메뉴 건너뛰기




Volumn 15, Issue 3, 2010, Pages 210-219

Will warfarin ever be replaced?

Author keywords

novel anticoagulant; thromboembolism; vitamin K antagonist; warfarin

Indexed keywords

ACETYLSALICYLIC ACID; APIXABAN; DABIGATRAN; DU 176B; ENOXAPARIN; PLACEBO; RIVAROXABAN; THIENOPYRIDINE DERIVATIVE; WARFARIN;

EID: 77956849181     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248410366448     Document Type: Review
Times cited : (16)

References (59)
  • 1
    • 0000726824 scopus 로고
    • Damaged sweet clover; The cause of a new disease in cattle stimulating haemorrhagic septicemia and black leg
    • Schofield FW Damaged sweet clover; the cause of a new disease in cattle stimulating haemorrhagic septicemia and black leg. J Am Vet Med Ass. 1924 ; 64: 553-556.
    • (1924) J Am Vet Med Ass , vol.64 , pp. 553-556
    • Schofield, F.W.1
  • 2
    • 0001796357 scopus 로고
    • A problem in the coagulation of the blood: "sweet clover disease of cattle."
    • Roderick LM A problem in the coagulation of the blood: "sweet clover disease of cattle.". Am J Physiol. 1931 ; 96: 413-425.
    • (1931) Am J Physiol , vol.96 , pp. 413-425
    • Roderick, L.M.1
  • 4
    • 0002530154 scopus 로고
    • The discovery of dicumarol and its sequels
    • Link KP The discovery of dicumarol and its sequels. Circulation. 1959 ; 19 (1). 97-107.
    • (1959) Circulation , vol.19 , Issue.1 , pp. 97-107
    • Link, K.P.1
  • 5
    • 0020396486 scopus 로고
    • Evidence that warfarin anticoagulant action involves two distinct reductase activities
    • Fasco MJ, Hildebrandt EF, Suttie JW Evidence that warfarin anticoagulant action involves two distinct reductase activities. J Biol Chem. 1982 ; 257 (19). 11210-11212.
    • (1982) J Biol Chem , vol.257 , Issue.19 , pp. 11210-11212
    • Fasco, M.J.1    Hildebrandt, E.F.2    Suttie, J.W.3
  • 6
    • 4644230820 scopus 로고    scopus 로고
    • The pharmacology and management of the vitamin K antagonists: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • DOI 10.1378/chest.126.3
    • Ansell J., Hirsh J., Poller L., Bussey H., Jacobson A., Hylek E. The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 ; 126 (3 suppl). 204S - 233S. (Pubitemid 39297955)
    • (2004) Chest , vol.126 , Issue.3 SUPPL.
    • Ansell, J.1    Hirsh, J.2    Poller, L.3    Bussey, H.4    Jacobson, A.5    Hijlek, E.6
  • 7
    • 38349147756 scopus 로고    scopus 로고
    • New oral anticoagulants in atrial fibrillation
    • Turpie AG New oral anticoagulants in atrial fibrillation. Eur Heart J. 2008 ; 29 (2). 155-165.
    • (2008) Eur Heart J , vol.29 , Issue.2 , pp. 155-165
    • Turpie, A.G.1
  • 8
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • Aithal GP, Day CP, Kesteven PJ, Daly AK Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet. 1999 ; 353 (9154). 717-719.
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3    Daly, A.K.4
  • 9
    • 11244332058 scopus 로고    scopus 로고
    • A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    • DAndrea G., DAmbrosio RL, Di Perna P., et al. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood. 2005 ; 105 (2). 645-649.
    • (2005) Blood , vol.105 , Issue.2 , pp. 645-649
    • Dandrea, G.1    Dambrosio, R.L.2    Di Perna, P.3
  • 11
    • 15844410955 scopus 로고    scopus 로고
    • Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: A record linkage study in a large
    • Jones M., McEwan P., Morgan CL, Peters JR, Goodfellow J., Currie CJ Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: a record linkage study in a large British population. Heart. 2005 ; 91 (4). 472-477.
    • (2005) British Population. Heart , vol.91 , Issue.4 , pp. 472-477
    • Jones, M.1    McEwan, P.2    Morgan, C.L.3    Peters, J.R.4    Goodfellow, J.5    Currie, C.J.6
  • 12
  • 13
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development
    • Eriksson BI, Quinlan DJ, Weitz JI Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clin Pharmacokinet. 2009 ; 48 (1). 1-22.
