Monosodium glutamate (MSG)-obese rats develop glucose intolerance and insulin resistance to peripheral glucose uptake

Brazilian Journal of Medical and Biological Research

Volumn 30, Issue 5, 1997, Pages 671-674

  Hirata, A E ^a   Andrade, I S ^a   Vaskevicius, P ^a   Dolnikoff, M S ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Clamp technique; Insulin resistance; Monosodium glutamate; Obesity

Indexed keywords

ANIMALIA; RATTUS NORVEGICUS;

GLUCOSE; GLUTAMATE SODIUM;

ANIMAL; ARTICLE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; MALE; METABOLISM; OBESITY; PHYSIOLOGY; RAT; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; MALE; OBESITY; RATS; RATS, WISTAR; SODIUM GLUTAMATE;

EID: 0031134821     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0100-879x1997000500016     Document Type: Article

References (15)

1. Marmo MR, Dolnikoff MS, Kettelhut IC, Matsuchita DM, Hell NS & Lima FB (1994). Neonatal monosodium glutamate treatment increases epididymal adipose tissue sensitivity to insulin in three-month old rats. Brazilian Journal of Medical and Biological Research, 27: 1249-1253.
2. Dolnikoff MS, Kater CE, Egami M, Andrade IS & Marmo MR (1988). Neonatal treatment with monosodium glutamate increases plasma corticosterone in the rat. Neuroendocrinology, 48: 645-649.
3. Le Marchand Y, Freychet P & Jeanrenaud B (1978). Longitudinal study on the establishment of insulin resistance in hypothalamic obese mice. Endocrinology, 102: 74-85.
4. Cameron DP, Cutbush L & Opat F (1978). Effects of monosodium glutamate-induced obesity in mice on carbohydrate metabolism in insulin secretion. Clinical and Experimental Pharmacology and Physiology, 5: 41-51.
5. Machado UF, Shimizu Y & Saito M (1993). Decreased glucose transporter (GLUT 4) content in insulin-sensitive tissues of obese aurothioglucose and monosodium glutamate-treated mice. Hormone and Metabolic Research, 25: 462-465.
6. De Fronzo R, Tobin JD & Andres R (1979). Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Physiology, 237: E214-E223.
7. Morgan CR & Lazarow A (1963). Immunoassay of insulin: two antibody system. Plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes, 12: 115-126.
8. Lengvári I (1977). Effect of perinatal monosodium glutamate treatment on endocrine functions of rats in maturity. Acta Biologica Academiae Scientiarum Hungaricae, 28: 133-141.
9. Sartin JL, Lamperti AA & Kemppainen RJ (1985). Alterations in insulin and glucagon secretion by monosodium glutamate lesions of the hypothalamic arcuate nucleus. Endocrine Research, 11: 145-155.
10. Wardazala LJ, Hirschman M, Pofcher E, Horton ED, Mead PM, Cushman SM & Horton ES (1985). Regulation of glucose utilization in adipose cells and muscle after long-term experimental hyperinsulinemia in rats. Journal of Clinical Investigation, 76: 460-469.
11. Matsuo T & Shino S (1972). Induction of diabetic alterations by goldthioglucose obesity in KK, ICR and C57BL mice. Diabetologia, 8: 391-397.
12. Nosadini R, Del Porto S & Tiengo A (1983). Insulin resistance in Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 57: 529-536.
13. Guillaume-Gentil C, Rohner-Jeanrenaud F, Bestetti GE, Abramo F, Rossi GL & Jeanrenaud B (1990). Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat. Endocrinology. 126: 1873-1879.
14. Guillaume-Gentil C, Assimacopoulos-Jeannet F & Jeanrenaud B (1993). Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats. Diabetologia, 36: 899-906.
15. Handberg A, Kayser L, Hoyer PE, Voldstedlund M, Hansen HP & Vinten J (1993). Metformin ameliorates diabetes but does not normalize the decreased GLUT4 content in skeletal muscle of obese (fa/fa) Zucker rats. Diabetologia, 36: 481-486.