Models of carcinogenesis: An overview

Carcinogenesis

Volumn 31, Issue 10, 2010, Pages 1703-1709

  Vineis, Paolo ^a   Schatzkin, Arthur ^b   Potter, John D ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; ERLOTINIB; FOLIC ACID; GEFITINIB;

ANTIANDROGEN THERAPY; CANCER MODEL; CARCINOGENESIS; CELL DEATH; CELL SELECTION; CHROMOSOME ABERRATION; CHROMOSOME NUMBER; COLON CANCER; DIET SUPPLEMENTATION; DNA METHYLATION; EPIGENETICS; EPITHELIUM; EVOLUTION; EXTRACELLULAR MATRIX; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HYPERINSULINEMIA; INFLAMMATION; INSULIN RESISTANCE; IONIZING RADIATION; LUNG CANCER; MATHEMATICAL MODEL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; REVIEW; SMOKING; STROMA; VASCULAR RESISTANCE; ANIMAL; DRUG RESISTANCE; GENETIC EPIGENESIS; GENETIC SELECTION; GENOMIC INSTABILITY; MUTATION; NEOPLASMS; THEORETICAL MODEL;

ANIMALS; DRUG RESISTANCE, NEOPLASM; EPIGENESIS, GENETIC; GENOMIC INSTABILITY; HUMANS; MODELS, THEORETICAL; MUTATION; NEOPLASMS; SELECTION, GENETIC;

EID: 77956290444     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq087     Document Type: Review

References (82)

