Increased oxidative stress and altered substrate metabolism in obese children

International Journal of Pediatric Obesity

Volumn 5, Issue 5, 2010, Pages 436-444

  Oliver, Stacy R ^a   Rosa, Jaime S ^a   Milne, Ginger L ^b   Pontello, Andria M ^a   Borntrager, Holly L ^b   Heydari, Shirin ^a   Galassetti, Pietro R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Childhood obesity; Dyslipidemia; Inflammation; Oxidative stress

Indexed keywords

ANTIOXIDANT; FATTY ACID; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; INSULIN; INTERLEUKIN 6; ISOPROSTANE DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ADOLESCENT; ARTICLE; CARBOHYDRATE METABOLISM; CHILD; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; LEUKOCYTE COUNT; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; OBESITY; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SCHOOL CHILD;

CARBOHYDRATE METABOLISM; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHILD; DYSLIPIDEMIAS; FEMALE; GLUCOSE; HUMANS; HYDROCORTISONE; INSULIN; INTERLEUKIN-6; LEUKOCYTE COUNT; LIPID METABOLISM; MALE; OBESITY; OXIDATIVE STRESS; RISK FACTORS; SEX CHARACTERISTICS;

EID: 77956637112     PISSN: 17477166     EISSN: 17477174     Source Type: Journal    
DOI: 10.3109/17477160903545163     Document Type: Article

References (41)

1. Hedley AA, Ogden CL, Johnson CL et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA. 2004;291:2847-50.
2. Kung HC, Hoyert DL, Xu J et al. Deaths: fi nal data for 2005. Natl Vital Stat Rep. 2008;56:1-120.
3. Hansson GK. Infl ammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685-95.
4. Nabel EG. Cardiovascular disease. N Engl J Med. 2003; 349:60-72.
5. Ross R. Atherosclerosis- an infl ammatory disease. N Engl J Med. 1999;340:115-26.
6. Milne GL, Yin H, Morrow JD. Human biochemistry of the isoprostane pathway. J Biol Chem. 2008;283:15533-7.
7. Williams DA, Xu H, Cancelas JA. Children are not little adults: just ask their hematopoietic stem cells. J Clin Invest. 2006;116:2593-6.
8. Barlow SE, the Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120:S164-92.
9. Slaughter MH, Lohman TG, Boileau RA et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol. 1988;60:709-23.
10. Hansen JR, Wu YT, Cook JS et al. Cross-validation of the Slaughter skinfold equations for children and adolescents. Med Sci Sports Exerc. 1993;25:1070-6.
11. Petersen AC, Crockett L, Richards M et al. A self-report measure of pubertal status: reliability, validity, and initial norms. J Youth Adolesc. 1988;17: 117-33.
12. Cooper DM, Weiler-Ravell D, Whipp BJ et al. Aerobic parameters of exercise as a function of body size during growth in children. J Appl Physiol. 1984;56:628-34.
13. Milne GL, Sanchez SC, Musiek ES et al. Quantifi cation of F2-isoprostanes as a biomarker of oxidative stress. Nat Protoc. 2007;2:221-6.
14. Kerksick C, Taylor LI, Harvey A et al. Gender-related differences in muscle injury, oxidative stress, and apoptosis. Med Sci Sports Exerc. 2008;40:1772-80.
15. Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in infl ammation. N Engl J Med. 2006;354:610-21.
16. Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes. 2005; 54:S114-24.
17. Störk S, Feelders RA, van den Beld AW et al. Prediction of mortality risk in the elderly. Am J Med. 2006;119: 519-25.
18. McMurray RG, Zaldivar F, Galassetti P et al. Cellular immunity and infl ammatory mediator responses to intense exercise in overweight children and adolescents. J Investig Med. 2007;55:120-9.
19. Kelly AS, Steinberger J, Kaiser DR et al. Oxidative stress and adverse adipokine profi le characterize the metabolic syndrome in children. J Cardiometab Syndr. 2006;1: 248-52.
20. Galassetti PR, Iwanaga K, Crisostomo M et al. I nfl ammatory cytokine, growth factor and counterregulatory responses to exercise in children with type 1 diabetes and healthy controls. Pediatr Diabetes. 2006;7:16-24.
21. Galassetti P, Tate D, Neill RA et al. Effect of differing antecedent hypoglycemia on counterregulatory responses to exercise in type 1 diabetes. Am J Physiol Endocrinol Metab. 2006;290: E1109-17.
22. Zaldivar F, McMurray RG, Nemet D et al. Body fat and circulating leukocytes in children. Int J Obes (Lond). 2006; 30:906-11.
23. Madjid M, Awan I, Willerson JT et al. Leukocyte count and coronary heart disease: Implications for risk assessment. J Am Coll Cardiol. 2004;44:1945-56.
24. Skalen K, Gustafsson M, Rydberg EK et al. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature. 2002;417:750-4.
25. Martinez-Hervas S, Fandos M, Real JT et al. Insulin resistance and oxidative stress in familial combined hyperlipidemia. Atherosclerosis. 2008;199:384-9.
26. Kadiiska MB, Gladen BC, Baird DD et al. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med. 2005;38:698-710.
27. Musiek E, Yin H, Milne G et al. Recent advances in the biochemistry and clinical relevance of the isoprostane pathway. Lipids. 2005;40:987-94.
28. Pratic D, Luliano L, Mauriello A et al. Localization of distinct F2-isoprostanes in human atherosclerotic lesions. J Clin Invest. 1997;100:2028-34.
29. Wang B, Pan J, Wang L et al. Associations of plasma 8- isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease. Atherosclerosis. 2006;184:425-30.
30. Sinaiko AR, Steinberger J, Moran A et al. Relation of body mass index and insulin resistance to cardiovascular risk factors, infl ammatory factors, and oxidative stress during adolescence. Circulation. 2005;111:1985-91.
31. Roberts CK, Barnard RJ, Sindhu RK et al. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metabolism. 2006;55:928-34.
32. Armutcu F, Ataymen M, Atmaca H et al. Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome. Clin Chem Lab Med. 2008;46:785-90.
33. Molnar D, Decsi T, Koletzko B. Reduced antioxidant status in obese children with multimetabolic syndrome. Int J Obes Relat Metab Disord. 2004;28:1197-202.
34. Galassetti P, Tate D, Neill RA et al. Effect of gender on counterregulatory responses to euglycemic exercise in type 1 diabetes. J Clin Endocrinol Metab. 2002;87: 5144-50.
35. Coto-Montes A, Boga JA, Tomas-Zapico C et al. Physiologic al oxidative stress model: Syrian hamster Harderian gland- sex differences in antioxidant enzymes. Free Radic Biol Med. 2001;30:785-92.
36. Bureau I, Gueux E, Mazur A et al. Female rats are protected against oxidative stress during copper defi ciency. J Am Coll Nutr. 2003;22:239-46.
37. Rush JWE, Sandiford SD. Plasma glutathione peroxidase in healthy young adults: infl uence of gender and physical activity. Clin Biochem. 2003;36:345-51.
38. Pansarasa O, Castagna L, Colombi B et al. Age and sex differences in human skeletal muscle: Role of reactive oxygen species. Free Radic Res. 2000;33:287-93.
39. Proteggente AR, England TG, Rehman A et al. Gender differences in steady-state levels of oxidative damage to DNA in healthy individuals. Free Radic Res. 2002;36: 157-62.
40. Lavoie J-C, Chessex P. Gender and maturation affect glutathione status in human neonatal tissues. Free Radic Biol Med. 1997;23:648-57.
41. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and infl ammatory markers: a systematic review. J Am Coll Cardiol. 2005;45:1563-9.