Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis

British Journal of Haematology

Volumn 151, Issue 1, 2010, Pages 54-61

  Peeters, Karen ^a   Loyen, Serena ^a   Van Kerckhoven, Soetkin ^a   Stoffels, Katinka ^b   Hoylaerts, Marc F ^a   Van Geet, Chris ^a,b   Freson, Kathleen ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

mega karyopoiesis; mouse; platelet; thrombocytopenia; VIP PACAP type 1 receptor (VPAC1)

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY VPAC1; THROMBOCYTE ANTIBODY; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; FEMALE; ISOGRAFT; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PASSIVE IMMUNE THROMBOCYTOPENIA; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; HUMAN; IMMUNOLOGY; MEGAKARYOCYTE; PATHOPHYSIOLOGY; PHYSIOLOGY; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SIGNAL TRANSDUCTION; THROMBOCYTE COUNT; ULTRASTRUCTURE; WHOLE BODY RADIATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA; THROMBOPOIESIS; WHOLE-BODY IRRADIATION;

EID: 77956804725     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08327.x     Document Type: Article

References (34)

1. Ballmaier, M., Germeshausen, M., Schulze, H., Cherkaoui, K., Lang, S., Gaudig, A., Krukemeier, S., Eilers, M., Strauss, G. Welte, K. (2001) c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood, 97, 139 146.
2. Broudy, V.C., Lin, N.L. Kaushansky, K. (1995) Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood, 85, 1719 1726.
3. Bussel, J.B., Kuter, D.J., George, J.N., McMillan, R., Aledort, L.M., Conklin, G.T., Lichtin, A.E., Lyons, R.M., Nieva, J., Wasser, J.S., Wiznitzer, I., Kelly, R., Chen, C.F. Nichol, J.L. (2006) AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP. The New England journal of medicine, 355, 1672 1681.
4. Bussel, J.B., Cheng, G., Saleh, M.N., Psaila, B., Kovaleva, L., Meddeb, B., Kloczko, J., Hassani, H., Mayer, B., Stone, N.L., Arning, M., Provan, D. Jenkins, J.M. (2007) Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. The New England journal of medicine, 357, 2237 2247.
5. Chang, A.N., Cantor, A.B., Fujiwara, Y., Lodish, M.B., Droho, S., Crispino, J.D. Orkin, S.H. (2002) GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 99, 9237 9242.
6. Deng, R. Balthasar, J.P. (2007) Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia. Blood, 109, 2470 2476.
7. Fibbe, W.E., Heemskerk, D.P., Laterveer, L., Pruijt, J.F., Foster, D., Kaushansky, K. Willemze, R. (1995) Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood, 86, 3308 3313.
8. Fischer, C., Jonckx, B., Mazzone, M., Zacchigna, S., Loges, S., Pattarini, L., Chorianopoulos, E., Liesenborghs, L., Koch, M., De Mol, M., Autiero, M., Wyns, S., Plaisance, S., Moons, L., van Rooijen, N., Giacca, M., Stassen, J.M., Dewerchin, M., Collen, D. Carmeliet, P. (2007) Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell, 131, 463 475.
9. Freson, K., Matthijs, G., Thys, C., Marien, P., Hoylaerts, M.F., Vermylen, J. Van Geet, C. (2002) Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation. Human molecular genetics, 11, 147 152.
10. Freson, K., Hashimoto, H., Thys, C., Wittevrongel, C., Danloy, S., Morita, Y., Shintani, N., Tomiyama, Y., Vermylen, J., Hoylaerts, M.F., Baba, A. Van Geet, C. (2004) The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation. The Journal of clinical investigation, 113, 905 912.
11. Freson, K., Peeters, K., De Vos, R., Wittevrongel, C., Thys, C., Hoylaerts, M.F., Vermylen, J. Van Geet, C. (2008) PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications. Blood, 111, 1885 1893.
12. Kaushansky, K. (1995) Thrombopoietin: the primary regulator of platelet production. Blood, 86, 419 431.
13. Kaushansky, K. (2005) The molecular mechanisms that control thrombopoiesis. The Journal of clinical investigation, 115, 3339 3347.
14. Kawakami, M., Kimura, T., Kishimoto, Y., Tatekawa, T., Baba, Y., Nishizaki, T., Matsuzaki, N., Taniguchi, Y., Yoshihara, S., Ikegame, K., Shirakata, T., Nishida, S., Masuda, T., Hosen, N., Tsuboi, A., Oji, Y., Oka, Y., Ogawa, H., Sonoda, Y., Sugiyama, H., Kawase, I. Soma, T. (2004) Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34+CD38- cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells. Leukemia, 18, 912 921.
