Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections

Journal of Biomedical Optics

Volumn 15, Issue 2, 2010, Pages

  Tuer, Adam ^a   Tokarz, Danielle ^a   Prent, Nicole ^a   Cisek, Richard ^a   Alami, Jennifer ^b   Dumont, Daniel J ^b   Bakueva, Ludmila ^b   Rowlands, John ^b   Barzda, Virginijus ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Medical imaging; Multiphoton processes; Nonlinear image processing; Nonlinear optics; Scanning microscopy; Tissues

Indexed keywords

ABSORPTION AND FLUORESCENCE SPECTROSCOPY; CELLULAR STRUCTURE; FLUORESCENCE LIFETIME IMAGING MICROSCOPY; FLUORESCENCE QUENCHING; HEALTHY TISSUES; HISTOLOGICAL SECTION; IMAGE CONTRASTS; MULTIPHOTONS; NONLINEAR EXCITATION; NONLINEAR IMAGE PROCESSING; NONLINEAR MICROSCOPY; SCANNING MICROSCOPY; SECOND HYPERPOLARIZABILITIES; SINGLE-CELL LEVEL; THIRD-HARMONIC GENERATION MICROSCOPY;

ABSORPTION SPECTROSCOPY; FLUORESCENCE; FLUORESCENCE MICROSCOPY; FLUORESCENCE SPECTROSCOPY; IMAGE PROCESSING; MULTIPHOTON PROCESSES; NONLINEAR OPTICS; OPTICAL DATA PROCESSING; QUANTUM OPTICS; TISSUE;

MEDICAL IMAGING;

CONTRAST MEDIUM; DIAGNOSTIC AGENT; EOSIN; HEMATOXYLIN;

ALGORITHM; ARTICLE; AUTOMATED PATTERN RECOGNITION; COMPUTER ASSISTED DIAGNOSIS; IMAGE ENHANCEMENT; METHODOLOGY; MICROSCOPY; NONLINEAR SYSTEM; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ALGORITHMS; CONTRAST MEDIA; EOSINE YELLOWISH-(YS); HEMATOXYLIN; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MICROSCOPY; NONLINEAR DYNAMICS; PATTERN RECOGNITION, AUTOMATED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 77956631903     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3382908     Document Type: Article

References (24)

