MR imaging of inflammation during myelin-specific T cell-mediated autoimmune attack in the EAE mouse spinal cord

Molecular Imaging and Biology

Volumn 12, Issue 3, 2010, Pages 240-249

  Robinson, Kristine M ^a   Njus, Jeffrey M ^b   Phillips, Daniel A ^c   Proctor, Thomas M ^a   Rooney, William D ^b   Jones, Richard E ^a,c  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

EAE; Feridex; Ferumoxide; MRI; Multiple sclerosis

Indexed keywords

MYELIN; PROTAMINE SULFATE; SUPERPARAMAGNETIC IRON OXIDE; IRON; PROTAMINE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GRAY MATTER; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE ENHANCEMENT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SPINAL CORD LESION; T LYMPHOCYTE; WHITE MATTER; ANIMAL; AUTOIMMUNITY; IMMUNOLOGY; INFLAMMATION; METABOLISM; MYELIN SHEATH; PATHOLOGY; SPINAL CORD; STAINING;

ANIMALIA; MUS;

ANIMALS; AUTOIMMUNITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INFLAMMATION; IRON; MAGNETIC RESONANCE IMAGING; MICE; MYELIN SHEATH; PROTAMINES; SPINAL CORD; STAINING AND LABELING; T-LYMPHOCYTES;

EID: 77956700485     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-009-0272-6     Document Type: Article

References (24)

1. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50(1):121-127
2. Barkhof F (2002) The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol 15(3):239-245
3. Wuerfel J, Tysiak E, Prozorovski T, Smyth M, Mueller S, Schnorr J, Taupitz M, Zipp F (2007) Mouse model mimics multiple sclerosis in the clinico-radiological paradox. Eur J Neurosci 26(1):190-198
4. Chopp M, Li Y, Zhang J (2008) Plasticity and remodeling of brain. J Neurol Sci 265(1-2):97-101
5. MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW (2006) Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. NeuroImage 32(3):1016-1023
6. Oweida AJ, Dunn EA, Karlik SJ, Dekaban GA, Foster PJ (2007) Ironoxide labeling of hematogenous macrophages in a model of experimental autoimmune encephalomyelitis and the contribution to signal loss in fast imaging employing steady state acquisition (FIESTA) images. J Magn Reson Imaging 26(1):144-151
7. Arbab AS, Yocum GT, Kalish H, Jordan EK, Anderson SA, Khakoo AY, Read EJ, Frank JA (2004) Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 104(4):1217-1223
8. Arbab AS, Yocum GT, Rad AM, Khakoo AY, Fellowes V, Read EJ, Frank JA (2005) Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells. NMR Biomed 18(8):553-559
9. Sykova E, Jendelova P (2005) Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann N Y Acad Sci 1049:146-160
10. Anderson SA, Shukaliak-Quandt J, Jordan EK, Arbab AS, Martin R, McFarland H, Frank JA (2004) Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis. Ann Neurol 55(5):654-659
11. Suzuki Y, Zhang S, Kundu P, Yeung AC, Robbins RC, Yang PC (2007) In vitro comparison of the biological effects of three transfection methods for magnetically labeling mouse embryonic stem cells with ferumoxides. Magn Reson Med 57(6):1173-1179
12. Sorgi FL, Bhattacharya S, Huang L (1997) Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther 4(9):961-968
13. Montet-Abou K, Montet X, Weissleder R, Josephson L (1997) Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging 6(1):1-9
14. Robinson KM, Markwardt S, Kitzerow N, Moes N, Estrada M, Jones RE (2008) Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimera. J Neuroimmunol 204(1-2):110-117
15. Nessler S, Boretius S, Stadelmann C, Bittner A, Merkler D, Hartung HP, Michaelis T, Bruck W, Frahm J, Sommer N, Hemmer B (2007) Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage. Brain 130(Pt 8):2186-2198
16. Smorodchenko A, Wuerfel J, Pohl EE, Vogt J, Tysiak E, Glumm R, Hendrix S, Nitsch R, Zipp F, Infante-Duarte C (2007) CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology. Eur J Neurosci 26(6):1387-1398
17. Schellenberg AE, Buist R, Yong VW, Del Bigio MR, Peeling J (2007) Magnetic resonance imaging of blood-spinal cord barrier disruption in mice with experimental autoimmune encephalomyelitis. Magn Reson Med 58(2):298-305
18. Kidd D, Barkhof F, McConnell R, Algra PR, Allen IV, Revesz T (2007) Cortical lesions in multiple sclerosis. Brain 122 ( Pt 1):17-26
19. Brochet B, Deloire MS, Touil T, Anne O, Caille JM, Dousset V, Petry KG (2006) Early macrophage MRI of inflammatory lesions predicts lesion severity and disease development in relapsing EAE. NeuroImage 32(1):266-274
20. Dousset V, Ballarino L, Delalande C, Coussemacq M, Canioni P, Petry KG, Caille JM(2006) Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadoliniumenhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis. AJNR Am J Neuroradiol 20(2):223-227
21. Bakshi R, Minagar A, Jaisani Z, Wolinsky JS (2006) Imaging of multiple sclerosis: role in neurotherapeutics. NeuroRx 2(2):277-303
22. Thrower BW (2007) Clinically isolated syndromes: predicting and delaying multiple sclerosis. Neurology 68(24 Suppl 4):S12-S15
23. Pawelczyk E, Arbab AS, Pandit S, Hu E, Frank JA (2006) Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging. NMR Biomed 19(5):581-592
24. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET (2006) A new transgene reporter for in vivo magnetic resonance imaging. Nat Med 11(4):450-454