In situ microindentation for determining local subchondral bone compressive modulus

Journal of Biomechanical Engineering

Volumn 132, Issue 9, 2010, Pages

  Gardner Morse, Mack G ^a   Tacy, Nelson J ^a   Beynnon, Bruce D ^a   Roemhildt, Maria L ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Microindentation; Modulus; Osteoarthritis; Stiffness; Subchondral bone

Indexed keywords

ARTICULAR CARTILAGES; COMPRESSIVE MODULI; IN-SITU; INDENTATION TEST; LOAD-DISPLACEMENT RESPONSE; MATERIAL PROPERTY; MEDIAL COMPARTMENT; MICRO INDENTATION; MICRO-INDENTATION TECHNIQUE; MODULUS; NANOINDENTATION METHOD; OSTEOARTHRITIS; POLYURETHANE FOAM; REFERENCE VALUES; REPEATED LOADING; SPRAGUE-DAWLEY RATS; SUBCHONDRAL BONE; TEST LOCATION;

CARTILAGE; HISTOLOGY; LIGAMENTS; LOCATION; MATERIALS PROPERTIES; NANOINDENTATION; REGRESSION ANALYSIS; STIFFNESS; UNLOADING;

BONE;

POLYURETHAN;

ARTICLE; BONE STRESS; COMPRESSION; OSTEOARTHRITIS; RIGIDITY; TIBIA; VALIDATION PROCESS; VISCOELASTICITY; YOUNG MODULUS; ANIMAL; ARTICULAR CARTILAGE; BONE; COMPARATIVE STUDY; COMPRESSIVE STRENGTH; EVALUATION; FEMALE; HARDNESS; HISTOLOGY; JOINT; KNEE; PATHOLOGY; PHYSIOLOGY; RAT; REGRESSION ANALYSIS; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STANDARD;

RATTUS;

ANIMALS; BONE AND BONES; CARTILAGE, ARTICULAR; COMPRESSIVE STRENGTH; FEMALE; HARDNESS; HARDNESS TESTS; JOINTS; KNEE JOINT; OSTEOARTHRITIS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; TIBIA;

EID: 77956795883     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4001872     Document Type: Article

References (16)

1. Karsdal, M. A., Leeming, D. J., Dam, E. B., Henriksen, K., Alexandersen, P., Pastoureau, P., Altman, R. D., and Christiansen, C., 2008, "Should Subchondral Bone Turnover Be Targeted When Treating Osteoarthritis?" Osteoarthritis Cartilage, 16(6), pp. 638-646.
2. Li, B., and Aspden, R. M., 1997, "Mechanical and Material Properties of the Subchondral Bone Plate From the Femoral Head of Patients With Osteoarthritis or Osteoporosis," Ann. Rheum. Dis., 56(4), pp. 247-254.
3. Coats, A. M., Zioupos, P., and Aspden, R. M., 2003, "Material Properties of Subchondral Bone From Patients With Osteoporosis or Osteoarthritis by Microindentation Testing and Electron Probe Microanalysis," Calcif. Tissue Int., 73(1), pp. 66-71.
4. Radin, E. L., and Rose, R. M., 1986, "Role of Subchondral Bone in the Initiation and Progression of Cartilage Damage," Clin. Orthop. Relat. Res., 213, pp. 34-40.
5. Martel-Pelletier, J., Lajeunesse, D., and Pelletier, J.-P., 2007, "Subchondral Bone and Osteoarthritis Progression: A Very Significant Role," Osteoarthritis, Inflammation and Degradation: A Continuum, J. A. Buckwalter, M. Lotz, and J.-F. Stoltz, eds., IOS, Amsterdam, pp. 206-218.
6. Oliver, W. C., and Pharr, G. M., 2004, "Measurement of Hardness and Elastic Modulus by Instrumented Indentation: Advances in Understanding and Refinements to Methodology," J. Mater. Res., 19(1), pp. 3-20.
7. Lewis, G., and Nyman, J. S., 2008, "The Use of Nanoindentation for Characterizing the Properties of Mineralized Hard Tissues: State-of-the Art Review," J. Biomed. Mater. Res., Part B: Appl. Biomater., 87B(1), pp. 286-301.
8. Hansma, P. K., Turner, P. J., Drake, B., and Fantner, G. E., 2006, "Bone Diagnostic Instrument," Rev. Sci. Instrum., 77(7), p. 075105.
9. Hansma, P., Turner, P., Drake, B., Yurtsev, E., Proctor, A., Mathews, P., Lulejian, J., Randall, C., Adams, J., Jungmann, R., Garza-De-Leon, F., Fantner, G., Mkrtchyan, H., Pontin, M., Weaver, A., Brown, M. B., Sahar, N., Rossello, R., and Kohn, D., 2008, "The Bone Diagnostic Instrument II: Indentation Distance Increase," Rev. Sci. Instrum., 79(6), p. 064303.
10. Hansma, P., Yu, H., Schultz, D., Rodriguez, A., Yurtsev, E. A., Orr, J., Tang, S., Miller, J., Wallace, J., Zok, F., Li, C., Souza, R., Proctor, A., Brimer, D., Nogues-Solan, X., Mellbovsky, L., Pena, M. J., Diez-Ferrer, O., Mathews, P., Randall, C., Kuo, A., Chen, C., Peters, M., Kohn, D., Buckley, J., Li, X., Pruitt, L., Diez-Perez, A., Alliston, T., Weaver, V., and Lotz, J., 2009, "The Tissue Diagnostic Instrument," Rev. Sci. Instrum., 80(5), p. 054303.
11. Hasler, E. M., Herzog, W., Wu, J. Z., Muller, W., and Wyss, U., 1999, "Articular Cartilage Biomechanics: Theoretical Models, Material Properties, and Biosynthetic Response," Crit. Rev. Biomed. Eng., 27(6), pp. 415-488.
12. Roemhildt, M. L., Coughlin, K. M., Peura, G. D., Fleming, B. C., and Beynnon, B. D., 2006, "Material Properties of Articular Cartilage in the Rabbit Tibial Plateau," J. Biomech., 39(12), pp. 2331-2337.
13. Tang, B., Ngan, A. H., and Lu, W. W., 2007, "An Improved Method for the Measurement of Mechanical Properties of Bone by Nanoindentation," J. Mater. Sci.: Mater. Med., 18(9), pp. 1875-1881.
14. Pacific Research Laboratories, Inc., 2009, "Average Material Properties, Solid Rigid Polyurethane Foam," http://www.sawbones.com/ products/bio/testblocks/solidfoam.aspx, accessed on Jan. 8.
15. Mente, P. L., and Lewis, J. L., 1994, "Elastic Modulus of Calcified Cartilage Is an Order of Magnitude Less Than That of Subchondral Bone," J. Orthop. Res., 12(5), pp. 637-647.
16. Rho, J.-Y., and Pharr, G. M., 1999, "Nanoindentation Testing of Bone," Mechanical Testing of Bone and the Bone-Implant Interface, Y. H. An and R. A. Draughn, eds., CRC, New York, pp. 257-269.