메뉴 건너뛰기




Volumn 10, Issue 10, 2010, Pages 956-965

Target therapies in systemic lupus erythematosus: Current state of the art

Author keywords

Anti cytokine therapy; B cells; BLyS; Clinical trials; Epratuzumab; LJP 394; Monoclonal antibodies; Rituximab; Systemic lupus erythematosus

Indexed keywords

ABATACEPT; ABETIMUS; ACETYLSALICYLIC ACID; ATACICEPT; BELIMUMAB; BG 9588; CD40 LIGAND; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DIPHENHYDRAMINE; EDRATIDE; EPRATUZUMAB; IMMUNOGLOBULIN G; IMMUNOMODULATING AGENT; INFLIXIMAB; INTERLEUKIN 6; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY IDEC 131; OCRELIZUMAB; PARACETAMOL; PREDNISONE; RITUXIMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VERATIDE;

EID: 77956674216     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955710792007187     Document Type: Article
Times cited : (5)

References (72)
  • 3
    • 0027380153 scopus 로고
    • Risk for susteined amenorrhea in patientswith systemic lupus erythematosus receiving intermittent pulse cy-clophosphamide
    • Boumpas, D.T.; Austin, H.A.; Vaughan, E.M.; Yaboro, C.H.; Klip-pel, J.H.; Balow, J.E. Risk for susteined amenorrhea in patientswith systemic lupus erythematosus receiving intermittent pulse cy-clophosphamide. Ann. Intern. Med., 1993, 119, 366-369.
    • (1993) Ann. Intern. Med , vol.119 , pp. 366-369
    • Boumpas, D.T.1    Austin, H.A.2    Vaughan, E.M.3    Yaboro, C.H.4    Klip-Pel, J.H.5    Balow, J.E.6
  • 4
    • 0033911285 scopus 로고    scopus 로고
    • Management of the patient with severe refractoryrheumathoid arthritis: Are the newer treatment options worth con-sidering?
    • Lacki, J.K. Management of the patient with severe refractoryrheumathoid arthritis: are the newer treatment options worth con-sidering? BioDrugs, 2000, 13, 425-435.
    • (2000) BioDrugs , vol.13 , pp. 425-435
    • Lacki, J.K.1
  • 6
    • 38449101693 scopus 로고    scopus 로고
    • B cell biology and dysfunction in SLE
    • Anolik, J.H. B cell biology and dysfunction in SLE. Bull NYUHosp Jt Dis., 2007, 65,182-186.
    • (2007) Bull NYUHosp Jt Dis , vol.65 , pp. 182-186
    • Anolik, J.H.1
  • 7
    • 23744432462 scopus 로고    scopus 로고
    • Balancing diversity and tolerance:Lessons from patients with systemic lupus erythematosus
    • Jacobi, A.M.; Diamond, B. Balancing diversity and tolerance:lessons from patients with systemic lupus erythematosus. J. Exp.Med., 2005, 202, 341-344.
    • (2005) J. Exp.Med , vol.202 , pp. 341-344
    • Jacobi, A.M.1    Diamond, B.2
  • 8
    • 0037638841 scopus 로고    scopus 로고
    • Rituximab therapy and autoimmunedisorders. Prospects for anti-B cell therapy
    • Silverman, J.G.; Wiesman, S. Rituximab therapy and autoimmunedisorders. Prospects for anti-B cell therapy. Arthritis Rheum., 2003,6, 1484-1492.
    • (2003) Arthritis Rheum , vol.6 , pp. 1484-1492
    • Silverman, J.G.1    Wiesman, S.2
  • 10
    • 34848912304 scopus 로고    scopus 로고
    • Delayed memory B cell recovery in periph-eral blood and lymphoid tissue in systemic lupus erythematosus af-ter B cell depletion therapy
    • Anolik, J.H.; Bernard, J.; Owen, T.; Zheng, B.; Kemshetti, S.; Looney, R.J.; Sanz, I. Delayed memory B cell recovery in periph-eral blood and lymphoid tissue in systemic lupus erythematosus af-ter B cell depletion therapy. Arthritis Rheum., 2007, 56, 3044-3056.
