Analysis of changes in DNA copy number in radiation-induced thymic lymphomas of susceptible C57BL/6, resistant C3H and hybrid F1 mice

Radiation Research

Volumn 169, Issue 4, 2008, Pages 426-436

  Takabatake, Takashi ^a,b   Kakinuma, Shizuko ^b   Hirouchi, Tokuhisa ^a   Nakamura, Masako M ^c   Fujikawa, Katsuyoshi ^a   Nishimura, Mayumi ^b   Oghiso, Yoichi ^a   Shimada, Yoshiya ^b   Tanaka, Kimio ^a  

^a INSTITUTE FOR ENVIRONMENTAL SCIENCES   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c Tohoku Environmental Sciences Services Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CHROMOSOME 10; CHROMOSOME 14; CHROMOSOME 15; CHROMOSOME 16; CHROMOSOME 5; COMPARATIVE GENOMIC HYBRIDIZATION; DNA DETERMINATION; FEMALE; GENE DELETION; GENE FREQUENCY; GENE LOCUS; GENE NUMBER; HETEROZYGOSITY LOSS; HYBRID; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RADIATION INDUCED THYMUS LYMPHOMA; THYMUS LYMPHOMA; TRISOMY;

ANIMALS; DISEASE SUSCEPTIBILITY; FEMALE; GENE DOSAGE; IMMUNOPHENOTYPING; LOSS OF HETEROZYGOSITY; LYMPHOMA; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NEOPLASMS, RADIATION-INDUCED; NUCLEIC ACID HYBRIDIZATION; SPECIES SPECIFICITY; THYMUS NEOPLASMS;

MUS;

EID: 42949166333     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1180.1     Document Type: Article

References (40)

