Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera

Planta Medica

Volumn 76, Issue 13, 2010, Pages 1454-1456

  Sartorelli, Patrícia ^a   Salomone Carvalho, Camila ^a   Quero Reimão, Juliana ^b   Lorenzi, Harri ^c   Tempone, André Gustavo ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO ADOLFO LUTZ   (Brazil)

^c Instituto Plantarum de Estudos da Flora   (Brazil)

Author keywords

Aristolochia cymbifera; Aristolochiaceae; copalic acid; kusunokinin; leishmaniasis; trypanosomiasis

Indexed keywords

ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; COPALIC ACID; DITERPENE; EPIEUDESMIN; FARGESIN; HINOKININ; KUSUNOKININ; LIGNAN; MEGLUMINE ANTIMONATE; PENTAMIDINE; SESAMIN; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARISTOLOCHIA CYMBIFERA; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HEMOLYSIS; IC 50; MAMMAL CELL; MEDICINAL PLANT; MOUSE; NONHUMAN; PLANT LEAF; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; ARISTOLOCHIA; CHAGAS DISEASE; DITERPENES; HEMOLYTIC AGENTS; INHIBITORY CONCENTRATION 50; LIGNANS; MACROPHAGES; MICE; MICE, INBRED BALB C; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ARISTOLOCHIA CYMBIFERA; ARISTOLOCHIACEAE; MAMMALIA; TRYPANOSOMA CRUZI;

EID: 77956676717     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1240952     Document Type: Article

References (16)

1. Tempone A G., Sartorelli P, Fernandes F, Mady C. From natural toxins to antitrypanosomal drugs: an overview of new drug prototypes for American trypanosomiasis. Cardiovasc Hematol Agents Med Chem 2007 5 222-235
2. Leitão G G., Kaplan M A. C., Galeffi C. Epi-popufolic acid from Aristolochia cymbifera. Phytochemistry 1992 31 3277-3279
3. Tempone A G., Sartorelli P, Teixeira D, Prado F O., Calixto I A., Lorenzi H, Melhem M S. Brazilian flora extracts as source of novel antileishmanial and antifungal compounds. Mem Inst Oswaldo Cruz 2008 103 443-449
4. Bastard J, Duc D, Fetizon M, Francis M J., Grant P K., Weavers R T. CMR spectroscopy of labdanic diterpenes and related substances. J Nat Prod 1984 47 592-599
5. Lopes L M. X., Bolzani V S., Trevisan L M. V. Clerodane diterpene from Aristolochia species. Phytochemistry 1987 26 2781-2784
6. Lopes L M. X., Yoshida M, Gottlieb O R. Further lignoids from Virola sebifera. Phytochemistry 1984 23 2647-2652
7. Kato M J., Yoshida M, Gottlieb O R. Lignoids and arylalkanones from fruits of Virola elongata. Phytochemistry 1990 29 1799-1810
8. Mendoza D T., Ureña-Gonzalez L D., Ortega-Barria E, Capson T L., Rios L C. Five new cassane diterpenes from Myrospermum frutescens with activity against Trypanosoma cruzi. J Nat Prod 2003 66 928-932
9. Batista R, Chiari E, Oliveira A B. Trypanosomicidal kaurane diterpenes from Wedelia paludosa. Planta Med 1999 65 283-284
10. Huang R L., Huang Y L., Ou J C., Chen C C., Hsu F L., Chang C. Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro. Phytother Res 2003 17 449-453
11. Caldas I S., Talvani A, Caldas S, Carneiro C M., de Lana M, da Matta Guedes P M., Bahia M T. Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions. Parasitol Res 2008 103 413-421
12. Sartorelli P, Andrade S P., Melhem M S., Prado F O., Tempone A G. Isolation of antileishmanial sterol from the fruits of Cassia fistula using bioguided fractionation. Phytother Res 2007 21 644-647
13. Lane J E., Ribeiro-Rodrigues R, Suarez C C., Bogitsh B J., Jones M M., Singh P K., Carter C E. In vitro trypanocidal activity of tetraethylthiuram disulfide and sodium diethylamine-N-carbodithioate on Trypanosoma cruzi. Am Soc Trop Med Hyg 1996 55 263-266
14. Tada H, Shiho O, Kuroshima K. An improved colorimetric assay for interleukin 2. J Immunol Methods 1986 93 157-165
15. Silva C F., Batista M M., Mota R A., De Souza E M., Stephens C E., Boykin D W., Soeiro M N. Activity of reversed diamidines against Trypanosoma cruzi in vitro. Biochem Pharmacol 2007 73 1939-1946
16. Moreira D R., Lima Leite A C., Pinheiro Ferreira P M., da Costa P M., Costa Lotufo L V., de Moraes M O., Brondani D J., Pessoa Cdo O. Synthesis and antitumour evaluation of peptidyl-like derivatives containing the 1,3-benzodioxole system. Eur J Med Chem 2007 42 351-357