    • (2007) Arthritis Rheum , vol.56 , pp. 3044-3056
    • Anolik, J.H.1    Bernard, J.2    Owen, T.3    Zheng, B.4    Kemshetti, S.5    Looney, R.J.6    Sanz, I.7
  • 11
    • 0036180868 scopus 로고    scopus 로고
    • Anti-CD20 monoclonal antibody (Rituximab) forlife-threatening autoimmune haemolytic anaemia in patient withsystemic lupus erythematosus
    • Perrotta, S.; Locatelli, F.; La Manna, A.; Cennamo, L.; De Stefano, P.; Nobili, B. Anti-CD20 monoclonal antibody (Rituximab) forlife-threatening autoimmune haemolytic anaemia in patient withsystemic lupus erythematosus. Br. J. Haematol., 2002, 116, 465-467.
    • (2002) Br. J. Haematol , vol.116 , pp. 465-467
    • Perrotta, S.1    Locatelli, F.2    la Manna, A.3    Cennamo, L.4    de Stefano, P.5    Nobili, B.6
  • 14
    • 28544449032 scopus 로고    scopus 로고
    • B-cell depletion in treatment of patients with sys-temic lupus erythematosus: A longitudinal analysis of 24 patients
    • Leandro, M.J.; Cambrige, G.; Edwards, J.C.; Ehrenstein, M.R.; Isenberg, D.A. B-cell depletion in treatment of patients with sys-temic lupus erythematosus: a longitudinal analysis of 24 patients.Rheumatology, 2005, 44, 1542-1545.
    • (2005) Rheumatology , vol.44 , pp. 1542-1545
    • Leandro, M.J.1    Cambrige, G.2    Edwards, J.C.3    Ehrenstein, M.R.4    Isenberg, D.A.5
  • 15
    • 18744405710 scopus 로고    scopus 로고
    • Humanized anti CD-20 monoclonal antibody in the treatment ofsevere resistant systemic lupus erythematosus in patient with anti-bodies against rituximab
    • Tahir, H.; Rohrer, J.; Bhatia, A.; Wegener, W.A.; Isenberg, D.A. Humanized anti CD-20 monoclonal antibody in the treatment ofsevere resistant systemic lupus erythematosus in patient with anti-bodies against rituximab. Rheumatology, 2005, 44, 561-562.
    • (2005) Rheumatology , vol.44 , pp. 561-562
    • Tahir, H.1    Rohrer, J.2    Bhatia, A.3    Wegener, W.A.4    Isenberg, D.A.5
  • 16
    • 33749331884 scopus 로고    scopus 로고
    • Long-termcomparison of rituximab treatment for refractory systemic lupuserythematosus and vasculitis. Remission, relapse, re-treatment
    • Smith, K.G.C.; Jones, R.B.; Burns, S.M.; Jayne, D.R.W. Long-termcomparison of rituximab treatment for refractory systemic lupuserythematosus and vasculitis. Remission, relapse, re-treatment. Ar-thritis Rheum., 2007, 54, 2970-2982.
    • (2007) Ar-thritis Rheum , vol.54 , pp. 2970-2982
    • Smith, K.G.C.1    Jones, R.B.2    Burns, S.M.3    Jayne, D.R.W.4
  • 17
    • 13444252282 scopus 로고    scopus 로고
    • Remission of proliferativelupus nephritis following B cell depletion therapy is preceded bydown-regulation of the T cell costimulatory molecule CD40 ligand. An open-label trial
    • Sfikakis, P.P.; Boletis, J.N.; Lionaki, S.; Vigklis, V.; Fragiadaki, K.G.; Iniotaki, A.; Moutsopoullos, H.M. Remission of proliferativelupus nephritis following B cell depletion therapy is preceded bydown-regulation of the T cell costimulatory molecule CD40 ligand.An open-label trial. Arthritis Rheum., 2005, 52, 501-513.
