Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 9, 2010, Pages

  Abbasi, Ali ^a   Corpeleijn, Eva ^a   Postmus, Douwe ^a   Gansevoort, Ron T ^a   De Jong, Paul E ^a   Gans, Rijk O B ^a   Struck, Joachim ^b   Hillege, Hans L ^a   Stolk, Ronald P ^a   Navis, Gerjan ^a   Bakker, Stephan J L ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b THERMO FISHER SCIENTIFIC   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; PROCALCITONIN; TRIACYLGLYCEROL; BIOLOGICAL MARKER; CALCITONIN; PROTEIN PRECURSOR;

ADULT; AGED; ARTICLE; BODY MASS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HYPERTENSION; IMMUNOASSAY; INSULIN RESISTANCE; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; POPULATION; PRIMARY PREVENTION; PRIORITY JOURNAL; SMOKING; WAIST CIRCUMFERENCE; BLOOD; MIDDLE AGED; PHYSIOLOGY; RISK FACTOR; UPREGULATION;

BACTERIA (MICROORGANISMS);

ADULT; AGED; BIOLOGICAL MARKERS; BODY MASS INDEX; CALCITONIN; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PROTEIN PRECURSORS; RISK FACTORS; UP-REGULATION;

EID: 77956573023     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0305     Document Type: Article

References (18)

1. Eckel RH, Grundy SM, Zimmet PZ 2005 The metabolic syndrome. Lancet 365:1415-1428
2. Fernández-Real JM, Ricart W 2003 Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24:278-301
3. Jacobs JW, Lund PK, Potts Jr JT, Bell NH, Habener JF 1981 Procalcitonin is a glycoprotein. J Biol Chem 256:2803-2807
4. Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM 1983 Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129-135
5. Becker KL, Nylén ES, White JC, Müller B, Snider Jr RH 2004 Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab 89:1512-1525
6. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C 1993 High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341:515-518
7. Briel M, Schuetz P, Mueller B, Young J, Schild U, Nusbaumer C, Périat P, Bucher HC, Christ-Crain M 2008 Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care. Arch Intern Med 168:2000-2007; discussion 2007-2008
8. Linscheid P, Seboek D, Nylen ES, Langer I, Schlatter M, Becker KL, Keller U, Müller B 2003 In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinology 144:5578-5584
9. Linscheid P, Seboek D, Schaer DJ, Zulewski H, Keller U, Müller B 2004 Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Crit Care Med 32:1715-1721
10. Linscheid P, Seboek D, Zulewski H, Keller U, Müller B 2005 Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. Endocrinology 146:2699-2708
11. Morgenthaler NG, Struck J, Fischer-Schulz C, Seidel-Mueller E, Beier W, Bergmann A 2002 Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA. Clin Lab 48:263-270
12. Lambers Heerspink HJ, Brantsma AH, de Zeeuw D, Bakker SJ, de Jong PE, Gansevoort RT; PREVEND Study Group 2008 Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality. Am J Epidemiol 168:897-905
13. National Cholesterol Education Program 2002 Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106:3143-3421
14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28:412-419
15. Puder JJ, Varga S, Kraenzlin M, De Geyter C, Keller U, Müller B 2005 Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance. J Clin Endocrinol Metab 90:6014-6021
16. van Ree RM, de Vries AP, Oterdoom LH, Seelen MA, Gansevoort RT, Schouten JP, Struck J, Navis G, Gans RO, van der Heide JJ, van Son WJ, Bakker SJ 2009 Plasma procalcitonin is an independent predictor of graft failure late after renal transplantation. Transplantation 88:279-287
17. Holewijn S, den Heijer M, Swinkels DW, Stalenhoef AF, de Graaf J 2009 The metabolic syndrome and its traits as risk factors for subclinical atherosclerosis. J Clin Endocrinol Metab 94:2893-2899
18. D'Aiuto F, Sabbah W, Netuveli G, Donos N, Hingorani AD, Deanfield J, Tsakos G 2008 Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey. J Clin Endocrinol Metab 93:3989-3994