    • (2009) Clin Pharmacokinet , vol.48 , Issue.1 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 15
    • 0037669041 scopus 로고    scopus 로고
    • The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: A mini-review
    • Gustafsson D., Elg M. The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review. Thromb Res. 2003 ; 109 (suppl 1). S9-15.
    • (2003) Thromb Res , vol.109 , Issue.1 , pp. 9-15
    • Gustafsson, D.1    Elg, M.2
  • 16
    • 17644400166 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    • Stangier J., Eriksson BI, Dahl OE, et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol. 2005 ; 45 (5). 555-563.
    • (2005) J Clin Pharmacol , vol.45 , Issue.5 , pp. 555-563
    • Stangier, J.1    Eriksson, B.I.2    Dahl, O.E.3
  • 17
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J., Rathgen K., Stahle H., Gansser D., Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol. 2007 ; 64 (3). 292-303.
    • (2007) Br J Clin Pharmacol , vol.64 , Issue.3 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 18
    • 37149005153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    • Stangier J., Stahle H., Rathgen K., Fuhr R. Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet. 2008 ; 47 (1). 47-59. (Pubitemid 350260888)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.1 , pp. 47-59
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3    Fuhr, R.4
  • 19
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • DOI 10.2165/00003088-200847050-00001
    • Stangier J. Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet. 2008 ; 47 (5). 285-295. (Pubitemid 351508116)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.5 , pp. 285-295
    • Stangier, J.1
  • 20
    • 0008348082 scopus 로고    scopus 로고
    • European Medicines Agency (EMEA)
    • European Medicines Agency (EMEA). European public assessment report: Pradaxa [online]. http://www.emea.europa.eu/humandocs/PDFs/EPAR/pradaxa/H-829- PI-en.pdf. Accessed January 15, 2010.
    • European Public Assessment Report: Pradaxa [Online]
  • 21
    • 34548575058 scopus 로고    scopus 로고
    • RE-NOVATE Study Group. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomised, double-blind, non-inferiority trial
    • Eriksson BI, Dahl OE, Rosencher N., et al. RE-NOVATE Study Group. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet. 2007 ; 370 (9591). 949-956.
    • (2007) Lancet , vol.370 , Issue.9591 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 22
    • 35449007749 scopus 로고    scopus 로고
    • RE-MODEL Study Group. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
    • Eriksson BI, Dahl OE, Rosencher N., et al. RE-MODEL Study Group. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost. 2007 ; 5 (11). 2178-2185.
    • (2007) J Thromb Haemost , vol.5 , Issue.11 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 23
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • RE-MOBILIZE Writing Committee
    • RE-MOBILIZE Writing Committee, Ginsberg JS, Davidson BL, Comp PC, et al. Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty. 2009 ; 24 (1). 1-9.
    • (2009) J Arthroplasty , vol.24 , Issue.1 , pp. 1-9
    • Ginsberg, J.S.1    Davidson, B.L.2    Comp, P.C.3
  • 24
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Kearon C. Kakkar AK
    • Schulman S., Kearon C., Kakkar AK, et al. RE-COVER Study Group. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med. 2009 ; 361 (24). 2342-2352.
    • (2009) N Engl J Med , vol.361 , Issue.24 , pp. 2342-2352
    • Schulman, S.1
  • 25
    • 77954378526 scopus 로고    scopus 로고
    • Late-Breaking Clinical Trial/Science Abstracts from the AHA Scientific Sessions 2009
    • Oldegren J. 2009 Late-Breaking Clinical Trial/Science Abstracts From the AHA Scientific Sessions 2009. Circulation. 2009 ; 120 (21). 2152-2161.
    • (2009) Circulation , vol.120 , Issue.21 , pp. 2152-2161
    • Oldegren, J.1
  • 26
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S., et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 ; 361 (12). 1139-1151.
    • (2009) N Engl J Med , vol.361 , Issue.12 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 27
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D., Becka M., Wensing G., Voith B., Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol. 2005 ; 61 (12). 873-880.
    • (2005) Eur J Clin Pharmacol , vol.61 , Issue.12 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 28
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D., Becka M., Voith B., Zuehlsdorf M., Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther. 2005 ; 78 (4). 412-421.