    • (2005) Arthritis Rheum , vol.52 , pp. 501-513
    • Sfikakis, P.P.1    Boletis, J.N.2    Lionaki, S.3    Vigklis, V.4    Fragiadaki, K.G.5    Iniotaki, A.6    Moutsopoullos, H.M.7
  • 18
    • 34247246405 scopus 로고    scopus 로고
    • Histhopathologic and clinicaloutcome of rituximab treatment in patients with cyclophos-phamide-resistant proliferative lupus nephritis
    • Gunnarson, I.; Sundelin, B.; Jónsdotir, T.; Jacobson, S.H.; Henriks-son, E.W.; von Vollenhoven, R.F. Histhopathologic and clinicaloutcome of rituximab treatment in patients with cyclophos-phamide-resistant proliferative lupus nephritis. Arthritis Rheum.,2007, 56, 1263-1272.
    • (2007) Arthritis Rheum , vol.56 , pp. 1263-1272
    • Gunnarson, I.1    Sundelin, B.2    Jónsdotir, T.3    Jacobson, S.H.4    Henriks-Son, E.W.5    von Vollenhoven, R.F.6
  • 20
    • 39549108298 scopus 로고    scopus 로고
    • Treatment of refractory SLE withrituximab plus cyclophosphamide: Clinical effects serologicalchanges and predictors of response
    • Jonsdottiur, T.; Gunnarson, I.; Risseada, A.; Nenriksson, E.W.; Klareskog, L.; Vollehowen, R.F. Treatment of refractory SLE withrituximab plus cyclophosphamide: clinical effects serologicalchanges and predictors of response. Ann. Rheum. Dis., 2008, 67,330-334.
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 330-334
    • Jonsdottiur, T.1    Gunnarson, I.2    Risseada, A.3    Nenriksson, E.W.4    Klareskog, L.5    Vollehowen, R.F.6
  • 21
    • 44349131653 scopus 로고    scopus 로고
    • Longterm clinical and immunologi-cal effects of anti-CD20 treatment in patients with refractory sys-temic lupus erythematosus
    • Lindholm, C.; Börjesson-Asp, K.; Zendjanchi, K.; Sundqvist, A-C.; Tarkowski, A.; Bokarewa, M. Longterm clinical and immunologi-cal effects of anti-CD20 treatment in patients with refractory sys-temic lupus erythematosus. J. Rheumatol., 2008, 35, 826-833.
    • (2008) J. Rheumatol , vol.35 , pp. 826-833
    • Lindholm, C.1    Börjesson-Asp, K.2    Zendjanchi, K.3    Sundqvist, A.-C.4    Tarkowski, A.5    Bokarewa, M.6
  • 22
    • 0037289807 scopus 로고    scopus 로고
    • The relationship of FcgammaRIIIa genotypeto degree of B cell depletion by rituximab in the treatment of sys-temic lupus erythematosus
    • Anolik, J.H.; Campbell, D.; Felgar, F.; Young, F.; Sanz, I.; Rosen-blatt, J.; Looney, R.J. The relationship of FcgammaRIIIa genotypeto degree of B cell depletion by rituximab in the treatment of sys-temic lupus erythematosus. Arthritis Rheum., 2003, 48, 455-459.
    • (2003) Arthritis Rheum , vol.48 , pp. 455-459
    • Anolik, J.H.1    Campbell, D.2    Felgar, F.3    Young, F.4    Sanz, I.5    Rosen-Blatt, J.6    Looney, R.J.7
  • 24
    • 77956682558 scopus 로고    scopus 로고
    • FDA. Information for healthcare professionals: Rituximab (mar-keted as Rituxan)
    • FDA. Information for healthcare professionals: Rituximab (mar-keted as Rituxan). http:/www.fda.gov/cder/drug/infopage/rituxi-mab/default.htm.
