Chapter 2.2 Cytokine activation of the hypothalamo-pituitary-adrenal axis

Techniques in the Behavioral and Neural Sciences

Volumn 15, Issue PART 2, 2005, Pages 157-174

  Dunn, Adrian J ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

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[No Author keywords available]

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EID: 77956672223     PISSN: 09210709     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0921-0709(05)80054-9     Document Type: Chapter

References (153)

1. Akil H., Shiomi H., and Matthews J. Induction of the intermediate pituitary by stress: synthesis and release of a nonopioid form of β-endorphin. Science 227 (1985) 424-426
2. Al-Damluji S. Adrenergic mechanisms in the control of corticotrophin secretion. J. Endocrinol. 119 (1988) 5-14
3. Ando T., and Dunn A.J. Mouse tumor necrosis factor-α increases brain tryptophan concentrations and norepinephrine metabolism while activating the HPA axis in mice. Neuroimmunomodulation 6 (1999) 319-329
4. Ando T., Rivier J., Yanaihara H., and Arimura A. Peripheral corticotropin-releasing factor mediates the elevation of plasma IL-6 by immobilization stress in rats. Am. J. Physiol. 275 (1998) R1461-R1467
5. Andreis P.G., Neri G., and Nussdorfer G.G. Corticotropin-releasing hormone (CRH) directly stimulates corticosterone secretion by the rat adrenal gland. Endocrinol. 128 (1991) 1198-1200
6. Antoni F.A. Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Front. Neuroendocrinol. 14 (1993) 76-122
7. Banks W.A., Kastin A.J., and Broadwell R.D. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 2 (1995) 241-248
8. Banks W.A., Farr S.A., La Scola M.E., and Morley J.E. Intravenous human interleukin-1α impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J. Pharmacol. Exptl Therap. 299 (2001) 1-6
9. Barney M., Call G.B., McIlmoil C.J., Husein O.F., Adams A., Balls A.G., Oliveira G.K., Miner E.C., Richards T.A., Crawford B.K., Heckmanu R.A., Bell J.D., and Judd A.M. Stimulation by interleukin-6 and inhibition by tumour necrosis factor of cortisol release from bovine adrenal zona fasciculata cells through their receptors. Endocrin. J. 13 (2000) 369-377
10. Berkenbosch F., van Oers J., del Rey A., Tilders F., and Besedovsky H. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238 (1987) 524-526
11. Berkenbosch F., De Goeij D.E.C., del Rey A., and Besedovsky H.O. Neuroendocrine, sympathetic and metabolic responses induced by interleukin-1. Neuroendocrinol. 50 (1989) 570-576
12. Bernardini B., Kamilaris T.C., Calogero A.E., Johnson E.O., Gomez M.T., Gold P.W., and Chrousos G.P. Interactions between tumor necrosis factor-α, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinol. 126 (1990) 2876-2881
13. Bernton E.W., Beach J.E., Holaday J.W., Smallridge R.C., and Fein H.G. Release of multiple hormones by a direct action of interleukin-1 on pituitary cells. Science 238 (1987) 519-521
14. Bertini R., Bianchi M., and Ghezzi P. Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor. J. Exptl. Med. 167 (1988) 1708-1712
15. Besedovsky H.O., and del Rey A. Physiological implications of the immune-neuro-endocrine network. In: Ader R., Felten D., and Cohen N. (Eds). Pyschoneuroimmunology. 2nd ed. (1991), Academic Press, Chichester 589-608
16. Besedovsky H.O., and del Rey A. Immune-neuro-endocrine circuits: integrative role of cytokines. Front. Neuroendocrinol. 13 (1992) 61-94
17. Besedovsky H.O., and del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocrine Rev. 17 (1996) 64-102
