TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma

International Journal of Oncology

Volumn 37, Issue 4, 2010, Pages 853-859

  Luo, Hairong ^a,b   Hao, Xiangfang ^b   Ge, Chao ^b   Zhao, Fangyu ^b   Zhu, Miaoxin ^b   Chen, Taoyang ^c   Yao, Ming ^b   He, Xianghuo ^b   Li, Jinjun ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c Qi Dong Liver Cancer Institute   (China)

Author keywords

E cadherin; Hepatocellular carcinoma; Metastasis; N cadherin; TC21

Indexed keywords

NERVE CELL ADHESION MOLECULE; PROTEIN TC21; RAS PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL MOTILITY; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 77956525558     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000736     Document Type: Article

References (25)

1. Drivas GT, Shih A, Coutavas E, Rush MG and D'Eustachio P: Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. Mol Cell Biol 10: 1793-1798, 1990.
2. Graham SM, Cox AD, Drivas G, Rush MG, D'Eustachio P and Der CJ: Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation. Mol Cell Biol 14: 4108-4115, 1994.
3. Chan AM, Miki T, Meyers KA and Aaronson SA: A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. Proc Natl Acad Sci USA 91: 7558-7562, 1994. (Pubitemid 24238224)
4. Graham SM, Oldham SM, Martin CB, C.B. Martin, Drugan JK, Zohn IE, Campbell S and Der CJ: TC21 and Ras share indistinguishable transforming and differentiating activities. Oncogene 18: 2107-2116, 1999.
5. Huang Y, Rangwala F, Fulkerson PC, Ling B, Reed E, Cox AD, Kamholz J and Ratner N: Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene 23: 368-378, 2004.
6. Clark GJ, Kinch MS, Gilmer TM, Burridge K and Der CJ: Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers. Oncogene 12: 169-176, 1996. (Pubitemid 26041253)
7. Barker KT and Crompton MR: Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo. Br J Cancer 78: 296-300, 1998.
8. Arora S, Matta A, Shukla NK, Deo SV and Ralhan R: Identification of differentially expressed genes in oral squamous cell carcinoma. Mol Carcinog 42: 97-108, 2005.
9. Sharma R, Sud N, Chattopadhyay TK and Ralhan R: TC21/R-Ras2 upregulation in esophageal tumorigenesis: potential diagnostic implications. Oncology 69: 10-18, 2005.
10. Macha MA, Matta A, Sriram U, Thakkar A, Shukla NK, Dattagupta S and Ralhan R: Clinical significance of TC21 overexpression in oral cancer. J Oral Pathol Med (In press).
11. Rosario M, Paterson HF and Marshall CJ: Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. EMBO J 18: 1270-1279, 1999.
12. Huang Y, Saez R, Chao L, Santos E, Aaronson SA and Chan AM: A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line. Oncogene 11: 1255-1260, 1995.
13. Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, Kelley GG and Der CJ: Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. J Biol Chem 277: 9966-9975, 2002.
14. Erdogan M, Pozzi A, Bhowmick N, Moses HL and Zent R: Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem 282: 27713-27720, 2007.
15. Rong R, He Q, Liu Y, Sheikh MS and Huang Y: TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. Oncogene 21: 1062-1070, 2002.
16. Poon D, Anderson BO, Chen LT, K. Tanaka, Lau WY, Van Cutsem E, Singh H, Chow WC, Ooi LL, Chow P, Khin MW and Koo WH: Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol 10: 1111-1118, 2009.
17. Teufel A, Staib F, Kanzler S, Weinmann A, Schulze-Bergkamen H and Galle PR: Genetics of hepatocellular carcinoma. World J Gastroenterol 13: 2271-2282, 2007.
18. Newell P, Toffanin S, Villanueva A, Chiang DY, Minguez B, Cabellos L, Savic R, Hoshida Y, Lim KH, Melgar-Lesmes P, Yea S, Peix J, Deniz K, Fiel MI, Thung S, Alsinet C, Tovar V, Mazzaferro V, Bruix J, Roayaie S, Schwartz M, Friedman SL and Llovet JM: Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol 51: 725-733, 2009.
19. Ikeguchi M, Makino M and Kaibara N: Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma. J Surg Oncol 77: 201-207, 2001. (Pubitemid 32645776)
20. Hajra KM, Chen DY and Fearon ER: The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 62: 1613-1618, 2002.
21. Wei Y, Van Nhieu JT, Prigent S, Srivatanakul P, Tiollais P and Buendia MA: Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features. Hepatology 36: 692-701, 2002.
22. Slagle BL, Zhou YZ, Birchmeier W and Scorsone KA: Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas. Hepatology 18: 757-762, 1993.
23. Schmidt CR, Washington MK, Gi YJ, Coffey RJ, Beauchamp RD and Pearson AS: Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am J Surg 186: 426-430, 2003.
24. Schmidt CR, Gi YJ, Patel TA, Coffey RJ, Beauchamp RD and Pearson AS: E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Surgery 138: 306-312, 2005.
25. Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL and Wu JC: Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 50: 1464-1474, 2009.