Hemodynamic responses to continuous versus pulsatile mechanical unloading of the failing left ventricle

ASAIO Journal

Volumn 56, Issue 5, 2010, Pages 410-416

  Bartoli, Carlo R ^a   Giridharan, Guruprasad A ^b   Litwak, Kenneth N ^c   Sobieski, Michael ^a   Prabhu, Sumanth D ^a   Slaughter, Mark S ^a   Koenig, Steven C ^b  

^a University of Louisville School of Medicine   (United States)

^b University of Louisville   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AORTIC PRESSURE; AORTIC VALVES; CONTINUOUS FLOWS; DIASTOLIC PRESSURE; ENERGY EQUIVALENT PRESSURES; HEART FAILURE; HEMODYNAMIC ENERGY; HEMODYNAMIC PARAMETERS; HEMODYNAMIC RESPONSE; LEFT VENTRICLES; LEFT VENTRICULAR; LEFT VENTRICULAR ASSIST DEVICES; MECHANICAL CIRCULATORY SUPPORT; PULSE PRESSURE; REPEATED MEASURES; SURPLUS HEMODYNAMIC ENERGIES; SYSTOLIC PRESSURE; T-TESTS;

ANIMALS; BLOOD VESSELS; ENERGY UTILIZATION; HEMODYNAMICS; HYDRODYNAMICS; PULSATILE FLOW; REGRESSION ANALYSIS; UNLOADING;

BLOOD PRESSURE;

ANIMAL; ARTICLE; BLOOD PRESSURE; CATTLE; HEART ASSIST DEVICE; HEART FAILURE; HEART VENTRICLE; HEMODYNAMICS; MALE; PHYSIOLOGY; PULSATILE FLOW;

ANIMALS; BLOOD PRESSURE; CATTLE; HEART FAILURE; HEART VENTRICLES; HEART-ASSIST DEVICES; HEMODYNAMICS; MALE; PULSATILE FLOW;

EID: 77956394931     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e3181e7bf3c     Document Type: Article

References (37)

