Reduced brain white matter integrity in trichotillomania a diffusion tensor imaging study

Archives of General Psychiatry

Volumn 67, Issue 9, 2010, Pages 965-971

  Chamberlain, Samuel R ^a   Hampshire, Adam ^b   Menzies, Lara A ^a   Garyfallidis, Eleftherios ^b   Grant, Jon E ^c,d   Odlaug, Brian L ^c,d   Craig, Kevin ^a   Fineberg, Naomi ^a   Sahakian, Barbara J ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DISEASE SEVERITY; DYSPHORIA; FEMALE; FRACTIONAL ANISOTROPY; HUMAN; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; PATHOPHYSIOLOGY; SCORING SYSTEM; TRICHOTILLOMANIA; WHITE MATTER;

ADULT; ANISOTROPY; ATROPHY; BRAIN; CLUSTER ANALYSIS; DEPRESSIVE DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIFFUSION TENSOR IMAGING; FEMALE; GYRUS CINGULI; HUMANS; MALE; MOTOR CORTEX; NEURAL PATHWAYS; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; TEMPORAL LOBE; TRICHOTILLOMANIA;

EID: 77956368530     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2010.109     Document Type: Article

References (72)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
2. Hallopeau H. Sur un nouveau cas de trichotillomanie. Ann Dermatol Syphiligr (Paris). 1894;5:541-543.
3. Chamberlain SR, Odlaug BL, Boulougouris V, Fineberg NA, Grant JE. Trichotillomania: neurobiology and treatment. Neurosci Biobehav Rev. 2009;33(6):831-842.
4. Greenberg HR, Sarner CA. Trichotillomania: symptom and syndrome. Arch Gen Psychiatry. 1965;12:482-489.
5. Christenson GA, Pyle RL, Mitchell JE. Estimated lifetime prevalence of trichotillomania in college students. J Clin Psychiatry. 1991;52(10):415-417.
6. Odlaug BL, Grant JE. Impulse control disorders in a college sample. Prim Care Companion J Clin Psychiatry. In press.
7. Woods DW, Flessner CA, Franklin ME, Keuthen NJ, Goodwin RD, Stein DJ, Walther MR; Trichotillomania Learning Center-Scientific Advisory Board. The Trichotillomania Impact Project (TIP): exploring phenomenology, functional impairment, and treatment utilization. J Clin Psychiatry. 2006;67(12):1877-1888.
8. Diefenbach GJ, Tolin DF, Hannan S, Crocetto J, Worhunsky P. Trichotillomania: impact on psychosocial functioning and quality of life. Behav Res Ther. 2005;43(7):869-884.
9. Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA. Lifting the veil on trichotillomania. Am J Psychiatry. 2007;164(4):568-574.
10. Odlaug BL, Grant JE. Trichotillomania and pathologic skin picking: clinical comparison with an examination of comorbidity. Ann Clin Psychiatry. 2008;20(2):57-63.
11. Fontenelle LF, Mendlowicz MV, Versiani M. Impulse control disorders in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci. 2005;59(1):30-37.
12. Richter MA, Summerfeldt LJ, Antony MM, Swinson RP. Obsessive-compulsive spectrum conditions in obsessive-compulsive disorder and other anxiety disorders. Depress Anxiety. 2003;18(3):118-127.
13. Lenane MC, Swedo SE, Rapoport JL, Leonard H, Sceery W, Guroff JJ. Rates of obsessive compulsive disorder in first degree relatives of patients with trichotillomania: a research note. J Child Psychol Psychiatry. 1992;33(5):925-933.
14. Kuzma JM, Black DW. Compulsive disorders. Curr Psychiatry Rep. 2004;6(1):58-65.
15. Hollander E, Rosen J. Impulsivity. J Psychopharmacol. 2000;14(2)(suppl 1):S39-S44.
16. Stein DJ, Simeon D, Cohen LJ, Hollander E. Trichotillomania and obsessive-compulsive disorder. J Clin Psychiatry. 1995;56(suppl 4):28-35.
17. Swedo SE, Leonard HL. Trichotillomania: an obsessive compulsive spectrum disorder? Psychiatr Clin North Am. 1992;15(4):777-790.
18. Ferrão YA, Miguel E, Stein DJ. Tourette's syndrome, trichotillomania, and obsessivecompulsive disorder: how closely are they related? Psychiatry Res. 2009;170(1):32-42.
19. Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev. 2008;32(3):525-549.
20. O'Sullivan RL, Rauch SL, Breiter HC, Grachev ID, Baer L, Kennedy DN, Keuthen NJ, Savage CR, Manzo PA, Caviness VS, Jenike MA. Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biol Psychiatry. 1997;42(1):39-45.
21. Singer HS, Reiss AL, Brown JE, Aylward EH, Shih B, Chee E, Harris EL, Reader MJ, Chase GA, Bryan RN, et al. Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. Neurology. 1993;43(5):950-956.