  • 25
    • 38049000341 scopus 로고    scopus 로고
    • The emergence of progressive multifocal leucoen-cephalopathy (PML) in rheumatic diseases
    • Boren, E.J.; Cheema, G.S.; Naguwa, S.M.; Ansari, A.A.; Gershwin, M.E. The emergence of progressive multifocal leucoen-cephalopathy (PML) in rheumatic diseases. Rev. J. Autoimmun.,2008, 30, 90-98.
    • (2008) Rev. J. Autoimmun , vol.30 , pp. 90-98
    • Boren, E.J.1    Cheema, G.S.2    Naguwa, S.M.3    Ansari, A.A.4    Gershwin, M.E.5
  • 28
    • 61549083672 scopus 로고    scopus 로고
    • New therapies insystemic lupus erythematosus trials, troubles and tribulations...working towards a solution
    • Isenberg, D.; Gordon, C.; Merrill, J.; Urovitz, M. New therapies insystemic lupus erythematosus trials, troubles and tribulations...working towards a solution. Lupus, 2008, 17, 967-970.
    • (2008) Lupus , vol.17 , pp. 967-970
    • Isenberg, D.1    Gordon, C.2    Merrill, J.3    Urovitz, M.4
  • 29
    • 0030993376 scopus 로고    scopus 로고
    • CD22, a lympho-cyte-specific adhesion molecule that regulates antigen receptor sig-naling
    • Tender, T.F.; Tuscano, J.; Sato, S.; Kehrl, J.H. CD22, a lympho-cyte-specific adhesion molecule that regulates antigen receptor sig-naling. Annu. Rev. Immunol., 1997, 15, 481-504.
    • (1997) Annu. Rev. Immunol , vol.15 , pp. 481-504
    • Tender, T.F.1    Tuscano, J.2    Sato, S.3    Kehrl, J.H.4
  • 30
    • 0027175115 scopus 로고
    • Association of CD22 with the B cellantigen receptor
    • Peaker
    • Peaker, C.J.; Neuberger, M.S. Association of CD22 with the B cellantigen receptor. Eur. J. Immunol., 1993, 23, 1358-1363.
    • (1993) Eur. J. Immunol , vol.23 , pp. 1358-1363
    • Peaker, C.J.1    Neuberger, M.S.2
  • 31
    • 0028817807 scopus 로고
    • The amino-terminal immunoglobulin-like domain of siaload-hesin contains the sialicic acid binding site. Comparison withCD22
    • Nato, D., van der Merwe, P.A.; Kelm, S.; Bradfield, P., Cocker, P.R. The amino-terminal immunoglobulin-like domain of siaload-hesin contains the sialicic acid binding site. Comparison withCD22. J. Biol. Chem., 1995, 270, 26184-26191.
    • (1995) J. Biol. Chem , vol.270 , pp. 26184-26191
    • Nato, D.1    van der Merwe, P.A.2    Kelm, S.3    Bradfield, P.4    Cocker, P.R.5
  • 32
    • 0027241438 scopus 로고
    • CD22, a B cell-specific receptor, mediates adhesionand signal transduction
    • Clarc, E.A. CD22, a B cell-specific receptor, mediates adhesionand signal transduction. J. Immunol., 1993, 15, 4715-4718.
    • (1993) J. Immunol , vol.15 , pp. 4715-4718
    • Clarc, E.A.1
  • 35
    • 53749095799 scopus 로고    scopus 로고
    • Initial clinical trial of epratuzumab (human-ized anti-CD22 antibody) for immunotherapy of systemic lupuserythematosus
    • Dörner, T.; Kaufmann, J.; Wegener, W.A.; Teoh, N.; Goldenberg, D.M.; Burmester, G.R. Initial clinical trial of epratuzumab (human-ized anti-CD22 antibody) for immunotherapy of systemic lupuserythematosus. Arthritis Res. Ther., 2006, 8, 1-11.