18. Besedovsky H.O., del Rey A., Sorkin E., and Dinarello C.A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233 (1986) 652-654
19. Besedovsky H.O., del Rey A., Klusman I., Furukawa H., Monge Arditi G., and Kabiersch A. Cytokines as modulators of the hypothalamus-pituitary-adrenal axis. J. Steroid Biochem. Molec. Biol. 40 (1991) 613-618
20. Bethin K.E., Vogt S.K., and Muglia L.J. IL-6 is an essential, corticotropin-releasing hormone-independent, stimulator of the adrenal axis during immune system activation. Proc. Natl Acad. Sci. USA 97 (2000) 9317-9322
21. Blalock J.E. The immune system as a sensory organ. J. Immunol. 132 (1984) 1067-1070
22. Blatteis C.M., and Sehic E. Fever: how may circulating pyrogens signal the brain. News Physiol. Sci. 12 (1997) 1-9
23. Bocci V. Interleukins: clinical pharmacokinetics and practical implications. Clin. Pharmacokinet. 21 (1991) 274-284
24. Brebner K., Hayley S., Zacharko R., Merali Z., and Anisman H. Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α: central monamine, corticosterone, and behavioral variations. Neuropsychopharmacol. 22 (2000) 566-580
25. Brouckaert P.G.G., Leroux-Roels G.G., Guisez Y., Tavernier J., and Fiers W. In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-γ, on a syngeneic murine melanoma. Int. J. Cancer 38 (1986) 763-769
26. Brouckaert P., Libert C., Everaerdt B., and Fiers W. Selective species specificity of tumor necrosis factor for toxicity in the mouse. Lymphokine Cytokine Res. 11 (1992) 193-196
27. Callahan T.A., and Piekut D.T. Differential Fos expression induced by IL-1β and IL-6 in rat hypothalamus and pituitary gland. J. Neuroimmunol. 7 (1997) 207-211
28. Cambronero J.C., Rivas F.J., Borrell J., and Guaza C. Is the adrenal cortex a putative site for the action of interleukin-1?. Horm. Metab. Res. 24 (1992) 48-49
29. Cao C., Matsumu K., and Watanabe Y. Induction of cyclooxygenase-2 in the brain by cytokines. Ann. N.Y. Acad. Sci. 813 (1997) 307-309
30. Cassidy E.M., Manning D., Byrne S., Bolger E., Murray F., Sharifi N., Wallace E., Keogan M., and O'Keane V. Acute effects of low-dose interferon-alpha on serum cortisol and plasma interleukin-6. J. Psychopharmacol. 16 (2002) 230-234
31. Chesnokova V., and Melmed S. Leukemia inhibitory factor mediates the hypothalamic pituitary adrenal axis response to inflammation. Endocrinol. 141 (2000) 4032-4040
32. Chesnokova V., Auernhammer C.J., and Melmed S. Murine leukemia inhibitory factor gene disruption attenuates the hypothalamo-pituitary-adrenal axis stress response. Endocrinol. 139 (1998) 2209-2216
33. Chowers I., Hammel H.T., Eisenman J., Abrams R.M., and McCann S.M. Comparison of effect of environmental and preoptic heating and pyrogen on plasma cortisol. Amer. J. Physiol. 210 (1966) 606-610
34. Chuluyan H., Saphier D., Rohn W.M., and Dunn A.J. Noradrenergic innervation of the hypothalamus participates in the adrenocortical responses to interleukin-1. Neuroendocrinol. 56 (1992) 106-111
35. Corssmit E.P., de Metz J., Sauerwein H.P., and Romijn J.A. Biologic responses to IFN-α administration in humans. J. Interferon Cytokine Res. 20 (2000) 1039-1047
36. Darling G., Goldstein D.S., Stull R., Gorschboth C.M., and Norton J.A. Tumor necrosis factor: immune endocrine interaction. Surgery 106 (1989) 1155-1160
37. Daynes R.A., Robertson B.A., Cho B.-H., Burnham D.K., and Newton R. α-Melanocyte-stimulating hormone exhibits target cell selectivity in its capacity to affect interleukin 1-inducible responses in vivo and in vitro. J. Immunol. 139 (1987) 103-109