22. Stein DJ, Coetzer R, Lee M, Davids B, Bouwer C. Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. Psychiatry Res. 1997;74(3):177-182.
23. Grachev ID. MRI-based morphometric topographic parcellation of human neocortex in trichotillomania. Psychiatry Clin Neurosci. 1997;51(5):315-321.
24. Keuthen NJ, Makris N, Schlerf JE, Martis B, Savage CR, McMullin K, Seidman LJ, Schmahmann JD, Kennedy DN, Hodge SM, Rauch SL. Evidence for reduced cerebellar volumes in trichotillomania. Biol Psychiatry. 2007;61(3):374-381.
25. Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ. Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study. Br J Psychiatry. 2008;193(3):216-221.
26. Greer JM, Capecchi MR. Hoxb8 is required for normal grooming behavior in mice. Neuron. 2002;33(1):23-34.
27. Garner JP, Weisker SM, Dufour B, Mench JA. Barbering (fur and whisker trimming) by laboratory mice as a model of human trichotillomania and obsessive-compulsive spectrum disorders. Comp Med. 2004;54(2):216-224.
28. Grant JE, Odlaug BL, Potenza MN. Addicted to hair pulling? how an alternate model of trichotillomania may improve treatment outcome. Harv Rev Psychiatry. 2007;15(2):80-85.
29. Novak CE, Keuthen NJ, Stewart SE, Pauls DL. A twin concordance study of trichotillomania. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(7):944-949.
30. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160(4):636-645.
31. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001;13(4):534-546.
32. Basser PJ, Mattiello J, LeBihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B. 1994;103(3):247-254.
33. Basser PJ, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B. 1996;111(3):209-219.
34. Beaulieu C. The basis of anisotropic water diffusion in the nervous system: a technical review. NMR Biomed. 2002;15(7-8):435-455.
35. Suckling J, Davis MH, Ooi C, Wink AM, Fadili J, Salvador R, Welchew D, Sendur L, Maxim V, Bullmore ET. Permutation testing of orthogonal factorial effects in a language-processing experiment using fMRI. Hum Brain Mapp. 2006;27(5):425-433.
36. Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET. White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiatry. 2008;165(10):1308-1315.
37. Suckling J, Bullmore E. Permutation tests for factorially designed neuroimaging experiments. Hum Brain Mapp. 2004;22(3):193-205.
38. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E, Brammer MJ. Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Trans Med Imaging. 1999;18(1):32-42.
39. Picard N, Strick PL. Motor areas of the medial wall: a review of their location and functional activation. Cereb Cortex. 1996;6(3):342-353.
40. Rubia K, Russell T, Overmeyer S, Brammer MJ, Bullmore ET, Sharma T, Simmons A, Williams SC, Giampietro V, Andrew CM, Taylor E. Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go and stop tasks. Neuroimage. 2001;13(2):250-261.
41. Stein DJ, Chamberlain SR, Fineberg N. An A-B-C model of habit disorders: hairpulling, skin-picking, and other stereotypic conditions. CNS Spectr. 2006;11(11):824-827.
42. Stern E, Silbersweig DA, Chee KY, Holmes A, Robertson MM, Trimble M, Frith CD, Frackowiak RS, Dolan RJ. A functional neuroanatomy of tics in Tourette syndrome. Arch Gen Psychiatry. 2000;57(8):741-748.
43. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(suppl 20):22-33.
44. Nelson HE. National Adult Reading Test (NART): Test Manual. Windsor, England: NFER-Nelson; 1982.
45. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382-389.
46. Keuthen NJ, O'Sullivan RL, Ricciardi JN, Shera D, Savage CR, Borgmann AS, Jenike MA, Baer L. The Massachusetts General Hospital (MGH) Hairpulling Scale, 1: development and factor analyses. Psychother Psychosom. 1995;64(3-4):141-145.
47. O'Sullivan RL, Keuthen NJ, Hayday CF, Ricciardi JN, Buttolph ML, Jenike MA, Baer L. The Massachusetts General Hospital (MGH) Hairpulling Scale, 2: reliability and validity. Psychother Psychosom. 1995;64(3-4):146-148.
48. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23(suppl 1):S208-S219.
49. Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry. 2006;163(7):1282-1284.