1. Hanahan, D. et al. (2000) The hallmarks of cancer. Cell, 100, 57-70.
2. Armitage, P. et al. (1954) The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer, 8, 1-12.
3. Doll, R. et al. (1978) Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J. Epidemiol. Community Health, 32, 303-313.
4. IARC. (1977) IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances. IARC Monogr. Eval. Carcinog. Risk Chem. Man, 13, 1-255.
5. McCann, J. et al. (1976) Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc. Natl Acad. Sci. USA, 73, 950-954.
6. Parada, L.F. et al. (1982) Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature, 297, 474-478.
7. Phillips, D.H. (2005) DNA adducts as markers of exposure and risk. Mutat. Res., 577, 284-292.
8. Slaga, T.J. (1984) Multistage skin carcinogenesis: a useful model for the study of the chemoprevention of cancer. Acta Pharmacol. Toxicol. (Copenh.), 55 (suppl. 2), 107-124.
9. Knudson, A. (2005) Retinoblastoma: teacher of cancer biology and medicine. PLoS Med., 2, e349.
10. Lohmann, D.R. (1999) RB1 gene mutations in retinoblastoma. Hum. Mutat., 14, 283-288.
11. Cairns, J. (1984) Familial cancers. Nature, 307, 116.
12. Duesberg, P. et al. (2006) Aneuploidy and cancer: from correlation to causation. Contrib. Microbiol., 13, 16-44.
13. Guimaraes, D.P. et al. (2002) TP53: a key gene in human cancer. Biochimie, 84, 83-93.
14. Norppa, H. et al. (2006) Chromosomal aberrations and SCEs as biomarkers of cancer risk. Mutat. Res., 600, 37-45.
15. Rowley, P.T. (2005) Inherited susceptibility to colorectal cancer. Annu. Rev. Med., 56, 539-554.
16. Cairns, J. (1980) The Leeuwenhoek Lecture, 1978. Bacteria as proper subjects for cancer research. Proc. R. Soc. Lond. B Biol. Sci., 208, 121-133.
17. Loeb, L.A. (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res., 51, 3075-3079.
18. Fearon, E.R. et al. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
19. Greaves, M.F. (2004) Biological models for leukaemia and lymphoma. IARC Sci. Publ., 351-372.
20. Greaves, M. (2007) Darwinian medicine: a case for cancer. Nat. Rev. Cancer, 7, 213-221.
21. Nowak, M. (2006) Evolutionary Dynamics: Exploring the Equations of Life. Harvard University Press, Cambridge.
22. Bissell, M.J. et al. (1999) Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res., 59, 1757s-1763s, discussion 1763s-1764s.
23. Laconi, E. et al. (2008) The microenvironments of multistage carcinogenesis. Semin. Cancer Biol., 18, 322-329.
24. Potter, J.D. (2001) Morphostats: a missing concept in cancer biology. Cancer Epidemiol. Biomarkers Prev., 10, 161-170.
25. Potter, J.D. (2007) Morphogens, morphostats, microarchitecture and malignancy. Nat. Rev. Cancer, 7, 464-474.
26. van den Brink, G.R. et al. (2007) The morphogenetic code and colon cancer development. Cancer Cell, 11, 109-117.
27. Schetter, A.J. et al. (2010) Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis, 31, 37-49.
28. Knudson, A.G.Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA, 68, 820-823.
29. Moolgavkar, S. et al. (1979) Two-event models for carcinogenesis: incidence curves for childhood and adult tumors. Math. Biosci., 47, 55-77.
30. Pierce, G.B. (1977) Relationship between differentiation and carcinogenesis. J. Toxicol. Environ. Health, 2, 1335-1342.
31. Brown, C.C. et al. (1987) Use of multistage models to infer stage affected by carcinogenic exposure: example of lung cancer and cigarette smoking. J. Chronic Dis., 40 (suppl. 2), 171S-179S.
32. Schollnberger, H. et al. (2006) Analysis of epidemiological cohort data on smoking effects and lung cancer with a multi-stage cancer model. Carcinogenesis, 27, 1432-1444.
33. Peto, R. et al. (2000) Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ, 321, 323-329.
34. Beerenwinkel, N. et al. (2007) Genetic progression and the waiting time to cancer. PLoS Comput. Biol., 3, e225.
35. de Gerlache, J. et al. (1984) Comparison of different models of rat liver carcinogenesis: conclusions from a systemic analysis. Toxicol. Pathol., 12, 374-382.
36. Barbason, H. et al. (1977) Variations of liver cell control during diethylnitrosamine carcinogenesis. Eur. J. Cancer, 13, 13-18.
37. Farber, E. (1973) Carcinogenesis-cellular evolution as a unifying thread: Presidential address. Cancer Res., 33, 2537-2550.
38. Lans, M. et al. (1983) Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis. Carcinogenesis, 4, 141-144.
39. Castelain, P. et al. (1989) Cell population kinetics and ploidy rate of early focal lesions during hepatocarcinogenesis in the rat. Br. J. Cancer, 60, 827-833.
40. Nowak, M.A. et al. (2003) The linear process of somatic evolution. Proc. Natl Acad. Sci. USA, 100, 14966-14969.
41. Fisher, R. (1930) The Genetical Theory of Natural Selection. Oxford University Press, Oxford.
42. Michod, R. (2000) Darwinian Dynamics. Princeton University Press, Princeton, NJ.
