GAD antibodies associated neurological disorders: Incidence and phenotype distribution among neurological inflammatory diseases

Journal of Neuroimmunology

Volumn 227, Issue 1-2, 2010, Pages 175-177

  Matà, Sabrina ^a   Muscas, Gian Carlo ^a   Cincotta, Massimo ^b   Bartolozzi, Maria Letizia ^c   Ambrosini, Stefano ^a   Sorbi, Sandro ^a  

^a Azienda Ospedaliero Universitaria di Careggi ^*  (Italy)

^b Piero Plagi Hospital   (Italy)

^c SAN GIUSEPPE HOSPITAL   (Italy)

Author keywords

Depression; Diabetes mellitus; Immunology; Limbic system; Stiff person syndrome

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; GLUTAMATE DECARBOXYLASE ANTIBODY; IMMUNOGLOBULIN; AUTOANTIBODY; GLUTAMATE DECARBOXYLASE;

ADULT; AGED; ANTIBODY SCREENING; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DELAYED DIAGNOSIS; ENCEPHALOMYELITIS; FEMALE; GENETIC HETEROGENEITY; HUMAN; IMMUNOFLUORESCENCE; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; INTESTINAL DYSMOTILITY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MYOCLONUS; NEUROLOGIC DISEASE; NEUROPATHY; PHENOTYPE; PLASMAPHERESIS; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STIFF MAN SYNDROME; SYMPTOM; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; BLOOD; COMPARATIVE STUDY; FOLLOW UP; IMMUNOLOGY; IMMUNOPHENOTYPING; INCIDENCE; INFLAMMATION; MIDDLE AGED; PATHOLOGY; PROSPECTIVE STUDY; STIFF-PERSON SYNDROME; YOUNG ADULT;

ADULT; AGED; AUTOANTIBODIES; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; FEMALE; FOLLOW-UP STUDIES; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOPHENOTYPING; INCIDENCE; INFLAMMATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; STIFF-PERSON SYNDROME; YOUNG ADULT;

EID: 77956649349     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.07.011     Document Type: Article

References (14)

1. Ameli R., Snow J., Rakocevic G., Dalakas M.C. A neuropsychological assessment of phobias in patients with stiff person syndrome. Neurology 2005, 64:1961-1963.
2. Brown P., Marsden C.D. The stiff man and stiff man plus syndromes. J. Neurol. 1999, 246:648-652.
3. Goldman-Rakic P.S. The "psychic" neuron of the cerebral cortex. Ann. NY Acad. Sci. 1999, 868:13-26.
4. Henningsen P., Meinck H.M. Specific phobia is a frequent non-motor feature in stiff man syndrome. J. Neurol. Neurosurg. Psychiatry 2003, 74:462-465.
5. Honnorat J., Trouillas P., Thivolet C., Aguera M., Belin M.F. Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements. Arch. Neurol. 1995, 52:462-468.
6. Koerner C., Wieland B., Richter W., Meinck H.M. Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity. Neurology 2004, 62:1357-1362.
7. Matà S., Muscas G.C., Naldi I., Rosati E., Paladini S., Cruciatti B., Bisulli F., Paganini M., Mazzi G., Sorbi S., Tinuper P. Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies. J. Neuroimmunol. 2008, 199:155-159.
8. Meinck H.M., Faber L., Morgenthaler N., Seissler J., Maile S., Butler M., Solimena M., DeCamilli P., Scherbaum W.A. Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. J. Neurol. Neurosurg. Psychiatry 2001, 71:100-103.
9. Miki Y., Taniyama K., Tanaka C., Tobe T. GABA, glutamic acid decarboxylase, and GABA transaminase levels in the myenteric plexus in the intestine of humans and other mammals. J. Neurochem. 1983, 40:861-865.
10. Pittock S.J., Yoshikawa H., Ahlskog J.E., Tisch S.H., Benarroch E.E., Kryzer T.J., Lennon V.A. Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction. Mayo Clin. Proc. 2006, 81:1207-1214.
11. Rizzi M., Knoth R., Hampe C.S., Lorenz P., Gougeon M.L., Lemercier B., Venhoff N., Ferrera F., Salzer U., Thiesen H.J., Peter H.H., Walker U.A., Eibel H. Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff person syndrome. PLoS ONE 2010, 5(5). May 26.
12. Rossi S., De Capua A., Tavanti M., Calossi S., Polizzotto N.R., Mantovani A., Falzarano V., Bossini L., Passero S., Bartalini S., Ulivelli M. Dysfunctions of cortical excitability in drug-naïve posttraumatic stress disorder patients. Biol. Psychiatry 2009, 66:54-61.
13. Saidha S., Murphy S., Ronayne A., McCarthy P., Hennessy M.J., Counihan T. Treatment of anti-glutamic acid decarboxylase antibody-associated limbic encephalitis with mycophenolate mofetil. J. Neurol. 2010, 2010(257):1035-1038.
14. Solimena M., Folli F., Denis-Donini S., Comi G.C., Pozza G., De Camilli P., Vicari A.M. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. N Engl J. Med. 1988, 318:1012-1020.