Nutrient regulation of cell cycle progression

Annual Review of Nutrition

Volumn 24, Issue , 2004, Pages 433-453

  Bohnsack, Brenda L ^a,b   Hirschi, Karen K ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

DNA synthesis; Iron; Proliferation; Vitamin A; Vitamin D

Indexed keywords

20 EPI 22 ETHOXY 24A,26A,27A TRIHOMO 9,10 SECOCHOLESTA 5,7,10(19) TRIEN 23 YNE 1ALPHA,3BETA,25 TRIOL; CALCITRIOL; CELL CYCLE PROTEIN; CYANOCOBALAMIN; FOLIC ACID; GLUCOSE; IRON; LEXACALCITOL; RETINOIC ACID; RETINOL; SEOCALCITOL; VITAMIN D; VITAMIN D DERIVATIVE; ZINC;

ANTINEOPLASTIC ACTIVITY; CANCER PREVENTION; CARCINOGENESIS; CELL ACTIVITY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIVISION; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; DEVELOPMENT; DISEASE COURSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENERGY RESOURCE; ENVIRONMENTAL FACTOR; HUMAN; METABOLISM; MITOSIS; NONHUMAN; NUTRIENT; PREVALENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

CELL CYCLE; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DIET; DISEASE PROGRESSION; FOLIC ACID; GLUCOSE; HUMANS; IRON; SIGNAL TRANSDUCTION; VITAMIN A; VITAMIN B 12; VITAMIN D; ZINC;

EID: 3142723133     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.23.011702.073203     Document Type: Review

References (108)