    • (2006) Arthritis Res. Ther , vol.8 , pp. 1-11
    • Dörner, T.1    Kaufmann, J.2    Wegener, W.A.3    Teoh, N.4    Goldenberg, D.M.5    Burmester, G.R.6
  • 36
    • 41849121941 scopus 로고    scopus 로고
    • Differential effects of epratuzumab onperipheral blood B cells of patients with systemic lupus erythema-tosus versus normal controls
    • Jacobi, A.M.; Goldenberg, D.M.; Hiepe, F.; Radbruch, A.; Burmester, G.R.; Dörner, T. Differential effects of epratuzumab onperipheral blood B cells of patients with systemic lupus erythema-tosus versus normal controls. Ann. Rheum. Dis., 2008; 67, 450-457.
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 450-457
    • Jacobi, A.M.1    Goldenberg, D.M.2    Hiepe, F.3    Radbruch, A.4    Burmester, G.R.5    Dörner, T.6
  • 37
    • 67651084006 scopus 로고    scopus 로고
    • Petri, M.; Hobbs; K.; Gordon, C.; Strand, V.; Wallace, D.; Kelly, L.; Wegener, W.; Barry, A. Randomized controlled trials (RCTS) of epratuzumab (anty-CD22 targeting B-cells) reveal clinically meaningful improvements in patients with moderate/severe SLE flares. Ann. Rheum. Dis., 2008, 67, 53S.
    • (2008) , vol.67
    • Petri, M.1    Hobbs2    , K.3    Gordon, C.4    Strand, V.5    Wallace, D.6    Kelly, L.7    Wegener, W.8    Barry, A.9
  • 39
    • 0034972257 scopus 로고    scopus 로고
    • Elevatedserum B lymphocyte stimulator levels in patients with systemicimmune-based rheumatic diseases
    • Cheema, G.S.; Roschke, V.; Hilbert, D.M.; Stohl, W. Elevatedserum B lymphocyte stimulator levels in patients with systemicimmune-based rheumatic diseases. Arthritis Rheum., 2001, 44,1313-1319.
    • (2001) Arthritis Rheum , vol.44 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3    Stohl, W.4
  • 41
    • 2942737094 scopus 로고    scopus 로고
    • A therapeutic role for BLyS antagonists
    • Stohl, W. A therapeutic role for BLyS antagonists. Lupus, 2004,13, 317-322.
    • (2004) Lupus , vol.13 , pp. 317-322
    • Stohl, W.1
  • 44
    • 4344597627 scopus 로고    scopus 로고
    • Mecha-nism of action of transmembrane activator and calcium modulatorligand interactor-Ig in murine systemic lupus erythematosus
    • Ramanujam, M.; Wang, X.; Huang, W.; Schiffer, L.; Grimaldi, C.; Akkerman, A.; Diamond, B.; Madaio, M.P.; Davidson, A. Mecha-nism of action of transmembrane activator and calcium modulatorligand interactor-Ig in murine systemic lupus erythematosus. J.Immunol., 2004, 173, 3524-3534.
    • (2004) J.Immunol , vol.173 , pp. 3524-3534
    • Ramanujam, M.1    Wang, X.2    Huang, W.3    Schiffer, L.4    Grimaldi, C.5    Akkerman, A.6    Diamond, B.7    Madaio, M.P.8    Davidson, A.9
  • 48
    • 37149032474 scopus 로고    scopus 로고
    • Merck Serono and ZymoGenetics AtaciceptStudy Group. Reduced B lymphocyte and immunoglobulin levelsafter atacicept treatment in patients with systemic lupus erythema-tosus. Results of multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial
    • Dall'Era, M.; Chacravarty, E.; Wallace, D.; Genovese, M.; Weis-man, M.; Kavanaugh, A.; Kalunian, K.; Dar, P.; Vincent, E.; Pena-Rossi, C.; Wofsy, D.; Merck Serono and ZymoGenetics AtaciceptStudy Group. Reduced B lymphocyte and immunoglobulin levelsafter atacicept treatment in patients with systemic lupus erythema-tosus. Results of multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum., 2007, 56, 4142-4150.
