Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 368, Issue 1925, 2010, Pages 3953-3965

  Li, Pan ^a   Wei, Wenjie ^b   Cai, Xing ^b   Soeller, Christian ^c   Cannell, Mark B ^c   Holden, Arun V ^d  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b SIMULA RESEARCH LABORATORY   (Norway)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Ca2+ sparks; Ca2+ waves; Confocal microscopy; Stochastic model

Indexed keywords

CONFOCAL MICROSCOPY; CRACK PROPAGATION; DYNAMICS; ELECTRIC SPARKS; INSECTICIDES; SIZE DISTRIBUTION; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; THREE DIMENSIONAL; WAVE PROPAGATION;

CA2+ SPARKS; CA2+ WAVES; CARDIAC ARRHYTHMIA; CARDIAC MYOCYTES; COMPUTATIONAL MODELLING; CONFOCAL IMAGING; DISC STRUCTURES; EXCITATION-CONTRACTION COUPLING; INITIATION AND PROPAGATION; INTRACELLULAR CA; MEMBRANE POTENTIALS; MURINE MODEL; MYOCYTES; PATHOLOGICAL CONDITIONS; QUANTITATIVE PREDICTION; RELEASE DYNAMICS; RYANODINE RECEPTORS; SCROLL WAVES; SENSITIVITY FACTORS; SIMPLE STOCHASTIC; SPATIAL DISTRIBUTION; TIME COURSE; TRAVELLING WAVES; VENTRICULAR CELLS; VENTRICULAR MYOCYTES; VENTRICULAR TACHYCARDIA; WAVE INITIATION;

CALCIUM;

ANTIARRHYTHMIC AGENT; CALCIUM; FLECAINIDE; RYANODINE RECEPTOR;

ANIMAL; ARTICLE; COMPUTER SIMULATION; CYTOLOGY; CYTOPLASM; DRUG EFFECT; HEART; HEART VENTRICLE; HUMAN; KINETICS; MUSCLE CELL; PHYSIOLOGY; RAT; STATISTICS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; COMPUTER SIMULATION; CYTOPLASM; FLECAINIDE; HEART; HEART VENTRICLES; HUMANS; KINETICS; MUSCLE CELLS; RATS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; STOCHASTIC PROCESSES;

EID: 77956472776     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2010.0146     Document Type: Article

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