38. Di Santo E., Sironi M., Pozzi P., Gnocchi P., Isetta A.M., Delvaux A., Goldman M., Marchant A., and Ghezzi P. Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin-1 beta production in the brain without affecting the activation of the hypothalamus-pituitary-adrenal axis. Neuroimmunomod. 2 (1995) 149-154
39. Donaldson C.J., Sutton S.W., Perrin M.H., Corrigan A.Z., Lewis K., Rivier J.E., Vaughan J.M., and Vale W.W. Cloning and characterization of human urocortin. Endocrinol. 137 (1996) 2167-2170
40. Dunn A.J. Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone. Life Sci. 43 (1988) 429-435
41. Dunn A.J. Interleukin-1 as a stimulator of hormone secretion. Prog. NeuroEndocrinImmunol. 3 (1990) 26-34
42. Dunn A.J. The role of interleukin-1 and tumor necrosis factor α in the neurochemical and neuroendocrine responses to endotoxin. Brain Res. Bull. 29 (1992) 807-812
43. Dunn A.J. Role of cytokines in infection-induced stress. Ann. N.Y. Acad. Sci. 697 (1993) 189-202
44. Dunn A.J. Nitric oxide synthase inhibitors prevent the cerebral tryptophan and serotonergic responses to endotoxin and interleukin-1. Neurosci. Res. Commun. 13 (1993) 149-156
45. Dunn A.J. Cytokine activation of the HPA axis. Ann. N.Y. Acad. Sci. 917 (2000) 608-617
46. Dunn A.J. Mechanisms by which cytokines signal the brain. In: Clow A., and Hucklebridge F. (Eds). Neurobiology of the Immune System, International Review of Biology (2002), Academic Press, New York 43-65
47. Dunn A.J. Stress neurochemistry. In: Adelman G. (Ed). Encyclopedia of Neuroscience. 3rd ed. (2004), Birkhauser Boston, San Diego
48. Dunn A.J., and Chuluyan H. The role of cyclooxygenase and lipoxygenase in the interleukin-1-induced activation of the HPA axis: dependence on the route of injection. Life Sci. 51 (1992) 219-225
49. Dunn A.J., and Swiergiel A.H. Behavioral responses to stress are intact in CRF-deficient mice. Brain Res. 845 (1999) 14-20
50. Dunn A.J., Wang J.-P., and Ando T. Effects of cytokines on central neurotransmission: Comparison with the effects of stress. Adv. Exptl. Med. Biol. 461 (1999) 117-127
51. Ericsson A., Ek M., Wahlstrom I., Kovacs K., Liu C., Hart R., and Sawchenko P.E. Pathways and mechanisms for interleukin-1 mediated regulation of the hypothalamo-pituitary-adrenal axis. In: McCarty R., Aguilera G., Sabban E., and Kvetnansky R. (Eds). Stress: Molecular Genetica and Neurobiological Advances (1996), Gordon and Breach Science Publishers, Cambridge, MA 101-120
52. Fagarasan M.O., Eskay R., and Axelrod J. Interleukin 1 potentiates the secretion of β-endorphin induced by secretagogues in a mouse pituitary cell line (AtT-20). Proc. Natl. Acad. Sci. USA 86 (1989) 2070-2073
53. Fagarasan M.O., Aiello F., Muegge K., Durum S., and Axelrod J. Interleukin 1 induces β-endorphin secretion via Fos and Jun in AtT-20 pituitary cells. Proc. Natl. Acad. Sci. USA 87 (1990) 7871-7874
54. Fleshner M., Goehler L.E., Hermann J., Relton J.K., Maier S.F., and Watkins L.R. Interleukin-1β induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res. Bull. 37 (1995) 605-610
55. Fleshner M., Goehler L.E., Schwartz B.A., McGorry M., Martin D., Maier S.F., and Watkins L.R. Thermogenic and corticosterone responses to intravenous cytokines (IL-1β and TNF-α) are attenuated by subdiaphragmatic vagotomy. J. Neuroimmunol. 86 (1998) 134-141
56. Fransen L., Müller R., Marmenout A., Tavernier J., Van der Heyden J., Kawashima E., Chollet A., Tizard R., Van Heuverswyn H., Van Vliet A., Ruysschaert M.-R., and Fiers W. Molecular cloning of mouse tumor necrosis factor cDNA and its eukaryotic expression. Nucleic Acids Res. 13 (1985) 4417-4429