43. Michod, R.E. et al. (2006) Life-history evolution and the origin of multicellularity. J. Theor. Biol., 239, 257-272.
44. Finette, B.A. et al. (2001) Accumulation of somatic mutations in proliferating T cell clones from children treated for leukemia. Leukemia, 15, 1898-1905.
45. Potter, J. (1996) Chemoprevention: pharmacology or biology? Oncology, 10, 1487-1488.
46. Bohnsack, B.L. et al. (2004) Nutrient regulation of cell cycle progression. Annu. Rev. Nutr., 24, 433-453.
47. Watson, W.H. et al. (2000) Diet and apoptosis. Annu. Rev. Nutr., 20, 485-505.
48. Adams, K.F. et al. (2005) Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial. Am. J. Clin. Nutr., 82, 620-626.
49. Cole, B.F. et al. (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA, 297, 2351-2359.
50. Ulrich, C.M. et al. (2007) Folate and cancer-timing is everything. JAMA, 297, 2408-2409.
51. Hoffbrand, A.V. et al. (2001) The history of folic acid. Br. J. Haematol., 113, 579-589.
52. Giovannucci, E. (2007) Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am. J. Clin. Nutr., 86, s836-s842.
53. McKeown-Eyssen, G. (1994) Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol. Biomarkers Prev., 3, 687-695.
54. Pollak, M. (2008) Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer, 8, 915-928.
55. Jensen, M. et al. (2009) Molecular mechanisms of differential intracellular signaling from the insulin receptor. Vitam. Horm., 80, 51-75.
56. Muoio, D.M. et al. (2008) Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat. Rev. Mol. Cell Biol., 9, 193-205.
57. Musi, N. et al. (2006) Insulin resistance and improvements in signal transduction. Endocrine, 29, 73-80.
58. Borisov, N. et al. (2009) Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol. Syst. Biol., 5, 256.
59. Oliver, S.E. et al. (2001) International trends in prostate-cancer mortality in the "PSA ERA". Int. J. Cancer, 92, 893-8.
60. Thompson, I.M. et al. (2003) The influence of finasteride on the development of prostate cancer. N. Engl. J. Med., 349, 215-224.
61. Redman, M.W. et al. (2008) Finasteride does not increase the risk of highgrade prostate cancer: a bias-adjusted modeling approach. Cancer Prev. Res. (Phila Pa), 1, 174-181.
62. Platz, E.A. (2007) Epidemiologic musing on statin drugs in the prevention of advanced prostate cancer. Cancer Epidemiol. Biomarkers Prev., 16, 2175-2180.
63. Pao, W. et al. (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med, 2, e73.
64. Duesberg, P. et al. (2000) Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc. Natl Acad. Sci. USA, 97, 14295-14300.
65. Breivik, J. et al. (1999) Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis. Semin. Cancer Biol., 9, 245-254.
66. Saletta, F. et al. (2007) Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells. Cancer Res., 67, 7088-7094.
67. Bardelli, A. et al. (2001) Carcinogen-specific induction of genetic instability. Proc. Natl Acad. Sci. USA, 98, 5770-5775.
68. Chong, S. et al. (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat. Genet., 39, 614-622.
69. Esteller, M. (2008) Epigenetics in cancer. N. Engl. J. Med., 358, 1148-1159.
70. Waterland, R.A. et al. (2003) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell. Biol., 23, 5293-5300.
71. Belinsky, S.A. et al. (2006) Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res., 66, 3338-3344.
72. Reamon-Buettner, S.M. et al. (2008) The next innovation cycle in toxicogenomics: environmental epigenetics. Mutat. Res., 659, 158-165.
73. Baker, S.G. et al. (2009) Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats. BMC Cancer, 9, 89.
74. Sonnenschein, C. et al. (1999) The Society of Cells: Cancer and Control of Cell Proliferation. Springer Verlag, New York.
75. Prehn, R.T. (1994) Cancers beget mutations versus mutations beget cancers. Cancer Res., 54, 5296-300.
76. Bizzarri, M. et al. (2008) Beyond the oncogene paradigm: understanding complexity in cancerogenesis. Acta Biotheor., 56, 173-196.
77. Laforge, B. et al. (2005) Modeling embryogenesis and cancer: an approach based on an equilibrium between the autostabilization of stochastic gene expression and the interdependence of cells for proliferation. Prog. Biophys. Mol. Biol., 89, 93-120.
78. Williams, D. (2008) Radiation carcinogenesis: lessons from Chernobyl. Oncogene, 27 (suppl. 2), S9-S18.
79. Little, M.P. et al. (2002) Modelling lung tumour risk in radon-exposed uranium miners using generalizations of the two-mutation model of Moolgavkar, Venzon and Knudson. Int. J. Radiat. Biol., 78, 49-68.
80. Barcellos-Hoff, M.H. et al. (2009) Radiation carcinogenesis in context: how do irradiated tissues become tumors? Health Phys., 97, 446-457.
81. Little, M.P. et al. (2008) Systems biological and mechanistic modelling of radiation-induced cancer. Radiat. Environ. Biophys., 47, 39-47.
82. Fox, C. et al. (2006) Evolutionary Genetics. Concepts and Case Studies. Oxford University Press, Oxford.