COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: An experimental examination

Behavioral and Brain Functions

Volumn 6, Issue , 2010, Pages

  Rosa, Elise C ^a   Dickinson, Dwight ^a   Apud, José ^a   Weinberger, Daniel R ^a   Elvevåg, Brita ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ALLELE; ARTICLE; CLINICAL ASSESSMENT; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; SCHIZOPHRENIA; ADULT; GENETICS; PSYCHOLOGY; REACTION TIME;

ADULT; ALLELES; CATECHOL O-METHYLTRANSFERASE; COGNITION; FEMALE; HUMANS; MALE; POLYMORPHISM, GENETIC; REACTION TIME; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 77956490392     PISSN: 17449081     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-9081-6-53     Document Type: Article

References (23)

1. Levy R, Goldman-Rakic PS. Segregation of Working Memory Functions Within the Dorsolateral Prefrontal Cortex. Exp Brain Res 2000, 133:23-32. 10.1007/s002210000397, 10933207.
2. Seamans JK, Yang CR. The Principal Features and Mechanisms of Dopamine Modulation in the Prefrontal Cortex. Prog Neurobiol 2004, 74:1-58. 10.1016/j.pneurobio.2004.05.006, 15381316.
3. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, et al. Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain. Am J Hum Genet 2004, 75:807-821. 10.1086/425589, 1182110, 15457404.
4. Papaleo F, Crawley JN, Song J, Lipska BK, Pickel J, Weinberger DR, et al. Genetic Dissection of the Role of Catechol-O-Methyltransferase in Cognition and Stress Reactivity in Mice. J Neurosci 2008, 28:8709-8723. 10.1523/JNEUROSCI.2077-08.2008, 2561993, 18753372.
5. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, et al. Effect of COMT Val108/158Met Genotype on Frontal Lobe Function and Risk for Schizophrenia. PNAS 2001, 98:6917-6922. 10.1073/pnas.111134598, 34453, 11381111.
6. Diaz-Asper CM, Goldberg TE, Kolachana BS, Straub RE, Egan MF, Weinberger DR. Genetic Variation in Catechol-O-Methyltransferase: Effects on Working Memory in Schizophrenic Patients, Their Siblings, and Healthy Controls. Biol Psychiatry 2008, 63:72-79. 10.1016/j.biopsych.2007.03.031, 17707347.
7. Bishop SJ, Fossella J, Croucher CJ, Duncan J. COMT Val158Met Genotype Affects Recruitment of Neural Mechanisms Supporting Fluid Intelligence. Cereb Cortex 2008, 240:1-9.
8. Blasi G, Mattay VS, Bertolino A, Elvevåg B, Callicott JH, Das S, et al. Effect of Catechol-O-Methyltransferase val158met Genotype on Attentional Control. J Neurosci 2005, 25:5038-5045. 10.1523/JNEUROSCI.0476-05.2005, 15901785.
9. Winterer G, Musso F, Vucurevic G, Stoeter P, Konrad A, Seker B, et al. COMT Genotype Predicts BOLD Signal and Noise Characteristics in Prefrontal Circuits. Neuroimage 2006, 32:1722-1732. 10.1016/j.neuroimage.2006.05.058, 16884927.
10. Barnett JH, Scoriels L, Munafò MR. Meta-Analysis of the Cognitive Effects of Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism. Biol Psychiatry 2008, 64:137-44. 10.1016/j.biopsych.2008.01.005, 18339359.
11. Burdick KE, Gunawardane N, Woodberry K, Malhotra A. The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders. Cogn Neuropsychiatry 2009, 14:299-311. 10.1080/13546800902805347, 2727853, 19634032.
12. Grace AA. Phasic Versus Tonic Dopamine Release and the Modulation of Dopamine System Responsivity: a Hypothesis for the Etiology of Schizophrenia. Neuroscience 1991, 41:1-24. 10.1016/0306-4522(91)90196-U, 1676137.
13. Bilder RM, Volavka J, Lachman HM, Grace AA. The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic-Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes. Neuropsychopharmacology 2004, 29:1943-61. 10.1038/sj.npp.1300542, 15305167.
14. Nolan KA, Bilder RM, Lachman HM, Volavka J. Catechol O-Methyltransferase Val158Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility. Am J Psychiatry 2004, 161:359-361. 10.1176/appi.ajp.161.2.359, 14754787.
15. Opgen-Rhein C, Neuhaus AH, Urbanek C, Hahn E, Sander T, Dettling M. Executive Attention in Schizophrenic Males and the Impact of COMT Val108/158Met Genotype on Performance on the Attention Network Test. Schizophr Bull 2008, 34:1231-1239. 10.1093/schbul/sbm155, 2632487, 18199630.
16. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, et al. Executive Subprocesses in Working Memory: Relationship to Catechol-O-Methyltransferase Val168Met Genotype and Schizophrenia. Arch Gen Psychiatry 2003, 60:889-96. 10.1001/archpsyc.60.9.889, 12963670.
17. Tan H, Chen Q, Goldberg TE, Mattay VS, Meyer-Lindenberg A, Weinberger DR, et al. Catechol-O-Methyltransferase Val158Met Modulation of Prefrontal-Parietal-Straital Brain Systems During Arithmetic and Temporal Transformations in Working Memory. J Neurosci 2007, 27:13393-401. 10.1523/JNEUROSCI.4041-07.2007, 18057197.
18. Diamond D, Briand L, Fossella J, Gehlback L. Genetic and Neurochemical Modulation of Prefrontal Cognitive Functions in Children. Am J Psychiatry 2004, 161:125-132. 10.1176/appi.ajp.161.1.125, 14702260.
19. Raz N, Rodrigue KM, Kennedy KM, Land S. Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE, and Hypertension. Neuropsychology 2009, 23:105-116. 10.1037/a0013487, 2729285, 19210038.
20. Reuter M, Peters K, Schroeter K, Koebke W, Lenardon D, Bloch B, et al. The Influence of the Dopaminergic System on Cognitive Functioning: A Molecular Genetic Approach. Behavl Brain Res 2005, 164:93-99.
21. Cohen J. The Effect Size Index:f. Statistical Power Analysis for the Behavioral Sciences 1988, 284-288. Hillsdale: Lawrence Erlbaum Associates, Inc, 2.
22. Dickinson D, Goldberg TE, Gold JM, Egan MF, Elvevåg B, Weinberger DR. Cognitive Factor structure and invariance in people with schizophrenia, their unaffected siblings, and controls. Schizophr Bull
23. Bilder RM, Volavka J, Czobar P, Malhotra AK, Kennedy JL, Ni X, et al. Neurocognitive Correlates of the COMT Val158Met Polymorphism in Chronic Schizophrenia. Biol Psychiatry 2002, 52:701-707. 10.1016/S0006-3223(02)01416-6, 12372660.