Airway hyperresponsiveness to methacholine, adenosine 5-monophosphate, mannitol, eucapnic voluntary hyperpnoea and fi eld exercise challenge in elite cross-country skiers

British Journal of Sports Medicine

Volumn 44, Issue 11, 2010, Pages 827-832

  Sue Chu, Malcolm ^a,b   Brannan, John D ^c   Anderson, Sandra D ^c   Chew, Nora ^d   Bjermer, Leif ^e  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d University of Sydney   (Australia)

^e LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; BRONCHOCONSTRICTING AGENT; MANNITOL; METHACHOLINE CHLORIDE; NITRIC OXIDE;

ADOLESCENT; ARTICLE; BRONCHUS; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EXERCISE; FEMALE; HUMAN; HYPERVENTILATION; INHALATION TEST; MALE; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SKIING;

ADENOSINE MONOPHOSPHATE; ADOLESCENT; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; EXERCISE; FEMALE; HUMANS; HYPERVENTILATION; MALE; MANNITOL; METHACHOLINE CHLORIDE; NITRIC OXIDE; SKIING;

EID: 77956570676     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsm.2009.071043     Document Type: Article

References (32)

1. Rice SG, Bierman CW, Shapiro GG, et al. Identifi cation of exercise-induced asthma among intercollegiate athletes. Ann Allergy 1985; 55: 790-793
2. Voy RO. The U.S. Olympic Committee experience with exercise-induced bronchospasm, 1984. Med Sci Sports Exerc 1986; 18: 328-330
3. Weiler JM, Metzger WJ, Donnelly AL, et al. Prevalence of bronchial hyperresponsiveness in highly trained athletes. Chest 1986; 90: 23-28
4. Larsson K, Ohlsén P, Larsson L, et al. High prevalence of asthma in cross country skiers. BMJ 1993; 307: 1326-1329
5. Kaelin M, Brändli O. Exertional asthma in Swiss top-ranking athletes. Schweiz Med Wochenschr 1993; 123: 174-182
6. Rupp NT, Brudno DS, Guill MF. The value of screening for risk of exercise-induced asthma in high school athletes. Ann Allergy 1993; 70: 339-342
7. Sue-Chu M, Larsson L, Bjermer L. Prevalence of asthma in young cross-country skiers in central Scandinavia: Differences between Norway and Sweden. Respir Med 1996; 90: 99-105
8. International Olympic Medical Commission. Beta2 adrenoceptor agonists and the Olympic Winter Games in Salt Lake City. http://www.olympic.org. (accessed Nov 2001-Feb 2002).
9. Rundell KW, Anderson SD, Spiering BA, et al. Field exercise vs laboratory eucapnic voluntary hyperventilation to identify airway hyperresponsiveness in elite cold weather athletes. Chest 2004; 125: 909-915
10. Holzer K, Anderson SD, Douglass J. Exercise in elite summer athletes: C hallenges for diagnosis. J Allergy Clin Immunol 2002;1 10: 374-380
11. Holzer K, Anderson SD, Chan HK, et al. Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003; 167: 534-537
12. Dickinson JW, Whyte GP, McConnell AK, et al. Screening elite winter athletes for exercise induced asthma: A comparison of three challenge methods. Br J Sports Med 2006; 40: 179 - 82 ; discussion 179-182
13. Pedersen L, Winther S, Backer V, et al. Airway responses to eucapnic hyperpnea, exercise, and methacholine in elite swimmers. Med Sci Sports Exerc 2008; 40: 1567-1572
14. Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respir Dis 1981; 123: 659-664
15. Sue-Chu M, Henriksen AH, Bjermer L. Non-invasive evaluation of lower airway infl ammation in hyper-responsive elite cross-country skiers and asthmatics. Respir Med 1999; 93: 719-725
16. Anderson SD, Brannan J, Spring J, et al. A new method for bronchialprovocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 1997; 156: 758-765
17. H enriksen A H, Sue-Chu M, Holmen TL, et al. E xhaled and nasal NO levels in allergic rhinitis: Relation to sensitization, pollen season and bronchial hyperresponsiveness. Eur Respir J 1999; 13: 301-306
18. Stensrud T, Mykland KV, Gabrielsen K, et al. Bronchial hyperresponsiveness in skiers: Fi eld test versus methacholine provocation? Med Sci Sports Exerc 2007; 39: 1681-1686
19. Leuppi JD, Kuhn M, Comminot C, et al. High prevalence of bronchial hyperresponsiveness and asthma in ice hockey players. Eur Respir J 1998; 12: 13-16
20. International Olympic Medical Commission. Beta2 adrenoceptor agonists and the Olympic Games in Beijing. http://www.olympic.org. (accessed March 2008).
21. A nderson S D, Kippelen P. Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes. J Allergy Clin Immunol 2008; 122: 225 - 35 ; quiz 236-237
22. C himenti L , Morici G, Paternò A, et al. E ndurance training damages small airway epithelium in mice. Am J Respir Crit Care Med 2007; 175: 442-449
23. L angdeau J B, Turcotte H, Desagné P, et al. I nfl uence of sympatho-vagal balance on airway responsiveness in athletes. Eur J Appl Physiol 2000; 83: 370-375
24. Bousquet P-J, Chinn S, Janson C, et al. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. Allergy 2007; 62: 301-309
25. Katelaris CH, Carrozzi FM, Burke TV, et al. A springtime olympics demands special consideration for allergic athletes. J Allergy Clin Immunol 2000; 106: 260-266
26. Brannan JD, Gulliksson M, Anderson SD, et al. Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur Respir J 2003; 22: 491-496
27. Kippelen P, Larsson J, Anderson SD, et al. Acute effects of beclomethasone on hyperpnea-induced bronchoconstriction. Med Sci Sports Exerc 2010; 42: 273-280
28. C rummy F , Livingston M, Ennis M, et al. M ast cell mediator release in nonasthmatic subjects after endobronchial adenosine challenge. J Allergy Clin Immunol 2004; 114: 34-39
29. O'Sullivan S, Dahlén B, Dahlén SE, et al. Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. J Allergy Clin Immunol 1996; 98: 421-432
30. Lund TK, Pedersen L, Anderson SD, et al. Are asthma-like symptoms in elite athletes associated with classical features of asthma? Br J Sports Med 2009; 43: 1131-1135
31. H eir T , L arsen S T he infl uence of training intensity, airway infections and environmental conditions on seasonal variations in bronchial responsiveness in crosscountry skiers. Scand J Med Sci Sports 1995; 5: 152-159
32. H emingson H B, Davis BE, Cockcroft DW. Seasonal fl uctuations in airway responsiveness in elite endurance athletes. Can Respir J 2004; 11: 399-401