1. 3. Proc. Natl. Acad. Sci. USA 78:4990-94
2. Abraham NG, Kushida T, McClung J, Weiss M, Quan S, et al. 2003. Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ. Res. 93:507-14
3. Alcantara O, Kalidas M, Baltathakis I, Boldt DH. 2001. Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron. Exp. Hematol. 29: 1060-69
4. Alisi A, Leoni S, Placentani A, Devirgillis LC. 2003. Retinoic acid modulates the cell cycle in fetal rat hepatocytes and HepG2 cells by regulating cyclin-CDK activities. Liver Int. 23:179-86
5. Arany I, Whitehead WE, Ember IA, Tyring SK. 2003. Dose-dependent activation of p21WAF1 transcription by all-trans-acid in cervical squamous carcinoma cells. Anticancer Res. 23:495-97
6. Ashcroft M, Taya Y, Vousden KH. 2000. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20:3224-33
7. Awazu M, Omori S, Ishikura K, Hida M, Fujita H. 2003. The lack of cyclin kinase inhibitor p27Kip1 ameliorates progression of diabetic nephropathy. J. Am. Soc. Nephrol. 14:699-708
8. Axel DI, Frigge A, Dittmann J, Runge H, Spyridopoulos I, et al. 2001. All-trans retinoic acid regulates proliferation, migration, differentiation, and extracellular matrix turnover of human arterial smooth muscle cells. Cardiovasc. Res. 49:851-62
9. Boyle J, Langenfeld J, Lonardo F, Sekula D, Reczek P, et al. 1999. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J. Natl. Cancer Inst. 91:373-79
10. Carr AM. 2000. Piecing together the p53 puzzle. Science 287:1765-66
11. Chatterjee M. 2001. Vitamin D and genomic stability. Mutat. Res. 475:69-88
12. Chen TH, Chang TC, Kang JO, Choudhary B, Makita T, et al. 2002. Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev. Biol. 250:198-207
13. Clagett-Dame M, DeLuca HF. 2002. The role of vitamin A in mammalian reproduction and embryonic development. Annu. Rev. Nutr. 22:347-31
14. Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC. 1978. Terminal differentiation of human promyelocytic leukemia HL-60 cells induced by dimethyl sulfoxide and other polar compounds. Proc. Natl. Acad. Sci. USA 75:2458-62
15. Conejo R, de Alvaro C, Benito M, Cuadrado A, Lorenzo M. 2002. Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-κB through an AKT/P70S6K/p38-MAPK pathway. Oncogene 21:3739-53
16. Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, et al. 2002. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: implications for diabetic nephropathy. PNAS 99:8301-5
17. Dezza L, Cazzola M, Danova M, Carlo-Stella C, Bergamaschi G, et al. 1989. Effects of desferrioxamine on normal and leukemic human hematopoietic cell growth: in vitro and in vivo studies. Leukemia 3:104-7
18. Dimberg A, Bahram F, Karlberg I, Larsson L-G, Nilsson K, Oberg F. 2002. Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27Kip1. Blood 99:2199-206
19. Dimberg A, Karlberg I, Nilsson K, Oberg F. 2003. Ser727/Tyr701- phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells. Blood 102:254-61
20. Donfrancesco A, Deb G, De Sio L, Cozza R, Castellano A. 1996. Role of desferrioxamine in tumor therapy. Acta Haematol. 95:66-69
21. Donfrancesco A, Deb G, Dominici C, Angioni A, Caniglia M, et al. 1992. Deferoxamine, cyclophosphamide, etoposide, carboplatin, and thiotepa (D-CECat): a new cytoreductave chelation-chemotherapy regimen in patients with advanced neuroblastoma. Am. J. Clin. Oncol. 15:319-22
22. Donfrancesco A, Deb G, Dominici C, Pileggi D, Castello MA, Helson L. 1990. Effects of a single course of deferoxamine in neuroblastoma patients. Cancer Res. 50:4929-30
23. Finch RA, Liu MC, Cory JG, Cory AH, Sartorelli AC. 1999. Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv. Enzyme Regul. 39:3-12
24. Finch RA, Liu MC, Grill SP, Rose R, Loomis KM, et al. 2000. Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): a potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. Biochem. Pharmacol. 59:983-91
25. 3 receptor-mediating cell cycle arrest and differentiation. J. Nutr. 129:581-868
26. Friso S, Choi S-W. 2002. Gene-nutrient interactions and DNA methylation. J. Nutr. 132:2382-878
27. Friso S, Choi S-W, Girelli D, Mason JB, Dolnikowski GG, et al. 2002. A common mutation in the 5,10-methyl-enetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. PNAS 99:5606-11
28. Gao J, Richardson DR. 2001. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents: IV. The mechanisms involved in inhibiting cell-cycle progression. Blood 98:842-50
29. 3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor α. J. Biol. Chem. 272:8997-9001
30. Grande A, Montanari M, Tagliafico E, Manfredini R, Marani TZ, et al. 2002. Physiological levels of 1α,25-dihydroxyvitamin D3 induce the monocytic commitment of CD34+ hematopoietic progenitors. J. Leukoc. Biol. 71:641-51
31. Gudas LJ, Sporn MB, Roberts AB. 1994. Cellular biology and biochemistry of retinoids. In The Retinoids: Biology, Chemistry, and Medicine, ed. MB Sporn, AB Roberts, DS Goodman, pp. 443-520. New York: Raven
32. 3 on the proliferation of human neuroblastoma: role of cell cycle regulators and the Myc-Id2 pathway. Biochem. Pharmacol. 65:1943-55
33. 3: implications in cell growth and differentiation. Endocr. Rev. 23:763-86
34. Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. 2002. Hypoxia links ATR and p53 through replication arrest. Mol. Cell. Biol. 22:1834-43
35. Hann HW, Stahlhut MW, Rubin R, Maddrey WC. 1992. Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice. Cancer 70:2051-56
36. Harrison PM, Arosio P. 1997. The ferritins: molecular properties, iron storage function and cellular regulation. Biochem. Biophys. Acta 1275:161-203