57. Fukata J., Usui Y., Naitoh Y., Nakai Y., and Imura H. Effects of recombinant human interleukin-1α, -1β, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumor line AtT-20. J. Endocrinol. 122 (1989) 33-39
58. Gaykema R.P.A., Dijkstra I., and Tilders F.J.H. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-releasing hormone neurons and ACTH secretion. Endocrinol. 136 (1995) 4717-4720
59. Gisslinger H., Svoboda T., Clodi M., Gilly B., Ludwig H., Havelec L., and Luger A. Interferon-α stimulates the hypothalamic-pituitary-adrenal axis in vivo and in vitro. Neuroendocrinol. 57 (1993) 489-495
60. Gwosdow A.R., Kumar M.S.A., and Bode H.H. Interleukin 1 stimulation of the hypothalamic-pituitary-adrenal axis. Amer. J. Physiol. 258 (1990) E65-E70
61. Hanisch U.K., Rowe W., van Rossum D., Meaney M.J., and Quirion R. Phasic activity of the HPA axis resulting from central IL-2 administration. Neuroreport 7 (1996) 2883-2888
62. Harbuz M.S., Stephanou A., Sarlis N., and Lightman S.L. The effects of recombinant human interleukin (IL)-1α, IL-1β or IL-6 on hypothalamo-pituitary-adrenal axis activation. J. Endocrinol. 133 (1992) 349-355
63. Harbuz M.S., Chover-Gonzalez A.J., Conde G.L., Renshaw D., Lightman S.L., and Jessop D.S. Interleukin-1β-induced effects on plasma oxytocin and arginine vasopressin: role of adrenal steroids and route of administration. Neuroimmunomodulation 3 (1996) 358-363
64. Harlin C.A., and Parker C.R. Investigation of the effect of interleukin-1β on steroidogenesis in the human fetal adrenal gland. Steroids 56 (1991) 72-76
65. Holsboer F., Stalla G.K., von Bardeleben U., Hammann K., Müller H., and Müller O.A. Acute adrenocortical stimulation by recombinant gamma interferan in human controls. Life Sci. 42 (1988) 1-5
66. Kabiersch A., del Rey A., Honegger C.G., and Besedovsky H.O. Interleukin-1 induces changes in norepinephrine metabolism in the rat brain. Brain Behav. Immun. 2 (1988) 267-274
67. Kapcala L.P., He J.R., Gao Y., Pieper J.O., and DeTolla L.J. Subdiaphragmatic vagotomy inhibits intra-abdominal interleukin-1β stimulation of adrenocorticotropin secretion. Brain Res. 728 (1996) 247-254
68. Karalis K., Muglia L.J., Bae D., Hilderbrand H., and Majzoub J.A. CRH and the immune system. J. Neuroimmunol. 72 (1997) 131-136
69. Karanth S., and McCann S.M. Anterior pituitary hormone control by interleukin-2. Proc. Natl. Acad. Sci. USA 88 (1991) 2961-2965
70. Katsuura G., Arimura A., Koves K., and Gottschall P.E. Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1β-induced ACTH release. Amer. J. Physiol. 258 (1990) E163-E171
71. Kehrer P., Turnill D., Dayer J.-M., Muller A.F., and Gaillard R.C. Human recombinant interleukin-1 beta and -alpha, but not recombinant tumor necrosis factor alpha stimulate ACTH release from rat anterior pituitary cells in vitro in a prostaglandin E2 and cAMP independent manner. Neuroendocrinol. 48 (1988) 160-166
72. Kovács K.J., and Elenkov I.J. Differential dependence of ACTH secretion induced by various cytokines on the integrity of the paraventricular nucleus. J. Neuroendocrinol. 7 (1995) 15-23
73. Krishnan R., Ellinwood E.H., Laszlo J., Hood L., and Ritchie J. Effect of gamma interferon on the hypothalamic-pituitary-adrenal system. Biol. Psychiat. 22 (1987) 1163-1165
74. Lacosta S., Merali Z., and Anisman H. Central monoamine activity following acute and repeated systemic interleukin-2 administration. Neuroimmunomod. 8 (2000) 83-90
75. Landgraf R., Neumann I., Holsboer F., and Pittman Q.J. Interleukin-1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat. Europ. J. Neurosci. 7 (1995) 592-598
