Analysis of a French cohort of patients with large granular lymphocyte leukemia: A report on 229 cases

Haematologica

Volumn 95, Issue 9, 2010, Pages 1534-1541

  Bareau, Benoît ^a   Rey, Jérôme ^b,c   Hamidou, Mohamed ^d   Donadieu, Jean ^e   Morcet, Jeff ^f   Reman, Oumedaly ^g   Schleinitz, Nicolas ^h   Tournilhac, Olivier ⁱ   Roussel, Mikael ^a   Fest, Thierry ^a,j   Lamy, Thierry ^a,j  

^a RENNES UNIVERSITY HOSPITAL   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d NANTES UNIVERSITY HOSPITAL   (France)

^e ARMAND TROUSSEAU HOSPITAL   (France)

^f UNIVERSITÉ DE RENNES 1   (France)

^g CAEN UNIVERSITY HOSPITAL   (France)

^h HÔPITAL DE LA CONCEPTION   (France)

ⁱ UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^j INSERM U917   (France)

more..

Author keywords

Large granular lymphocyte leukemia; LGL leukemia; NK lymphocytosis

Indexed keywords

ALEMTUZUMAB; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DANAZOL; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; METHOTREXATE; PREDNISONE; PURINE DERIVATIVE; STEROID; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; AGED; AGGRESSIVE NK CELL LEUKEMIA; ANEMIA; ARTICLE; AUTOIMMUNE DISEASE; CANCER RADIOTHERAPY; CHILD; DEATH; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG RESPONSE; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FEMALE; FRANCE; GENE REARRANGEMENT; HUMAN; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; LYMPHOCYTIC INFILTRATION; LYMPHOCYTOSIS; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; SCHOOL CHILD; SPLENECTOMY; T CELL LEUKEMIA; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; COHORT STUDIES; FEMALE; FRANCE; HUMANS; KILLER CELLS, NATURAL; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; LYMPHOCYTOSIS; MALE; MIDDLE AGED; REGISTRIES; T-LYMPHOCYTES; TREATMENT OUTCOME;

EID: 77956840179     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.018481     Document Type: Article

References (32)

