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Volumn 31, Issue 9, 2010, Pages 1694-1701

Genomic and gene expression signatures of radiation in medulloblastomas after low-dose irradiation in Ptch1 heterozygous mice

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PROTEIN PATCHED 1;

EID: 77956286589     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq145     Document Type: Article
Times cited : (20)

References (47)
  • 1
    • 73149113560 scopus 로고    scopus 로고
    • Projected cancer risks from computed tomographic scans performed in the United States in 2007
    • Berrington de Gonzalez, A. et al. (2009) Projected cancer risks from computed tomographic scans performed in the United States in 2007. Arch. Intern. Med., 169, 2071-2077.
    • (2009) Arch. Intern. Med. , vol.169 , pp. 2071-2077
    • Berrington de Gonzalez, A.1
  • 2
    • 36549007486 scopus 로고    scopus 로고
    • Computed tomography-an increasing source of radiation exposure
    • Brenner, D.J. et al. (2007) Computed tomography-an increasing source of radiation exposure. N. Engl. J. Med., 357, 2277-2284.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2277-2284
    • Brenner, D.J.1
  • 3
    • 33746604073 scopus 로고    scopus 로고
    • Cancer risks following diagnostic and therapeutic radiation exposure in children
    • Kleinerman, R.A. (2006) Cancer risks following diagnostic and therapeutic radiation exposure in children. Pediatr. Radiol., 36 (suppl 2), 121-125.
    • (2006) Pediatr. Radiol. , vol.36 , Issue.SUPPL 2 , pp. 121-125
    • Kleinerman, R.A.1
  • 4
    • 2142650712 scopus 로고    scopus 로고
    • Health risks of low dose ionizing radiation in humans: a review
    • (Maywood)
    • Prasad, K.N. et al. (2004) Health risks of low dose ionizing radiation in humans: a review. Exp. Biol. Med. (Maywood), 229, 378-382.
    • (2004) Exp. Biol. Med. , vol.229 , pp. 378-382
    • Prasad, K.N.1
  • 5
    • 73149110471 scopus 로고    scopus 로고
    • Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer
    • Smith-Bindman, R. et al. (2009) Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch. Intern. Med., 169, 2078-2086.
    • (2009) Arch. Intern. Med. , vol.169 , pp. 2078-2086
    • Smith-Bindman, R.1
  • 6
    • 40949104442 scopus 로고    scopus 로고
    • The 2007 Recommendations of the International Commission on Radiological Protection
    • ICRP
    • ICRP (2007) The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. Ann. ICRP, 37, 1-332.
    • (2007) ICRP publication 103. Ann. ICRP , vol.37 , pp. 1-332
  • 8
    • 0033864575 scopus 로고    scopus 로고
    • Radiation-related cancer risks at low doses among atomic bomb survivors
    • Pierce, D.A. et al. (2000) Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat. Res., 154, 178-186.
    • (2000) Radiat. Res. , vol.154 , pp. 178-186
    • Pierce, D.A.1
  • 9
    • 0141764894 scopus 로고    scopus 로고
    • Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950-1997
    • Preston, D.L. et al. (2003) Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950-1997. Radiat. Res., 160, 381-407.
    • (2003) Radiat. Res. , vol.160 , pp. 381-407
    • Preston, D.L.1
  • 10
    • 34249696084 scopus 로고    scopus 로고
    • The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry: estimates of radiationrelated cancer risks
    • Cardis, E. et al. (2007) The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry: estimates of radiationrelated cancer risks. Radiat. Res., 167, 396-416.
    • (2007) Radiat. Res. , vol.167 , pp. 396-416
    • Cardis, E.1
  • 11
    • 58149240065 scopus 로고    scopus 로고
    • Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers
    • Muirhead, C.R. et al. (2009) Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br. J. Cancer, 100, 206-212.