76. Levine S., Berkenbosch F., Suchecki D., and Tilders F.J.H. Pituitary-adrenal and interleukin-6 responses to recombinant interleukin-1 in neonatal rats. Psychoneuroendocrinol. 19 (1994) 143-154
77. Lewis M., Tartaglia L.A., Lee A., Bennett G.L., Rice G.C., Wong G.H.W., Chen E.Y., and Goeddel D.V. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA 88 (1991) 2830-2834
78. Li C., Vaughan J., Sawchenko P.E., and Vale W.W. Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression. J. Neurosci. 22 (2002) 991-1001
79. Lissoni P., Rovelli F., Rivolta M.R., Frigerio C., Mandala M., Barni S., Ardizzoia A., Malugani F., and Tancini G. Acute endocrine effects of interleukin-12 in cancer patients. J. Biol. Regulat. Homeost. Agents 11 (1997) 154-156
80. Lyson K., Milenkovic L., and McCann D.J.J. The stimulatory effect of interleukin 6 on corticotropin-releasing hormone and thyrotropin-releasing hormone release. Prog. Neuro. Endocrin. Immunol. 4 (1991) 161-165
81. Mastorakos G., Chrousos G.P., and Weber J.S. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J. Clin. Endocrinol. Metab. 77 (1993) 1690-1694
82. Mastorakos G., Weber J.S., Magiakou M.-A., Gunn H., and Chrousos G.P. Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J. Clin. Endocrinol. Metab. 79 (1994) 934-939
83. Matta S.G., Weatherbee J., and Sharp B.M. A central mechanism is involved in the secretion of ACTH in response to IL-6 in rats: comparison to and interaction with IL-1β. Neuroendocrinol. 56 (1992) 516-525
84. McGillis J.P., Hall N.R., and Goldstein A.L. Thymosin fraction 5 (TF5) stimulates secretion of adrenocorticotropic hormone (ACTH) from cultured rat pituitaries. Life Sci. 42 (1988) 2259-2268
85. Menzies R.A., Phelps C.P., Wiranowska M., Oliver J., Chen L.T., Horvath E., and Hall N.R.S. The effect of interferon-alpha on the pituitary-adrenal axis. J. Interferon Cytokine Res. 16 (1996) 619-629
86. Muglia L.J., Bethin K.E., Jacobson L., Vogt S.K., and Majzoub J.A. Pituitary-adrenal axis regulation in CRH-deficient mice. Endocrine Res. 26 (2000) 1057-1066
87. Mulé J.J., McIntosh J.K., Jablons D.M., and Rosenberg S.A. Antitumor activity of recombinant interleukin 6 in mice. J. Exptl Med. 171 (1990) 629-636
88. Müller H., Hammes E., Hiemke C., and Hess G. Interferon-alpha-2-induced stimulation of ACTH and cortisol secretion in man. Neuroendocrinol. 54 (1991) 499-503
89. Naito Y., Fukata J., Tominaga T., Masui Y., Hirai Y., Murakami N., Tamai S., Mori K., and Imura H. Adrenocorticotropic hormone-releasing activities of interleukins in a homologous in vivo system. Biochem. Biophys. Res. Commun. 164 (1989) 1262-1267
90. Naitoh Y., Fukata J., Tominaga T., Nakai Y., Tamai S., Mori K., and Imura H. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem. Biophys. Res. Commun. 155 (1988) 1459-1463
91. Nakatsuru K., Ohgo S., Oki Y., and Matsukura S. Interleukin-1 (IL1) stimulates arginine vasopressin (AVP) release from superfused rat hypothalamo-neurohypophyseal complexes independently of cholinergic mechanism. Brain Res. 554 (1991) 38-45
92. Olsen N.J., Nicholson W.E., DeBold C.R., and Orth D.N. Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. Endocrinol. 130 (1992) 2113-2119
93. Ovadia H., Abramsky O., Barak V., Conforti N., Saphier D., and Weidenfeld J. Effect of interleukin-1 on adrenocortical activity in intact and hypothalamic deafferentated male rats. Exptl. Brain Res. 76 (1989) 246-249
