Oncological outcomes in rats given nephrocarcinogenic exposure to dietary ochratoxin a, followed by the tumour promoter sodium barbital for life: A pilot study

Toxins

Volumn 2, Issue 4, 2010, Pages 552-571

  Mantle, Peter G ^a   Dobrota, Miloslav ^b   Gillett, Cheryl E ^c   Odell, Edward W ^d   Pinder, Sarah E ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Angiosarcoma; DNA ploidy; Latency; Mammary tumour; Mononuclear leukaemia; Renal tumour

Indexed keywords

BARBITAL; CREATININE; OCHRATOXIN; POTASSIUM; PROTEIN;

ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; FOOD CONTAMINATION; HISTOPATHOLOGY; LATENT PERIOD; LIVER CARCINOGENESIS; MALE; NONHUMAN; OVERALL SURVIVAL; PILOT STUDY; POLYURIA; POTASSIUM EXCRETION; POTASSIUM URINE LEVEL; PROTEINURIA; RAT; SEX DIFFERENCE; URINE VOLUME;

ANIMALS; BARBITAL; FEMALE; KIDNEY NEOPLASMS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MYCOTOXINS; OCHRATOXINS; PILOT PROJECTS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 77956639183     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2040552     Document Type: Article

References (30)

1. Boorman, G.A. Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies); Technical Report 358; Research Triangle Park: Research Triangle region, CA, USA, 1989.
2. Castegnaro, M; Mohr, U.; Pfohl-Leszkowicz, A.; Esteve, J.; Steinmann, J.; Tillmann, T.; Michelon, J.; Azemar, B.; Bartsch, H. Strain- and sex-specific induction of renal tumours by ochratoxin A in rats correlates with DNA adduction. Int. J. Cancer 1998, 77, 70-75.
3. Mantle, P.; Kulinskaya, E.; Nestler, S. Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A. Food Addit. Contam., 2005, 22 (Suppl. 1), 58-64.
4. Mantle, P.G. Interpretation of pharmacodynamics of ochratoxin A in blood plasma of rats, during and after acute or chronic ingestion. Food Chem. Toxicol. 2008, 46, 1808-1816.
5. Kitagawa, K.; Sugano, H. Enhancing effect of phenobarbital on the development of enzyme- altered islands and hepatocellular carcinomas initiated by 3-methyl-4-(dimethylamino)azobenzene or diethyl-nitrosamine. Gann 1978, 69, 679-687.
6. Watanabe, K.; Williams, G.M. Enhancement of rat hepatocellular-altered foci by the liver promoter phenobarbital: Evidence that foci are precursors of neoplasms and that the promoter acts as carcinogen-induced lesions. J. Natl. Cancer Inst. 1978, 61, 1311-1314.
7. Lans, M.; de Gerlache, J.; Taper, H.S.; Preat, V.; Roberfroid, M.B. Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis. Carcinogenesis 1983, 4, 141-144.
8. Kasprzak, K.S.; Diwan, B.A.; Knonishi, N.; Misra, M.; Rice, J.M. Initiation by nickel(ll) acetate and promotion by sodium barbital of renal cortical epithelial tumours in male F344 rats. Carcinogenesis 1990, 11, 647-652.
9. Wolf, D.C.; Goldsworthy, T.L.; Janszen, D.B.; Harden, R.; Donner, E.M.; David, C.S.; Everitt, J.I. Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumours in Eker rats. Carcinogenesis 1990, 21, 1553-1558.
10. Stemmer, K.; Ellinger-Ziegelbauer, H.; Ahr, H.-J.; Dietrich, D.R. Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis. Cancer Res. 2007, 67, 4052-4068.
11. Burtis, C.A.; Ashwood, E.R.; Bruns, D.E. Tietz fundamentals of clinical chemistry; WB Saunders Company: Philadelphia, PA, USA, 2005.