1. K. A. Frazer, E. Eskin, H. M. Kang, M. A. Bogue, D. A. Hinds, E. J. Beilharz, R. V. Gupta, J. Montgomery, M. M. Morenzoni and D. R. Cox, A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448, 1050-1053 (2007).
2. E. K. Cho, J. Tchinda, J. L. Freeman, Y-J. Chung, W. W. Cai and C. Lee, Array-based comparative genomic hybridization and copy number variation in cancer research. Cytogenet. Genome Res. 115, 262-272 (2006).
3. T. A. Dragani, 10 years of mouse cancer modifier loci: human relevance. Cancer Res. 63, 3011-3018 (2003).
4. J. Santos, I. Pérez de Castro, M. Herranz, A. Pellicer and J. Fernández-Piqueras, Allelic losses on chromosome 4 suggest the existence of a candidate tumor suppressor gene region of about 0.6 cM in γ-radiation-induced mouse primary thymic lymphomas. Oncogene 12, 669-676 (1996).
5. J. Santos, M. Herranz, I. Pérez de Castro, A. Pellicer and J. Fernández-Piqueras, A new candidate site for a tumor suppressor gene involved in mouse thymic lymphomagenesis is located on the distal part of chromosome 4. Oncogene 17, 925-929 (1998).
6. M. Okumoto, C. W. Song, K. Tabata, M. Ishibashi, N. Mori, Y. G. Park, R. Kominami, Y. Matsumoto, Y. Takamori and K. Esaki, Putative tumor suppressor gene region within 0.85 cM on chromosome 12 in radiation-induced murine lymphomas. Mol. Carcinog. 22, 175-181 (1998).
7. M. Okumoto, Y. G. Park, C. W. Song and N. Mori, Frequent loss of heterozygosity on chromosomes 4, 12 and 19 in radiation-induced lymphomas in mice. Cancer Lett. 135, 223-228 (1999).
8. Y. Matsumoto, S. Kosugi, T. Shinbo, D. Chou, M. Ohashi, Y. Wakabayashi, K. Sakai, M. Okumoto, N. Mori and R. Kominami, Allelic loss analysis of γ-ray-induced mouse thymic lymphomas: two candidate tumor suppressor gene loci on chromosomes 12 and 16. Oncogene 16, 2747-2754 (1998).
9. B. Meléndez, J. Santos and J. Fernández-Piqueras, Loss of heterozygosity at the proximal-mid part of mouse chromosome 4 defines two novel tumor suppressor gene loci in T-cell lymphomas. Oncogene 18, 4166-4169 (1999).
10. H. Okano, Y. Saito, T. Miyazawa, T. Shinbo, D. Chou, S. Kosugi, Y. Takahashi, S. Odani, O. Niwa and R. Kominami, Homozygous deletions and point mutations of the Ikaros gene in gamma-ray-induced mouse thymic lymphomas. Oncogene 18, 6677-6683 (1999).
11. Y. Shimada, M. Nishimura, S. Kakinuma, M. Okumoto, T. Shiroishi, K. H. Clifton and S. Wakana, Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. Radiat. Res. 154, 293-300 (2000).
12. Y. Wakabayashi, J. Inoue, Y. Takahashi, A. Matsuki, H. Kosugi-Okano, T. Shinbo, Y. Mishima, O. Niwa and R. Kominami, Homozygous deletions and point mutations of the Rit1/Bcl11b gene in γ-ray induced mouse thymic lymphomas. Biochem. Biophys. Res. Commun. 301, 598-603 (2003).
13. A. G. Knudson, Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68, 820-823 (1971).
14. A. G. Knudson, Hereditary cancer: two hits revisited. J. Cancer Res. Clin. Oncol. 122, 135-140 (1996).
15. S. Kakinuma, M. Nishimura, S. Sasanuma, K. Mita, G. Suzuki, Y. Katsura, T. Sado and Y. Shimada, Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice. Radiat. Res. 157, 331-340 (2002).
16. S. Kakinuma, Y. Kodama, Y. Amasaki, S. Yi, Y. Tokairin, M. Arai, M. Nishimura, M. Monobe, S. Kojima and Y. Shimada, Ikaros is a mutational target for lymphomagenesis in Mlh1-deficient mice. Oncogene 26, 2945-2949 (2006).
17. J. Sakata, J. Inoue, H. Ohi, H. Kosugi-Okano, Y. Mishima, K. Hatakeyama, O. Niwa and R. Kominami, Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in γ-ray-induced thymic lymphomas and in normal thymus of the mouse. Carcinogenesis 25, 1069-1075 (2004).
18. INK4a alterations in murine primary T-cell lymphomas. Oncogene 14, 1361-1370 (1997).
19. INK4b 3′-untranslated region interferes with its transcriptional regulation in primary lymphomas. Oncogene 18, 385-396 (1999).
20. H. J. Cleary, E. Boulton and M. Plumb, Allelic loss and promoter hypermethylation of the p15INK4b gene features in mouse radiation-induced lymphoid - but not myeloid - leukaemias. Leukemia 13, 2049-2052 (1999).