94. Papadopoulos A.D., and Wardlaw S.L. Endogenous α-MSH modulates the hypothalamic-pituitary-adrenal response to the cytokine interleukin-1β. J. Neuroendocrinol. 11 (1999) 315-319
95. Path G., Scherbaum W.A., and Bornstein S.R. The role of interleukin-6 in the human adrenal gland. Europ. J. Clin. Invest. 30 Suppl. 3 (2000) 91-95
96. Pauli S., Linthorst A.C., and Reul J.M. Tumour necrosis factor-α and interleukin-2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic-pituitary-adrenocortical axis activity in the rat. Europ. J. Neurosci. 10 (1998) 868-878
97. Perlstein R.S., Mougey E.H., Jackson W.E., and Neta R. Interleukin-1 and interleukin-6 act synergistically to stimulate the release of adrenocorticotropic hormone in vivo. Lymph. Cytok. Res. 10 (1991) 141-146
98. Perlstein R.S., Whitnall M.H., Abrams J.S., Mougey E.H., and Neta R. Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinol. 132 (1993) 946-952
99. Perlstein R.S., Metha N.R., Mougey E.H., Neta R., and Whitnall M.H. Systemically administered histamine H1 and H2 receptor antagonists do not block the ACTH response to bacterial lipopolysaccharide and interleukin-1. Neuroendocrinol. 60 (1994) 418-425
100. Plotsky P.M., Cunningham E.T., and Widmaier E.P. Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocrine Rev. 10 (1989) 437-458
101. Quan N., Whiteside M., and Herkenham M. Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res. 802 (1998) 189-197
102. Quan N., Stern E.L., Whiteside M.B., and Herkenham M. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J. Neuroimmunol. 93 (1999) 72-80
103. Reichlin S. Editorial: what's in a name or what does leukemia inhibitory factor have to do with the pituitary gland?. Endocrinol. 139 (1998) 2199-2200
104. Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A., Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., and Sawchenko P.E. Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl Acad. Sci. USA 98 (2001) 2843-2848
105. Rivest S. How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinol. 26 (2001) 761-788
106. Rivest S., and Rivier C. Influence of the paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by intermittent footshock or interleukin. Endocrinol. 129 (1991) 2049-2057
107. Rivier C. Blockade of nitric oxide formation augments adrenocorticotropin released by blood-borne interleukin-1β: role of vasopressin, prostaglandins, and α1-adrenergic receptors. Endocrinol. 136 (1995) 3597-3603
108. Rivier C. Influence of immune signals on the hypothalamic-pituitary axis of the rodent. Front. Neuroendocrinol. 16 (1995) 151-182
109. Rivier C., Chizzonite R., and Vale W. In the mouse, the activation of the hypothalamic-pituitary-adrenal axis by a lipopolysaccharide (endotoxin) is mediated through interleukin-1. Endocrinol. 125 (1989) 2800-2805
110. Roh M.S., Drazenovich K.A., Barbose J.J., Dinarello C.A., and Cobb C.F. Direct stimulation of the adrenal cortex by interleukin-1. Surgery 102 (1987) 140-146
111. Salas M.A., Evans S.W., Levell M.J., and Whicher J.T. Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin. Exptl. Immunol. 79 (1990) 470-473
112. Saphier D. Neurophysiological and endocrine consequences of immune activity. Psychoneuroendocrinol. 14 (1989) 63-87
113. Saphier D., and Feldman S. Adrenoreceptor specificity in the central regulation of adrenocortical secretion. Neuropharmacol. 28 (1989) 1231-1237
114. 1A agonists is mediated by sympathomedullary activation. J. Pharmacol. Exptl Therapeut. 270 (1994) 905-917
115. 1 -opioid receptors in the rat. Europ. J. Pharmacol. 236 (1993) 183-191