1. Alekshun TJ, Sokol L. Diseases of large granular lymphocytes. Cancer Control. 2007;14(2):141-50.
2. Bowman SJ, Sivakumaran M, Snowden N, Bhavnani M, Hall MA, Panayi GS, et al. The large granular lymphocyte syndrome with rheumatoid arthritis. Immunogenetic evidence for a broader definition of Felty's syndrome. Arthritis Rheum. 1994;37(9):1326-30.
3. Dhodapkar MV, Li CY, Lust JA, Tefferi A, Phyliky RL. Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance? Blood. 1994;84(5):1620-7.
4. Friedman J, Schattner A, Shvidel L, Berrebi A. Characterization of T-cell large granular lymphocyte leukemia associated with Sjogren's syndrome-an important but under-recognized association. Semin Arthritis Rheum. 2006;35(5):306-11.
5. Go RS, Lust JA, Phyliky RL. Aplastic anemia and pure red cell aplasia associated with large granular lymphocyte leukemia. Semin Hematol. 2003;40(3):196-200.
6. Lamy T, Loughran TP Jr. Clinical features of large granular lymphocyte leukemia. Semin Hematol. 2003;40(3):185-95
7. Loughran TP Jr. Clonal diseases of large granular lymphocytes. Blood. 1993;82(1):1-14.
8. McKenna RW, Arthur DC, Gajl-Peczalska KJ, Flynn P, Brunning RD. Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder? Blood. 1985;66(2):259-66.
9. Oshimi K, Yamada O, Kaneko T, Nishinarita S, Iizuka Y, Urabe A, et al. Laboratory findings and clinical courses of 33 patients with granular lymphocyteproliferative disorders. Leukemia. 1993;7(6):782-8.
10. Pandolfi F, Loughran TP, Jr., Starkebaum G, Chisesi T, Barbui T, Chan WC, et al. Clinical course and prognosis of the lymphoproliferative disease of granular lymphocytes. A multicenter study. Cancer. 1990;65(2):341-8.
11. Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Oncologist. 2006; 11(3):263-73.
12. Swerdlow SH, Campo E, Harris NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (4th Ed). Lyon, France: IARC; 2008.
13. Semenzato G, Zambello R, Starkebaum G, Oshimi K, Loughran TP Jr. The lymphoproliferative disease of granular lymphocytes: updated criteria for diagnosis. Blood. 1997;89(1):256-60.
14. Siebert JD, Mulvaney DA, Potter KL, Fishkin PA, Geoffroy FJ. Relative frequencies and sites of presentation of lymphoid neoplasms in a community hospital according to the revised European-American classification. Am J Clin Pathol. 1999;111(3):379-86.
15. Neben MA, Morice WG, Tefferi A. Clinical features in T-cell vs. natural killercell variants of large granular lymphocyte leukemia. Eur J Haematol. 2003;71(4):263-5.
16. Lamy T, Bauer FA, Liu JH, Li YX, Pillemer E, Shahidi H, et al. Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice. Br J Haematol. 2000; 108(4):717-23.
17. Rossoff LJ, Genovese J, Coleman M, Dantzker DR. Primary pulmonary hypertension in a patient with CD8/T-cell large granulocyte leukemia: amelioration by cladribine therapy. Chest. 1997;112(2):551-3.
18. Semenzato G, Pandolfi F, Chisesi T, De Rossi G, Pizzolo G, Zambello R, et al. The lymphoproliferative disease of granular lymphocytes. A heterogeneous disorder ranging from indolent to aggressive conditions. Cancer. 1987;60(12):2971-8.
19. Karasawa M, Mitsui T, Isoda A, Tsumita Y, Irisawa H, Yokohama A, et al. TCR Vbeta repertoire analysis in CD56+ CD16(dim/-) T-cell large granular lymphocyte leukaemia: association with CD4 single and CD4/CD8 double positive phenotypes. Br J Haematol. 2003;123(4):613-20.
20. Langerak AW, van Den Beemd R, Wolvers-Tettero IL, Boor PP, van Lochem EG, Hooijkaas H, et al. Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations. Blood. 2001;98(1):165-73.
21. Lima M, Almeida J, Dos Anjos Teixeira M, Alguero Md Mdel C, Santos AH, Balanzategui A, et al. TCRalphabeta+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder. Am J Pathol. 2003;163(2):763-71.
22. Lima M, Almeida J, Santos AH, dos Anjos Teixeira M, Alguero MC, Queiros ML, et al. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into th pathogenesis of the disease. Am J Pathol. 2001;159(5):1861-8.
23. Suzuki R, Suzumiya J, Nakamura S, Aoki S, Notoya A, Ozaki S, et al. Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. Leukemia. 2004;18(4):763-70.
24. Hamidou MA, Sadr FB, Lamy T, Raffi F, Grolleau JY, Barrier JH. Low-dose methotrexate for the treatment of patients with large granular lymphocyte leukemia associated with rheumatoid arthritis. Am J Med. 2000;108(9):730-2
25. Loughran TP Jr, Kidd PG, Starkebaum G. Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate. Blood. 1994;84(7):2164-70.
26. Mohan SR, Maciejewski JP. Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia. Curr Opin Hematol. 2009;16(1):27-34.
27. Aribi A, Huh Y, Keating M, O'Brien S, Ferrajoli A, Faderl S, et al. T-cell large granular lymphocytic (T-LGL) leukemia: experience in a single institution over 8 years. Leuk Res. 2007;31(7):939-45.
28. Battiwalla M, Melenhorst J, Saunthararajah Y, Nakamura R, Molldrem J, Young NS, et al. HLA-DR4 predicts haematological response to cyclosporine in T-large granular lymphocyte lymphoproliferative disorders. Br J Haematol. 2003;123(3):449-53.
29. Go RS, Li CY, Tefferi A, Phyliky RL. Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood. 2001;98(2):483-5.
30. Osuji N, Matutes E, Tjonnfjord G, Grech H, Del Giudice I, Wotherspoon A, et al. Tcell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature. Cancer. 2006;107(3):570-8.
31. Sood R, Stewart CC, Aplan PD, Murai H, Ward P, Barcos M, et al. Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. Blood. 1998;91(9):3372-8.
32. Subbiah V, Viny AD, Rosenblatt S, Pohlman B, Lichtin A, Maciejewski JP. Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. Exp Hematol. 2008;36(9):1078-83.