    • (2009) Br. J. Cancer , vol.100 , pp. 206-212
    • Muirhead, C.R.1
  • 12
    • 34548581922 scopus 로고    scopus 로고
    • Solid cancer incidence in atomic bomb survivors: 1958-1998
    • Preston, D.L. et al. (2007) Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat. Res., 168, 1-64.
    • (2007) Radiat. Res. , vol.168 , pp. 1-64
    • Preston, D.L.1
  • 13
    • 67749103618 scopus 로고    scopus 로고
    • Assessing cancer risks of low-dose radiation
    • Mullenders, L. et al. (2009) Assessing cancer risks of low-dose radiation. Nat. Rev. Cancer, 9, 596-604.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 596-604
    • Mullenders, L.1
  • 14
    • 0003582936 scopus 로고    scopus 로고
    • Genetic susceptibility to cancer. ICRP publication 79. Approved by the Commission in May 1997. International Commission on Radiological Protection
    • ICRP
    • ICRP (1998) Genetic susceptibility to cancer. ICRP publication 79. Approved by the Commission in May 1997. International Commission on Radiological Protection. Ann. ICRP, 28, 1-157.
    • (1998) Ann. ICRP , vol.28 , pp. 1-157
  • 15
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale, J. et al. (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature, 411, 349-354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1
  • 16
    • 11844301282 scopus 로고    scopus 로고
    • Medulloblastoma: developmental mechanisms out of control
    • Marino, S. (2005) Medulloblastoma: developmental mechanisms out of control. Trends Mol. Med., 11, 17-22.
    • (2005) Trends Mol. Med. , vol.11 , pp. 17-22
    • Marino, S.1
  • 17
    • 20444468917 scopus 로고    scopus 로고
    • Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics
    • Romer, J. et al. (2005) Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res., 65, 4975-4978.
    • (2005) Cancer Res. , vol.65 , pp. 4975-4978
    • Romer, J.1
  • 18
    • 0033525812 scopus 로고    scopus 로고
    • Patient described by Chun et al. may not present Antley-Bixler syndrome
    • Gorlin, R.J. (1999) Patient described by Chun et al. may not present Antley-Bixler syndrome. Am. J. Med. Genet., 83, 64.
    • (1999) Am. J. Med. Genet. , vol.83 , pp. 64
    • Gorlin, R.J.1
  • 19
    • 0012472092 scopus 로고
    • Multiple basal cell epitheliomas in a 5 year old child
    • Scharnagel, I.M. et al. (1949) Multiple basal cell epitheliomas in a 5 year old child. Am. J. Dis. Child., 77, 647-51.
    • (1949) Am. J. Dis. Child. , vol.77 , pp. 647-651
    • Scharnagel, I.M.1
  • 20
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich, L.V. et al. (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science, 277, 1109-1113.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1
  • 21
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn, H. et al. (1998) Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat. Med., 4, 619-622.
    • (1998) Nat. Med. , vol.4 , pp. 619-622
    • Hahn, H.1
  • 22
    • 61349116190 scopus 로고    scopus 로고
    • Physical, heritable and age-related factors as modifiers of radiation cancer risk in patched heterozygous mice
    • Pazzaglia, S. et al. (2009) Physical, heritable and age-related factors as modifiers of radiation cancer risk in patched heterozygous mice. Int. J. Radiat. Oncol. Biol. Phys., 73, 1203-1210.
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.73 , pp. 1203-1210
    • Pazzaglia, S.1
  • 23
    • 33748426636 scopus 로고    scopus 로고
    • Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice
    • Pazzaglia, S. et al. (2006) Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice. Oncogene, 25, 5575-5580.
    • (2006) Oncogene , vol.25 , pp. 5575-5580
    • Pazzaglia, S.1
  • 24
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang, Z.J. et al. (2008)Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell, 14, 135-145.
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1
  • 25
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K.J. et al. (2001) Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1
  • 26
    • 0015043748 scopus 로고
    • Mutation and cancer: statistical study of retinoblastoma
    • Knudson, A.G. Jr. (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA, 68, 820-823.
