Attenuation of radiation-and chemoradiation-induced mucositis using gamma-d-glutamyl-l-tryptophan (SCV-07)

Oral Diseases

Volumn 16, Issue 7, 2010, Pages 655-660

  Watkins, B ^a   Pouliot, K ^a   Fey, E ^a   Tuthill, C ^b   Sonis, S ^c  

^a Biomodels   (United States)

^b SciClone Pharmaceuticals Inc   (United States)

^c Harvard Farber Cancer Center   (United States)

Author keywords

animal models; gamma d glutamyl l tryptophan; mucositis; radiation; SCV 07

Indexed keywords

CISPLATIN; GAMMA D GLUTAMYLLEUCYL TRYPTOPHAN; IMMUNOMODULATING AGENT; SCV 07; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHEEK MUCOSA; CONTROLLED STUDY; DRUG EFFICACY; MALE; MUCOSA INFLAMMATION; NONHUMAN; ORAL MUCOSAL DISEASE; PRIORITY JOURNAL; RADIATION ATTENUATION; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION HAZARD; RADIATION RESPONSE; SYRIAN HAMSTER;

ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; CRICETINAE; DIPEPTIDES; DISEASE MODELS, ANIMAL; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GINGIVITIS, NECROTIZING ULCERATIVE; IMMUNOLOGIC FACTORS; MALE; MESOCRICETUS; MOUTH MUCOSA; ORAL ULCER; PLACEBOS; RADIOTHERAPY; SINGLE-BLIND METHOD; STOMATITIS; TIME FACTORS;

EID: 77956852244     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2010.01671.x     Document Type: Article

References (15)

1. Alvarez E, Fey EG, Valax P, et al. (2003). Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapyradition-induced oral mucositis. Clin Cancer Res 9 : 3454 3461.
2. Handschel J, Sunderkötter C, Prott FJ, et al. (2001). Increase of RM31-positive macrophages in radiation-induced oral mucositis. J Pathol 193 : 242 247.
3. Logan RM, Stringer AM, Bowen JM, et al. (2007). The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 33 : 448 460.
4. Nagabhushanam V, Subbarao K, Ramachandran M, Reddy J, Tuthill C. Inhibition of STAT3 driven gene expression in melanoma cells by SCV-07. Presented Abstract at the 2008 American Society of Clinical Oncology General Meeting :
5. Otero DC, Poli V, David M, Rickert RC (2006). Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol 177 : 6593 6597.
6. Park HR, Jo SK, Paik SG (2005). Factors effecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells. Int J Radiat Biol 81 : 221 231.
7. Rubenstein EB, Peterson DE, Schubert M, et al. (2004). Mucositis study section of the multinational association for supportive care in cancer; International Society for Oral Oncology. Cancer 100 : 2026 2046.
8. Sengupta TK, Schmitt EM, Ivashkiv LB (1996). Inhibition of cytokines and JAKSTAT activation by distinct signaling pathways. Proc Natl Acad Sci 93 : 9499 9550.
9. Shen Y, Devgan G, Darnell JE, Bromberg JF (2001). Constitutively activated Stat3 protects fibroblast from serum withdrawl and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci USA 98 : 1543 1548.
10. Simbirtsev A, Kolobov A, Zabolotnych N, et al. (2003). Biological activity of peptide SCV-07 against murine tuberculosis. Russ J Immunol 8 : 11 22.
11. Sonis ST (2007). Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 5 : 3 11.
12. Sonis ST (2004). The pathobiology of mucositis. Nature Rev Cancer 4 : 277 284.
13. Sonis ST, Peterson RL, Edwards LJ, et al. (2000). Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters. Oral Oncol 36 : 373 381.
14. Sonis ST (2002). Animal models of oral mucositis induced by antineoplastic agents and radiation. Tumor models in cancer research. Humana Press, Beverly Teicher :
15. Vera-Llonch M, Oster G, Hagiwara M, Sonis S (2006). Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer 106 : 329 336.