116. Sapolsky R., Rivier C., Yamamoto G., Plotsky P., and Vale W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238 (1987) 522-524
117. Shalts E., Feng Y.-J., Ferin M., and Wardlaw S.L. α-Melanocyte-stimulating hormone antagonizes the neuoendocrine effects of corticotropin-releasing factor and interleukin-1α in the primate. Endocrinol. 131 (1992) 132-138
118. Sharp B., and Linner K. What do we know about the expression of proopiomelanocortin transcripts and related peptides in lymphoid tissue?. Endocrinol. 133 (1993) 1921-1922
119. Sharp B.M., and Matta S.G. Prostaglandins mediate the adrenocorticotropin response to tumor necrosis factor in rats. Endocrinol. 132 (1993) 269-274
120. Sharp B.M., Matta S.G., Peterson P.K., Newton R., Chao C., and McAllen K. Tumor necrosis factor-α is a potent ACTH secretagogue: comparison to interleukin-1β. Endocrinol. 124 (1989) 3131-3133
121. Sherry B., Jue D.M., Zentella A., and Cerami A. Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor. Biochem. Biophys. Res. Commun. 173 (1990) 1072-1078
122. Silverman M.N., Pearce B.D., and Miller A.H. Cytokines and HPA axis regulation. In: Kronfol Z. (Ed). Cytokines and Mental Health (2003), Kluwer Academic Publishers, New York 85-122
123. Smagin G.N., Swiergiel A.H., and Dunn A.J. Peripheral administration of interleukin-1 increases extracellular concentrations of norepinephrine in rat hypothalamus: comparison with plasma corticosterone. Psychoneuroendocrinol. 21 (1996) 83-93
124. Smith L.R., Brown S.L., and Blalock J.E. Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor a-chain-like molecule on pituitary cells. J. Neuroimmunol. 21 (1989) 249-254
125. Smith E.M., Cadet P., Stefano G.B., Opp M.R., and Hughes T.K.J. IL-10 as a mediator in the HPA axis and brain. J. Neuroimmunol. 100 (1999) 140-148
126. Spangelo B.L., Jarvis W.D., Judd A.M., and MacLeod R.M. Induction of interleukin-6 release by interleukin-1 in rat anterior pituitary cells in vitro: evidence for an eicosanoid-dependent mechanism. Endocrinol. 129 (1991) 2886-2894
127. Spath-Schwalbe E., Hansen K., Schmidt F., Schrezenmeier H., Marshall L., Burger K., Fehm H.L., and Born J. Endocrine effects of recombinant interleukin 6 on endocrine and central nervous sleep functions in healthy men. Clin. Endocrinol. Metab. 83 (1998) 1573-1579
128. Spinedi E., Hadid R., Daneva T., and Gaillard R.C. Cytokines stimulate the CRH but not the vasopressin neuronal system: evidence for a median eminence site of interleukin-6 action. Neuroendocrinol. 56 (1992) 46-53
129. Stouthard J.M.L., Romijn J.A., Van der Poll T., Endert E., Klein S., Bakker P.J.M., Veenhof C.H.N., and Sauerwein H.P. Endocrinologic and metabolic effects of interleukin-6 in humans. Amer. J. Physiol. 268 (1995) E813-E819
130. Suda T., Tozawa F., Ushiyama T., Tomori N., Sumitomo T., Nakagami Y., Yamada M., Demura H., and Shizume K. Effects of protein kinase-C-related adrenocorticotropin secretagogues and interleukin-1 on proopiomelanocortin gene expression in rat anterior pituitary cells. Endocrinol. 124 (1989) 1444-1449
131. Swiergiel A.H., Dunn A.J., and Stone E.A. The role of cerebral noradrenergic systems in the Fos response to interleukin-1. Brain Res. Bull. 41 (1996) 61-64
132. Tallarida R.J., Porreca F., and Cowan A. Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci. 45 (1989) 947-961
133. Tilders F.J.H., DeRijk R.H., Van Dam A.-M., Vincent V.A.M., Schotanus K., and Persoons J.H.A. Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: routes and intermediate signals. Psychoneuroendocrinol. 19 (1994) 209-232