    • (1971) Proc. Natl Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson A.G., Jr.1
  • 27
    • 0029919109 scopus 로고    scopus 로고
    • Hereditary cancer: two hits revisited
    • Knudson, A.G. (1996) Hereditary cancer: two hits revisited. J. Cancer Res. Clin. Oncol., 122, 135-140.
    • (1996) J. Cancer Res. Clin. Oncol. , vol.122 , pp. 135-140
    • Knudson, A.G.1
  • 28
    • 0038630797 scopus 로고    scopus 로고
    • Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells
    • Ciani, E. et al. (2003) Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells. Brain Res. Dev. Brain Res., 142, 193-202.
    • (2003) Brain Res. Dev. Brain Res. , vol.142 , pp. 193-202
    • Ciani, E.1
  • 29
    • 0028181828 scopus 로고
    • Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation
    • Constam, D.B. et al. (1994) Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation. Eur. J. Neurosci., 6, 766-778.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 766-778
    • Constam, D.B.1
  • 30
    • 1842831283 scopus 로고    scopus 로고
    • Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers
    • Kho, A.T. et al. (2004) Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev., 18, 629-640.
    • (2004) Genes Dev. , vol.18 , pp. 629-640
    • Kho, A.T.1
  • 31
    • 34047263220 scopus 로고    scopus 로고
    • Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    • Zindy, F. et al. (2007) Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res., 67, 2676-2684.
    • (2007) Cancer Res. , vol.67 , pp. 2676-2684
    • Zindy, F.1
  • 32
    • 60549090233 scopus 로고    scopus 로고
    • Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency
    • Frappart, P.O. et al. (2009) Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc. Natl Acad. Sci. USA, 106, 1880-1885.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1880-1885
    • Frappart, P.O.1
  • 33
    • 33748441548 scopus 로고    scopus 로고
    • Microarray comparative genomic hybridization reveals genome-wide patterns of DNA gains and losses in post-Chernobyl thyroid cancer
    • Kimmel, R.R. et al. (2006) Microarray comparative genomic hybridization reveals genome-wide patterns of DNA gains and losses in post-Chernobyl thyroid cancer. Radiat. Res., 166, 519-531.
    • (2006) Radiat. Res. , vol.166 , pp. 519-531
    • Kimmel, R.R.1
  • 34
    • 0033935588 scopus 로고    scopus 로고
    • Loss of heterozygosity in spontaneous and X-rayinduced intestinal tumors arising in F1 hybrid min mice: evidence for sequential loss of APC(+) and Dpc4 in tumor development
    • Haines, J. et al. (2000) Loss of heterozygosity in spontaneous and X-rayinduced intestinal tumors arising in F1 hybrid min mice: evidence for sequential loss of APC(+) and Dpc4 in tumor development. Genes Chromosomes Cancer, 28, 387-394.
    • (2000) Genes Chromosomes Cancer , vol.28 , pp. 387-394
    • Haines, J.1
  • 35
    • 28344456401 scopus 로고    scopus 로고
    • Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice
    • Mao, J.H. et al. (2005) Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene, 24, 7924-7934.
    • (2005) Oncogene , vol.24 , pp. 7924-7934
    • Mao, J.H.1
  • 36
    • 0033817818 scopus 로고    scopus 로고
    • Radiation-associated loss of heterozygosity at the Zna1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas
    • Shimada, Y. et al. (2000) Radiation-associated loss of heterozygosity at the Zna1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. Radiat. Res., 154, 293-300.
    • (2000) Radiat. Res. , vol.154 , pp. 293-300
    • Shimada, Y.1
  • 37
    • 33745924129 scopus 로고    scopus 로고
    • Array-CGH analyses of murine malignant lymphomas: genomic clues to understanding the effects of chronic exposure to low-dose-rate gamma rays on lymphomagenesis
    • Takabatake, T. et al. (2006) Array-CGH analyses of murine malignant lymphomas: genomic clues to understanding the effects of chronic exposure to low-dose-rate gamma rays on lymphomagenesis. Radiat. Res., 166, 61-72.
