Two-step in vivo tumor targeting by biotin- Conjugated antibodies and superparamagnetic nanoparticles assessed by magnetic resonance imaging at 1.5 T

Molecular Imaging and Biology

Volumn 12, Issue 3, 2010, Pages 305-315

  Baio, Gabriella ^a   Fabbi, Marina ^a   Salvi, Sandra ^a   De Totero, Daniela ^a   Truini, Mauro ^a   Ferrini, Silvano ^a   Neumaier, Carlo Emanuele ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Antibody; In vivo small animal MRI; Iron oxide particles; Magnetic resonance imaging; Targeted contrast agent

Indexed keywords

ANTIBODY CONJUGATE; AVIDIN; BIOTIN CONJUGATED MONOCLONAL ANTIBODY CH L; BIOTIN CONJUGATED MONOCLONAL ANTIBODY LD6; CD70 ANTIGEN; FERRIC FERROCYANIDE; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE ANTIBIOTIN CONJUGATE; UNCLASSIFIED DRUG; BIOTIN; CANCER ANTIBODY; CD70 PROTEIN, HUMAN; DEXTRAN; FERUMOXTRAN 10; FERUMOXTRAN-10; MAGNETITE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIGEN EXPRESSION; ARTICLE; CELL LABELING; CONTROLLED STUDY; DOSE CALCULATION; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LYMPHOMA CELL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TUMOR DIAGNOSIS; TUMOR XENOGRAFT; CHEMISTRY; DRUG SCREENING; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; LYMPHOMA; METABOLISM; METASTASIS; METHODOLOGY; NEOPLASM; PATHOLOGY; STAINING; TUMOR CELL LINE;

ANIMALIA; MUS;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIGENS, CD70; BIOTIN; CELL LINE, TUMOR; DEXTRANS; FERROSOFERRIC OXIDE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOCONJUGATES; LYMPHOMA; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; NEOPLASM METASTASIS; NEOPLASMS; STAINING AND LABELING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77956707999     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-009-0264-6     Document Type: Article

References (26)

1. McEarchern JA, Oflazoglu E, Francisco L et al (2007) Engineered anti- CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities. Blood 109(3):1185-1192
2. Israel BF, Gulley M, Elmore S et al (2005) Anti-CD70 antibodies: a potential treatment for EBV+ CD70-expressing lymphomas. Mol Cancer Ther 4(12):2037-2044
3. Massoud TF, Paulmurugan R, Gambhir SS (2004) Molecular imaging of homodimeric protein-protein interactions in living subjects. FASEB J 18(10):1105-1107
4. Tanimoto A, Oshio K, Suematsu M et al (2001) Relaxation effects of clustered particles. J Magn Reson Imaging 14:72-77
5. Ferrucci JT, Stark DD (1990) Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years. AJR Am J Roentgenol 155:943-950
6. Small WC, Nelson RC, Bernardino ME (1993) Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron-oxide. Magn Reson Iamging 11:645-654
7. Li W, Tutton S, Vu AT et al (2005) First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)-based blood pool agent. J Magn Reson Imaging 21(1):46-52
8. Kelloff GJ, Krohn KA, Larson SM et al (2005) The progress and promise of molecular imaging probes in oncologic drug development. Clin Cancer Res 11(22):7967-7985
9. Reynolds PR, Larkman DJ, Haskard DO et al (2006) Detection of vascular expression of E-selectin in vivo with MR imaging. Radiology 241(2):469-476
10. Kang HW, Torres D, Wald L et al (2006) Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer. Lab Invest 86(6):599-609
11. Pirko I, Johnson A, Ciric B et al (2003) In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies. FASEB J. doi:10.1096/fj.02-1124fje
12. Pirko I, Ciric B, Gamez J et al (2004) A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS. FASEB J. doi:10.1096/fj.04-2026fje
13. Tazzari PL, de Totero D, Bolognesi A et al (1999) An Epstein-Barr virus-infected lymphoblastoid cell line (D430B) that grows in SCIDmice with the morphologic features of a CD30+ anaplastic large cell lymphoma, and is sensitive to anti-CD30 immunotoxins. Haematologica 84:988-995
14. Ferrini S, Cantoni C, Ciccone E et al (1991) A novel surface molecule expressed by long-term cultured T and natural killer cells is involved in cell activation. Eur J Immunol 21(9):1981-1987
15. Orengo AM, Cantoni C, Neglia F et al (1997) Reciprocal expression of CD70 and of its receptor, CD27, in human long term-activated T and natural killer (NK) cells: inverse regulation by cytokines and role in induction of cytotoxicity. Clin Exp Immunol 107(3):608-613
16. Cauda R, Goletti D, Lucia MB et al (1994) Analysis of natural killer (NK) cell subsets defined by the expression of two novel surface antigens (EB6 and GL183) in AIDS and AIDS-related conditions. Clin Immunol Immunopathol 70(3):198-1120
17. Harlow E, Lane D (1988) Storing and purifying antibodies. In: Harlow E, Lane D (eds) Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 283-312
18. Gee PA (1998) Immunomagnetic cell separation using antibodies and superparamagnetic microspheres. In: Recktenwald D, Radbruch A (eds) Cell separation methods and applications. Marcel Dekker, New York, pp 175-208
19. Baio G, Fabbi M, de Totero D et al (2006) Magnetic resonance imaging at 1.5 T with immunospecific contrast agent in vitro and in vivo in a xenotransplant model. MAGMA 19(6):313-320
20. Wolff SD, Balaban RS (1997) Assessing contrast on MR images. Radiology 202:25-29
21. Ito A, Shinkai M, Honda H et al (2005) Medical application of functionalized magnetic nanoparticles. J Biosci Bioeng 100(1):1-11
22. Neumaier CE, Baio G, Ferrini S et al (2008) MR and iron magnetic nanoparticles. Imaging opportunities in preclinical and translational research. Tumori 94(2):226-233
23. Tai JH, Foster P, Rosales A et al (2006) Imaging islets labeled with magnetic nanoparticles at 1.5 Tesla. Diabetes 55(11):2931-2938
24. Heyn C, Ronald JA, Mackenzie LT et al (2006) In vivo magnetic resonance imaging of single cells in mouse brain with optical validation. Magn Reson Med 55:23-29
25. Jendelovà P, Herynek V, Urdzìkovà L et al (2004) Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res 76:232-243
26. Jendelovà P, Herynek V, Urdzìkovà L et al (2005) Magnetic resonance tracking of human CD34+ progenitors cells separated by means of immunomagnetic selection and transplanted into injure rat brain. Cell Transplant 14:173-182