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.4 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 29
    • 55549139511 scopus 로고    scopus 로고
    • Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects
    • Kubitza D., Becka M., Roth A., Mueck W. Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects. Curr Med Res Opin. 2008 ; 24 (10). 2757-2765.
    • (2008) Curr Med Res Opin , vol.24 , Issue.10 , pp. 2757-2765
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 30
    • 40749131754 scopus 로고    scopus 로고
    • New anticoagulants for treatment of venous thromboembolism
    • Gross PL, Weitz JI New anticoagulants for treatment of venous thromboembolism. Arterioscler Thromb Vasc Biol. 2008 ; 28 (3). 380-386.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.3 , pp. 380-386
    • Gross, P.L.1    Weitz, J.I.2
  • 31
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    • Kubitza D., Becka M., Zuehlsdorf M., Mueck W. Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects. J Clin Pharmacol. 2006 ; 46 (5). 549-558.
    • (2006) J Clin Pharmacol , vol.46 , Issue.5 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 32
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct factor Xa inhibitor-are not affected by aspirin
    • Kubitza D., Becka M., Mueck W., Zuehlsdorf M. Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct factor Xa inhibitor-are not affected by aspirin. J Clin Pharmacol. 2006 ; 46 (9). 981-990.
    • (2006) J Clin Pharmacol , vol.46 , Issue.9 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 33
    • 33746784959 scopus 로고    scopus 로고
    • No interaction between the novel, oral direct Factor Xa inhibitor BAY 59-7939 and digoxin. (Abstract 11)
    • kubitza D., Becka M., Zuelsdorf M., Mueck W. No interaction between the novel, oral direct Factor Xa inhibitor BAY 59-7939 and digoxin. (Abstract 11). J Clin Pharmacol. 2006 ; 46: 702.
    • (2006) J Clin Pharmacol , vol.46 , pp. 702
    • Kubitza, D.1    Becka, M.2    Zuelsdorf, M.3    Mueck, W.4
  • 34
    • 45949099359 scopus 로고    scopus 로고
    • RECORD1 Study Group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson BI, Borris LC, Friedman RJ, et al. RECORD1 Study Group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med. 2008 ; 358 (26). 2765-2775.
    • (2008) N Engl J Med , vol.358 , Issue.26 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 35
    • 46049106502 scopus 로고    scopus 로고
    • RECORD2 Investigators. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled trial
    • Kakkar AK, Brenner B., Dahl OE, et al. RECORD2 Investigators. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet. 2008 ; 372 (9632). 31-39.
    • (2008) Lancet , vol.372 , Issue.9632 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 36
    • 45949103416 scopus 로고    scopus 로고
    • RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen MR, Ageno W., Borris LC, et al. RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med. 2008 ; 358 (26). 2776-2786.
    • (2008) N Engl J Med , vol.358 , Issue.26 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 37
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • Turpie AGG, Lassen MR, Davidson BL, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet. 2009 ; 373 (9676). 1673-1679.
    • (2009) Lancet , vol.373 , Issue.9676 , pp. 1673-1679
    • Agg, T.1    Lassen, M.R.2    Davidson, B.L.3
  • 39
    • 74949139434 scopus 로고    scopus 로고
    • The new oral anticoagulants
    • Garcia D., Libby E., Crowther MA The new oral anticoagulants. Blood. 2010 ; 115 (1). 15-20.
    • (2010) Blood , vol.115 , Issue.1 , pp. 15-20
    • Garcia, D.1    Libby, E.2    Crowther, M.A.3
  • 40
    • 53849123533 scopus 로고    scopus 로고
    • A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: The Einstein-DVT Dose-Ranging Study
    • Buller HR, Lensing AWA, Prins MH, et al, on behalf of the Einstein-DVT Dose-Ranging Study investigators. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood. 2008 ; 112 (6). 2242-2247.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2242-2247
    • Buller, H.R.1    Awa, L.2    Prins, M.H.3    Dose-Ranging, E.4
  • 41
    • 67649562905 scopus 로고    scopus 로고
    • ATLAS ACS-TIMI 46 study group. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): A randomised, double-blind, phase II trial
    • Mega JL, Braunwald E., Mohanavelu S., et al. ATLAS ACS-TIMI 46 study group. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet. 2009 ; 374 (9683). 29-38.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 42
    • 85058721877 scopus 로고    scopus 로고
    • Rivaroxaban-oncedaily, oral, direct factor xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation: Rationale and design of the ROCKET AF study
    • The Executive Steering Committee on behalf of the ROCKET AF Study Investigators
    • The Executive Steering Committee, on behalf of the ROCKET AF Study Investigators. Rivaroxaban-oncedaily, oral, direct factor xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation: Rationale and design of the ROCKET AF study. Am Heart J. 2010 ; 159: 340, 347.el.
