170.
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 151-170
    • Longo, R.1    Gasparini, G.2
  • 41
    • 19944432454 scopus 로고    scopus 로고
    • Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis
    • Shaked Y, Bertolini F, Man S et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 2005;7:101-111.
    • (2005) Cancer Cell , vol.7 , pp. 101-111
    • Shaked, Y.1    Bertolini, F.2    Man, S.3
  • 42
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients
    • Willett CG, Boucher Y, Duda DG et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 2005;23:8136-8139.
    • (2005) J Clin Oncol , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3
  • 43
    • 55949102088 scopus 로고    scopus 로고
    • Preoperative bevacizumab combined with letrozole and chemotherapy in locally advanced ER- and /or PgR-positive breast cancer: Clinical and biological activity
    • Torrisi R, Bagnardi V, Cardillo A et al. Preoperative bevacizumab combined with letrozole and chemotherapy in locally advanced ER- and /or PgR-positive breast cancer: Clinical and biological activity. Br J Cancer 2008;99:1564-1571.
    • (2008) Br J Cancer , vol.99 , pp. 1564-1571
    • Torrisi, R.1    Bagnardi, V.2    Cardillo, A.3
  • 44
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey A, Sugrue MM, Purdie DM et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE). J Clin Oncol 2008;26:5326-5334.
    • (2008) J Clin Oncol , vol.26 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 45
    • 77953456555 scopus 로고    scopus 로고
    • The role of maintenance bevacizumab in patients with metastatic breast cancer treated with chemotherapy and bevacizumab upon achieving complete response or maximal radiologic response with stable disease
    • Waintraub SE, Tuchman V. The role of maintenance bevacizumab in patients with metastatic breast cancer treated with chemotherapy and bevacizumab upon achieving complete response or maximal radiologic response with stable disease. J Clin Oncol 2008;26(20 suppl):12022.
    • (2008) J Clin Oncol , vol.26 , Issue.20 SUPPL. , pp. 12022
    • Waintraub, S.E.1    Tuchman, V.2
  • 46
    • 85046912575 scopus 로고    scopus 로고
    • Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer
    • Tappenden P, Jones R, Paisley S et al. Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer. Health Technol Assess 2007;11:1-128, iii-iv.
    • (2007) Health Technol Assess , vol.11
    • Tappenden, P.1    Jones, R.2    Paisley, S.3
  • 47
    • 77956834862 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. TA118 Colorectal Cancer (Metastatic) - Bevacizumab & Cetuximab: Guidance; January 2007. Available at, accessed July 29
    • National Institute for Health and Clinical Excellence. TA118 Colorectal Cancer (Metastatic) - Bevacizumab & Cetuximab: Guidance; January 2007. Available at http://www.nice.org.uk/nicemedia/live/11612/33930/33930.pdf, accessed July 29, 2009.
    • (2009)


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