ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Marshall, Andrew K ^a   Barrett, Oliver P T ^a   Cullingford, Timothy E ^a   Shanmugasundram, Achchuthan ^a   Sugden, Peter H ^a   Clerk, Angela ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; CELL PROTEIN; ENDOTHELIN 1; EXOENZYME C3; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN ABRA; PROTEIN AREG; PROTEIN EREG; PROTEIN HBEGF; PROTEIN SRF; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION PROFILING; HYPERTROPHY; METABOLISM; PATHOLOGY; TIME;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; ENDOTHELIN-1; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPERTROPHY; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; RATS; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 77956312760     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010027     Document Type: Article

References (28)

1. Dorn GW, II, Robbins J, Sugden PH (2003) Phenotyping hypertrophy: eschew obfuscation. Circ Res 92: 1171-1175.
2. Dorn GW, 2nd (2007) The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49: 962-970.
3. Eghbali M, Deva R, Alioua A, Minosyan TY, Ruan H, et al. (2005) Molecular and functional signature of heart hypertrophy during pregnancy. Circ Res 96: 1208-1216.
4. Allen DL, Harrison BC, Maass A, Bell ML, Byrnes WC, et al. (2001) Cardiac and skeletal muscle adaptation to voluntary wheel running in the mouse. J Appl Physiol 90: 1900-1908.
5. Opie LH, Commerford PJ, Gersh BJ, Pfeffer MA (2006) Controversies in ventricular remodelling. Lancet 367: 356-367.
6. Clerk A, Cullingford TE, Fuller SJ, Giraldo A, Markou T, et al. (2007) Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. J Cell Physiol 212: 311-322.
7. Sugden PH (2003) An overview of endothelin signaling in the cardiac myocyte. J Mol Cell Cardiol 35: 871-886.
8. Brown JH, Del Re DP, Sussman MA (2006) The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res 98: 730-742.
9. Pipes GC, Creemers EE, Olson EN (2006) The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev 20: 1545-1556.
10. Cullingford TE, Markou T, Fuller SJ, Giraldo A, Pikkarainen S, et al. (2008) Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes. Genome Biol 9: R32.
11. Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105.
12. Kennedy RA, Kemp TJ, Sugden PH, Clerk A (2006) Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes. J Mol Cell Cardiol 41: 236-247.
13. Vogelsgesang M, Pautsch A, Aktories K (2007) C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins. Naunyn Schmiedebergs Arch Pharmacol 374: 347-360.
14. Dean JL, Sully G, Clark AR, Saklatvala J (2004) The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathwaymediated mRNA stabilisation. Cell Signal 16: 1113-1121.
15. Bromann PA, Korkaya H, Webb CP, Miller J, Calvin TL, et al. (2005) Plateletderived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts. J Biol Chem 280: 10253-10263.
16. Amit I, Citri A, Shay T, Lu Y, Katz M, et al. (2007) A module of negative feedback regulators defines growth factor signaling. Nat Genet 39: 503-512.
17. Sen-Banerjee S, Mir S, Lin Z, Hamik A, Atkins GB, et al. (2005) Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation 112: 720-726.
18. Cicha I, Goppelt-Struebe M, Muehlich S, Yilmaz A, Raaz D, et al. (2008) Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress. Atherosclerosis 196: 136-145.
19. Del Re DP, Miyamoto S, Brown JH (2007) RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem 282: 8069-8078.
20. Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, et al. (2008) Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J 22: 4011-4021.
21. Liao JK, Laufs U (2005) Pleitropic effects of statins. Annu Rev Pharmacol Toxicol 45: 89-118.
22. Fuller SJ, Sivarajah K, Sugden PH (2008) ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium. J Mol Cell Cardiol 44: 831-854.
23. Fischer P, Hilfiker-Kleiner D (2008) Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects. Br J Pharmacol 153: S414-S427.
24. Moustakas A, Heldin CH (2009) The regulation of TGFbeta signal transduction. Development 136: 3699-3714.
25. Clerk A, Pham FH, Fuller SJ, Sahai E, Aktories K, et al. (2001) Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein, Rac1. Mol Cell Biol 21: 1173-1184.
26. Clerk A, Gillespie-Brown J, Fuller SJ, Sugden PH (1996) Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogenactivated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response. Biochem J 317: 109-118.
27. Clerk A, Michael A, Sugden PH (1998) Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G proteincoupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy? J Cell Biol 142: 523-535.
28. Bogoyevitch MA, Ketterman AJ, Sugden PH (1995) Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular signalregulated protein kinases in cultured ventricular myocytes. J Biol Chem 270: 29710-29717.