12. Diwakar, N.; Sperandio, M.; Sheriff, M.; Brown, A.; Odell, E.W. Heterogeneity, histological features and DNA ploidy in oral carcinoma by image-based analysis. Oral Oncol. 2005, 41, 416-422.
13. Hedley, D.W. DNA analysis from paraffin-embedded blocks. Method Cell Biol. 1994, 41, 231-240.
14. Howard, P.C. Technical report on the toxicology and carcinogenesis studies of Fumonisin B1 (CAS No. 116355-83-0) in F344/N rats and B6C3F-1 mice (feed studies); Report number 496; Research Triangle Park: Research Triangle region, CA, USA, 2001.
15. Moloney, W.C.; Boschetti, A.E.; King, V.P. Spontaneous leukaemia in Fischer rats. Cancer Res. 1970, 30, 41-43.
16. Mantle, P.G.; Nagy, J.M. Binding of ochratoxin A to a urinary globulin; a new concept to account for gender difference in rat nephrocarcinogenic responses. Int. J. Mol. Sci. 2008, 9, 719-735.
17. Brown, A.; Odell, E.W.; Mantle, P.G. DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A. Exp. Toxicol. Pathol. 2007, 59, 85-95.
18. Vettorazzi, A.; Gonzalez-Penas, E.; Troconiz, I.F.; Arbillaga, L.; Corcuera, L.A.; Gil, A.G.; Lopez de Cerain, A. A different kinetic profile of ochratoxin A in mature male rats. Food Chem. Toxicol. 2009, 47, 1921-1927.
19. Lee, H.B.; Blaufox, M.D. Blood volume in the rat. J. Nuclear Med. 1985, 25, 72-76.
20. Arbillaga, L.; Vettorazzi, A.; Gil, A.G.; van Delft, J.H.M.; Garcia-Jalon, J.; Lopez de Cerain, A. Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration. Toxicol. Appl. Pharmacol. 2008, 230, 197-207.
21. Son, W.-C.; Kamino, K.; Lee, Y.-S.; Kang, K.-S. Strain-specific mammary proliferation lesion development following lifetime oral administration of ochratoxin A in DA and Lewis rats. Int. J. Cancer 2003, 105, 305-311.
22. Castegnaro, M.; Bartsch, H.; Tillmann, T.; Mohr, U. Ochratoxin study. Int. J. Cancer 2004, 112, 1083.
23. Pfohl-Leszkowicz, A.; Pinelli, E.; Bartsch, H.; Mohr, U.; Castegnaro, M. Sex- and strain-specific expression of cytochrome P450s in ochratoxin A-induced genotoxicity and carcinogenicity in rats. Molec. Carcinog. 1998, 23, 76-85.
24. Mackenzie, W.F.; Gardner, F.M. Comparison of neoplasms from six sources of rats. J. Natl. Cancer Inst. 1973, 50, 1243-1257.
25. Cheung, S.Y.; Choi, H.L.; James, A.E.; Chen, Z.Y.; Huang, Y.; Chan, F.L. Spontaneous mammary tumours in ageing Noble rats. Int. J. Oncol. 2003, 22, 449-457.
26. Greenacre, C. Spontaneous tumours of small mammals. Vet. Clin. N. Amer. Exot. Anim. Pract. 2004, 7, 627-651.
27. Hardisty, J.F.; Elwell, M.R.; Ernst, H.; Greaves, P.; Kolenda-Roberts, H.; Malarkey, D.E.; Mann, P.C.; Tellier, P.A. Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicol. Pathol. 2007, 35, 928-941.
28. Clark, H.A.; Snedeker, S.M. Ochratoxin A: Its cancer risk and potential for exposure. J. Toxicol. Environ. Health Part B 2006, 9, 265-296.
29. Mantle, P.G.; Faucet-Marquis, V.; Manderville, R.M.; Squillaci, B.; Pfohl-Leszkowicz, A. Structures of covalent adducts between DNA and ochratoxin A: A new factor in debate about genotoxicity and human risk assessment. Chem. Res. Toxicol. 2010, 23, 89-98.
30. Mantle, P.G. Minimum tolerable exposure period and maximum threshold dietary intake for causing renal cancer in Dark Agouti rats. Food Chem.Toxicol. 2009, 47, 2419-2424.