1. J. A. Kiernan, Histological and Histochemical Methods, 3rd ed., Butterworth Heinemann, Woburn, MA (1999).
2. R. Carriles, D. N. Schafer, K. E. Sheetz, J. J. Field, R. Cisek, V. Barzda, and J. Squier, "Imaging techniques for harmonic and multiphoton absorption fluorescence microscopy", Rev. Sci. Instrum. 80, 081101 (2009).
3. R. Cisek, N. Prent, C. Greenhalgh, D. Sandkuijl, A. Tuer, A. Major, and V. Barzda, "Multicontrast nonlinear microscopy", in Biochemical Applications of Nonlinear Spectroscopy, V. V. Yakovlev, Ed., pp. 71-102, CRC Press, Boca Raton, FL (2009).
4. C. Bettinger and H. Zimmerman, "New investigations on hematoxylin, hematein, and hematein-aluminum-complexes. II. Hemateinaluminum complexes and hemalum staining", Histochemistry 96, 215-228 (1991).
5. C. Bettinger and H. Zimmerman, "New investigations on hematoxylin, hematein, and hematein-aluminum-complexes. I. Spectroscopic and physico-chemical properties of hematoxylin and hematein", Histochemistry 95, 279-288 (1991).
6. A. Tuer, L. Bakueva, R. Cisek, J. Alami, D. J. Dumont, J. Rowlands, and V. Barzda, "Enhancement of third-harmonic contrast with harmonophores in multimodal non-linear microscopy of histological sections", Proc. SPIE 6860, 686005 (2008).
7. C. Yu, S. Tai, C. Kung, W. Lee, Y. Chan, H Liu, J. Lyu, and C. Sun, "Molecular third-harmonic-generation microscopy through resonance enhancement with absorbing dye", Opt. Express 33, 387-389 (2008). (Pubitemid 351328208)
8. M. W. Conklin, P. P. Provenzano, K. W. Eliceiri, R. Sullivan, and P. J. Keely, "Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast", Cell Biochem. Biophys. 53, 145-157 (2009).
9. C. Greenhalgh, N. Prent, C. Green, R. Cisek, A. Major, B. Stewart, and V. Barzda, "Influence of semicrystalline order on the secondharmonic generation efficiency in the anisotropic bands of myocytes", Appl. Opt. 46, 1852-1859 (2007). (Pubitemid 46659552)
10. A. Major, D. Sandkuijl, and V. Barzda, "Efficient frequency doubling of a femtosecond Yb:KGW laser in a BiB3O6 crystal", Opt. Express 17, 12039-42 (2009).
11. J. Squier and M. Müller, "High resolution nonlinear microscopy: a review of sources and methods for achieving optimal imaging", Rev. Sci. Instrum. 72, 2855-2867 (2001). (Pubitemid 33606682)
12. W. Becker, The bh TCSPC Handbook, 3rd ed., Becker & Hickl GmbH, Berlin (2008).
13. G. O. Clay, A. C. Millard, C. B. Schaffer, J. Aus-der-Au, P. S. Tai, J. A. Squier, and D. Kleinfeld, "Spectroscopy of third-harmonic generation: evidence for resonances in model compounds and ligated hemoglobin", J. Opt. Soc. Am. B 23, 932-950 (2005).
14. J. M. Schins, T. Schrama, J. A. Squier, G. J. Brakenhoff, and M. Müller, "Determination of material properties by use of thirdharmonic generation microscopy", J. Opt. Soc. Am. B 19, 1627-1634 (2001).
15. V. Shcheslavskiy, G. I. Petrov, S. Saltiel, and V. V. Yakovlev, "Quantitative characterization of aqueous solutions probed by the thirdharmonic generation microscopy", J. Struct. Biol. 147, 42-29 (2004).
16. N. Greenberg, F. DeMayo, M. Finegold, D. Medina, W. Tilley, J. Aspinall, G. Cunha, A. Donjacour, R. Matusik, and J. Rosen, "Prostate cancer in a transgenic mouse", Proc. Natl. Acad. Sci. U. S. A. 92, 3439-3443 (1995).
17. L. Montanaro, D. Trere, and M. Derenzini, "Nucleolus, ribosomes, and cancer", Am. J. Pathol. 173, 301-310 (2008).
18. P. N. Butcher and D. Cotter, The Elements of Nonlinear Optics, Cambridge University Press, Avon, U. K. (1990).
19. G. R. Jones, D. A. Duddell, D. Murray, R. B. Cundall, and R. Catterall, "Eosin Y-macromolecule complexes, Part 1. Application of exciton theory to the study of the arrangement of eosin Y molecules in polycation-induced eosin Y dimers", J. Chem. Soc, Faraday Trans. 2 80, 1181-1199 (1984).
20. G. R. Jones, R. B. Cundall, D. Murray, and D. A. Duddell, "Eosin Y-macromolecule complexes, Part 2. Interactions between eosin Y and polycations, a cationic surfactant and proteins", J. Chem. Soc, Faraday Trans. 2 80, 1201-1213 (1984).
21. C. Y. Fu, U. S. Dinish, B. K. Ng, V. M. Murukeshan, L. K. Seah, and S. K. Lim-Tan, "Fluorescence lifetime imaging of haematoxylin and eosin-stained cervical tissue", in Proc. Int. Conf. on Biomedical and Pharmaceutical Engineering, pp. 368-372 (2006).
22. S. R. Marder, W. E. Torruellas, M. Blanchard-Desce, V. Ricci, G. I. Stegeman, S. Gilmour, J.-L. Bredas, J. Li, G. U. Bublitz, and S. G. Boxer, "Large molecular third-order optical nonlinearities in polarized carotenoids", Science 276, 1233-1236 (1997).
23. R. R. Tykwinski, U. Gubler, R. E. Martin, F. Diederich, C. Bosshard, and P. Gunter, "Structure-property relationships in third-order nonlinear optical chromophores", J. Phys. Chem. B 102, 4451-4465 (1998). (Pubitemid 128578308)
24. T. Bjornholm, "Development of molecules for all-optical switching devices", Isr. J. Chem. 36, 349-356 (1996). (Pubitemid 126337466)