Serum cytokine receptors in ankylosing spondylitis: Relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms

Journal of Rheumatology

Volumn 37, Issue 9, 2010, Pages 1907-1910

  Haroon, Nigil ^a   Tsui, Florence W L ^a   Chiu, Basil ^b   Tsui, Hing W O ^b   Inman, Robert D ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ankylosing spondylitis; Arts 1; ERAP1; ERAP2; Receptor shedding

Indexed keywords

AMINOPEPTIDASE; C REACTIVE PROTEIN; CYTOKINE RECEPTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; DNA POLYMORPHISM; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; ERAP 1 GENE; ERAP 2 GENE; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AMINOPEPTIDASES; BIOLOGICAL MARKERS; CYTOKINES; FEMALE; HUMANS; INFLAMMATION; ISOENZYMES; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, CYTOKINE; SEVERITY OF ILLNESS INDEX; SPONDYLITIS, ANKYLOSING;

EID: 77956470985     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.100019     Document Type: Article

References (13)

1. Khan MA, Mathieu A, Sorrentino R, Akkoc N. The pathogenetic role of HLA-B27 and its subtypes. Autoimmun Rev 2007;6:183-9.
2. Sims AM, Timms AE, Bruges-Armas J, Burgos-Vargas R, Chou CT, Doan T, et al. Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis. Ann Rheum Dis 2008;67:1305-9.
3. Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329-37.
4. Rahman P, Inman RD, Gladman DD, Reeve JP, Peddle L, Maksymowych WP. Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum 2008;58:1020-5.
5. Tsui FW, Haroon N, Reveille JD, Rahman P, Chiu B, Tsui HW, et al. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. Ann Rheum Dis 2010;69:733-6.
6. Cui X, Hawari F, Alsaaty S, Lawrence M, Combs CA, Geng W, et al. Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. J Clin Invest 2002;110:515-26.
7. Cui X, Rouhani FN, Hawari F, Levine SJ. Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding. J Immunol 2003;171:6814-9.
8. Cui X, Rouhani FN, Hawari F, Levine SJ. An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding. J Biol Chem 2003;278:28677-85.
9. York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, et al. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol 2002;3:1177-84.
10. Hammer GE, Gonzalez F, James E, Nolla H, Shastri N. In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol 2007;8:101-8.
11. Tsujimoto M, Hattori A. The oxytocinase subfamily of M1 aminopeptidases. Biochim Biophys Acta 2005;1751:9-18.
12. Saveanu L, Carroll O, Lindo V, Del Val M, Lopez D, Lepelletier Y, et al. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol 2005;6:689-97.
13. Tanioka T, Hattori A, Masuda S, Nomura Y, Nakayama H, Mizutani S, et al. Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. J Biol Chem 2003;278:32275-83.