50. Bates JF, Goldman-Rakic PS. Prefrontal connections of medial motor areas in the rhesus monkey. J Comp Neurol. 1993;336(2):211-228.
51. Luppino G, Matelli M, Camarda R, Rizzolatti G. Corticocortical connections of area F3 (SMA-proper) and area F6 (pre-SMA) in the macaque monkey. J Comp Neurol. 1993;338(1):114-140.
52. Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ. The neural basis of moodcongruent processing biases in depression. Arch Gen Psychiatry. 2002;59(7):597-604.
53. Chambers CD, Bellgrove MA, Stokes MG, Henderson TR, Garavan H, Robertson IH, Morris AP, Mattingley JB. Executive "brake failure" following deactivation of human frontal lobe. J Cogn Neurosci. 2006;18(3):444-455.
54. Chambers CD, Garavan H, Bellgrove MA. Insights into the neural basis of response inhibition from cognitive and clinical neuroscience. Neurosci Biobehav Rev. 2009;33(5):631-646.
55. Rubia K, Smith AB, Brammer MJ, Taylor E. Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage. 2003;20(1):351-358.
56. Aron AR, Fletcher PC, Bullmore ET, Sahakian BJ, Robbins TW. Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nat Neurosci. 2003;6(2):115-116.
57. Hampshire A, Chamberlain SR, Monti MM, Duncan J, Owen AM. The role of the right inferior frontal gyrus: inhibition and attentional control. Neuroimage. 2010;50(3):1313-1319.
58. Stein DJ, Hollander E, Simeon D, Cohen L, Islam MN, Aronowitz B. Neurological soft signs in female trichotillomania patients, obsessive-compulsive disorder patients, and healthy control subjects. J Neuropsychiatry Clin Neurosci. 1994;6(2):184-187.
59. Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ. A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania. Neuropsychologia. 2007;45(4):654-662.
60. Rosen HJ, Wilson MR, Schauer GF, Allison S, Gorno-Tempini ML, Pace-Savitsky C, Kramer JH, Levenson RW, Weiner M, Miller BL. Neuroanatomical correlates of impaired recognition of emotion in dementia. Neuropsychologia. 2006;44(3):365-373.
61. Diefenbach GJ, Tolin DF,Meunier S, Worhunsky P. Emotion regulation and trichotillomania: a comparison of clinical and nonclinical hair pulling. J Behav Ther Exp Psychiatry. 2008;39(1):32-41.
62. Christenson GA, Ristvedt SL, Mackenzie TB. Identification of trichotillomania cue profiles. Behav Res Ther. 1993;31(3):315-320.
63. Diefenbach GJ, Mouton-Odum S, Stanley MA. Affective correlates of trichotillomania. Behav Res Ther. 2002;40(11):1305-1315.
64. Flessner CA, Woods DW, Franklin ME, Keuthen NJ, Piacentini J. Cross-sectional study of women with trichotillomania: a preliminary examination of pulling styles, severity, phenomenology, and functional impact. Child Psychiatry Hum Dev. 2009;40(1):153-167.
65. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997;386(6627):824-827.
66. Johansen-Berg H, Gutman DA, Behrens TE, Matthews PM, Rushworth MF, Katz E, Lozano AM, Mayberg HS. Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cereb Cortex. 2008;18(6):1374-1383.
67. Chamberlain SR, Menzies L. Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential. Expert Rev Neurother. 2009;9(8):1133-1146.
68. Grant JE, Correia S, Brennan-Krohn T. White matter integrity in kleptomania: a pilot study. Psychiatry Res. 2006;147(2-3):233-237.
69. Szeszko PR, Ardekani BA, Ashtari M, Malhotra AK, Robinson DG, Bilder RM, Lim KO. White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Arch Gen Psychiatry. 2005;62(7):782-790.
70. Cannistraro PA, Makris N, Howard JD, Wedig MM, Hodge SM, Wilhelm S, Kennedy DN, Rauch SL. A diffusion tensor imaging study of white matter in obsessivecompulsive disorder. Depress Anxiety. 2007;24(6):440-446.
71. Plessen KJ, Grüner R, Lundervold A, Hirsch JG, Xu D, Bansal R, Hammar A, Lundervold AJ, Wentzel-Larsen T, Lie SA, Gass A, Peterson BS, Hugdahl K. Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome. J Child Psychol Psychiatry. 2006;47(10):1013-1022.
72. Thomalla G, Siebner HR, Jonas M, Bäumer T, Biermann-Ruben K, Hummel F, Gerloff C, Müller-Vahl K, Schnitzler A, Orth M, Münchau A. Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome. Brain. 2009;132(pt 3):765-777.