37. Hartwell LH, Kastan MB. 1994. Cell cycle control and cancer. Science 266:1821-28
38. 3 inhibits normal human keratinocyte growth by increasing transforming growth factor β2 release. Biochem. Biophys. Res. Commun. 229:618-23
39. Hoffman B, Sharma K, Zhu Y, Ziyadeh FN. 1998. Transcriptional activation of transforming growth factor-β1 in mesangial cell culture by high glucose concentration. Kidney Int. 54:1107-16
40. Hong WK, Itri LM. 1994. Retinoids and human cancer. In The Retinoids: Biology, Chemistry, and Medicine, ed. MB Sporn, AB Roberts, DS Goodman, pp. 597-630. New York: Raven
41. 3. Endocrinology 113:1950-57
42. Imai T, Jiang M, Kastner P, Chambon P, Metzger D. 2001. Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proc. Natl. Acad. Sci. USA 98:4581-86
43. Itin PH, Pittelkow MR, Kumar R. 1994. Effects of vitamin D metabolites on proliferation and differentiation of cultured human epidermal keratinocytes grown in serum-free or defined culture medium. Endocrinology 135:1793-98
44. Jetten AM, Brody AR, Deas MA, Hook GE, Rearick JI, Thacher SM. 1987. Retinoic acid and substratum regulate the differentiation of rabbit tracheal epithelial cells into squamous and secretory phenotype. Morphological and biochemical characterization. Lab. Invest. 56:654-64
45. Johnson CS, Hershberger PA, Bernardi RJ, McGuire TF, Trump DL. 2002. Vitamin D receptor: a potential target for intervention. Urology 60:123-31
46. Johnson DG, Walker CL. 1999. Cyclins and cell cycle checkpoints. Annu. Rev. Pharmacol. Toxicol. 39:295-312
47. Kastner P, Mark M, Leid M, Gansmuller A, Chin W, et al. 1996. Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 10:80-92
48. Kawashima K, Yamakawa K, Takahashi W, Takizawa S, Yin P, et al. 2002. The estrogen-occupied estrogen receptor functions as a negative regulator to inhibit cell proliferation induced by insulin/IGF-1: a cell context-specific antimitogenic action of estradiol on rat lactotrophs in culture. Endocrinology 143:2750-58
49. Kim YI, Pogribny IP, Basnekiau AG, Miller JW, Sellers J, et al. 1997. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am. J. Clin. Nutr. 65:46-52
50. Kim YI, Pogribny IP, Salomon RN, Choi S-W, Smith DE, et al. 1996. Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation of dietary folate. Am. J. Pathol. 149:1129-37
51. Kosaka C, Sasaguri T, Komiyama Y, Takahashi H. 2001. All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases. Hypertens. Res. 24:579-88
52. Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, et al. 1998. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 279:863-67
53. Kulp KS, Green SL, Vulliet PR. 1996. Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclinD/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells. Exp. Cell Res. 229:60-68
54. Lahfa M, Morowietz U, Koenig M, Simon JC. 2003. Calcitriol ointment and clobetasol propionate cream: a new regimen for the treatment of plaque psoriasis. Eur. J. Dermatol. 13:261-65
55. Lai L, Bohnsack BL, Niederreither K, Hirschi KK. 2003. Retinoic acid regulates endothelial cell proliferation during vasculogenesis. Development 130:6465-74
56. Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E. 1997. Post-translational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism. PNAS 94:12070-74
57. Langenfeld J, Lonardo F, Kiyokawa H, Passalaris T, Ahu MJ, et al. 1996. Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation. Oncogene 13:1983-90
58. 3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production. Biochem. Biophys. Res. Commun. 176:1020-26
59. Le NTV, Richardson DR. 2002. The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochem. Biophys. Acta 1603:31-46
60. Le NTV, Richardson DR. 2003. Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1, but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation. Carcinogenesis 24:1045-58
61. Lee TH, Chang HC, Chuang LY, Hung WC. 2003. Involvement of PKA and Sp1 in the induction of p21(Kip1) by tamoxifen. Biochem. Pharmacol. 66:371-77
62. Lin HM, Pestell RG, Raz A, Kim HR. 2002. Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells. Oncogene 21:8001-10
63. Liu M, lavarone A, Freedman L. 1996. Transcriptional activation of the human p21WAF1/CIP1 gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. J. Biol. Chem. 271:31723-28
64. McGinn S, Poronnik P, King M, Gallery EDM, Pollock CA. 2003. High glucose and endothelial cell growth: novel effects independent of autocrine IGF-β1 and hyperosmolarity. Am. J. Physiol. Cell Physiol. 284:C1374-86
65. McGinn S, Saad S, Poronnik P, Pollock CA. 2003. High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase. Am. J. Physiol. Endocrinol. Metab. 285:E708-17
66. 2 in vitro. Am. J. Pathol. 138:37-51
67. Moore EC, Hurlbert RB. 1989. The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY). In Inhibitors of Ribonucleoside Diphosphate Reductase Activity, ed. JG Cory, AH Cory, pp. 165-201. Oxford: Pergamon
68. Morgan EH. 1981. Transferrin: biochemistry, physiology and clinical significance. Mol. Aspects Med. 4:1-123
69. Muller G, Behrens J, Nussbaumer U, Bohlen P, Birchmeier W. 1987. Inhibitory action of transforming growth factor β on endothelial cells. PNAS 84:5600-4
70. Nagata D, Suzuki E, Nishimatsu H, Satonaka H, Goto A, et al. 2001. Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells. J. Biol. Chem. 276:662-69
