Risk factors for obesity in childhood survivors of suprasellar brain tumours: A retrospective study

Acta Paediatrica, International Journal of Paediatrics

Volumn 99, Issue 10, 2010, Pages 1522-1526

  Lek, Ngee ^a,b   Prentice, Philippa ^a   Williams, Rachel M ^a,b   Ong, Ken K ^b,c   Burke, Gladstone Austin Amos ^b   Acerini, Carlo L ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

Author keywords

Body mass index; Obesity; Risk factors; Suprasellar brain tumours

Indexed keywords

ANTINEOPLASTIC AGENT;

ADOLESCENT; ARTICLE; ASTROCYTOMA; BODY MASS; BRAIN TUMOR; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN DEFICIENCY; CRANIOPHARYNGIOMA; DIABETES INSIPIDUS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; FOLLOW UP; GLIOMA; GROWTH HORMONE DEFICIENCY; HAZARD RATIO; HUMAN; MALE; OBESITY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROLACTINOMA; RETROSPECTIVE STUDY; SCHOOL CHILD; SEX DIFFERENCE; SUPRASELLAR BRAIN TUMOR; SURVIVAL; TUMOR DIAGNOSIS;

ASTROCYTOMA; BODY MASS INDEX; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; CRANIOPHARYNGIOMA; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; OBESITY; PITUITARY NEOPLASMS; RETROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; SURVIVORS;

EID: 77956357923     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2010.01867.x     Document Type: Article

References (17)

1. Lustig RH, Post SR, Srivannaboon K, Danish RK, Burghen GA, et al. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 2003 88: 611 616.
2. Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, et al. Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab 2004 89: 3298 3305.
3. Adachi M, Tsuchiya T, Muroya K, Asakura Y, Sekido K, Sato H. Prevalence of obesity, hyperlipidemia and insulin resistance in children with suprasellar brain tumours. Clin Pediatr Endocrinol 2007 16: 1 9.
4. Pietila S, Makipernaa A, Sievanen H, Koivisto AM, Wigren T, Lenko HL. Obesity and metabolic changes are common in young childhood brain tumour survivors. Pediatr Blood Cancer 2009 52: 853 859.
5. Pan H, Cole TJ. User's guide to lmsGrowth. MRC 2002-07.
6. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000 320: 1240.
7. NHS Information Centre. Summary of key findings: Craig R, Shelton N, editors. Health survey for England 2007. Available from: URL: http://www.ic.nhs.uk/statistics-and-data-collections/health-and-lifestyles- related-surveys/health-survey-for-england.
8. Magnanti BL, Dorak MT, Parker L, Craft AW, James PW, McNally RJQ. Sex-specific incidence and temporal trends in solid tumours in young people from Northern England, 1968-2005. BMC Cancer 2008 8: 89.
9. Roth C, Wilken B, Hanefeld F, Schroter W, Leonhardt U. Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite. Eur J Endocrinol 1998 138: 89 91.
10. Shaikh MG, Grundy R, Kirk J. Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children. Eur J Endocrinol 2008 159: 791 797.
11. Saad MF, Damani S, Gingerich RL, Riad-Gabriel MG, Khan A, Boyadjian R, et al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 1997 82: 579 584.
12. Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab 1997 82: 1293 1300.
13. Razzouk BI, Rose SR, Hongeng S, Wallace D, Smeltzer MP, Zacher M, et al. Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma. J Clin Oncol 2007 25: 1183 1189.
14. Ahmet A, Blaser S, Stephens D, Guger S, Rutkas JT, Hamilton J. Weight gain in craniopharyngioma-a model for hypothalamic obesity. J Pediatr Endocrinol Metab 2006 19: 121 127.
15. Pinkney J, Wilding J, Williams G, MacFarlane I. Hypothalamic obesity in humans: what do we know and what can be done? Obes Rev 2002 3: 27 34.
16. Lustig RH. Hypothalamic obesity: causes, consequences, treatment. Pediatr Endocrinol Rev 2008 6: 220 227.
17. Lee M, Korner J. Review of physiology, clinical manifestations, and management of hypothalamic obesity in humans. Pituitary 2009 12: 87 95.