    • (2006) Radiat. Res. , vol.166 , pp. 61-72
    • Takabatake, T.1
  • 38
    • 33750480568 scopus 로고    scopus 로고
    • Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations
    • Mizuno, T. et al. (2006) Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations. Carcinogenesis, 27, 2286-2294.
    • (2006) Carcinogenesis , vol.27 , pp. 2286-2294
    • Mizuno, T.1
  • 39
    • 0028956518 scopus 로고
    • Molecular analysis of gamma-ray-induced mutations at the hprt locus in primary human skin fibroblasts by multiplex polymerase chain reaction
    • Park, M.S. et al. (1995) Molecular analysis of gamma-ray-induced mutations at the hprt locus in primary human skin fibroblasts by multiplex polymerase chain reaction. Radiat. Res., 141, 11-18.
    • (1995) Radiat. Res. , vol.141 , pp. 11-18
    • Park, M.S.1
  • 40
    • 0036494714 scopus 로고    scopus 로고
    • Tissue-specific deletion and discontinuous loss of heterozygosity are signatures for the mutagenic effects of ionizing radiation in solid tissues
    • Ponomareva, O.N. et al. (2002) Tissue-specific deletion and discontinuous loss of heterozygosity are signatures for the mutagenic effects of ionizing radiation in solid tissues. Cancer Res., 62, 1518-1523.
    • (2002) Cancer Res. , vol.62 , pp. 1518-1523
    • Ponomareva, O.N.1
  • 41
    • 0037157223 scopus 로고    scopus 로고
    • Radiation-induced genetic instability in vivo depends on p53 status
    • Liang, L. et al. (2002) Radiation-induced genetic instability in vivo depends on p53 status. Mutat. Res., 502, 69-80.
    • (2002) Mutat. Res. , vol.502 , pp. 69-80
    • Liang, L.1
  • 42
    • 0347383877 scopus 로고    scopus 로고
    • Genetic interactions between Pten and p53 in radiation-induced lymphoma development
    • Mao, J.H. et al. (2003) Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene, 22, 8379-8385.
    • (2003) Oncogene , vol.22 , pp. 8379-8385
    • Mao, J.H.1
  • 43
    • 42949166333 scopus 로고    scopus 로고
    • Analysis of changes in DNA copy number in radiation-induced thymic lymphomas of susceptible C57BL/6, resistant C3H and hybrid F1 mice
    • Takabatake, T. et al. (2008) Analysis of changes in DNA copy number in radiation-induced thymic lymphomas of susceptible C57BL/6, resistant C3H and hybrid F1 mice. Radiat. Res., 169, 426-436.
    • (2008) Radiat. Res. , vol.169 , pp. 426-436
    • Takabatake, T.1
  • 44
    • 0036204339 scopus 로고    scopus 로고
    • Spectrum of Zna1(Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice
    • Kakinuma, S. et al. (2002) Spectrum of Zna1(Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice. Radiat. Res., 157, 331-340.
    • (2002) Radiat. Res. , vol.157 , pp. 331-340
    • Kakinuma, S.1
  • 45
    • 77649179938 scopus 로고    scopus 로고
    • Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas
    • Yamaguchi, Y. et al. (2010) Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas. Mutat. Res., 686, 30-38.
    • (2010) Mutat. Res. , vol.686 , pp. 30-38
    • Yamaguchi, Y.1
  • 46
    • 33644529131 scopus 로고    scopus 로고
    • Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice
    • Pazzaglia, S. et al. (2006) Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice. Oncogene, 25, 1165-1173.
    • (2006) Oncogene , vol.25 , pp. 1165-1173
    • Pazzaglia, S.1
  • 47
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • Kool, M. et al. (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One, 3, e3088.
    • (2008) PLoS One , vol.3
    • Kool, M.1


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