Simultaneous inhibition of TXA2and PGI2 synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats

Clinical Science

Volumn 119, Issue 7, 2010, Pages 283-292

  Xavier, Fabiano E ^a   Blanco Rivero, Javier ^b   Sastre, Esther ^b   Badimón, Lina ^c   Balfagón, Gloria ^b  

^a DEPARTAMENTO DE MICOLOGIA   (Brazil)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c Institut Català de Ciències Cardiovasculars   (Spain)

Author keywords

Cirrhosis; Cyclo oxygenase (COX); Nitric oxide; Prostaglandin I2; Thromboxane A2

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLCHOLINE; C REACTIVE PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FUREGRELATE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHO ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROSTACYCLIN; PROSTANOID; SUPEROXIDE; THROMBOXANE A2; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME SYNTHESIS; FEMALE; LIVER CIRRHOSIS; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASODILATATION; WESTERN BLOTTING;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; C-REACTIVE PROTEIN; LIPID METABOLISM; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MESENTERIC ARTERIES; NITRIC OXIDE; ORGAN SIZE; PROSTAGLANDINS; PROSTAGLANDINS A; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; SUPEROXIDES; THROMBOXANE A2; VASODILATION;

EID: 77956378276     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090536     Document Type: Article

References (33)

1. Gatta, A., Bolognesi, M. and Merkel, C. (2008) Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis. Mol. Aspects Med. 29, 119-129
2. Moncada, S. and Higgs, A. (1993) Mechanisms of disease: the l-arginine-nitric oxide pathway. N. Engl. J. Med., 329, 1977-1981
3. Lowenstein, C. J., Dinerman, J. L. and Snyder, S. H. (1994) Nitric oxide: a physiologic messenger. Ann. Intern. Med. 120, 227-237
4. Morales-Ruiz, M., Jiménez, W., Pérez-Sala, D., Ros, J., Leivas, A., Lamas, S., Rivera, F. and Arroyo, V. (1996) Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. Hepatology 24, 1481-1486 (Pubitemid 26399053)
5. Iwakiri, Y. (2007) The molecules: mechanisms of arterial vasodilatation observed in the splanchnic and systemic circulation in portal hypertension. J. Clin. Gastroenterol. 41, S288-S294
6. Gracia-Sancho, J., Laviña, B., Rodríguez-Vilarrupla, A., García-Calderó, H., Bosch, J. and García-Pagán, J. C. (2007) Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. J. Hepatol. 47, 220-227
7. Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S. and Salvemini, D. (2005) Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol. Rev. 57, 217-252
8. Xu, L., Carter, E. P., Ohara, M., Martin, P. Y., Rogachev, B., Morris, K., Cadnapaphornchai, M., Knotek, M. and Schrier, R. W. (2000) Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis. Am. J. Physiol. Renal Physiol. 279, F1110-F1115
9. Fang, H. L., Lai, J. J., Lin, W. L. and Lin, W. C. (2007) A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats. Biosci. Biotechnol. Biochem. 71, 1154-1161
10. Buñag, R. D. (1974) Validation in awake rats of a tail-cuff method for measuring systolic pressure. J. Appl. Physiol. 34, 279-282
11. Corcuera, M. T., Nava, M. P., Angulo, A., Aller, M. A., Gomez, F., Casado, I., Alonso, M. J. and Arias, J. (2005) Remodelación esplácnica secundaria a hipertension portal prehepática experimental. An. Med. Int. 22, 317-322
12. Diéguez, B., Aller, M. A., Nava, M. P., Palma, M. D., Arias, J. L., López, L. and Arias, J. (2002) Chronic portal hypertension in the rat by triple-portal stenosing ligation. J. Invest. Surg. 15, 329-336
13. Mulvany, M. J. and Halpern, W. (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41, 19-26
