Fructose, exercise, and health

Current Sports Medicine Reports

Volumn 9, Issue 4, 2010, Pages 253-258

  Johnson, Richard J ^a   Murray, Robert ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Sports Science Insights   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBOHYDRATE; FRUCTOSE;

BEVERAGE; CALORIC INTAKE; DIETARY INTAKE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; EXERCISE; FRUCTOSE METABOLISM; FRUIT; HEALTH STATUS; HUMAN; HYPERTENSION; INFLAMMATION; INSULIN RESISTANCE; METABOLIC DISORDER; OBESITY; OXIDATION; REVIEW; THROMBOSIS; TRAINING;

ATHLETES; ENERGY INTAKE; EXERCISE; FRUCTOSE; HEALTH STATUS; HUMANS; METABOLIC SYNDROME X; OBESITY;

EID: 77956813842     PISSN: 1537890X     EISSN: 15378918     Source Type: Journal    
DOI: 10.1249/JSR.0b013e3181e7def4     Document Type: Review

References (66)

1. American Academy of Pediatrics. Dietary recommendations for children and adolescents: A guide for practitioners. Pediatrics. 2006; 117:544-59.
2. Bell RC, Carlson JC, Storr KC, Herbert K, Sivak J. High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney. Br. J. Nutr. 2000; 84:575-82.
3. Beyer CL, Caviar EM, McCallum RW. Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults. J. Am. Diet. Assoc. 2005; 105:1559-61.
4. Bode JC, Zelder O, Rumpelt HJ, Wittkamp U. Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat. Eur. J. Clin. Invest. 1973; 3:436-41.
5. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am. J. Clin. Nutr. 2004; 79:537-43.
6. Cirillo P, Gersch MS, Mu W, et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J. Am. Soc. Nephrol. 2009; 20:545-53.
7. Cirillo P, Sautin YY, Kanellis J, et al. Systemic inflammation, metabolic syndrome and progressive renal disease. Nephrol. Dial. Transplant. 2009; 24:1384-7.
8. Coggan AR, Coyle EF. Reversal of fatigue during prolonged exercise by carbohydrate infusion or ingestion. J. Appl. Physiol. 1987; 63: 2388-95.
9. Coyle EF, Coggan AR, Hemmert MK, Ivy JL. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J. Appl. Physiol. 1986; 61:165-72.
10. Deer N. The History of Sugar. London: Chapman and Hall; 1949.
11. Dennison BA, Rockwell HL, Baker SL. Excess fruit juice consumption by preschool-aged children is associated with short stature and obesity. Pediatrics. 1997; 99:15-22.
12. Dhingra R, Sullivan L, Jacques PF, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. 2007; 116:480-8.
13. Dwyer JT, Evans M, Stone EJ, et al. Adolescents' eating patterns influence their nutrient intakes. J. Am. Diet. Assoc. 2001; 101:798-802.
14. Fordtran JS. Stimulation of active and passive sodium absorption by sugars in the human jejunum. J. Clin. Invest. 1975; 55:728-37.
15. Fox IH, Kelley WN. Studies on the mechanism of fructose-induced hyperuricemia in man. Metabolism. 1972; 21:713-21.
16. Franz MJ, Bantle JP, Beetle CA, et al. Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care. 2003; 26(Suppl. 1):S51-61.
17. Gersch MS, Mu W, Cirillo P, et al. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am. J. Physiol. Renal Physiol. 2007; 293:F1256-61.
18. Glushakova O, Kosugi T, Roncal C, et al. Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J. Am. Soc. Nephrol. 2008; 19:1712-20.
19. Havel PJ. Dietary fructose: Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr. Rev. 2005; 63: 133-57.
20. Herbert KL, Sivak JG, Bell RC. Effect of diabetes and fructose/non-fructose diet on the optical quality (cataracts) of the rat lens. Curr. Eye Res. 1999; 19:305-12.
21. Jentjens RL, Shaw C, Birtles T, et al. Oxidation of combined ingestion of glucose and sucrose during exercise. Metabolism. 2005; 54:610-8. (Pubitemid 40585651)