    • (2010) Am Heart J , vol.159 , pp. 340
  • 43
    • 0035854054 scopus 로고    scopus 로고
    • Validation of clinical classification schemes for predicting stroke: Results from the National Registry of Atrial Fibrillation
    • Gage BF, Waterman AD, Shannon W., Boechler M., Rich MW, Radford MJ Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA. 2001 ; 285 (22). 2864-2870.
    • (2001) JAMA , vol.285 , Issue.22 , pp. 2864-2870
    • Gage, B.F.1    Waterman, A.D.2    Shannon, W.3    Boechler, M.4    Rich, M.W.5    Radford, M.J.6
  • 44
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • Ogata K., Mendell-Harary J., Tachibana M., et al. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol. 2010 [Epub ahead of print].
    • (2010) J Clin Pharmacol
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3
  • 45
    • 77950623005 scopus 로고    scopus 로고
    • The factor Xa inhibitor edoxaban (DU-176b) is safe in healthy subjects 24 hours post warfarin treatment: A randomized, double-blind study [abstracts]
    • Mendell J., Noveck R., Rubets I., Luo R., Shi M., Salazar D. The factor Xa inhibitor edoxaban (DU-176b) is safe in healthy subjects 24 hours post warfarin treatment: a randomized, double-blind study [abstracts]. J Thromb Haemost. 2009 ; 7 (suppl 2) 1636.
    • (2009) J Thromb Haemost , vol.7 , Issue.2 , pp. 1636
    • Mendell, J.1    Noveck, R.2    Rubets, I.3    Luo, R.4    Shi, M.5    Salazar, D.6
  • 46
    • 77956823153 scopus 로고    scopus 로고
    • The oral factor xa inhibitor edoxaban (DU-176b): Population pharmacokinetic and pharmacodynamic models of coagulation biomarkers, efficacy and safety [abstract]
    • Mendell J., Rohatagi R., Rombout F., et al. The oral factor xa inhibitor edoxaban (DU-176b): population pharmacokinetic and pharmacodynamic models of coagulation biomarkers, efficacy and safety [abstract]. Clin Pharmacol Ther. 2009 ; 85 (S1). S36.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.S1 , pp. 36
    • Mendell, J.1    Rohatagi, R.2    Rombout, F.3
  • 47
    • 77956633995 scopus 로고    scopus 로고
    • The relationship between oral factor xa (FXa) inhibitor DU-176b pharmacokinetics (PK) and the probability of bleeding events (BE) in patients with atrial fibrillation (AF) [abstract]
    • Giugliano RP, Rohatagi R., Kastrissios H., et al. The relationship between oral factor xa (FXa) inhibitor DU-176b pharmacokinetics (PK) and the probability of bleeding events (BE) in patients with atrial fibrillation (AF) [abstract]. J Thromb Haemost. 2009 ; 7: 200.
    • (2009) J Thromb Haemost , vol.7 , pp. 200
    • Giugliano, R.P.1    Rohatagi, R.2    Kastrissios, H.3
  • 48
    • 67649897732 scopus 로고    scopus 로고
    • Randomized, parallel group, multicenter, multinational study evaluating safety of DU-176b compared with warfarin in subjects with non-valvular atrial fibrillation [abstract]
    • Weitz JI, Connolly SJ, Kunitada S., Jin J., Patel I. Randomized, parallel group, multicenter, multinational study evaluating safety of DU-176b compared with warfarin in subjects with non-valvular atrial fibrillation [abstract]. Blood. 2008 ; 112 (11). 33.
    • (2008) Blood , vol.112 , Issue.11 , pp. 33
    • Weitz, J.I.1    Connolly, S.J.2    Kunitada, S.3    Jin, J.4    Patel, I.5
  • 49
    • 0042670044 scopus 로고    scopus 로고
    • The pros and cons of noninferiority trials
    • Pocock SJ The pros and cons of noninferiority trials. Fundam Clin Pharmacol. 2003 ; 17 (4). 483-490.
