Effect of glutamine supplementation on lymphocyte subsets in children with acute diarrhea

Turkish Journal of Pediatrics

Volumn 52, Issue 3, 2010, Pages 262-266

  Yalçin, S Songül ^a   Yurdakök, Kadriye ^a   Tezcan, Ilhan ^a   Tuncer, Murat ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Acute diarrhea; Children; Glutamine; Lymphocyte subset; Supplementation

Indexed keywords

CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; GLUTAMINE; PLACEBO;

ACUTE DIARRHEA; ARTICLE; BREAST FEEDING; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEHYDRATION; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INFANT; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEX; BLOOD; INFANTILE DIARRHEA;

DIARRHEA, INFANTILE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GLUTAMINE; HUMANS; INFANT; LYMPHOCYTE SUBSETS; MALE; PROSPECTIVE STUDIES;

EID: 77956824105     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Calder PC. Glutamine and the immune system. Clin Nutr 1994; 13: 2-8.
2. Crawford J, Cohen HJ. The essential role of L-glutamine in lymphocyte differentiation in vitro. J Cell Physiol 1985; 124: 275-282.
3. Gismondo MR, Drago L, Fassina MC, et al. Immunostimulating effect of oral glutamine. Dig Dis Sci 1998; 43: 1752-1754.
4. Kew S, Wells SM, Yaqoob P, et al. Dietary glutamine enhances murine T-lymphocyte responsiveness. J Nutr 1999; 129: 1524-1531.
5. Jensen GL, Miller RH, Talabiska DG, et al. A double blind, prospective, randomized study of glutamineenriched compared with standard peptide-based feeding in critically ill patients. Am J Clin Nutr 1996; 64: 615-621.
6. O'Riordain M, Fearon KC, Ross JA, et al. Glutamine supplemented parenteral nutrition enhances Tlymphocyte response in surgical patients undergoing colorectal resection. Ann Surg 1994; 220: 212-221.
7. Ziegler TR, Bye RL, Persinger RL, et al. Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study. Am J Med Sci 1998; 315: 314.
8. Neu J, Roig JC, Meetze WH, et al. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr 1997; 131: 691-699.
9. Abcouwer SF. Effects of glutamine on immune cells. Nutrition 2000; 16: 67-77.
10. Reeds PJ, Burrin DG. Glutamine and the bowel. J Nutr 2001; 131: 2505S-2508S.
11. Yalçi{dotless}n SS, Yurdakök K, Tezcan I, Öner L. Effect of glutamine supplementation on diarrhea and interleukin- 8 and secretory immunoglobulin A in children with acute diarrhea. J Pediatr Gastroenterol Nutr 2004; 38: 494-501.
12. Hamill PV, Drizd TA, Johnson CL, et al. Physical growth: National Center for Health Statistics percentiles. Am J Clin Nutr 1979; 32: 607-629.
13. World Health Organization (WHO). A manual for the treatment of acute diarrhea for use by the physicians and other senior health workers. Geneva: WHO; 1984, WHO/CDD/SER 80.2 REV 1.
14. Bongers T, Griffiths RD, McArdle A. Exogenous glutamine: the clinical evidence. Crit Care Med 2007; 35(Suppl): S545-552.
15. Lai YN, Yeh SL, Lin MT, et al. Glutamine supplementation enhances mucosal immunity in rats with gut-derived sepsis. Nutrition 2004; 20: 286- 291.
16. López-Pedrosa JM, Manzano M, Baxter JH, et al. N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs. Dig Dis Sci 2007; 52: 650-658.
17. Yeh SL, Lai YN, Shang HF, et al. Effects of glutamine supplementation on innate immune response in rats with gut-derived sepsis. Br J Nutr 2004; 91: 423-429.
18. Lin MT, Kung SP, Yeh SL, et al. The effect of glutaminesupplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients. Clin Nutr 2002; 21: 213-218.
19. Taniguchi K, Rikimaru T, Yartey JE, et al. Immunological background in children with persistent diarrhea in Ghana. Pediatr Int 1999; 41: 162-167.
20. Luo M, Bazargan N, Griffith DP, et al. Metabolic effects of enteral versus parenteral alanyl-glutamine dipeptide administration in critically ill patients receiving enteral feeding: a pilot study. Clin Nutr 2008; 27: 297-306.