Modulation on the P-glycoprotein in the jejunum by combined use of Glycyrrhiza inflata and Sargassum in Vitro

Chinese Pharmaceutical Journal

Volumn 45, Issue 8, 2010, Pages 585-589

  Sun, Ya Bin ^a   Li, Guo Feng ^a   Liu, Si Jia ^a   Chen, Ying ^a   Tang, Zhong Kun ^a   Zhao, Bo Xin ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Glycyrrhiza inflata; P glycoprotein; Sargassum; Ussing chamber

Indexed keywords

FLUORESCEIN SODIUM; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; GLYCYRRHIZA INFLATA EXTRACT; PLANT EXTRACT; RHODAMINE 123; SARGASSUM EXTRACT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFECT; DRUG TRANSPORT; FLUOROMETRY; GLYCYRRHIZA; GLYCYRRHIZA INFLATA; IN VITRO STUDY; JEJUNUM; MEMBRANE PERMEABILITY; NONHUMAN; PROTEIN FUNCTION; RAT; SARGASSUM;

EID: 77956461789     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. XU L, SUN X J, WANG Z G. Effects of water extracts of Gancao and Haizao alone or combined on the hepatic microsomal drug metabolism enzyme [J]. Liaoning J Tradit Chin Med, 1998, 25(2):84-85.
2. MIU H J, LIU G L. P-glycoprotein and pharmacokinetics [J]. China Pharm, 2002, 13(1):49-51.
3. ZHOU S, LIM L Y, CHOWBAY B. Herbal modulation of P-glycoprotein [J]. Drug Metab Rev, 2004, 36(1):57-104.
4. SHONO Y, NISHIHARA H, MATSUDA Y, et al. Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes [J]. J Pharm Sci, 2004, 93(4):877-885.
5. KAMATH A V, YAO M, ZHANG Y, et al. Effect of fruit juices on the oral bioavailability of fexofenadine in rats [J]. J Pharm Sci, 2005, 94(2):233-239.
6. HILGERS A R, CONRADI R A, BURTON P S. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa [J]. Pharm Res, 1990, 7(9):902-910. (Pubitemid 20349761)
7. WATANABE E, TAKAHASHI M, HAYASHI M. A possibility to predict the absorbability of poorly water-soluble drugs in humans based on rat intestinal permeability assessed by an in vitro chamber method [J]. Eur J Pharm Biopharm, 2004, 58(3):659-665.
8. WALLON C, BRAAF Y, WOLVING M, et al. Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon [J]. Scand J Gastroenterol, 2005, 40(5):586-595.
9. YANG H, FINALY R, DANIEL H. Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutrition [J]. Crit Care Med, 2003, 31(4):1118-1125.
10. LIN Y, SHEN Q, KATSUMI H, et al. Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats [J]. Biol Pharm Bull, 2007, 30(7):1301-1307.
11. SHEN Q, LIN Y L, HANDA T, et al. Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies [J]. Int J Pharm, 2006, 313(1-2):49-56.
12. NISHIMURA N. Effect of Chinese herbal medicines on intestinal drug absorption [J]. Pharm Soc Japan, 2005, 125(4):363-369.