    • (2003) Fundam Clin Pharmacol , vol.17 , Issue.4 , pp. 483-490
    • Pocock, S.J.1
  • 50
    • 38949135933 scopus 로고    scopus 로고
    • Assessing non-inferiority: A combination approach
    • Gao P., Ware JH Assessing non-inferiority: a combination approach. Stat Med. 2008 ; 27 (3). 392-406.
    • (2008) Stat Med , vol.27 , Issue.3 , pp. 392-406
    • Gao, P.1    Ware, J.H.2
  • 51
    • 28244432534 scopus 로고    scopus 로고
    • Trials and tribulations of non-inferiority: The ximelagatran experience
    • Kaul S., Diamond GA, Weintraub WS Trials and tribulations of non-inferiority: the ximelagatran experience. J Am Coll Cardiol. 2005 ; 46 (11). 1986-1995.
    • (2005) J Am Coll Cardiol , vol.46 , Issue.11 , pp. 1986-1995
    • Kaul, S.1    Diamond, G.A.2    Weintraub, W.S.3
  • 52
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N., Frost CE, Yu Z., et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos. 2009 ; 37 (1). 74-81.
    • (2009) Drug Metab Dispos , vol.37 , Issue.1 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 53
    • 33748590510 scopus 로고    scopus 로고
    • Emerging anticoagulants for the treatment of venous thromboembolism
    • Weitz JI Emerging anticoagulants for the treatment of venous thromboembolism. Thromb Haemost. 2006 ; 96 (3). 274-284.
    • (2006) Thromb Haemost , vol.96 , Issue.3 , pp. 274-284
    • Weitz, J.I.1
  • 55
    • 74249102000 scopus 로고    scopus 로고
    • The ADVANCE-2 Study: A randomized double-blind trial comparing apixaban with enoxaparin for thromboprophylaxis after total knee replacement ISTH Late Breaking Clinical Trials 2009 (LB-MO-004)
    • Lassen MR, Gallus AS, Pineo GF, Raskob GE The ADVANCE-2 Study: a randomized double-blind trial comparing apixaban with enoxaparin for thromboprophylaxis after total knee replacement ISTH Late Breaking Clinical Trials 2009 (LB-MO-004). J Thromb Haemost. 2009 ; 7 (suppl 2). 1203-1204.
    • (2009) J Thromb Haemost , vol.7 , Issue.2 , pp. 1203-1204
    • Lassen, M.R.1    Gallus, A.S.2    Pineo, G.F.3    Raskob, G.E.4
  • 56
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome. Results of the apixaban for prevention of acute ischemic and safety events (APPRAISE) trial
    • Investigators ASCa. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome. Results of the apixaban for prevention of acute ischemic and safety events (APPRAISE) trial. Circulation. 2009 ; 119 (22). 2877-2885.
    • (2009) Circulation. , vol.119 , Issue.22 , pp. 2877-2885
    • Asca, I.1
  • 57
    • 77649249878 scopus 로고    scopus 로고
    • Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: Design and rationale
    • Lopes RD, Alexander JH, Al-Khatib SM, et al. Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: Design and rationale. Am Heart J. 2010 ; 159: 331-339.
    • (2010) Am Heart J , vol.159 , pp. 331-339
    • Lopes, R.D.1    Alexander, J.H.2    Al-Khatib, S.M.3
  • 58
    • 23944434055 scopus 로고    scopus 로고
    • SPORTIF Executive Steering Committee for the SPORTIF v Investigators. Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: A randomized trial
    • Albers GW, Diener HC, Frison L., et al; SPORTIF Executive Steering Committee for the SPORTIF V Investigators. Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a randomized trial. JAMA. 2005 ; 293 (6). 690-698.
    • (2005) JAMA , vol.293 , Issue.6 , pp. 690-698
    • Albers, G.W.1    Diener, H.C.2    Frison, L.3
  • 59
    • 0345414673 scopus 로고    scopus 로고
    • Committee of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial
    • Olsson SB ;. Executive Steering Committee of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial. Lancet. 2003 ; 362 (9397). 1691-1698.
    • (2003) Lancet , vol.362 , Issue.9397 , pp. 1691-1698
    • Olsson, S.B.1    Steering, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.