An efficient and versatile synthesis of GlcNAcstatins - Potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

Tetrahedron

Volumn 66, Issue 39, 2010, Pages 7838-7849

  Borodkin, Vladimir S ^a   Van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE INHIBITOR; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; RING CLOSING METATHESIS;

EID: 77956392832     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.07.037     Document Type: Article

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40. Numbering used for the spectra description is based on 1-(1H-imidazol-2-yl)pent-4-ene-1,2,3-triol backbone as shown for compound 16 (Scheme 2).
41. Numbering used for the spectra description is based on the 5-(hydroxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol backbone as shown for compound 18 (Scheme 3).
42. Numbering used for the spectra description is based on 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine-7,8,9-triol backbone as shown for compound 25 (Scheme 5).