Dilated intercellular spaces in subtypes of gastroesophagic reflux disease

Revista Espanola de Enfermedades Digestivas

Volumn 102, Issue 5, 2010, Pages 302-307

  Alvaro Villegas J C ^a   Sobrino Cossio S ^a   Hernandez Guerrero A ^a   Alonso Larraga J O ^a   de la Mora Levy, J G ^a   Molina Cruz, A ^b   Dominguez Malagon H R ^b   Herrera Esquivel, J J ^c  

^a Services of Endoscopy   (Mexico)

^b INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

^c HOSPITAL GENERAL DR MANUEL GEA GONZÁLEZ   (Mexico)

Author keywords

Barrett's esophagus; Dilated intercellular spaces; Erosive esophagitis; Gastroesophageal reflux disease

Indexed keywords

ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; BIOPSY TECHNIQUE; COLUMNAR EPITHELIUM; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE MARKER; DISEASE SEVERITY; ELECTRON MICROSCOPY; ENDOSCOPY; ESOPHAGUS MUCOSA; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERCELLULAR SPACE; MALE; NON EROSIVE REFLUX DISEASE; PH MEASUREMENT; PROSPECTIVE STUDY; REFLUX ESOPHAGITIS; SQUAMOUS EPITHELIUM; BIOPSY; CLASSIFICATION; DIFFERENTIAL DIAGNOSIS; ESOPHAGOSCOPY; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; BARRETT ESOPHAGUS; BIOPSY; CROSS-SECTIONAL STUDIES; DIAGNOSIS, DIFFERENTIAL; ESOPHAGOSCOPY; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 77956413525     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: 10.4321/S1130-01082010000500003     Document Type: Article

References (21)

1. Kahrilas PJ. GERD pathogenesis, pathophysiology, and clinical manifestations. Cleveland Clinic Journal of Medicine 2003; 70(Supl. 5): S4-s19.
2. Caviglia R, Ribolisi M, Gentile M. Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gastrooesophageal reflux disease. Alimentar Pharm Ther 2007; 25: 629-636.
3. Malenstein H, Farré R, Sifrim D. Esophageal dilated Intercellular spaces (DIS) and nonerosive reflux disease. Am J Gastroenterol 2007; 102: 1-8.
4. Rey E, Álvarez-Sánchez A, Rodríguez-Artalejo F, Moreno C, Almansa C, Díaz-Rubio M. Onset and disappearance rates of gastroesophageal reflux symptoms in the Spanish population, and their impact on quality of life. Rev Esp Enferm Dig 2009; 101: 477-482.
5. Pérez H, Urdiales G, Fernández J, España L, Rodríguez J, Martínez M, et al. Preoperative workup to assess indication for laparoscopic treatment in gastroesophageal reflux disease. Rev Esp Enferm Dig 2008; 100: 405-410.
6. Fass R, Ofman JJ. Gastroesophageal reflux disease. Should we adopt a new conceptual framework? Am J Gastroenterol 2002; 97: 1901-1909.
7. Zentilin P, Savarino V, Mastracci L, Spaggiari P, Dulbecco P, Ceppa P, et al. Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group. Am J Gastroenterol 2005; 100: 2299-2306.
8. Caviglia R, Rivolsi M, Mariano N. Dilated intercellular spaces of esophageal epithelium in non-erosive reflux disease patients with physiological esophageal acid exposure. Am J Gastreoenterol 2005; 100: 543-548.
9. Tutuian R. Update in the diagnosis of gastroesophageal reflux disease. J Gastrointestin Liver Dis 2006; 15: 243-247.
10. Cappell MS. Clinical presentation, diagnosis, and management of gastroesophageal reflux disease. Med Clin North Am 2005; 89: 243-291.
11. Armstrong D. Review article: gastric pH -the most relevant predictor of benefit in reflux disease? Alimentar Pharm Ther 2004; 20: 19-26.
12. Tack J. Review article: the role of bile and pepsin in the pathophysiology and treatment of gastro-oesophageal reflux disease. Alimentar Pharm Ther 2006; 24: 10-16.
13. Numans ME, De Wit NJ. Reflux symptoms in general practice: diagnostic evaluation of the Carlsson-Dent gastro-oesophageal reflux disease questionnaire. Aliment Pharmacol Ther 2003; 17: 1049-1055.
14. Carlsson R, Dent J, Bolling-Sternvald E, Johnsson F, Junghard O, Lauritsen K, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol 1998; 33: 1023-1029.
15. Cameron AJ, Zinsmeister AR, Ballard DJ, Carney JA. Prevalence of columnar-lined (Barrett's) esophagus. Comparison of population-based clinical and autopsy findings. Gastroenterology 1990; 99: 918-922.
16. Revicki DA, Wood M, Maton PM, Sorensen S. The impact of gastroesophageal reflux disease on health related quality of life. Am J Med 1998; 104: 252-258.
17. Cappell MS. Clinical presentation, diagnosis, and management of gastroesophageal reflux disease. Med Clin North Am 2005; 89: 243-291.
18. Tobey NA, Carson JL, Alkiek RA, Orlando RC. Dilated intercellular spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology 1996; 111: 1200.
19. Calabrese C, Fabbri A, Bortolotti M, Cenacchi G, Areni A, Scialpi C, et al. Dilated intercellular spaces as a marker of oesophageal damage: comparative results in gastro-oesophageal reflux disease with or without bile reflux. Aliment Pharmacol Ther 2003; 18: 525-532.
20. Villanacci V, Grigolato PG, Cestari R, Missale G, Cengia G, Klersy C, et al. Dilated intercellular spaces as markers of reflux disease: histology, semiquantitative score and morphometry upon light microscopy. Digestion 2001; 64: 1-8.
21. Shapiro M, Green C, Faybush EM, Esquivel RF, Fass R. The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups. Aliment Pharmacol Ther 2006; 23(2): 321-329.