134. Tsagarakis S., Gillies G., Rees L.H., Besser M., and Grossman A. Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus. Neuroendocrinol. 49 (1989) 98-101
135. Turnbull A.V., and Rivier C. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev. 79 (1999) 1-71
136. Turnbull A.V., Smith G.W., Lee S., Vale W.W., Lee K.F., and Rivier C. CRF type 1 receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. Endocrinol. 140 (1999) 1013-1017
137. Uehara A., Gillis S., and Arimura A. Effects of interleukin-1 on hormone release from normal rat pituitary cells in primary culture. Neuroendocrinol. 45 (1987) 343-347
138. Uehara A., Gottschall P.E., Dahl R.R., and Arimura A. Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin releasing factor. Endocrinol. 121 (1987) 1580-1582
139. van Dam A.M., Bauer J., Tilders F.J.H., and Berkenbosch F. Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: a light and electron microscopic study. Neuroscience 65 (1995) 815-826
140. van der Meer M.J.M., Sweep C.G.J., Rijnkels C.E.M., Pesman G.J., Tilders F.J.H., Kloppenborg P.W.C., and Hermus A.R.M.M. Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1β, TNFα and IL-6: a dose response study. J. Endocrinol. Invest. 19 (1996) 175-182
141. Wang J.P., and Dunn A.J. Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism. Neurochem. Intl. 33 (1998) 143-154
142. Wang J.P., and Dunn A.J. The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis induced by endotoxin and interleukin-1β. Brain Res. 815 (1999) 337-348
143. 2 , corticotropin-releasing factor, and arginine vasopressin in several hypothalamic areas of freely moving rats: estimation by push-pull perfusion. Neuroendocrinol. 60 (1994) 8-15
144. Watkins L.R., Maier S.F., and Goehler L.E. Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Sci. 57 (1995) 1011-1026
145. Weber M.M., Michl P., and Auernhammer C.J. Interleukin-3 and interleukin-6 act synergistically to stimulate the release of corticosterone from adult human adrenal gland cells. Endocrinol. 138 (1997) 2207-2210
146. Weidenfeld J., Abramsky O., and Ovadia H. Evidence for the involvement of the central adrenergic system in interleukin 1-induced adrenocortical response. Neuropharmacol. 28 (1989) 1411-1414
147. Weiss J.M., Sundar S.K., Cierpial M.A., and Ritchie J.C. Effects of interleukin-1 infused into brain are antagonized by α-MSH in a dose-dependent manner. Europ. J. Pharmacol. 192 (1991) 177-179
148. Wieczorek M., and Dunn A.J. Dissociation of noradrenergic and HPA responses to interleukin-1 using indomethacin: a microdialysis study. Brain Behav. Immun. 17 (2003) 209
149. Wilkinson M.F., Horn T.F.W., Kasting N.W., and Pittman Q.J. Central interleukin-1 beta stimulation of vasopressin release into the rat brain: activation of an antipyretic pathway. J. Physiol. Lond. 481 (1994) 641-646
150. Winter J.S.D., Gow K.W., Perry Y.S., and Greenberg A.H. A stimulatory effect of interleukin-1 on adrenocortical cortisol secretion mediated by prostaglandins. Endocrinol. 127 (1990) 1904-1909
151. Woloski B.M.R.N.J., Smith E.M., Meyer W.J., Fuller G.M., and Blalock J.E. Corticotropin-releasing activity of monokines. Science 230 (1985) 1035-1037
152. Yasin S.A., Costa A., Forsling M.L., and Grossman A. Interleukin-1β and interleukin-6 stimulate neurohypophysial hormone release in vitro. J. Neuroendocrinol. 6 (1994) 179-184
153. Zelazowski P., Patchev V.K., Zelazowska E.B., Chrousos G.P., Gold P.W., and Sternberg E.M. Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1β and αMSH: studies in rats with different susceptibility to inflammatory disease. Brain Res. 631 (1993) 22-26