Role of calpain-mediated p53 truncation in semaphorin 3A-induced axonal growth regulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 31, 2010, Pages 13883-13887

  Qin, Gyu ^a   Liao, Guanghong ^a   Baudry, Michel ^b   Bi, Xiaoning ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

ERK; Hippocampus; p38 MAPK; Phosphorylation; Rho kinase

Indexed keywords

CALPAIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; RHO KINASE; SEMAPHORIN 3A; SMALL INTERFERING RNA; SYNAPTOPHYSIN; CALPAIN 2; M-CALPAIN; MITOGEN ACTIVATED PROTEIN KINASE P38; SEMA3A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GROWTH REGULATION; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; GENE DELETION; GENETICS; GROWTH CONE; METABOLISM; NERVE FIBER; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CALPAIN; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE DELETION; GROWTH CONES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SEMAPHORIN-3A; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77956365523     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008652107     Document Type: Article

References (32)

1. Diefenbach TJ, et al. (2002) Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone. J Cell Biol 158:1207-1217.
2. Lowery LA, Van Vactor D (2009) The trip of the tip: Understanding the growth cone machinery. Nat Rev Mol Cell Biol 10:332-343.
3. Schaefer AW, et al. (2008) Coordination of actin filament and microtubule dynamics during neurite outgrowth. Dev Cell 15:146-162.
4. Witte H, Neukirchen D, Bradke F (2008) Microtubule stabilization specifies initial neuronal polarization. J Cell Biol 180:619-632.
5. Giniger E (2002) How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics. Differentiation 70:385-396.
6. Pak CW, Flynn KC, Bamburg JR (2008) Actin-binding proteins take the reins in growth cones. Nat Rev Neurosci 9:136-147.
7. Gallo G (2006) RhoA-kinase coordinates F-actin organization and myosin II activity during semaphorin-3A-induced axon retraction. J Cell Sci 119:3413-3423.
8. Rex CS, et al. (2009) Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol 186:85-97.
9. Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83: 731-801.
10. Carragher NO, Frame MC (2002) Calpain: a role in cell transformation and migration. Int J Biochem Cell Biol 34:1539-1543.
11. Perrin BJ, Huttenlocher A (2002) Calpain. Int J Biochem Cell Biol 34:722-725.
12. Flevaris P, et al. (2007) A molecular switch that controls cell spreading and retraction. J Cell Biol 179:553-565.
13. Robles E, Huttenlocher A, Gomez TM (2003) Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain. Neuron 38:597-609.
14. Mingorance-Le Meur A, O'Connor TP (2009) Neurite consolidation is an active process requiring constant repression of protrusive activity. EMBO J 28:248-260.
15. To KC, Church J, O'Connor TP (2008) Growth cone collapse stimulated by both calpain- and Rho-mediated pathways. Neuroscience 153:645-653.
16. Fábián Z, Vecsernyés M, Pap M, Szeberényi J (2006) The effects of a mutant p53 protein on the proliferation and differentiation of PC12 rat phaeochromocytoma cells. J Cell Biochem 99:1431-1441.
17. Zhang J, Yan W, Chen X (2006) p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death Differ 13:2118-2128.
18. Di Giovanni S, et al. (2006) The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J 25:4084-4096.
19. Qin Q, et al. (2009) A novel function for p53: regulation of growth cone motility through interaction with Rho kinase. J Neurosci 29:5183-5192.
20. Qin Q, Liao G, Baudry M, Bi X (2010) Cholesterol perturbation in mice results in p53 degradation and axonal pathology through p38 MAPK and Mdm2 activation. PLoS ONE 5:e9999.
21. Kubbutat MH, Vousden KH (1997) Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability. Mol Cell Biol 17:460-468.
22. Pariat M, et al. (1997) Proteolysis by calpains: A possible contribution to degradation of p53. Mol Cell Biol 17:2806-2815.
23. Glading A, et al. (2004) Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. Mol Cell Biol 24:2499-2512.
24. Zadran S, et al. (2010) Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation. J Neurosci 30:1086-1095.
25. Zadran S, et al. (2009) 17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation. Proc Natl Acad Sci USA 106:21936-21941.
26. Shiraha H, Glading A, Chou J, Jia Z, Wells A (2002) Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol 22:2716-2727.
27. Bechara A, et al. (2008) FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J 27:1549-1562.
28. Zhang XF, Schaefer AW, Burnette DT, Schoonderwoert VT, Forscher P (2003) Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow. Neuron 40:931-944.
29. Niapour M, Berger S (2007) Flow cytometric measurement of calpain activity in living cells. Cytometry A 71:475-485.
30. Lohof AM, Quillan M, Dan Y, Poo MM (1992) Asymmetric modulation of cytosolic cAMP activity induces growth cone turning. J Neurosci 12:1253-1261.
31. Ming GL, et al. (1997) cAMP-dependent growth cone guidance by netrin-1. Neuron 19:1225-1235.
32. Hou ST, Jiang SX, Smith RA (2008) Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration. Int Rev Cell Mol Biol 267:125-181.