22. Jentjens RL, Jeukendrup AE. High rates of exogenous carbohydrate oxidation from a mixture of glucose and fructose ingested during prolonged cycling exercise. Br. J. Nutr. 2005; 93:485-92.
23. Jentjens RL, Moseley L, Waring RH, Harding LK, Jeukendrup AE. Oxidation of combined ingestion of glucose and fructose during exercise. J. Appl. Physiol. 2004; 96:1277-84.
24. Jentjens RL, Achten J, Jeukendrup AE. High oxidation rates from combined carbohydrates ingested during exercise. Med. Sci. Sports Exerc. 2004; 36:1551-8.
25. Johnson RJ, Perez-Pozo SE, Sautin YY, et al. Hypothesis: Could excessive fructose intake and uric acid cause type 2 diabetes? Endocr. Rev. 2009; 30:96-116.
26. Johnson RJ, Sautin YY, Oliver WJ, et al. Lessons from comparative physiology: Could uric acid represent a physiologic alarm signal gone awry in western society? J. Comp. Physiol. B. 2009; 179:67-76.
27. Johnson RJ, Gower T. The Sugar Fix: The High-Fructose Fallout that is Making You Fat and Sick, 1st ed. New York (NY): Rodale; 2008.
28. Johnson RJ, Segal MS, Sautin Y, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am. J. Clin. Nutr. 2007; 86:899-906.
29. Koivisto VA, Yki-Jarvinen H. Fructose and insulin sensitivity in patients with type 2 diabetes. J. Intern. Med. 1993; 233:145-53.
30. Kranz S, Smiciklas-Wright H, Siega-Riz AM, Mitchell D. Adverse effect of high added sugar consumption on dietary intake in American preschoolers. J. Pediatr. 2005; 146:105-11.
31. Ludwig DS, Peterson KE, Gortmaker SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: A prospective, observational analysis. Lancet. 2001; 357:505-8.
32. Maenpaa PH, Raivio KO, Kekomaki MP. Liver adenine nucleotides: Fructose-induced depletion and its effect on protein synthesis. Science. 1968; 161:1253-4.
33. Moore MC, Cherrington AD, Mann SL, Davis SN. Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J. Clin. Endocrinol. Metab. 2000; 85:4515-9.
34. Morris RC Jr, Nigon K, Reed EB. Evidence that the severity of depletion of inorganic phosphate determines the severity of the disturbance of adenine nucleotide metabolism in the liver and renal cortex of the fructose-loaded rat. J. Clin. Invest. 1978; 61:209-20.
35. Murray R. The effects of consuming carbohydrate-electrolyte beverages on gastric emptying and fluid absorption during and following exercise. Sports Med. 1987; 4:322-51.
36. Nagy S. Vitamin C contents of citrus fruit and their products: A review. J. Agric. Food Chem. 1980; 28:8-18.
37. Nair S, - PC, Arnold C, Diehl AM. Hepatic ATP reserve and efficiency of replenishing: Comparison between obese and nonobese normal individuals. Am. J. Gastroenterol. 2003; 98:466-70.
38. Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am. J. Physiol. Renal Physiol. 2006; 290:F625-31. (Pubitemid 43724964)
39. Nielsen SJ, Popkin BM. Changes in beverage intake between 1977 and 2001. Am. J. Prev. Med. 2004; 27:205-10.
40. Olsen WA, Ingelfinger FJ. The role of sodium in intestinal glucose absorption in man. J. Clin. Invest. 1968; 47:1133-42.
41. Osei K, Bossetti B. Dietary fructose as a natural sweetener in poorly controlled type 2 diabetes: A 12-month crossover study of effects on glucose, lipoprotein and apolipoprotein metabolism. Diabet. Med. 1989; 6: 506-11.
42. Ouyang X, Cirillo P, Sautin Y, et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J. Hepatol. 2008; 48:993-9.
43. Perez-Pozo SE, Schold J, Nakagawa T, et al. Excessive fructose induces the features of metabolic syndrome in healthy adult men: Role of uric acid in the hypertensive response. Int. J. Obes. (Lond.) 2009; 1-8 [Epub ahead of print. Available from: Http://www.ncbi.nlm.nih.gov/pubmed/ 20029377?itool= EntrezSystem2.PEntrez.Pubmed.Pubmed-ResultsPanel. Pubmed- RVDocSum&ordinalpos=1].
