The in vitro hemolytic effect of diltiazem on erythrocytes exposed to varying osmolarity

Toxicology Mechanisms and Methods

Volumn 20, Issue 8, 2010, Pages 435-439

  Watts, T J ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Calcium; Erythrocyte; Hemolysis; Osmotic stress

Indexed keywords

DILTIAZEM; VERAPAMIL;

ANALYSIS OF VARIANCE; ARTICLE; CELL VOLUME; CONTROLLED STUDY; DILUTION; ERYTHROCYTE; HEMOLYSIS; IN VITRO STUDY; ION TRANSPORT; OSMOLARITY; OSMOTIC STRESS; PRIORITY JOURNAL;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HEMOLYSIS; HORSES; HYPOTONIC SOLUTIONS; OSMOLAR CONCENTRATION;

EID: 77956804259     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.491519     Document Type: Article

References (26)

1. Bender AS, Neary JT, Blicharska LO, Norenberg LO, Norenberg MD. 1992. Role of calmodulin and protein kinase C in astrocytic cell volume regulation. J Neurochem 58:1874-1882.
2. Berridge MJ, Bootman MD, Roderick HL. 2003. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4:517-529.
3. Bowman ZS, Morrow JD, Jollow DJ, McMillan DC. 2005. Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine. J Pharmacol Exp Ther 314:838-845.
4. Carafoli E. 1982. Membrane transport of calcium. London: Academic Press Inc. Ltd.
5. Claas SA, Glasser SP. 2005. Long-acting diltiazem HCl for the chronotherapeutic treatment of hypertension and chronic stable angina pectoris. Expert Opin Pharmacother 6:765-776.
6. Cossins AR, Gibson JS. 1997. Volume sensitive transport systems and volume homeostasis in vertebrate red blood cells. J Exp Biol 200:343-352.
7. Dong Z, Saikumar P, Weinburg JM, Venkatachalam MA. 2006. Calcium in cell injury and death. Annu Rev Pathol Mech Dis 1:405-434.
8. Freedman MP. 2000. Autoimmune haemolytic anaemia: a history. Transfusion Med Rev 14:223-233.
9. Garcia-Romeu F, Cossins AR, Motais R. 1991. Cell volume regulation by trout erythrocytes - characteristics of the transport systems activated by hypotonic swelling. J Physiol 440:547-567.
10. Gardos G. 1958. The function of calcium in the potassium permeability of human erythrocytes. Biochim Biophys Acta 30:653-654.
11. Gibson JS, Hall AC. 1995. Stimulation of the KCl co-transport in equine erythrocytes by hydrostatic pressure: the effects of kinase/ phosphatase inhibition. Pflugers Archiv 429:446-448.
12. Hoffbrand AV, Pettit JE, Moss PAH. 2001. Essential haematology. 4th ed. Oxford: Blackwell Science.
13. Hoffman EK. 1992. Cell swelling and volume regulation. Can J Physiol Pharmacol 70:310-313.
14. Holden C. 2003. Genetics. First cloned mule races to finish line. Science 300:1354.
15. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D. 1998. Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247-306. (Pubitemid 28070981)
16. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, Morishima S. 2001. Receptormediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol 532:3-16.
17. Petz LD. 1980. Drug-induced haemolytic anaemia. Clin Haematol 9: 455-482.
18. Raess BU, Gersten MH. 1987. Calmodulin-stimulated plasma membrane (Ca2+ +Mg2+)-ATPase: inhibition by calcium channel entry blockers. Biochem Pharmacol 36:2455-2459.
19. Raess BU, Record DM. 1990. Inhibition of erythrocyte calcium pump by calcium antagonists. Biochem Pharmacol 40:2549-2555.
20. Ramoska EA, Spiller HA, Winter M, Borys D. 1993. A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment. Anal Emerg Med 22:196-200.
21. Rang HP, Dale MM, Ritter JM. 1999. Pharmacology. Edinburgh: Church Livingstone.
22. Romero PJ, Romero EA. 1999. The role of calcium metabolism in human red blood cell ageing: a proposal. Blood Cells Mol Dis 25:9-19.
23. Salamino F, Sparatore B, Melloni E. 1994. The plasma membrane calcium pump is the preferred calpain substrate within the erythrocytes. Cell Calcium 15:28-35.
24. Schatzmann HJ. 1975. Active calcium transport and calcium ion activated ATPase in human red blood cells. Curr Topics Membr Trans 6: 125-168.
25. Vanderklish PW, Bahr BA. 2000. The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states. Int J Exp Pathol 81:323-339.
26. Watts TJ, Handy RD. 2007. The haemolytic effect of verapamil on erythrocytes exposed to varying osmolarity. Toxicol in Vitro 21:835-839.