    • (2007) Arthritis Rheum , vol.56 , pp. 4142-4150
    • Dall'Era, M.1    Chacravarty, E.2    Wallace, D.3    Genovese, M.4    Weis-Man, M.5    Kavanaugh, A.6    Kalunian, K.7    Dar, P.8    Vincent, E.9    Pena-Rossi, C.10    Wofsy, D.11
  • 49
    • 2942733370 scopus 로고    scopus 로고
    • CTLA4Ig: A novel inhibitor of costimula-tion
    • Dall'Era, M.; Davis, J. CTLA4Ig: a novel inhibitor of costimula-tion. Lupus, 2004, 13, 372-376.
    • (2004) Lupus , vol.13 , pp. 372-376
    • Dall'Era, M.1    Davis, J.2
  • 52
    • 0035284737 scopus 로고    scopus 로고
    • Cutting edge: Reversal of murine lupusnephritis with CTLA-4Ig and cyclophosphamide
    • Daikh, D.; Wofsky, D. Cutting edge: Reversal of murine lupusnephritis with CTLA-4Ig and cyclophosphamide. J. Immunol.,2001, 166, 2913-2916.
    • (2001) J. Immunol , vol.166 , pp. 2913-2916
    • Daikh, D.1    Wofsky, D.2
  • 53
    • 2942718786 scopus 로고    scopus 로고
    • The role of CD40 ligand in systemic lupuserythematosus
    • Yazdany, J.; Davis, J. The role of CD40 ligand in systemic lupuserythematosus. Lupus, 2004, 13, 377-380.
    • (2004) Lupus , vol.13 , pp. 377-380
    • Yazdany, J.1    Davis, J.2
  • 54
    • 0035163042 scopus 로고    scopus 로고
    • Phase I clinical trial of monoclonal antibody against CD40-Ligand (IDEC-131) in patients with systemic lupus erythematosus
    • Davis, J.C.; Totoritis, M.C.; Rosenberg, J.; Sklenar, T.A.; Wofsy,D. Phase I clinical trial of monoclonal antibody against CD40-Ligand (IDEC-131) in patients with systemic lupus erythematosus.J. Rheumatol., 2001, 28, 95-101.
    • (2001) J. Rheumatol , vol.28 , pp. 95-101
    • Davis, J.C.1    Totoritis, M.C.2    Rosenberg, J.3    Sklenar, T.A.4    Wofsy, D.5
  • 55
    • 0036899589 scopus 로고    scopus 로고
    • For the IDEC-131 Lupus Study Group. Treatment ofsystemic lupus erythematosus by inhibition of T cell costimulationwith anti-CD154
    • Kalunian, K.C.; Davis, J.C. Jr.; Merrill, J.T.; Totoritis, M.C.; Wofsy, D.; for the IDEC-131 Lupus Study Group. Treatment ofsystemic lupus erythematosus by inhibition of T cell costimulationwith anti-CD154. Arthritis Rheum., 2002, 46, 3252-3258.
    • (2002) Arthritis Rheum , vol.46 , pp. 3252-3258
    • Kalunian, K.C.1    Davis Jr., J.C.2    Merrill, J.T.3    Totoritis, M.C.4    Wofsy, D.5
  • 56
    • 0037333857 scopus 로고    scopus 로고
    • BG9598 Lupus Nephritis Trial Group. A short course of BG9588 (anti-CD-40L antibody) improves sero-logic activity and decreases hematuria in patients with proliferativelupus gromerulonephritis
    • Boumpas, D.T.; Furie, R.; Manzi, S.; Illei, G.G.; Wallace, D.J.; Balow, J.E.; Vaishnaw, A. BG9598 Lupus Nephritis Trial Group.A short course of BG9588 (anti-CD-40L antibody) improves sero-logic activity and decreases hematuria in patients with proliferativelupus gromerulonephritis. Arthritis Rheum., 2003, 48, 719-727.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3    Illei, G.G.4    Wallace, D.J.5    Balow, J.E.6    Vaishnaw, A.7
  • 58
    • 20244383590 scopus 로고    scopus 로고
    • LJP 394 Invastigator Consortium. Relationship betweendouble-stranded DNA antibodies and exacerbation of renal diseasein patients with systemic lupus erythematosus
    • Linnik, M.D.; Hu, J.Z.; Heilbrunn, K.R.; Strand, V.; Hurley, F.L.; Joh, T.; LJP 394 Invastigator Consortium. Relationship betweendouble-stranded DNA antibodies and exacerbation of renal diseasein patients with systemic lupus erythematosus. Arthritis Rheum.,2005, 52, 1129-1137.