44. Reungjui S, Roncal CA, Mu W, et al. Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J. Am. Soc. Nephrol. 2007; 18: 2724-31.
45. Rowlands DS, Thorburn MS, Thorp, RM, Boradbent S, Shi X. Effect of graded fructose coingestion with maltodextrin on exogenous 14C-fructose and 13C-glucose oxidation efficiency and high-intensity cycling performance. J. Appl. Physiol. 2008; 104:1709-19.
46. Rumessen JJ, Gudmand-Hoyer E. Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut. 1986; 27:1161-8.
47. Sanchez-Lozada LG, Mu W, Roncal C, et al. Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur. J. Nutr. [Internet] 2009. Available from: Http://www.ncbi.nlm.nih.gov/sites/entrez. Accessed June 7, 2010.
48. Sanchez-Lozada LG, Tapia E, Bautista-Garcia P, et al. Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am. J. Physiol. Renal Physiol. 2008; 294:F710-8.
49. Sanchez-Lozada LG, Tapia E, Jimenez A, et al. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.Am. J. Physiol. Renal Physiol. 2007; 292:F423-9.
50. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am. J. Physiol. Cell Physiol. 2007; 293:C584-96.
51. Schulze MB, Manson JE, Ludwig DS, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA. 2004; 292:927-34.
52. Shi X, Summers RW, Schedl HP, et al. Effects of carbohydrate type and concentration and solution osmolality on water absorption. Med. Sci. Sports Exerc. 1995; 27:1607-15.
53. Shiota M, Moore MC, Galassetti P, et al. Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes. 2002; 51:469-78.
54. Shiota M, Galassetti P, Monohan M, Neal DW, Cherrington AD. Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes. 1998; 47:867-73.
55. Shoham DA, Durazo-Arvizu R, Kramer H, et al. Sugary soda consumption and albuminuria: Results from the National Health and Nutrition Examination Survey, 1999-2004. PLoS ONE. 2008; 3:e3431.
56. Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructosesweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J. Clin. Invest. 2009; 119:1322-34.
57. Stanhope KL, Havel PJ. Fructose consumption: Potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr. Opin. Lipidol. 2008; 19:16-24.
58. Stanhope KL, Griffen SC, Keim NL, et al. Consumption of fructose-, but not glucose-sweetened beverages produces an atherogenic lipid profile in overweight/obese men and women. Diabetes. 2007; 56(Suppl 1):A16.
59. Stirpe F, Della Corte E, Bonetti E, et al. Fructose-induced hyperuricaemia. Lancet. 1970; 2:1310-1.
60. Swarbrick MM, Stanhope KL, Elliott SS, et al. Consumption of fructosesweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. Br. J. Nutr. 2008; 100:947-52.
61. Takagi Y, Kashiwagi A, Tanaka Y, et al. Significance of fructose-induced protein oxidation and formation of advanced glycation end product. J. Diabetes Complications. 1995; 9:87-91.
62. Tokita Y, Hirayama Y, Sekikawa A, et al. Fructose ingestion enhances atherosclerosis and deposition of advanced glycated end-products in cholesterol-fed rabbits. J. Atheroscler. Thromb. 2005; 12:260-7.
63. Ushijima K, Riby JE, Fujisawa T, Kretchmer N. Absorption of fructose by isolated small intestine of rats is via a specific saturable carrier in the absence of glucose and by the disaccharidase-related transport system in the presence of glucose. J. Nutr. 1995; 125:2156-64.
64. Vasdev S, Gill V, Parai S, Longerich L, Gadag V. Dietary vitamin E and C supplementation prevents fructose induced hypertension in rats. Mol. Cell. Biochem. 2002; 241:107-14. (Pubitemid 35385841)
65. Yudkin J. Evolutionary and historical changes in dietary carbohydrates. Am. J. Clin. Nutr. 1967; 20:108-15.
66. Zhao CX, Xu X, Cui Y, et al. Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. J. Pharmacol. Exp. Ther. 2009; 328:610-20.