1. Goldstein DJ, Oz MC, Rose EA: Implantable left ventricular assist devices. N Engl J Med 339: 1522-1533, 1998.
2. Rose EA, Gelijns AC, Moskowitz AJ, et al: Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 345: 1435-1443, 2001.
3. Slaughter MS, Rogers JG, Milano CA, et al: Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 361: 2241-2251, 2009.
4. Birks EJ, Yacoub MH, Banner NR, et al: The role of bridge to transplantation: Should LVAD patients be transplanted? Curr Opin Cardiol 19: 148-153, 2004.
5. Frazier OH, Myers TJ: Left ventricular assist system as a bridge to myocardial recovery. Ann Thorac Surg 68: 734-741, 1999.
6. Birks EJ, Tansley PD, Hardy J, et al: Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med 355: 1873-1884, 2006.
7. Reitz BA: Mechanical devices and US Food and Drug Adminis-tration (FDA) approval. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 123-127, 2006.
8. Thoratec: Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II. [Press release]. 2009.
9. Takatani S: Progress of rotary blood pumps. Artif Organs 30: 317-321, 2006.
10. Ji B, Undar A: Comparison of perfusion modes on microcircula-tion during acute and chronic cardiac support: Is there a difference? Perfusion 22: 115-119, 2007.
11. Giridharan GA, Ewert DL, Pantalos GM, et al: Left ventricular and myocardial perfusion responses to volume unloading and after load reduction in a computer simulation. ASAIO J 50: 512-518, 2004.
12. Koenig SC, Pantalos GM, Gillars KJ, et al: Hemodynamic and pressure-volume responses to continuous and pulsatile ventricular assist in an adult mock circulation. ASAIO J 50: 15-24, 2004.
13. Koenig SC, Giridharan GA, Ewart DL, et al: Human, bovine and porcine systematic vascular input impedances are not equivalent: Implications for device testing and xenotransplanta-tion in heart failure. J Heart Lung Transplant 27: 1340-1347, 2008.
14. Pantalos GM, Giridharan G, Colyer J, et al: Effect of continuous and pulsatile flow left ventricular assist on pulsatility in a pe-diatric animal model of left ventricular dysfunction: Pilot observations. ASAIO J 53: 385-391, 2007.
15. Travis AR, Giridharan GA, Pantalos GM, et al: Vascular pulsatility in patients with a pulsatile-or continuous-flow ventricular assist device. J Thorac Cardiovasc Surg 133: 517-524, 2007.
16. Litwak KN, McMahan A, Lott KA, et al: Monensin toxicosis in the domestic bovine calf: A large animal model of cardiac dysfunction. Contemp Top Lab Anim Sci 44: 45-49, 2005.
17. Tomlinson CW, McGrath GM, McNeill JH: Adriamycin cardio-myopathy: Pathological and membrane functional changes in a canine model with mild impairment of left ventricular function. Can J Cardiol 2: 368-374, 1986.
18. Sabbah HN, Stein PD, Kono T, et al: A canine model of chronic heart failure produced by multiple sequential coronary micro-embolizations. Am J Physiol 260: H1379-H1384, 1991.
19. Bartoli CR, Wilson GC, Giridharan GA, et al: A novel subcutane-ous counterpulsation device: Acute hemodynamic responses to pharmacologically- induced hypertension, hypotension, and heart failure. Artif Organs 2010 (in press).
20. Koenig SC, Woolard C, Drew G, et al: Integrated data acquisition system for medical device testing and physiology research in compliance with good laboratory practices. Biomed Instrum Technol 38: 229-240, 2004.
21. Rooke GA, Feigl EO: Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting. Circ Res 50: 273-286, 1982.
22. Schroeder MJ, Perreault B, Ewert DL, Koenig SC: HEART: An automated beat-to-beat cardiovascular analysis package using Matlab. Comput Biol Med 34: 371-388, 2004.
23. Haga JH, Li YS, Chien S: Molecular basis of the effects of mechan-ical stretch on vascular smooth muscle cells. J Biomech 40: 947-960, 2007.
24. Kinoshita M, Takano H, Taenaka Y, et al: Cardiac disuse atrophy during LVAD pumping. ASAIO Trans 34: 208-212, 1988.
25. Kinoshita M, Takano H, Takaichi S, et al: Influence of prolonged ventricular assistance on myocardial histopathology in intact heart. Ann Thorac Surg 61: 640-645, 1996.
26. Angell James JE, Daly Mde B: Effects of graded pulsatile pressure on the reflex vasomotor responses elicited by changes of mean pressure in the perfused carotid sinus-aortic arch regions of the dog. J Physiol 214: 51-64, 1971.
27. Nishimura T, Tatsumi E, Takaichi S, et al: Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall. Artif Organs 22: 405-410, 1998.
28. Nishimura T, Tatsumi E, Nishinaka T, et al: Diminished vasocon-strictive function caused by long-term nonpulsatile left heart bypass. Artif Organs 23: 722-726, 1999. (Pubitemid 29383313)
29. Nishinaka T, Tatsumi E, Nishimura T, et al: Change in vasocon-strictive function during prolonged nonpulsatile left heart bypass. Artif Organs 25: 371-375, 2001. (Pubitemid 32830466)
30. Lahpor J, Khaghani A, Hetzer R, et al: European results with a continuous-flow ventricular assist device for advanced heart-failure patients. Eur J Cardiothorac Surg 37: 357-361, 2010.
31. Klovaite J, Gustafsson F, Mortensen SA, et al: Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II). J Am Coll Cardiol 53: 2162-2167, 2009.
32. Geisen U, Heilmann C, Beyersdorf F, et al: Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease. Eur J Cardiothorac Surg 33: 679-684, 2008.
33. Haft J, Armstrong W, Dyke DB, et al: Hemodynamic and exercise performance with pulsatile and continuous-flow left ventricular assist devices. Circulation 116(suppl 11): I8-I15, 2007.
34. Crow S, John R, Boyle A, et al: Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. J Thorac Cardiovasc Surg 137: 208-215, 2009.
35. Rose AG, Park SJ: Pathology in patients with ventricular assist devices: A study of 21 autopsies, 24 ventricular apical core biopsies and 24 explanted hearts. Cardiovasc Pathol 14: 19-23, 2005.
36. Vandenberghe S, Segers P, Steendijk P, et al: Modeling ventricular function during cardiac assist: Does time-varying elastance work? ASAIO J 52: 4-8, 2006.
37. Slaughter MS, Bartoli CR, Sobieski MA, et al: Intraoperative eval-uation of the HeartMate II flow estimator. J Heart Lung Transpl 28: 39-43, 2009.