Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes

Toxicology

Volumn 276, Issue 2, 2010, Pages 115-121

  Liu, Huigang ^a   Liu, Jing ^b   Xu, Lihong ^c   Zhou, Shanshan ^a   Li, Ling ^a   Liu, Weiping ^a,b  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Chiral pesticide; Cytotoxicity; Enantioselectivity; Isocarbophos; JNK pathway

Indexed keywords

ANTIOXIDANT; ISOCARBOPHOS; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ORGANOPHOSPHATE PESTICIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; INSECTICIDE; MALATHION;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIVER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; HEPG2 CELL LINE; METABOLISM; STEREOISOMERISM; TOXICITY;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSECTICIDES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALATHION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; STEREOISOMERISM;

EID: 77956418049     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.07.018     Document Type: Article

References (32)

1. Aprea C., Strambi M., Novelli M.T., Lunghini L., Bozzi N. Biologic monitoring of exposure to organophosphorus pesticides in 195 Italian children. Environ. Health Perspect. 2000, 108:521-525.
2. Barr D.B., Bravo R., Weerasekera G., Caltabiano L.M., Whitehead R.D., Olsson A.O., Caudill S.P., Schober S.E., Pirkle J.L., Sampson E.J., Jackson R.J., Needham L.L. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environ. Health Perspect. 2004, 112:186-200.
3. Barr D.B., Allen R., Olsson A.O., Bravo R., Caltabiano L.M., Montesano A., Nguyen J., Udunka S., Walden D., Walker R.D., Weerasekera G., Whitehead R.D., Schober S.E., Needham L.L. Concentrations of selective metabolites of organophosphorus pesticides in the United States population. Environ. Res. 2005, 99:314-326.
4. Chen L., Willis S.N., Wei A., Smith B.J., Fletcher J.I., Hinds M.G., Colman P.M., Day C.L., Adams J.M., Huang D.C. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell. 2005, 17:393-403.
5. Chishti M.A., Rotkiewicz T. Ultrastructural alterations produced in cockerels after mercuric chloride toxicity and subsequent interaction with an organophosphate insecticide. Arch. Environ. Contam. Toxicol. 1992, 22:445-451.
6. Chishti M.A., Rotkiewicz T. Hepatic and renal ultrastructural changes in cockerels exposed to cadmium chloride and subsequent interaction with organophosphate insecticide. J. Environ. Pathol. Toxicol. Oncol. 1993, 12:35-45.
7. Circu M.L., Aw T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med. 2010, 48:749-762.
8. Curl C.L., Fenske R.A., Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ. Health Perspect. 2003, 111:377-382.
9. Czaja M.J. Cell signaling in oxidative stress-induced liver injury. Semin. Liver Dis. 2007, 27:378-389.
10. Fletcher J.I., Huang D.C. Controlling the cell death mediators Bax and Bak: puzzles and conundrums. Cell Cycle 2008, 7:39-44.
11. Garrison A.W. Probing the enantioselectivity of chiral pesticides. Environ. Sci. Technol. 2006, 40:16-23.
12. Hreljac I., Zajc I., Lah T., Filipic M. Effects of model organophosphorous pesticides on DNA damage and proliferation of HepG2 cells. Environ. Mol. Mutagen. 2008, 49:360-367.
13. Hu F., Li L., Wang C., Zhang Q., Zhang X.F., Zhao M.R. Enantioselective induction of oxidative stress by permethrin in rat adrenal pheochromocytoma (PC12) cells. Environ. Toxicol. Chem. 2010, 29:683-690.
14. Jia Z.Q., Li Y., Lu S., Peng H.Z., Ge J.Y., Chen S.D. Treatment of organophosphate-contaminated wastewater by acidic hydrolysis and precipitation. J. Hazard. Mater. 2006, 129:234-238.
15. Jin M.Q., Zhang Y., Ye J., Huang C.J., Zhao M.R., Liu W.P. Dual enantioselective effect of the insecticide bifenthrin on locomotor behavior and development in embryo-larval zebrafish. Environ. Toxicol. Chem. 2010, 29:1561-1567.
16. Lin K., Liu W., Li L., Gan J. Single and joint acute toxicity of isocarbophos enantiomers to Daphnia magna. J. Agric. Food Chem. 2008, 56:4273-4277.
17. Liu H., Zhao M., Zhang C., Ma Y., Liu W. Enantioselective cytotoxicity of the insecticide bifenthrin on a human amnion epithelial (FL) cell line. Toxicology 2008, 253:89-96.
18. Liu H., Xu L., Zhao M., Liu W., Zhang C., Zhou S. Enantiomer-specific, bifenthrin-induced apoptosis mediated by MAPK signalling pathway in Hep G2 cells. Toxicology 2009, 261:119-125.
19. Lu C., Knutson D.E., Fisker-Andersen J., Fenske R.A. Biological monitoring survey of organophosphorus pesticide exposure among pre-school children in the Seattle metropolitan area. Environ. Health Perspect. 2001, 109:299-303.
20. Lu X., Hu F., Ma Y., Wang C., Zhang Y., Zhao M. The role of oxidative stress in enantiomer-specific, bifenthrin-induced cytotoxicity in PC12 cells. Environ. Toxicol. 2009, (Epub ahead of print).
21. Mebratu Y., Tesfaigzi Y. How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?. Cell Cycle 2009, 8:1168-1175.
22. Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 2006, 12:440-450.
23. Singh R., Czaja M.J. Regulation of hepatocyte apoptosis by oxidative stress. J. Gastroenterol. Hepatol. 2007, 22(Suppl. 1):S45-S48.
24. Wang L., Ye W., Zhou S., Lin K., Zhao M., Liu W. Acute and chronic toxicity of organophosphate monocrotophos to Daphnia magna. J. Environ. Sci. Health B 2009, 44:38-43.
25. Wang L., Zhou S., Lin K., Zhao M., Liu W., Gan J. Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line. Environ. Toxicol. Chem. 2009, 28:1-8.
26. Wullaert A., Heyninck K., Beyaert R. Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem. Pharmacol. 2006, 72:1090-1101.
27. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331.
28. Xu W.N., Liu W.B., Liu Z.P. Trichlorfon-induced apoptosis in hepatocyte primary cultures of Carassius auratus gibelio. Chemosphere 2009, 77:895-901.
29. Zhao M., Liu W. Enantioselectivity in the immunotoxicity of the insecticide acetofenate in an in vitro model. Environ. Toxicol. Chem. 2009, 28:578-585.
30. Zhao M., Zhang Y., Liu W., Xu C., Wang L., Gan J. Estrogenic activity of lambda-cyhalothrin in the MCF-7 human breast carcinoma cell line. Environ. Toxicol. Chem. 2008, 27:1194-1200.
31. Zhao M., Wang C., Liu K.K., Sun L., Li L., Liu W. Enantioselectivity in chronic toxicology and accumulation of the synthetic pyrethroid insecticide bifenthrin in Daphnia magna. Environ. Toxicol. Chem. 2009, 28:1475-1479.
32. Zhao M., Chen F., Wang C., Zhang Q., Gan J., Liu W. Integrative assessment of enantioselectivity in endocrine disruption and immunotoxicity of synthetic pyrethroids. Environ. Pollut. 2010, 158:1968-1973.