Onapristone and prostaglandin E2 induction of delivery in the rat in late pregnancy: A model for the analysis of cervical softening

American Journal of Obstetrics and Gynecology

Volumn 175, Issue 3 PART I, 1996, Pages 719-723

  Rechberger, Tomasz ^a   Abramson, Susan R ^a   Woessner Jr , J Frederick ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Antiprogesterone; Cervical dilatation; Decorin; Prostaglandin E2; Rat collagen

Indexed keywords

COLLAGEN; DECORIN; ONAPRISTONE; PROSTAGLANDIN E2; PROTEOGLYCAN; ESTRADIOL; GONANE DERIVATIVE; SCLEROPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DELIVERY; DRUG EFFECT; FEMALE; HORMONE ACTION; LABOR INDUCTION; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; RAT; THIRD TRIMESTER PREGNANCY; UTERINE CERVIX DILATATION; ANIMAL; BIOLOGICAL MODEL; BIOMECHANICS; BIRTH WEIGHT; HISTOLOGY; METABOLISM; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT; UTERINE CERVIX;

ANIMALS; BIOMECHANICS; BIRTH WEIGHT; CERVIX UTERI; COLLAGEN; DINOPROSTONE; ESTRADIOL; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GONANES; LABOR, INDUCED; MODELS, BIOLOGICAL; PREGNANCY; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030236766     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1053/ob.1996.v175.a74254     Document Type: Article

References (23)

1. Leppert PC. Cervical softening, effacement, and dilatation: a complex biochemical cascade. J Matern Fetal Meet 1992;1: 213-23.
2. Aspden RM. Collagen organisation in the cervix and its relation to mechanical function. Collagen Rel Res 1988;8: 103-12.
3. Yu SY, Tozzi CA, Babiarz J, Leppert PC. Collagen changes in rat cervix in pregnancy-polarized light microscopic and electron microscopic studies. Proc Soc Exp Biol Med 1995;209:360-8.
4. Hillier K, Wallis RM. Collagen solubility and tensile properties of the rat uterine cervix in late pregnancy: effects of arachidonic acid and prostaglandin F2α. J Endocrinol 1982;95:341-7.
5. Downing SJ, Sherwood OD. The physiological role of relaxin in the pregnant rat, IV: the influence of relaxin on cervical collagen and glycosaminoglycans. Endocrinology 1986;118:471-9.
6. Kokenyesi R, Woessner JF Jr. Relationship between dilatation of the rat uterine cervix and a small dermatan sulfate proteoglycan. Biol Reprod 1990;42:87-97.
7. Rajabi M, Dean DD, Woessner JF Jr. High levels of serum collagenase in premature labor - a potential biochemical marker. Obstet Gynecol 1987;69:179-86.
8. Rajabi MR, Dean DD, Beydoun SN, Woessner JF Jr. Elevated tissue levels of collagenase during dilation of uterine cervix in human parturition. Am J Obstet Gynecol 1988;159:971-6.
9. Osmers R, Rath W, Adelmann-Grill BC, Fittkow C, Severenyi M, Kuhn W. Collagenase activity in the cervix of non-pregnant and pregnant women. Arch Gynecol Obstet 1990;248: 75-80.
10. Ekman G, Almström H, Granström L, Malmström A, Norman M, Woessner JF Jr. Connective tissue in human cervical ripening. In: Leppert PC, Woessner JF Jr, editors. The extracellular matrix of the uterus, cervix, and fetal membranes: synthesis, degradation and hormonal regulation. Ithaca: Perinatology Press, 1991:87-96.
11. Raynes JG, Anderson JC, Fitzpatrick RJ, Dobson H. Increased collagenase activity is not detectable in cervical softening in the ewe. Collagen Rel Res 1988;8:461-9.
12. Rath W, Adelmann-Grill BC, Osmers R, Kuhn W. Enzymatic collagen degradation in the pregnant guinea pig cervix during physiological maturation of the cervix and after local application of prostaglandins. Eur J Obstet Gynecol Reprod Biol 1989;32:199-204.
13. Kokenyesi R, Woessner JF Jr. Relationship between dilatation of the rat uterine cervix and small dermatan sulfate proteoglycan. In: Leppert PC, Woessner JF Jr, editors. The extracellular matrix of the uterus, cervix and fetal membranes: synthesis, degradation and hormonal regulation. Ithaca: Perinatology Press, 1991:97-104.
14. Uldbjerg N, Carlstedt I, Ekman G, Malmström A, Ulmsten U, Wingerup L. Dermatan sulphate and mucin glycopeptides from the human uterine cervix. Gynecol Obstet Invest 1983;16:199-209.
15. Vogel KG, Paulsson M, Heinegård D. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem J 1984;223:587-97.
16. Uldbjerg N, Danielsen CC. A study of the interaction in vitro between type I collagen, and a small dermatan sulfate proteoglycan. Biochem J 1988;251:643-8.
17. Kokenyesi R, Woessner JF Jr. Effects of hormonal perturbations on the small dermatan sulfate proteoglycan and mechanical properties of the uterine cervix of late pregnant rats. Connect Tissue Res 1991;26:199-205.
18. Rechberger T, Woessner JF Jr. Collagenase, its inhibitors, and decorin in the lower uterine segment in pregnant women. Am J Obstet Gynecol 1993;168:1598-603.
19. Farndale RW, Buttle DJ, Barren AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883: 173-7.
20. Woessner JF Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961;93:440-7.
21. Harper JF. Peritz' F test: basic program of a robust multiple comparison test for statistical analysis of all differences among group means. Comput Biol Med 1984;14:437-45.
22. Knudsen UB, Spanggaard H, Uldbjerg N, Danielsen CC. Biomechanical analysis of cervix uteri in nonpregnant, pregnant and antigestagen (ZK 98 299) treated pregnant rats. Connect Tissue Res 1994;31:67-74.
23. Ikuta Y, Matsuura K, Okamura H, Oyamada I, Usuku G. Effects of RU486 on the interstitial collagenase in the process of cervical ripening in the pregnant rat. Endocrinol Jpn 1991:38:491-6.