15. Kuter, D.J. Begley, C.G. (2002) Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood, 100, 3457 3469.
16. Kuter, D.J., Bussel, J.B., Lyons, R.M., Pullarkat, V., Gernsheimer, T.B., Senecal, F.M., Aledort, L.M., George, J.N., Kessler, C.M., Sanz, M.A., Liebman, H.A., Slovick, F.T., de Wolf, J.T., Bourgeois, E., Guthrie, Jr., T.H., Newland, A., Wasser, J.S., Hamburg, S.I., Grande, C., Lefrere, F., Lichtin, A.E., Tarantino, M.D., Terebelo, H.R., Viallard, J.F., Cuevas, F.J., Go, R.S., Henry, D.H., Redner, R.L., Rice, L., Schipperus, M.R., Guo, D.M. Nichol, J.L. (2008) Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet, 371, 395 403.
17. Lambert, M.P., Rauova, L., Bailey, M., Sola-Visner, M.C., Kowalska, M.A. Poncz, M. (2007) Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood, 110, 1153 1160.
18. Mathur, A., Hong, Y., Wang, G. Erusalimsky, J.D. (2004) Assays of megakaryocyte development: surface antigen expression, ploidy, and size. Methods in molecular biology, 272, 309 322.
19. Mattia, G., Vulcano, F., Milazzo, L., Barca, A., Macioce, G., Giampaolo, A. Hassan, H.J. (2002) Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release. Blood, 99, 888 897.
20. Nam, C., Case, A.J., Hostager, B.S. O'Dorisio, M.S. (2009) The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation. The journal of molecular neuroscience, 37, 160 167.
21. Orkin, S.H., Shivdasani, R.A., Fujiwara, Y. McDevitt, M.A. (1998) Transcription factor GATA-1 in megakaryocyte development. Stem Cells, 16 (Suppl 2 79 83.
22. Park, S.K., Olson, T.A., Ercal, N., Summers, M. O'Dorisio, M.S. (1996) Characterization of vasoactive intestinal peptide receptors on human megakaryocytes and platelets. Blood, 87, 4629 4635.
23. Peeters, K., Stassen, J.M., Collen, D., Van Geet, C. Freson, K. (2008) Emerging treatments for thrombocytopenia: increasing platelet production. Drug discovery today, 13, 798 806.
24. Rameshwar, P., Gascon, P., Oh, H.S., Denny, T.N., Zhu, G. Ganea, D. (2002) Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor. Experimental hematology, 30, 1001 1009.
25. Schulze, H. Shivdasani, R.A. (2005) Mechanisms of thrombopoiesis. Journal of thrombosis and haemostasis, 3, 1717 1724.
26. Schuster, M.W., Beveridge, R., Frei-Lahr, D., Abboud, C.N., Cruickshank, S., Macri, M., Menchaca, D., Holden, J. Waller, E.K. (2002) The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation. Experimental hematology, 30, 1044 1050.
27. Shivdasani, R.A. Orkin, S.H. (1996) The transcriptional control of hematopoiesis. Blood, 87, 4025 4039.
28. Szalai, G., LaRue, A.C. Watson, D.K. (2006) Molecular mechanisms of megakaryopoiesis. Cellular and molecular life sciences, 63, 2460 2476.
29. Teeling, J.L., Jansen-Hendriks, T., Kuijpers, T.W., de Haas, M., van de Winkel, J.G., Hack, C.E. Bleeker, W.K. (2001) Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Blood, 98, 1095 1099.
30. Vaudry, D., Falluel-Morel, A., Bourgault, S., Basille, M., Burel, D., Wurtz, O., Fournier, A., Chow, B.K., Hashimoto, H., Galas, L. Vaudry, H. (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacological reviews, 61, 283 357.
31. Vyas, P., Ault, K., Jackson, C.W., Orkin, S.H. Shivdasani, R.A. (1999) Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood, 93, 2867 2875.
32. Wang, B., Nichol, J.L. Sullivan, J.T. (2004) Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clinical pharmacology and therapeutics, 76, 628 638.
33. Weich, N.S., Fitzgerald, M., Wang, A., Calvetti, J., Yetz-Aldape, J., Neben, S. Turner, K.J. (2000) Recombinant human interleukin-11 synergizes with steel factor and interleukin-3 to promote directly the early stages of murine megakaryocyte development in vitro. Blood, 95, 503 509.
34. Wolff, S.N., Herzig, R., Lynch, J., Ericson, S.G., Greer, J.P., Stein, R., Goodman, S., Benyunes, M.C., Ashby, M., Jones, Jr., D.V. Fay, J. (2001) Recombinant human thrombopoietin (rhTPO) after autologous bone marrow transplantation: a phase I pharmacokinetic and pharmacodynamic study. Bone marrow transplantation, 27, 261 268.