Furostanol glycosides from the rhizomes of Helleborus orientalis

Journal of Natural Medicines

Volumn 64, Issue 4, 2010, Pages 452-459

  Mimaki, Yoshihiro ^a   Matsuo, Yukiko ^a   Watanabe, Kazuki ^b   Sakagami, Hiroshi ^c  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b AOMORI UNIVERSITY   (Japan)

^c MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

Cytotoxic activity; Furostanol glycoside; Helleborus orientalis Lam.; HSC 2 cell; Ranunculaceae

Indexed keywords

1 BETA 3 BETA 11 ALPHA TRIHYDROXY 22 ALPHA METHOXYFUROST 5 EN 26 YL BETA DEXTRO GLUCOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 11 ALPHA HYDROXY 22 ALPHA METHOXYFUROST 5 EN 3 BETA YL O ALPHA RHAMNOPYRANOSYL BETA DEXTRO GLUCOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 11 ALPHA HYDROXY 22 ALPHA METHOXYFUROST 5 EN 3 BETA YL O BETA DEXTRO GLUCOPYRANOSYL O [ALPHA RHAMNOPYRANOSYL]BETA DEXTRO GLUCOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 11 ALPHA HYDROXY 22 ALPHA METHOXYFUROSTA 5,25 (27) DIEN 3 BETA YL O ALPHA RHAMNOPYRANOSYL BETA DEXTRO GLUCOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 11 ALPHA HYDROXY 22 ALPHA METHOXYFUROSTA 5,25 (27) DIEN 3 BETA YL O BETA DEXTRO GLUCOPYRANOSYL O [ALPHA RHAMNOPYRANOSYL]BETA DEXTRO GLUCOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3 BETA HYDROXY 22 ALPHA METHOXYFUROSTA 5,25 (27) DIEN 1 BETA YL O ALPHA RHAMNOPYRANOSYL ALPHA ARABINOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3 BETA HYDROXY 22 ALPHA METHOXYFUROSTA 5,25 (27) DIEN 1 BETA YL O ALPHA RHAMNOPYRANOSYL O [BETA DEXTRO XYLOPYRANOSYL]ALPHA ARABINOPYRANOSIDE; 3 BETA 11 ALPHA DIHYDROXY 22 ALPHA METHOXYFUROST 5 EN 26 YL BETA DEXTRO GLUCOPYRANOSIDE; 3 BETA 11 ALPHA DIHYDROXY 22 ALPHA METHOXYFUROSTA 5,25 (27) DIEN 26 YL BETA DEXTRO GLUCOPYRANOSIDE; FUROSTANOL GLYCOSIDE; HELLEBORUS ORIENTALIS EXTRACT; PLANT EXTRACT; SPIROST 5,25 (27) DIENE 3 BETA 11 APHA DIOL; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HELLEBORUS ORIENTALIS; HUMAN; HUMAN CELL; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; RHIZOME; SQUAMOUS CELL CARCINOMA; VERATRUM;

CELL LINE, TUMOR; GLYCOSIDES; HELLEBORUS; HUMANS; PLANT EXTRACTS; RHIZOME;

EID: 77956655365     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-010-0432-7     Document Type: Article

References (8)

1. W Wissner H Kating 1974 Botanical and phytochemical investigations of species of the genus Helleborus growing in Europe and Asian Minor Planta Med 26 228 249
2. Watanabe K, Mimaki Y, Sakuma C, Sashida Y (2002) A novel polyoxygenated spirostanol trisdesmoside from the rhizomes of Helleborus orientalis. Chem Lett 772-773
3. K Watanabe Y Mimaki H Sakagami Y Sashida 2003 Bufadienolide and spirostanol glycosides from the rhizomes of Helleborus orientalis J Nat Prod 66 236 241 (Pubitemid 36278236)
4. K Watanabe Y Mimaki C Sakuma H Sakagami Y Sashida 2003 Novel polyoxygenated spirostanol glycosides from the rhizomes of Helleborus orientalis Helv Chim Acta 86 398 407 (Pubitemid 36348391)
5. K Watanabe H Sakagami Y Mimaki 2005 Four new steroidal saponins from the rhizomes of Helleborus orientalis Heterocycles 65 775 785
6. Y Mimaki M Kuroda A Kameyama A Yokosuka Y Sashida 1998 New steroidal constituents of the underground parts of Ruscus aculeatus and their cytotoxic activity on HL-60 cells Chem Pharm Bull 46 289 303
7. ES Rothman ME Wall 1958 Steroidal sapogenins. XLIX. C-ring oxygenated derivatives of correllogenin J Org Chem 23 1741 1744
8. SM Vladimirov DS Živanov-Stakić BJ Ribar 1991 A steroidal sapogenin from Helleborus multifidus subsp. serbicus Phytochemistry 30 1724 1725