    • (2005) Arthritis Rheum , vol.52 , pp. 1129-1137
    • Linnik, M.D.1    Hu, J.Z.2    Heilbrunn, K.R.3    Strand, V.4    Hurley, F.L.5    Joh, T.6
  • 59
    • 2942703965 scopus 로고    scopus 로고
    • LJP 394 (abetimus sodium, Riquent) inthe management of systemic lupus erythematosus
    • Wallece, D.J.; Tumlin, J.A. LJP 394 (abetimus sodium, Riquent) inthe management of systemic lupus erythematosus. Lupus, 2004, 13,323-327.
    • (2004) Lupus , vol.13 , pp. 323-327
    • Wallece, D.J.1    Tumlin, J.A.2
  • 60
    • 0037331980 scopus 로고    scopus 로고
    • LJP 394 Investigator Consortium. LJP 394 for the prevention of re-nal flare in patients with systemic lupus erythematosus. Resultsfrom a randomized, double-blind, placebo controlled study
    • Alarc n-Segovia, D.; Tumlin, J.A.; Furie, R.A.; McKay, J.D.; Cardiel, M.H.; Strand, V.; Bagin, R.G.; Linnik, M.D.; Hepburn, B.;LJP 394 Investigator Consortium. LJP 394 for the prevention of re-nal flare in patients with systemic lupus erythematosus. Resultsfrom a randomized, double-blind, placebo controlled study. Arthri-tis Rheum., 2003, 48, 442-454.
    • (2003) Arthri-tis Rheum , vol.48 , pp. 442-454
    • Alarcn-Segovia, D.1    Tumlin, J.A.2    Furie, R.A.3    McKay, J.D.4    Cardiel, M.H.5    Strand, V.6    Bagin, R.G.7    Linnik, M.D.8    Hepburn, B.9
  • 61
    • 0030850755 scopus 로고    scopus 로고
    • Cytokine concentration in serum of lupus erythematosus pa-tients: The effect on acute phase response
    • Lacki, J.K.; Leszczynski, P.; Kelemen, J.; Muller, W.; Mackiewicz,S.H. Cytokine concentration in serum of lupus erythematosus pa-tients: the effect on acute phase response. J. Med., 1997, 28, 99-107.
    • (1997) J. Med , vol.28 , pp. 99-107
    • Lacki, J.K.1    Leszczynski, P.2    Kelemen, J.3    Muller, W.4    Mackiewicz, S.H.5
  • 63
    • 0037167382 scopus 로고    scopus 로고
    • Drug-induced systemic lupus erythematosus and TNF-alpha block-ers
    • Mohan, A.K.; Edwards, E.T.; Cote, T.R.; Siegel, J.N.; Braun, M.M.Drug-induced systemic lupus erythematosus and TNF-alpha block-ers. Lancet, 2002, 360, 646.
    • (2002) Lancet , vol.360 , pp. 646
    • Mohan, A.K.1    Edwards, E.T.2    Cote, T.R.3    Siegel, J.N.4    Braun, M.M.5
  • 64
    • 2942733373 scopus 로고    scopus 로고
    • Tumor necrosis factor and other proin-flammatory cytokines in systemic lupus erythematosus: Rational fortherapeutic intervention
    • Aringer, M.; Smolen, J.S. Tumor necrosis factor and other proin-flammatory cytokines in systemic lupus erythematosus: rational fortherapeutic intervention. Lupus, 2004, 13, 344-347.
