Hypofractionation does not increase radiation pneumonitis risk with modern conformal radiation delivery techniques

Acta Oncologica

Volumn 49, Issue 7, 2010, Pages 1052-1057

  Vogelius, Ivan S ^a,b   Westerly, David C ^a   Cannon, George M ^a   Bentzen, Søren M ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL ARTICLE; COMPUTER ASSISTED RADIOTHERAPY; HUMAN; HYPOFRACTIONATED RADIOTHERAPY; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION PNEUMONIA; TOMOTHERAPY;

CALIBRATION; CARCINOMA, NON-SMALL-CELL LUNG; DOSE FRACTIONATION; DOWN-REGULATION; HUMANS; LUNG NEOPLASMS; RADIATION DOSAGE; RADIATION PNEUMONITIS; RADIATION TOLERANCE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; RISK FACTORS; SOCIAL CHANGE; THERAPEUTIC EQUIVALENCY; TOMOGRAPHY, SPIRAL COMPUTED;

EID: 77956573578     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2010.498835     Document Type: Article

References (23)

1. Bentzen SM. Quantitative clinical radiobiology. Acta Oncol 1993;32:259-275
2. Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bentzen SM, et al. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet 2008;371:1098-1107
3. Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bliss JM, et al. The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet Oncol 2008;9:331-341
4. Lukka H, Hayter C, Julian JA, Warde P, Morris WJ, Gospodarowicz M, et al. Randomized trial comparing two fractionation schedules for patients with localized prostate cancer. J Clin Oncol 2005;23:6132-6138
5. Bentzen SM. High-tech in radiation oncology: Should there be a ceiling? Int J Radiat Oncol Biol Phys 2004;58:320-330
6. Jin JY, Kong FM, Chetty IJ, Ajlouni M, Ryu S, Ten HR, et al. Impact of fraction size on lung radiation toxicity: Hypo-fractionation may be beneficial in dose escalation of radiotherapy for lung cancers. Int J Radiat Oncol Biol Phys 2010;76:782-788
7. Rowell NP, O'rourke NP. Concurrent chemoradiotherapy in non-small cell lung cancer. Cochrane Database Syst Rev 2004:CD002140.
8. Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS, et al. Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys 2010;76:S70-S76.
9. Belderbos JS, Heemsbergen WD, De JK, Baas P, Lebesque J V. Final results of a Phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2006;66:126-34. [10]
10. Bradley J. A review of radiation dose escalation trials for non-small cell lung cancer within the Radiation Therapy Oncology Group. Semin Oncol 2005;32(2 Suppl 3):S111-S113.
11. Kong FM, Ten Haken RK, Schipper MJ, Sullivan MA, Chen M, Lopez C, et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys 2005;63:324-333
12. Sause W, Kolesar P, Taylor S IV, Johnson D, Livingston R, Komaki R, et al. Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group. Chest 2000; 117:358-364
13. Fowler JF. Biological factors infl uencing optimum fractiona-tion in radiation therapy. Acta Oncol 2001;40:712-717
14. Adkison JB, Khuntia D, Bentzen SM, Cannon GM, Tome WA, Jaradat H, et al. Dose escalated, hypofractionated radiotherapy using helical tomotherapy for inoperable non-small cell lung cancer: Preliminary results of a risk-stratifi ed phase I dose escalation study. Technol Cancer Res Treat 2008;7:441-447
15. Saunders M, Dische S, Barrett A, Harvey A, Griffi ths G, Palmar M. Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: Mature data from the randomised multicentre trial. CHART Steering committee. Radiother Oncol 1999;52:137-148
16. Bentzen SM, Skoczylas JZ, Bernier J. Quantitative clinical radiobiology of early and late lung reactions. Int J Radiat Biol 2000;76:453-462
17. Jackson A, Kutcher GJ, Yorke ED. Probability of radiation-induced complications for normal tissues with parallel architecture subject to non-uniform irradiation. Med Phys 1993; 20:613-625 (Pubitemid 23195700)
18. Lyman J T. Complication probability as assessed from dose-volume histograms. Radiat Res Suppl 1985;8: S13-S19.
19. Bentzen SM, Tucker SL. Quantifying the position and steepness of radiation dose-response curves. Int J Radiat Biol 1997;71:531-542
20. Deasy JO, Blanco AI, Clark VH. CERR: A computational environment for radiotherapy research. Med Phys 2003; 30:979-985
21. Ritter M. Rationale, conduct, and outcome using hypofrac-tionated radiotherapy in prostate cancer. Semin Radiat Oncol 2008;18:249-256
22. Ronde HS, Hoffmann L. Validation of Varian's AAA algorithm with focus on lung treatments. Acta Oncol 2009; 48:209-215
23. Korreman SS, Juhler-Nottrup T, Fredberg PG, Navrsted PA, Enmark M, Nystrom H, et al. The role of image guidance in respiratory gated radiotherapy. Acta Oncol 2008;47:1390-1396