α-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis

Clinical and Experimental Immunology

Volumn 162, Issue 1, 2010, Pages 178-187

  Wu, C Y ^a   Feng, Y ^a   Qian, G C ^d   Wu, J H ^a   Luo, J ^b   Wang, Y ^c   Chen, G J ^c   Guo, X K ^a   Wang, Z J ^a  

^a Cancer Hospital   (China)

^b Shanghai Municipal Key Clinical Specialty   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d First Affiliated Hospital of Guangxi College of TCM   (China)

Author keywords

galactosylceramide; coxsackievirus; myocarditis; NK T cell

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; COXSACKIE VIRUS B3; DISEASE COURSE; HEART; HEART INJURY; IMMUNE RESPONSE; MACROPHAGE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; SPLEEN; SPLEEN CELL; UPREGULATION; VIRUS LOAD; VIRUS MYOCARDITIS; VIRUS TRANSCRIPTION; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; CELLS, CULTURED; COXSACKIEVIRUS INFECTIONS; CYTOKINES; ENTEROVIRUS B, HUMAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GALACTOSYLCERAMIDES; HEART; HOST-PATHOGEN INTERACTIONS; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MYOCARDITIS; MYOCARDIUM; NATURAL KILLER T-CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SURVIVAL RATE; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; VIRAL LOAD;

EID: 77956550863     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04233.x     Document Type: Article

References (35)

1. Henke A, Jarasch N, Wutzler P. Coxsackievirus B3 vaccines: use as an expression vector for prevention of myocarditis. Exp Rev Vaccines 2008 7 : 1557 1567.
2. Kawai C. From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 1999 99 : 1091 1100.
3. Whitton JL, Feuer R. Myocarditis, microbes and autoimmunity. Autoimmunity 2004 37 : 375 386.
4. Sada-Ovalle I, Chiba A, Gonzales A, Brenner MB, Behar SM. Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. PLoS Pathog 2008 4 : e1000239.
5. Kinjo T, Fujita J, Kawakami K. Cooperative regulation of the host defense to cryptococcal infection by innate immune lymphocytes. Nippon Ishinkin Gakkai Zasshi 2006 47 : 201 207.
6. Stanley AC, Zhou Y, Amante FH et al. Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis. PLoS Pathog 2008 4 : e1000028.
7. Galli G, Pittoni P, Tonti E et al. Invariant NKT cells sustain specific B cell responses and memory. Proc Natl Acad Sci USA 2007 104 : 3984 3989.
8. Fujita K, Sandford AP, Kobayashi M, Hanafusa T, Herndon DN, Suzuki F. Role of natural killer T (NKT) cells lacking interleukin (IL)-4 producing abilities on the CC-chemokine ligand 2-associated herpes simplex virus type 1 infection in human severe combined immunodeficiency (SCID) mouse chimeras. Burns 2005 31 : 145 152.
9. Long BR, Erickson AE, Chapman JM et al. Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2. Immunology 2009 129 : 186 196.
10. Larranaga CL, Ampuero SL, Luchsinger VF et al. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr Infect Dis J 2009 28 : 867 873.
11. Ito H, Ando K, Ishikawa T et al. Role of Valpha14 + NKT cells in the development of hepatitis B virus-specific CTL: activation of Valpha14 + NKT cells promotes the breakage of CTL tolerance. Int Immunol 2008 20 : 869 879.
12. Nattermann J, Feldmann G, Ahlenstiel G, Langhans B, Sauerbruch T, Spengler U. Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut 2006 55 : 869 877.
13. Kobayashi E, Motoki K, Natori T, Uchida T, Fukushima H, Koezuka Y. Enhancing effects of agelasphin-11 on natural killer cell activities of normal and tumor-bearing mice. Biol Pharm Bull 1996 19 : 350 353.
14. Miyake S, Yamamura T. Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases. Curr Drug Targets Immune Endocr Metabol Disord 2005 5 : 315 322.
15. Grajewski RS, Hansen AM, Agarwal RK et al. Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol 2008 181 : 4791 4797.
16. Brunetti L, DeSantis ER. Treatment of viral myocarditis caused by coxsackievirus B. Am J Health Syst Pharm 2008 65 : 132 137.
17. Mason JW, O'Connell JB, Herskowitz A et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N Engl J Med 1995 333 : 269 275.
18. Camargo PR, Snitcowsky R, da Luz PL et al. Favorable effects of immunosuppressive therapy in children with dilated cardiomyopathy and active myocarditis. Pediatr Cardiol 1995 16 : 61 8.
19. Wojnicz R, Nowalany-Kozielska E, Wojciechowska C et al. Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. Circulation 2001 104 : 39 45.
20. Chen H, Liu J, Yang M. Corticosteroids for viral myocarditis. Cochrane Database Syst Rev 2006 4 : CD004471.
21. Li W, Ji F, Zhang Y et al. Cooperation of invariant NKT cells and CD4 + CD25 + T regulatory cells in prevention of autoimmune diabetes in non-obese diabetic mice treated with alpha-galactosylceramide. Acta Biochim Biophys Sin 2008 40 : 381 390.
22. Ouyang Q, Chen K, Wang X et al. [The study of changes on NKT cells of experimental autoimmune encephalomyelitis (EAE) mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009 25 : 894 896.
23. Ho LP, Denney L, Luhn K, Teoh D, Clelland C, McMichael AJ. Activation of invariant NKT cells enhances the innate immune response and improves the disease course in influenza A virus infection. Eur J Immunol 2008 38 : 1913 1922.
24. Ranson T, Bregenholt S, Lehuen A et al. Invariant V alpha 14 + NKT cells participate in the early response to enteric Listeria monocytogenes infection. J Immunol 2005 175 : 1137 1144.
25. Ronet C, Darche S, Leite de Moraes M et al. NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii. J Immunol 2005 175 : 899 908.
26. Wilson MT, Johansson C, Olivares-Villagomez D et al. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci USA 2003 100 : 10913 10918.
27. Crowe NY, Uldrich AP, Kyparissoudis K et al. Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol 2003 171 : 4020 4027.
28. Parekh VV, Lalani S, Van Kaer L. The in vivo response of invariant natural killer T cells to glycolipid antigens. Int Rev Immunol 2007 26 : 31 48.
29. Parekh VV, Wilson MT, Olivares-Villagomez D et al. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J Clin Invest 2005 115 : 2572 2583.
30. Parekh VV, Singh AK, Wilson MT et al. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J Immunol 2004 173 : 3693 3706.
31. Hu X, Chakravarty SD, Ivashkiv LB. Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol Rev 2008 226 : 41 56.
32. Saura M, Zaragoza C, McMillan A et al. An antiviral mechanism of nitric oxide: inhibition of a viral protease. Immunity 1999 10 : 21 8.
33. Yuan J, Liu Z, Lim T et al. CXCL10 inhibits viral replication through recruitment of natural killer cells in coxsackievirus B3-induced myocarditis. Circ Res 2009 104 : 628 638.
34. Eberl G, MacDonald HR. Rapid death and regeneration of NKT cells in anti-CD3epsilon- or IL-12-treated mice: a major role for bone marrow in NKT cell homeostasis. Immunity 1998 9 : 345 353.
35. Eberl G, MacDonald HR. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells. Eur J Immunol 2000 30 : 985 992.