21. W. W. Cai, J. H. Mao, C. W. Chow, S. Damani, A. Balmain and A. Bradley, Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat. Biotechnol. 20, 393-396 (2002).
22. J. H. Mao, J. Li, T. Jiang, Q. Li, D. Wu, J. Perez-Losada, R. DelRosario, L. Peterson, A. Balmain and W. W. Cai, Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene 24, 7924-7934 (2005).
23. H. M. Kang, J. J. Jang, C. Langford, S. H. Shin, S. Y. Park and Y. J. Chung, DNA copy number alterations and expression of relevant genes in mouse thymic lymphomas induced by γ-irradiation and N-methyl-N-nitrosourea. Cancer Genet. Cytogenet. 166, 27-35 (2006).
24. S. Kakinuma, Y. Shang, Y. Amasaki, K. Nojima, M. Monobe, T. Imaoka, M. Nishimura and Y. Shimada, Influence of genetic background on RBE of carbon ions for tumor induction. Biol. Sci. Space 18, 190 (2005).
25. T. Takabatake, K. Fujikawa, S. Tanaka, T. Hirouchi, M. Nakamura, S. Nakamura, I. Braga-Tanaka, K. Ichinohe and K. Tanaka, Array-CGH analyses of murine malignant lymphomas: Genomic clues to understanding the effects of chronic exposure to low-dose-rate gamma rays on lymphomagenesis. Radiat. Res. 166, 61-72 (2006).
26. Y. Shimada, M. Nishimura, S. Kakinuma, T. Ogiu, H. Fujimoto, A. Kubo, J. Nagai, K. Kobayashi, K. Tano and K. K. Bhakat, Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea. Int. J. Radiat. Biol. 79, 423-430 (2003).
27. H. Szymanska, M. Sitarz, E. Krysiak, J. Piskorowska, A. Czarnomska, H. Skurzak, A. A. Hart, D. de Jong and P. Demant, Genetics of susceptibility to radiation-induced lymphomas, leukemias and lung tumors studied in recombinant congenic strains. Int. J. Cancer 83, 674-678 (1999).
28. A. Matsuki, H. Kosugi-Okano, Y. Ochiai, Si. Kosugi, T. Miyazawa, Y. Wakabayashi, K. Hatakeyama, O. Niwa and R. Kominami, Allelic loss mapping and physical delineation of a region harboring a thymic lymphoma suppressor gene on mouse chromosome 16. Biochem. Biophys. Res. Commun. 282, 16-20 (2001).
29. J. Santos, M. Herranz, M. Fernández, C. Vaquero, P. López and J. Fernández-Piqueras, Evidence of a possible epigenetic inactivation mechanism operating on a region of mouse chromosome 19 in γ-radiation- induced thymic lymphomas. Oncogene 20, 2186-2189 (2001).
30. H. Piper, S. Litwin and R. Mehr, Models for antigen receptor gene rearrangement. II. Multiple rearrangement in the TCR: allelic exclusion or inclusion? J. Immunol. 163, 1799-1808 (1999).
31. H. Tsuji, H. Ishii-Ohba, T. Katsube, H. Ukai, S. Aizawa, M. Doi, K. Hioki and T. Ogiu, Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas. Cancer Res. 64, 8882-8890 (2004).
32. R. Marculescu, T. Le, P. Simon, U. Jaeger and B. Nadel, V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites. J. Exp. Med. 195, 85-98 (2002).
33. Y. Kitagawa, K. Inoue, S. Sasaki, Y. Hayashi, Y. Matsuo, M. R. Lieber, H. Mizoguchi, J. Yokota and T. Kohno, Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia. J. Biol. Chem. 277, 46289-46297 (2002).
34. G. Hodgson, J. H. Hager, S. Volik, S. Hariono, M. Wernick, D. Moore, N. Nowak, D. G. Albertson, D. Pinkel and J. W. Gray, Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nat. Genet. 29, 459-464 (2001).
35. H. Ohi, Y. Mishima, K. Kamimura, M. Maruyama, K. Sasai and R. Kominami, Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after γ-irradiation. Oncogene 26, 5280-5289 (2007).
36. N. Mori, Y. Matsumoto, M. Okumoto, N. Suzuki and J. Yamate, Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene 20, 3609-3619 (2001).
37. J. Santos, X. Montagutelli, A. Acevedo, P. López, C. Vaquero, M. Fernández, M-R. Arnau, M. Szatanik, E. Salido and J. Fernández- Piqueras, A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene 21, 6680-6683 (2002).
38. M. Villa-Morales, J. Santos and J. Fernández-Piqueras, Functional Fas (Cd95/Apo-1) promoter polymorphisms in inbred mouse strains exhibiting different susceptibility to gamma-radiation-induced thymic lymphoma. Oncogene 25, 2022-2029 (2006).
39. M. A. Yoshida, A. Nakata, M. Akiyama, S. Kakinuma, T. Sado, M. Nishimura and Y. Shimada, Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas. Cancer Genet. Cytogenet. 179, 1-10 (2007).
40. 1 hybrid mice. J. Radiat. Res. 43, 187-194 (2002).