    • (2004) Lupus , vol.13 , pp. 344-347
    • Aringer, M.1    Smolen, J.S.2
  • 65
    • 0031569093 scopus 로고    scopus 로고
    • Kinetics of cytokine production in experimental sys-temic lupus erythematosus: Involvement of T helper cell/T helpercell 2-type cytokines in disease
    • Segal, S.; Bermas, B.; Dayan, M.; Kaluah, F.; Shearer, G.M.; ozes, E. Kinetics of cytokine production in experimental sys-temic lupus erythematosus: involvement of T helper cell/T helpercell 2-type cytokines in disease. J. Immunol., 1997, 158, 3009-3016.
    • (1997) J. Immunol , vol.158 , pp. 3009-3016
    • Segal, S.1    Bermas, B.2    Dayan, M.3    Kaluah, F.4    Shearer, G.M.5    Ozes, E.6
  • 66
    • 5644258326 scopus 로고    scopus 로고
    • Safety andefficacy of tumor necrosis factor alpha blockade in systemic lupuserythematosus. An open-label study
    • Aringer, M.; Graninger, W.B.; Steiner, G.; Smolen, J.S. Safety andefficacy of tumor necrosis factor alpha blockade in systemic lupuserythematosus. An open-label study. Arthritis Rheum., 2004, 50,3161-3169.
    • (2004) Arthritis Rheum , vol.50 , pp. 3161-3169
    • Aringer, M.1    Graninger, W.B.2    Steiner, G.3    Smolen, J.S.4
  • 67
    • 2942752122 scopus 로고    scopus 로고
    • Rationale for interleukin-6blockade in systemic lupus erythematosus
    • Tackey, Y.; Lipsky, P.E.; Illei, G.G. Rationale for interleukin-6blockade in systemic lupus erythematosus. Lupus, 2004, 13, 339-343.
    • (2004) Lupus , vol.13 , pp. 339-343
    • Tackey, Y.1    Lipsky, P.E.2    Illei, G.G.3
  • 68
    • 0030982298 scopus 로고    scopus 로고
    • Interleukin-10 andinterleukin-6 in lupus erythematosus and rheumatoid arthritis, cor-relations with acute phase proteins
    • Lacki, J.K.; Samborski, W.; Mackiewicz, S.H. Interleukin-10 andinterleukin-6 in lupus erythematosus and rheumatoid arthritis, cor-relations with acute phase proteins. Clin. Rheumatol., 1997, 16,275-278.
    • (1997) Clin. Rheumatol , vol.16 , pp. 275-278
    • Lacki, J.K.1    Samborski, W.2    Mackiewicz, S.H.3
  • 69
    • 33750011260 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody inhibits auto-immune responses in a murine model of systemic lupus erythema-tosus
    • Liang, B.; Gardner, D.B.; Griswold, D.E.; Bugelski, P.J.; SongXiao, Y.R: Anti-interleukin-6 monoclonal antibody inhibits auto-immune responses in a murine model of systemic lupus erythema-tosus. Immunology, 2006, 119, 296-305.
    • (2006) Immunology , vol.119 , pp. 296-305
    • Liang, B.1    Gardner, D.B.2    Griswold, D.E.3    Bugelski, P.J.4    Songxiao, Y.R.5
  • 70
    • 0037480240 scopus 로고    scopus 로고
    • The cardiovascular burden of lupus: Acomplex challenge
    • Schattner, A.; Liang, M.H. The cardiovascular burden of lupus: acomplex challenge. Arch. Intern. Med., 2003, 163, 1507-1510.
    • (2003) Arch. Intern. Med , vol.163 , pp. 1507-1510
    • Schattner, A.1    Liang, M.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.