14. 2 in rat mesenteric resistance arteries: interaction between EP1 and TP receptors. Br. J. Pharmacol. 158, 1787-1795
15. Wiest, R. (2007) Splanchnic and systemic vasodilation: the experimental models. J. Clin. Gastroenterol. 41, S272-S287
16. Sánchez-Patán, F., Anchuelo, R., Aller, M. A., Vara, E., García, C., Nava, M. P. and Arias, J. (2008) Chronic prehepatic portal hypertension in the rat: is it a type of metabolic inflammatory syndrome? Lipids Health Dis. 7, 4
17. Vaughan, R. B., Angus, J. A. and Angus, P. W. (2005) Vasoconstrictor responses are normal but prostanoid-mediated vasodilatation is enhanced in human cirrhotic mesenteric arteries. J. Gastroenterol. Hepatol. 20, 1158-1164
18. Malyshev, E., Tazi, K. A., Moreau, R. and Lebrec, D. (2007) Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats. J. Gastroenterol. Hepatol. 22, 2195-2201
19. Rodriguez-Villarrupla, A., Fernandez, M., Bosch, J. and Garcia-Pagan, J. C. (2007) Current concepts on the pathophysiology of portal hypertension. Ann. Hepatol. 6, 28-36
20. Bomzon, A. and Ljubuncic, P. (2001) Oxidative stress and vascular smooth muscle cell function in liver disease. Pharmacol. Ther. 89, 295-308
21. Gracia-Sancho, J., Laviña, B., Rodríguez-Vilarrupla, A., García-Calderó, H., Fernández, M., Bosch, J. and García-Pagán, J. C. (2008) Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability. Hepatology 47, 1248-1256
22. Aller, M. A., Arias, J. L., Cruz, A. and Arias, J. (2007) Inflammation: a way to understanding the evolution of portal hypertension. Theor. Biol. Med. Model. 4, 44
23. Bucova, M., Bernadic, M. and Buckingham, T. (2008) C-reactive protein, cytokines and inflammation in cardiovascular diseases. Bratisl. Lek. Listy 109, 333-340
24. Georgopoulos, P., Mowat, C., McMillan, D. C., Kingstone, K., Ghosh, S. and Stanley, A. J. (2005) Is portal hypertension associated with protein-losing enteropathy? J. Gastroenterol. Hepatol. 20, 103-107
25. Birney, Y., Redmond, E. M., Sitzmann, J. V. and Cahill, P. A. (2003) Eicosanoids in cirrhosis and portal hypertension. Prostaglandins Other Lipid Mediat. 72, 3-18
26. Xavier, F. E., Aras-López, R., Arroyo-Villa, I., Campo, L. D., Salaices, M., Rossoni, L. V., Ferrer, M. and Balfagón, G. (2008) Aldosterone induces endothelial dysfunction in resistance arteries from normotensive and hypertensive rats by increasing thromboxane A2 and prostacyclin. Br. J. Pharmacol. 154, 1225-1235
27. Yin, J., Leng, X. and Zhu, J. (1995) Plasma prostacyclin (PGI2) levels in peripheral venous, arterial and portal venous blood in cirrhotic patients with portal hypertension and their clinical implication. Zhonghua Wai Ke Za Zhi 33, 563-565
28. Cao, H., Xu, J., Hua, R., Meng, F. B., Qiu, J. F. and Wu, Z. Y. (2006) Expression of cyclooxygenase in hyperdynamic portal hypertensive rats. Hepatobiliary Pancreat. Dis. Int. 5, 252-256
29. Xu, J., Cao, H., Liu, H. and Wu, Z. Y. (2008) Role of nitric oxide synthase and cyclooxygenase in hyperdynamic splanchnic circulation of portal hypertension. Hepatobiliary Pancreat. Dis. Int. 7, 503-508
30. Martorell, A., Blanco-Rivero, J., Aras-López, R., Sagredo, A., Balfagoń, G. and Ferrer, M. (2008) Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholineinduced relaxation in the rat aorta. Cardiovasc. Res. 77, 590-599
31. 2. Clin. Sci. 117, 365-374
32. Tu, C. T., Guo, J. S., Wang, M. and Wang, J. Y. (2007) Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. J. Gastroenterol. Hepatol. 22, 877-884
33. Kim, S. M., Park, K. C., Kim, H. G. and Han, S. J. (2008) Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts. Hepatol. Res. 38, 800-809