71. Newcomb LL, Diderich JA, Slattery MG, Heideman W. 2003. Glucose regulation of Saccharomyces cerevisiae cell cycle genes. Eukaryot. Cell 2:143-49
72. Niederreither K, Subbarayan V, Dolle P, Chambon P. 1999. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat. Genet. 21:444-48
73. Nyholm S, Thelander L, Graslund A. 1993. Reduction and loss of the iron centre in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea. Biochemistry 32:11569-74
74. Ohllson I, Gullberg U, Ivhed I, Nilsson K. 1983. Induction of differentiation of the human histiocytic lymphoma cell line U-937 by 1,25 dihydroxyvitamin D3. Cancer Res. 43:5862-70
75. Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, et al. 2002. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-α and PPAR expression. Biochem. Biophys. Acta 1592:107-16
76. Pakala R, Benedict CR. 2000. RAR gamma agonists inhibit proliferation of vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 35:302-8
77. Pogribny IP, Basnakian AG, Miller BJ, Lopatina NG, Poirier LA, James SJ. 1995. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl deficient rats. Cancer Res. 55:1894-901
78. Ponka P, Beaumont C, Richardson DR. 1998. Function and regulation of transferrin and ferritin. Semin. Hematol. 35:35-54
79. Rearick JI, Jetten AM. 1989. Effect of substratum and retinoids upon the mucosecretory differentiation of airway epithelial cells in vitro. Environ. Health Persp. 80:229-37
80. Richardson DR. 2002. Iron chelators as therapeutic agents for the treatment of cancer. Crit. Rev. Oncol. Hematol. 42:267-81
81. Richardson DR, Ponka P. 1997. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochem. Biophys. Acta 1331:1-40
82. Ross SA, McCaffery PJ, Drager UC, De Luca LM. 2000. Retinoids in embryonal development. Physiol. Rev. 80:1021-54
83. Rots NY, Iavarone A, Bromleigh V, Freedman LP. 1999. Induced differentiation of U937 cells by 1,25-dihydroxyvitamin D3 involves cell cycle arrest in G1 that is preceded by a transient proliferative burst and an increase in cyclin expression. Blood 93:2721-29
84. Rots NY, Liu M, Anderson EC, Freedman LP. 1998. A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells. Mol. Cell. Biol. 18:1911-18
85. 3 analogs mediated by p27, CDK2, cyclin E, and the reginoblastoma protein. Biochem. Pharmacol. 66:495-504
86. Schneider RA, Hu D, Rubenstein JLR, Maden M, Helms JA. 2001. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development 128:2755-67
87. Segaert S, Degreef H, Bouillon R. 2000. Vitamin D receptor expression is linked to cell cycle control in normal human keratinocytes. Biochem. Biophys. Res. Commun. 279:89-94
88. Sherr CJ, Roberts JM. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501-12
89. Simonart T, Degraef C, Andrei G, Mosselmans R, Hermans P, et al. 2000. Iron chelators inhibit the growth and induce the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors. J. Invest. Dermatol. 115:893-900
90. Singh G, Lakkis CL, Lauciraca R, Epner DE. 1999. Regulation of prostate cancer cell division by glucose. J. Cell. Physiol. 180:431-38
91. Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ, Dmitrovsky E. 1999. Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. J. Biol. Chem. 274:22013-18
92. Stuckmann I, Evans S, Lassar AB. 2003. Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation. Dev. Biol. 255:334-49
93. Sun Y, Bian J, Wang Y, Jacobs C. 1997. Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound. Oncogene 14:385-93
94. Suzui M, Masuda M, Lim JTE, Albanese C, Pestell RG, Weinstein IB. 2002. Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. Cancer Res. 62:3997-4006
95. Swami S, Raghavachari N, Muller UR, Bao YP, Feldman D. 2003. Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray. Breast Cancer Res. Treat. 80:49-62
96. Takeda E, Weber G. 1981. Role of ribonucleotide reductase in expression in the neoplastic program. Life Sci. 28:1007-14
97. Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, et al. 1999. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. PNAS 96:2907-12
98. Uhoda I, Quatresooz P, Hermanns-Le T, Pierard-Franchimont C, Arrese JE, Pierard GE. 2003. Histometric assessment of psoriatic plaques treated by vitamin D(3) derivatives. Dermatology 206:366-69
99. Walters M. 1992. Newly identified actions of the vitamin D endocrine system. Endocr. Rev. 13:719-64
100. Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, et al. 2000. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol. Cell. Biol. 20:4436-44
101. Wang F, Elliott RL, Head JF. 1999. Inhibitor effect of deferoxamine mesylate and low iron diet on the 13762NF rat mammary adenocarcinoma. Anticancer Res. 19:445-50
102. Witt L, Yap T, Blakley RL. 1978. Regulation of ribonucleotide reductase activity and its possible exploitation in chemotherapy. Adv. Enzyme Regul. 17:157-71
103. Wolbach SB, Howe PR. 1925. Tissue changes following deprivation of fat-soluble vitamin A. J. Exp. Med. 42:753-77
104. Wolf G. 2000. Cell cycle regulation in diabetic nephropathy. Kidney Int. Suppl. 77:859-66
105. Kip1, an inhibitor of cyclin-dependent kinases. Am. J. Pathol. 158:1091-100
106. Wolf G, Ziyadeh FN. 1999. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int. Suppl. 56:393-405
107. Yuza Y, Agawa M, Matsuzaki M, Yamada H, Urashima M. 2003. Gene and protein expression profiling during differentiation of neuroblastoma cells triggered by 13-cis retinoic acid. J. Pediatr. Hematol. Oncol. 25:715-20
108. Zile MH. 2001. Function of vitamin A in vertebrate embryonic development. J. Nutr. 131:705-8